ES8801251A1 - Un procedimiento para la preparacion del acido 5(-)-9-halogeno-3-alquil-10-(4-alquil-1-piperazimil)-7-oxo-2,3-dihidro-7h-piriolo (1,2,3,-de)-1,4 benzoxalin-6-carboxilico. - Google Patents

Un procedimiento para la preparacion del acido 5(-)-9-halogeno-3-alquil-10-(4-alquil-1-piperazimil)-7-oxo-2,3-dihidro-7h-piriolo (1,2,3,-de)-1,4 benzoxalin-6-carboxilico.

Info

Publication number
ES8801251A1
ES8801251A1 ES556292A ES556292A ES8801251A1 ES 8801251 A1 ES8801251 A1 ES 8801251A1 ES 556292 A ES556292 A ES 556292A ES 556292 A ES556292 A ES 556292A ES 8801251 A1 ES8801251 A1 ES 8801251A1
Authority
ES
Spain
Prior art keywords
optically active
preparing
active pyridobenzoxazine
derivatives
pyridobenzoxazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556292A
Other languages
English (en)
Other versions
ES556292A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27281433&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8801251(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP60226499A external-priority patent/JPH0720946B2/ja
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Publication of ES8801251A1 publication Critical patent/ES8801251A1/es
Publication of ES556292A0 publication Critical patent/ES556292A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN COMPUESTO DE FORMULA (I). COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II) O UNO DE SUS COMPUESTOS QUELATO-BF2 CON UNA AMINA DE FORMULA (III), PARA FORMAR UN COMPUESTO DE FORMULA (I), EN LAS QUE X1 Y X2 SON HALOGENO, Y R1 Y R3 REPRESENTAN ALQUILO C1-6. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UN ACEPTOR DE ACIDO, A UNA TEMPERATURA COMPRENDIDA ENTRE 70JC Y 150JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIMICROBIANA.
ES556292A 1985-06-20 1986-06-19 Un procedimiento para la preparacion del acido 5(-)-9-halogeno-3-alquil-10-(4-alquil-1-piperazimil)-7-oxo-2,3-dihidro-7h-piriolo (1,2,3,-de)-1,4 benzoxalin-6-carboxilico. Expired ES8801251A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP13471285 1985-06-20
JP60226499A JPH0720946B2 (ja) 1985-10-11 1985-10-11 光学活性３−メチルベンゾオキサジン誘導体およびその製法
JP1649686 1986-01-28

Publications (2)

Publication Number Publication Date
ES8801251A1 true ES8801251A1 (es) 1988-01-01
ES556292A0 ES556292A0 (es) 1988-01-01

Family

ID=27281433

Family Applications (1)

Application Number Title Priority Date Filing Date
ES556292A Expired ES8801251A1 (es) 1985-06-20 1986-06-19 Un procedimiento para la preparacion del acido 5(-)-9-halogeno-3-alquil-10-(4-alquil-1-piperazimil)-7-oxo-2,3-dihidro-7h-piriolo (1,2,3,-de)-1,4 benzoxalin-6-carboxilico.

Country Status (16)

Country Link
US (3) US5053407A (es)
EP (1) EP0206283B1 (es)
KR (2) KR920010048B1 (es)
AT (1) ATE85057T1 (es)
BG (1) BG60527B2 (es)
CA (1) CA1304080C (es)
DE (2) DE3687599T2 (es)
DK (1) DK170473B1 (es)
ES (1) ES8801251A1 (es)
FI (1) FI90241C (es)
GR (1) GR861625B (es)
HK (1) HK91793A (es)
IE (1) IE59463B1 (es)
NL (1) NL980016I2 (es)
NO (1) NO166131C (es)
YU (3) YU44918B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2055656A1 (es) * 1992-10-07 1994-08-16 Etilo Derivados Procedimiento para la obtencion de benzoxazinas utiles para sintesis de ofloxacina, levofloxacina y derivados.

