ES2161879T3 - Nuevos compuestos benzisoselen-azolin y -azina, su procedimiento de preparacion y sus aplicaciones terapeuticas. - Google Patents

Nuevos compuestos benzisoselen-azolin y -azina, su procedimiento de preparacion y sus aplicaciones terapeuticas.

Info

Publication number
ES2161879T3
ES2161879T3 ES95916723T ES95916723T ES2161879T3 ES 2161879 T3 ES2161879 T3 ES 2161879T3 ES 95916723 T ES95916723 T ES 95916723T ES 95916723 T ES95916723 T ES 95916723T ES 2161879 T3 ES2161879 T3 ES 2161879T3
Authority
ES
Spain
Prior art keywords
sup
azina
new
benzisoselen
azolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95916723T
Other languages
English (en)
Inventor
Irene Erdelmeier
Jean Chaudiere
Marc Moutet
Jean-Claude Yadan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxis Isle of Man Ltd
Original Assignee
Oxis Isle of Man Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxis Isle of Man Ltd filed Critical Oxis Isle of Man Ltd
Application granted granted Critical
Publication of ES2161879T3 publication Critical patent/ES2161879T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
    • C07D293/10—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D293/00—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms
    • C07D293/10—Heterocyclic compounds containing rings having nitrogen and selenium or nitrogen and tellurium, with or without oxygen or sulfur atoms, as the ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D293/12—Selenazoles; Hydrogenated selenazoles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS DERIVADOS DE BENZISOSELENAZOLINA Y AZINA. ESTOS NUEVOS DERIVADOS RESPONDE A LA FORMULA GENERAL (II), EN LA QUE : R{SUP, 1} A R{SUP,8) TIENEN DIVERSAS REPRESENTACIONES Y EN PARTICULAR H, ALKILO, ETC; R{SUP,9} = (A), Y{SUP-} REPRESENTA EL ANION DE UN ACIDO FARMACEUTICAMENTE ACEPTABLE; N = 0, 1; M= 0,1,2: P = 1,2,3; Q = 2,3,4; R = 0,1; Y SUS SALES DE ACIDOS O BASES FARMACEUTICAMENTE ACEPTABLES SABIENDO QUE NO PUEDE HABER A LO SUMO MAS QUE UN SOLO SUSTITUYENTE R{SUP,9} EN EL SENO DE CADA MOLECULA QUE RESPONDE A LA FORMULA GENERAL (I). ESTOS NUEVOS DERIVADOS SON UTILES COMO MEDICAMENTO.
ES95916723T 1994-04-07 1995-04-07 Nuevos compuestos benzisoselen-azolin y -azina, su procedimiento de preparacion y sus aplicaciones terapeuticas. Expired - Lifetime ES2161879T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9404107A FR2718441B1 (fr) 1994-04-07 1994-04-07 Nouveaux composés de structure benzisoséléna-zoline et -zine, leur procédé de préparation et leurs applications thérapeutiques.

Publications (1)

Publication Number Publication Date
ES2161879T3 true ES2161879T3 (es) 2001-12-16

Family

ID=9461850

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95916723T Expired - Lifetime ES2161879T3 (es) 1994-04-07 1995-04-07 Nuevos compuestos benzisoselen-azolin y -azina, su procedimiento de preparacion y sus aplicaciones terapeuticas.

Country Status (10)

Country Link
US (2) US5968920A (es)
EP (1) EP0701554B1 (es)
JP (1) JP4044133B2 (es)
AU (1) AU692542B2 (es)
CA (1) CA2164642C (es)
DE (2) DE69521465T2 (es)
DK (1) DK0701554T3 (es)
ES (1) ES2161879T3 (es)
FR (1) FR2718441B1 (es)
WO (1) WO1995027706A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2751328B1 (fr) * 1996-07-17 1998-10-09 Oxis International Sa Utilisation de nouveaux composes organoselenies comme agents pro-oxydants ainsi que leurs procedes de preparation et des compositions pharmaceutiques en comportant application
AU727067B2 (en) * 1996-07-17 2000-11-30 Oxis Isle Of Man, Limited Use of novel organoselenium compounds as pro-oxidizing agents, their methods of preparation and pharmaceutical compositions and application thereof
US6407083B1 (en) 1996-07-17 2002-06-18 Oxis International, Inc. Uses of novel organoselenium compounds with pro-oxidant activity
FR2757860B1 (fr) * 1996-12-27 1999-04-23 Oxis International Sa Composes organoselenies cycliques, leur preparation et leurs utilisations, notamment therapeutiques
FR2757857B1 (fr) * 1996-12-27 1999-04-23 Oxis International Sa Diselenures et selenosulfures aromatiques, leur preparation et leurs utilisations, notamment therapeutiques
PT1393277E (pt) * 2001-05-21 2006-09-29 Alcon Inc Utilizacao de inibidores de nf-kb para tratar disturbios de olho seco
US20080234283A1 (en) * 2007-02-16 2008-09-25 Noah Berkowitz Glutathione peroxidase mimetics for treatment of neurodegenerative, pulmonary and inflammatory diseases
US20080207679A1 (en) * 2007-02-16 2008-08-28 Noah Berkowitz Glutathione peroxidase mimetics for the treatment of dermatoses
EP2220208A4 (en) * 2007-11-23 2010-12-29 Rappaport Family Inst For Res USE OF HAPTOGLOBIN GENOTYPING IN THE DIAGNOSIS AND TREATMENT OF CARDIOVASCULAR DISEASE
KR102023339B1 (ko) * 2012-07-25 2019-09-20 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 조직 보존액 및 조직 보존 방법
US10058542B1 (en) 2014-09-12 2018-08-28 Thioredoxin Systems Ab Composition comprising selenazol or thiazolone derivatives and silver and method of treatment therewith
CN106866581B (zh) 2015-12-14 2020-06-02 杭州健昵福生物科技有限公司 一种具有药物活性的1，3，4-硒二唑类化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3027074A1 (de) * 1980-07-17 1982-02-18 A. Nattermann & Cie GmbH, 5000 Köln Benzisoselenazolon enthaltende pharmazeutische praeparate und ihre verwendung
DE3407511A1 (de) * 1984-03-01 1985-09-05 A. Nattermann & Cie GmbH, 5000 Köln Benzisoselenazolthione, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3444135A1 (de) * 1984-12-04 1986-06-05 A. Nattermann & Cie GmbH, 5000 Köln Selenoxide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
FR2669633B1 (fr) * 1990-11-23 1993-01-22 Adir Nouveaux derives de la benzoselenazolinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
JPH11501005A (ja) 1999-01-26
WO1995027706A1 (fr) 1995-10-19
FR2718441A1 (fr) 1995-10-13
EP0701554A1 (fr) 1996-03-20
DK0701554T3 (da) 2001-10-08
AU692542B2 (en) 1998-06-11
US6093532A (en) 2000-07-25
DE69521465D1 (de) 2001-08-02
DE69521465T2 (de) 2002-05-29
EP0701554B1 (fr) 2001-06-27
FR2718441B1 (fr) 1996-06-28
US5968920A (en) 1999-10-19
DE701554T1 (de) 1996-10-10
JP4044133B2 (ja) 2008-02-06
AU2311195A (en) 1995-10-30
CA2164642C (en) 2008-03-25
CA2164642A1 (en) 1995-10-19

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