ES2069500A1 - Perfeccionamientos introducidos en el objeto de la patente espa¦ola n 9201983 por "procedimiento para la obtencion de benzoxazinas utiles para la sintesis de oflexacina, levofloxacina y derivados. - Google Patents

Perfeccionamientos introducidos en el objeto de la patente espa¦ola n 9201983 por "procedimiento para la obtencion de benzoxazinas utiles para la sintesis de oflexacina, levofloxacina y derivados.

Info

Publication number
ES2069500A1
ES2069500A1 ES09302080A ES9302080A ES2069500A1 ES 2069500 A1 ES2069500 A1 ES 2069500A1 ES 09302080 A ES09302080 A ES 09302080A ES 9302080 A ES9302080 A ES 9302080A ES 2069500 A1 ES2069500 A1 ES 2069500A1
Authority
ES
Spain
Prior art keywords
levofloxacin
synthesis
ofloxacin
derivatives
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09302080A
Other languages
English (en)
Other versions
ES2069500B1 (es
Inventor
Gonzalvez Juan Carlo Carretero
Gonzalez Juan Carlos Carretero
Sanchez Mercedes Victioso
Ruano Jose Luis Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deretil SA
Original Assignee
Derivados del Etilo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Derivados del Etilo SA filed Critical Derivados del Etilo SA
Priority to US08/244,455 priority Critical patent/US5521310A/en
Priority to PCT/ES1993/000080 priority patent/WO1994007873A1/es
Priority to KR1019940701925A priority patent/KR0131914B1/ko
Priority to JP6508738A priority patent/JPH07501835A/ja
Priority to AU51118/93A priority patent/AU674542B2/en
Priority to EP93921930A priority patent/EP0619311A1/en
Priority to CA002125287A priority patent/CA2125287A1/en
Priority to ZA945098A priority patent/ZA945098B/xx
Publication of ES2069500A1 publication Critical patent/ES2069500A1/es
Application granted granted Critical
Publication of ES2069500B1 publication Critical patent/ES2069500B1/es
Priority to AU65878/96A priority patent/AU686955B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Abstract

PERFECCIONAMIENTOS INTRODUCIDOS EN EL OBJETO DE LA PATENTE ESPAÑOLA NUMERO 9201983 POR "PROCEDIMIENTO PARA LA OBTENCION DE BENZOXAZINAS UTILES PARA LA SINTESIS DE OFLOXACINA, LEVOFLOXACINA Y DERIVADOS". ESTOS PERFECCIONAMIENTOS CONSISTEN EN UTILIZAR N-HEPTANO COMO DISOLVENTE EN LAS ETAPAS DE: 1) PROTECCION DEL GRUPO AMINO DE LA 3,4-DIFLUORO-ANILINA, Y 2) METILENMALONACION DEL GRUPO AMINO DE LA 2-HIDROXI-3,4-DIFLUORO-ANILINA. ASIMISMO, SE PROPORCIONAN OTROS PERFECCIONAMIENTOS DIRIGIDOS A LA SINTESIS DE OFLOXACINA Y LEVOFLOXACINA QUE CONSISTEN EN HACER REACCIONAR EL ACIDO 9,10-DIFLUORO-3-METIL-7-OXO-2,3-DIHIDRO-7H-PIRIDO[1,2,3-DE]BENZOXAZINA-6-CARBOXILICO, RACEMATO O ISOMERO 3-(S)-, CON N-METILPIPERAZINA, A 100 C DURANTE DOS HORAS, CON LO QUE SE FORMA OFLOXACINA (A PARTIR DEL RACEMATO) O LEVOFLOXACINA. LA OFLOXACINA Y LA LEVOFLOXACINA SON AGENTES ANTIMICROBIANOS DE APLICACION EN MEDICINA Y VETERINARIA.
ES9302080A 1992-10-07 1993-10-04 Perfeccionamientos introducidos en el objeto de la patente espa¦ola n 9201983 por "procedimiento para la obtencion de benzoxazinas utiles para la sintesis de oflexacina, levofloxacina y derivados. Expired - Lifetime ES2069500B1 (es)

Priority Applications (9)