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE110061T1 (de) * 1986-12-25 1994-09-15 Daiichi Seiyaku Co Optisch aktive 2,3-dihydrobenzoxazinderivate und verfahren zu deren herstellung.
NO172846C (no) * 1987-12-25 1993-09-15 Daiichi Seiyaku Co Fremgangsmaate for fremstilling av 7,8-dihalogen-3-metyl-2,3-dihydro-2m-benzoksazinderivater og propoksybenzenderivater for utoevelse av fremgangsmaaten.
US5175160A (en) * 1988-08-09 1992-12-29 Daiichi Pharmaceutical Co., Ltd. Antimicrobial agent for animals
MY104139A (en) * 1988-08-09 1994-02-28 Daiichi Seiyaku Co Antimicrobial agent for animals
AU4376589A (en) * 1988-11-07 1990-05-10 Gist-Brocades N.V. Optically active benzoxazines and benzothiazines
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
FR2655545B1 (fr) 1989-12-11 1994-06-10 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
TW208013B (es) * 1990-03-01 1993-06-21 Daiichi Co Ltd
NO179912C (no) * 1990-11-28 1997-01-08 Daiichi Seiyaku Co Analogifremgangsmåte for fremstilling av et terapeutisk virksomt optisk aktivt pyridobenzoksazinderivat
EP0619311A1 (en) * 1992-10-07 1994-10-12 Derivados Del Etilo, S.A. Process for obtaining benzoxazines useful for the synthesis of ofloxacin, levofloxacin and derivatives thereof
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
ZA946853B (en) * 1993-09-10 1995-04-24 Daiichi Seiyaku Co Crystals of antimicrobial compound.
US5686095A (en) * 1995-10-23 1997-11-11 Price, Jr.; Francis W. Method of treating canker sores
PT934061E (pt) 1996-07-24 2003-10-31 Warner Lambert Co Isobutilgaba e seus derivados para o tratamento da dor
US5997893A (en) * 1998-01-20 1999-12-07 Ethicon, Inc. Alcohol based anti-microbial compositions with cosmetic appearance
US6022551A (en) * 1998-01-20 2000-02-08 Ethicon, Inc. Antimicrobial composition
US5972358A (en) * 1998-01-20 1999-10-26 Ethicon, Inc. Low tack lotion, gels and creams
US6248343B1 (en) 1998-01-20 2001-06-19 Ethicon, Inc. Therapeutic antimicrobial compositions
KR100309871B1 (ko) 1999-02-24 2001-10-29 윤종용 (-)피리도벤즈옥사진 카르복실산 유도체의 제조방법
EP1135132A2 (en) 1998-12-04 2001-09-26 Influx, Inc. Inhibitors of multidrug transporters
KR100617952B1 (ko) * 1999-03-04 2006-08-30 보령제약 주식회사 광학활성 피리도 벤즈옥사진 유도체의 제조방법
ES2409383T3 (es) 1999-09-08 2013-06-26 Daiichi Sankyo Company, Limited Proceso para producir derivado de benzoxazina y productos intermedios para la producción del mismo
KR20010103346A (ko) * 2000-05-09 2001-11-23 이후근 패각 입자와 접착제 그리고 물감을 혼합하여 그림 밑칠용재료를 제조하는 방법
JP2004518677A (ja) * 2000-12-21 2004-06-24 ファルマシア・アンド・アップジョン・カンパニー 抗菌性キノロン誘導体および細菌感染を治療するためのその使用
DE60233307D1 (de) * 2001-03-07 2009-09-24 Daiichi Sankyo Co Ltd Verfahren zur herstellung optisch aktiver propoxyanilinderivate
WO2002088411A1 (en) 2001-04-27 2002-11-07 Research Institute Of Industrial Science & Technology High manganese duplex stainless steel having superior hot workabilities and method for manufacturing thereof
AU2002341991A1 (en) 2001-10-03 2003-04-14 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
US7425628B2 (en) 2001-10-03 2008-09-16 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
