ATE204268T1 - Diarylmethylidenefuran-derivate, verfahren zu deren herstellung und ihre verwendungen in therapie - Google Patents

Diarylmethylidenefuran-derivate, verfahren zu deren herstellung und ihre verwendungen in therapie

Info

Publication number
ATE204268T1
ATE204268T1 AT97919476T AT97919476T ATE204268T1 AT E204268 T1 ATE204268 T1 AT E204268T1 AT 97919476 T AT97919476 T AT 97919476T AT 97919476 T AT97919476 T AT 97919476T AT E204268 T1 ATE204268 T1 AT E204268T1
Authority
AT
Austria
Prior art keywords
therapy
production
diarylmethylidenefuran derivatives
diarylmethylidenefuran
derivatives
Prior art date
Application number
AT97919476T
Other languages
English (en)
Inventor
Eric Nicolai
Jean-Marie Teulon
Original Assignee
Union Pharma Scient Appl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Union Pharma Scient Appl filed Critical Union Pharma Scient Appl
Application granted granted Critical
Publication of ATE204268T1 publication Critical patent/ATE204268T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychiatry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT97919476T 1996-04-04 1997-04-03 Diarylmethylidenefuran-derivate, verfahren zu deren herstellung und ihre verwendungen in therapie ATE204268T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9604236A FR2747123B1 (fr) 1996-04-04 1996-04-04 Nouveaux derives diarylmethylidene tetrahydrofurane, leurs procedes de preparation, et leurs utilisations en therapeutique
FR9607922A FR2747124B1 (fr) 1996-04-04 1996-06-26 Nouveaux derives diarylmethylidene furaniques, leurs procedes de preparation et leurs utilisations en therapeutique
PCT/FR1997/000602 WO1997037984A1 (fr) 1996-04-04 1997-04-03 Nouveaux derives diarylmethylidene furaniques, leurs procedes de preparation et leurs utilisations en therapeutique

Publications (1)

Publication Number Publication Date
ATE204268T1 true ATE204268T1 (de) 2001-09-15

Family

ID=9490907

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97919476T ATE204268T1 (de) 1996-04-04 1997-04-03 Diarylmethylidenefuran-derivate, verfahren zu deren herstellung und ihre verwendungen in therapie

Country Status (28)

Country Link
EP (1) EP0891345B1 (de)
JP (1) JP2000508638A (de)
KR (1) KR20000005146A (de)
CN (1) CN1215396A (de)
AR (1) AR006539A1 (de)
AT (1) ATE204268T1 (de)
AU (1) AU717146B2 (de)
BG (1) BG62808B1 (de)
BR (1) BR9708510A (de)
CA (1) CA2248949A1 (de)
CZ (1) CZ318898A3 (de)
DE (1) DE69706157T2 (de)
DK (1) DK0891345T3 (de)
EE (1) EE03687B1 (de)
ES (1) ES2162678T3 (de)
FR (2) FR2747123B1 (de)
GE (1) GEP20032924B (de)
IL (1) IL126105A (de)
NO (1) NO984624L (de)
NZ (1) NZ331672A (de)
PL (1) PL329213A1 (de)
PT (1) PT891345E (de)
RU (1) RU2189979C2 (de)
SI (1) SI0891345T1 (de)
SK (1) SK283292B6 (de)
TW (1) TW353660B (de)
WO (1) WO1997037984A1 (de)
ZA (1) ZA972894B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180651B1 (en) * 1996-04-04 2001-01-30 Bristol-Myers Squibb Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics
WO1998043966A1 (en) * 1997-04-02 1998-10-08 Merck Frosst Canada & Co. Alpha-methylene gamma lactones as selective cyclooxygenase-2 inhibitors
FR2775477B1 (fr) * 1998-02-27 2000-05-19 Union Pharma Scient Appl Nouveaux derives diarylmethylene heterocycliques, leurs procedes de preparation et leurs utilisations en therapeutique
CN1106392C (zh) * 2000-10-24 2003-04-23 中国科学院上海有机化学研究所 一种β位不含取代基的丁烯酸内酯及其合成的方法
CN102579427A (zh) * 2002-11-05 2012-07-18 马格纳化学国际实验室公司 合成的内酯制剂及其使用方法
WO2004087644A1 (en) * 2003-03-31 2004-10-14 Council Of Scientific And Industrial Research Mercapto-phenyl-naphthyl-methane derivatives and preparation thereof
AU2004237439B2 (en) 2003-05-07 2009-09-10 Osteologix A/S Treating cartilage/bone conditions with water-soluble strontium salts
US8779168B2 (en) * 2010-12-16 2014-07-15 Transitions Optical, Inc. Lactone compounds and materials made therefrom
WO2022195579A1 (en) 2021-03-15 2022-09-22 Saul Yedgar Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69406903T2 (de) * 1993-01-15 1998-04-09 Searle & Co 3,4-diarylthiophene und analoga davon, sowie deren verwendung als entzündungshemmende mittel
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5585504A (en) * 1994-09-16 1996-12-17 Merck & Co., Inc. Process of making cox-2 inhibitors having a lactone bridge

Also Published As

Publication number Publication date
NO984624D0 (no) 1998-10-02
AR006539A1 (es) 1999-09-08
BR9708510A (pt) 1999-08-03
FR2747124A1 (fr) 1997-10-10
KR20000005146A (ko) 2000-01-25
AU2393397A (en) 1997-10-29
SI0891345T1 (en) 2002-02-28
CA2248949A1 (fr) 1997-10-16
CN1215396A (zh) 1999-04-28
ZA972894B (en) 1997-11-04
EP0891345A1 (de) 1999-01-20
TW353660B (en) 1999-03-01
BG102771A (en) 1999-06-30
EE03687B1 (et) 2002-04-15
NO984624L (no) 1998-11-30
AU717146B2 (en) 2000-03-16
IL126105A (en) 2001-08-26
IL126105A0 (en) 1999-05-09
EP0891345B1 (de) 2001-08-16
NZ331672A (en) 2000-02-28
GEP20032924B (en) 2003-03-25
JP2000508638A (ja) 2000-07-11
PL329213A1 (en) 1999-03-15
DE69706157T2 (de) 2002-04-11
DE69706157D1 (de) 2001-09-20
SK137598A3 (en) 1999-02-11
FR2747123B1 (fr) 1998-06-26
WO1997037984A1 (fr) 1997-10-16
DK0891345T3 (da) 2001-12-03
EE9800333A (et) 1999-04-15
FR2747123A1 (fr) 1997-10-10
BG62808B1 (bg) 2000-08-31
CZ318898A3 (cs) 1999-01-13
SK283292B6 (sk) 2003-05-02
FR2747124B1 (fr) 1998-06-26
PT891345E (pt) 2002-02-28
ES2162678T3 (es) 2002-01-01
RU2189979C2 (ru) 2002-09-27

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UEP Publication of translation of european patent specification