Application Number Priority Date Filing Date Title
EP93921930A EP0619311A1 (en) 1992-10-07 1993-10-06 Process for obtaining benzoxazines useful for the synthesis of ofloxacin, levofloxacin and derivatives thereof
KR1019940701925A KR0131914B1 (ko) 1992-10-07 1993-10-06 오플로옥사진, 레보플로옥사진과 이 유도체의 합성에 이용될 수 있는 벤조옥사진의 수득과정
JP6508738A JPH07501835A (ja) 1992-10-07 1993-10-06 オフロキサジン，レボフロキサジン及び誘導体の合成に使用されるベンゾキサジンの製造法
AU51118/93A AU674542B2 (en) 1992-10-07 1993-10-06 Process for obtaining benzoxazines useful for the synthesis of ofloxacin, levofloxacin and derivatives thereof
US08/244,455 US5521310A (en) 1992-10-07 1993-10-06 Process to obtain benzoxazines to be used for the synthesis of ofloxazine, levofloxazine and derivatives
CA002125287A CA2125287A1 (en) 1992-10-07 1993-10-06 Process to obtain benzoxazines to be used for the synthesis of ofloxazine, levofloxazine and derivatives
PCT/ES1993/000080 WO1994007873A1 (es) 1992-10-07 1993-10-06 Prodedimiento para la obtencion de benzoxazinas utiles para la sintesis de ofloxacina, levofloxacina y derivados
ZA945098A ZA945098B (en) 1993-10-04 1994-07-13 Process to obtain benzoxazines to be used for the synthesis of ofloxazine levofloxazine and derivatives
AU65878/96A AU686955B2 (en) 1992-10-07 1996-09-27 Process to obtain benzoxazines to be used for the synthesis of ofloxazine, levofloxazine and derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9201983A ES2055656B1 (es) 1992-10-07 1992-10-07 Procedimiento para la obtencion de benzoxazinas utiles para sintesis de ofloxacina, levofloxacina y derivados.

Publications (2)

Publication Number Publication Date
ES2069500A1 true ES2069500A1 (es) 1995-05-01
ES2069500B1 ES2069500B1 (es) 1996-03-01

Family

ID=8278329

Family Applications (2)

Application Number Title Priority Date Filing Date
ES9201983A Expired - Lifetime ES2055656B1 (es) 1992-10-07 1992-10-07 Procedimiento para la obtencion de benzoxazinas utiles para sintesis de ofloxacina, levofloxacina y derivados.
ES9302080A Expired - Lifetime ES2069500B1 (es) 1992-10-07 1993-10-04 Perfeccionamientos introducidos en el objeto de la patente espa¦ola n 9201983 por "procedimiento para la obtencion de benzoxazinas utiles para la sintesis de oflexacina, levofloxacina y derivados.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES9201983A Expired - Lifetime ES2055656B1 (es) 1992-10-07 1992-10-07 Procedimiento para la obtencion de benzoxazinas utiles para sintesis de ofloxacina, levofloxacina y derivados.

Country Status (1)

Country Link
ES (2) ES2055656B1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005504818A (ja) 2001-10-03 2005-02-17 テバ ファーマシューティカル インダストリーズ リミティド レボフロキサシンおよびその形態の調製

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8801251A1 (es) * 1985-06-20 1988-01-01 Daiichi Seiyaku Co Un procedimiento para la preparacion del acido 5(-)-9-halogeno-3-alquil-10-(4-alquil-1-piperazimil)-7-oxo-2,3-dihidro-7h-piriolo (1,2,3,-de)-1,4 benzoxalin-6-carboxilico.
EP0322815A2 (en) * 1987-12-25 1989-07-05 Daiichi Pharmaceutical Co., Ltd. Propoxybenzene derivatives and process for preparing the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3522406A1 (de) * 1985-06-22 1987-01-02 Bayer Ag Verfahren zur herstellung von 1,8-verbrueckten 4-chinolon-3-carbonsaeuren
US4826985A (en) * 1986-04-25 1989-05-02 Abbott Laboratories Intermediates for preparation of racemate and optically active ofloxacin and related derivatives
DE3639465A1 (de) * 1986-11-18 1988-05-19 Hoechst Ag Optisch aktive gyrasehemmer, ihre herstellung und verwendung als antibiotika
ES2061481T3 (es) * 1986-12-25 1994-12-16 Daiichi Seiyaku Co Derivados de 3,4-dihidrobenzoazina opticamente activos y procedimiento para la preparacion de los mismos.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8801251A1 (es) * 1985-06-20 1988-01-01 Daiichi Seiyaku Co Un procedimiento para la preparacion del acido 5(-)-9-halogeno-3-alquil-10-(4-alquil-1-piperazimil)-7-oxo-2,3-dihidro-7h-piriolo (1,2,3,-de)-1,4 benzoxalin-6-carboxilico.
EP0322815A2 (en) * 1987-12-25 1989-07-05 Daiichi Pharmaceutical Co., Ltd. Propoxybenzene derivatives and process for preparing the same

Also Published As

Publication number Publication date
ES2055656A1 (es) 1994-08-16
ES2055656B1 (es) 1995-11-16
ES2069500B1 (es) 1996-03-01

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