KR100440192B1 (ko) * 2001-11-22 2004-07-12 이수화학 주식회사 광학 활성 퀴놀론카르복실산 유도체의 제조방법
IL162172A0 (en) * 2001-11-29 2005-11-20 Teva Pharma Methods for the purification of levofloxacin
NZ534104A (en) * 2001-12-24 2007-03-30 Teva Pharma Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
CA2495271A1 (en) * 2002-08-14 2004-08-19 Teva Pharmaceutical Industries Ltd Synthesis of gatifloxacin
US20040152701A1 (en) * 2002-12-02 2004-08-05 Dr. Reddy's Laboratories Limited Novel anhydrous crystalline form of Levofloxacin and process for preparation there of
FR2859471B1 (fr) 2003-09-09 2006-02-03 Solvay Procede pour la fabrication d'un compose enantiopur
CA2596993A1 (en) 2005-02-07 2006-08-10 Mitsubishi Pharma Corporation Optically active tetrahydronaphthalene derivative
US7838532B2 (en) * 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8524735B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
WO2007097940A2 (en) * 2006-02-13 2007-08-30 Trustees Of Boston University Reca inhibitors with antibiotic activity, compositions and methods of use
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
US20070197548A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US20100234348A1 (en) * 2006-08-04 2010-09-16 Trustees Of Boston University Compositions and methods for potentiating antibiotic activity
US20100029938A1 (en) * 2006-12-22 2010-02-04 Farmaprojects, S. A. Process for the preparation of an antibacterial quinolone compound
EP1939206A1 (en) * 2006-12-22 2008-07-02 Farmaprojects, S.A. Process for the preparation of an antibacterial quinolone compound
US7964723B2 (en) 2008-08-02 2011-06-21 Apeloa-Kangyu And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
HUE050147T2 (hu) 2008-10-07 2020-11-30 Horizon Orphan Llc Tüdõgyulladás csökkentése levofloxacin belélegzése útján
NO2344129T3 (es) 2008-10-07 2018-07-21
NZ596492A (en) 2009-05-15 2013-08-30 Redx Pharma Ltd Redox drug derivatives
RU2563809C2 (ru) 2009-09-04 2015-09-20 Мпекс Фармасьютикалс, Инк. Применение левофлоксацина в форме аэрозоля для лечения муковисцидоза
CN101659669B (zh) * 2009-09-04 2011-07-20 诚达药业股份有限公司 左旋氧氟沙星的制备方法
CN102775424A (zh) * 2012-07-09 2012-11-14 浙江司太立制药股份有限公司 一种左氧氟沙星杂质的制备方法
MX2015011760A (es) 2013-03-15 2016-06-10 Melinta Therapeutics Inc Metodos para tratar infecciones en pacientes obesos y con sobrepeso usando antibioticos.
CA2948595C (en) * 2014-05-09 2021-07-13 Tecnimede Sociedade Tecnico-Medicinal S.A. Pharmaceutically acceptable salts of pirlindole enantiomers for use in medicine
CN105037388A (zh) * 2015-08-28 2015-11-11 安徽环球药业股份有限公司 一种安妥沙星的制备方法
CN105367585B (zh) * 2015-12-02 2017-11-17 山东齐都药业有限公司 左氧氟沙星杂质的制备方法
EP4149427A1 (en) 2020-06-11 2023-03-22 Sentiss Pharma Private Limited Ophthalmic compositions comprising a combination of fluoroquinolone antibacterial agent and an anti-inflammatory agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
JPS5852290A (ja) * 1981-09-21 1983-03-28 Dai Ichi Seiyaku Co Ltd ピリドベンゾオキサジンカルボン酸誘導体
DE3543513A1 (de) * 1985-12-10 1987-06-11 Bayer Ag Enantiomerenreine 1,8-verbrueckte 4-chinolon-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel und ihre verwendung zur herstellung von arzneimitteln

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2055656A1 (es) * 1992-10-07 1994-08-16 Etilo Derivados Procedimiento para la obtencion de benzoxazinas utiles para sintesis de ofloxacina, levofloxacina y derivados.
ES2069500A1 (es) * 1992-10-07 1995-05-01 Etilo Derivados Perfeccionamientos introducidos en el objeto de la patente espa¦ola n 9201983 por "procedimiento para la obtencion de benzoxazinas utiles para la sintesis de oflexacina, levofloxacina y derivados.

Also Published As

Publication number Publication date
CA1304080C (en) 1992-06-23
DE19875012I2 (de) 2006-06-29
DK285086D0 (da) 1986-06-18
NO166131C (no) 1991-06-05
KR920010048B1 (ko) 1992-11-13
EP0206283A2 (en) 1986-12-30
NO166131B (no) 1991-02-25
KR940003757B1 (ko) 1994-04-30
KR870000340A (ko) 1987-02-17
FI90241B (fi) 1993-09-30
YU45524B (en) 1992-05-28
ES556292A0 (es) 1988-01-01
YU209889A (en) 1990-04-30
YU186788A (en) 1989-04-30
KR920009279A (ko) 1992-05-28
DE3687599D1 (de) 1993-03-11
DK170473B1 (da) 1995-09-11
US5053407A (en) 1991-10-01
FI90241C (fi) 1994-01-10
HK91793A (en) 1993-09-10
EP0206283B1 (en) 1993-01-27
GR861625B (en) 1986-10-21
US4985557A (en) 1991-01-15
IE59463B1 (en) 1994-02-23
IE861631L (en) 1986-12-20
YU45512B (en) 1992-05-28
EP0206283A3 (en) 1988-08-10
FI862643A (fi) 1986-12-21
US5142046A (en) 1992-08-25
FI862643A0 (fi) 1986-06-19
NL980016I1 (nl) 1998-07-01
DK285086A (da) 1986-12-21
ATE85057T1 (de) 1993-02-15
YU107386A (en) 1988-02-29
DE3687599T2 (de) 1993-05-19
NO862426D0 (no) 1986-06-18
NO862426L (no) 1986-12-22
NL980016I2 (nl) 1998-08-03
BG60527B2 (bg) 1995-07-28
YU44918B (en) 1991-04-30

Similar Documents

Publication Publication Date Title
HK91793A (en) Optically active pyridobenzoxazine derivatives
HU9801934D0 (en) Process for producing of herbicidal activity substituted aryl-halogenalkyl-pyrazol derivatives
AU577928B2 (en) Labd-14-en-11-one derivatives
ES2001794A6 (es) Un procedimiento para la preparacion de derivados de quinolina
AU575342B2 (en) Gamma - butyrolactone derivatives
AU578489B2 (en) Proline derivatives
CA1265131C (en) ERYTHROMYCYLAMINE DERIVATIVES
MY106512A (en) Process for the preparation of 6-(substitutedaminopro- pionyl)-derivatives of fokskolin.
PT85645A (en) 2-(1-oxo-1-imino-1-thiacylcloalkyl)-thiopenem derivatives
GR81773B (es)
ES2052812T3 (es) Un procedimiento para la preparacion de derivados de pirrolizina.
SU1455633A1 (ru) О,о-диизопропил-о-[1, 1-диметил-2-пропилтио-2-(о-о-диизопропилфосфорил)- имино]-этилфосфат, обладающий бактерицидной активностью
DE3560948D1 (en) A n-(6-substituted pyridine-2-carbonyl)-3-substituted histidine derivative, a method of preparing the same and its use as an anti-tumor agent
SU1573830A1 (ru) Фосфорилированные оксиэтиловые эфиры 2,4-дихлорфеноксиуксусной кислоты, обладающие гербицидной активностью
UA11675A1 (uk) 1-БЕtА-ОКСИЕТИЛАМІHО-3-КЕТО-5,5-ДИМЕТИЛЦИКЛОГЕКСЕH -1, ЯКИЙ МАЄ АHАЛЬГЕТИЧHУ АКТИВHІСТЬ

Legal Events

Date Code Title Description
PC1A Transfer granted
SPCF Request for supplementary protection certificate filed

Free format text: TAVANIC (LEVOFLOXACIN)

Spc suppl protection certif: C9900014

Filing date: 19990326

PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20100528