DE19875012I2 - Optisch aktive Pyridobenzoxazinderivate - Google Patents

Optisch aktive Pyridobenzoxazinderivate

Info

Publication number
DE19875012I2
DE19875012I2 DE19863687599 DE3687599C DE19875012I2 DE 19875012 I2 DE19875012 I2 DE 19875012I2 DE 19863687599 DE19863687599 DE 19863687599 DE 3687599 C DE3687599 C DE 3687599C DE 19875012 I2 DE19875012 I2 DE 19875012I2
Authority
DE
Germany
Prior art keywords
optically active
preparing
active pyridobenzoxazine
derivatives
pyridobenzoxazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE19863687599
Other languages
English (en)
Other versions
DE3687599T2 (de
DE3687599D1 (de
Inventor
Isao Hayakawa
Shohgo Atarashi
Shuichi Yokohama
Masazumi Imamura
Katsuichi Sakano
Nobuyuki Higashihashi
Masayuki Oshima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27281433&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE19875012(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP60226499A external-priority patent/JPH0720946B2/ja
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE19875012I2 publication Critical patent/DE19875012I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19863687599 1985-06-20 1986-06-20 Optisch aktive Pyridobenzoxazinderivate Active DE19875012I2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP13471285 1985-06-20
JP60226499A JPH0720946B2 (ja) 1985-10-11 1985-10-11 光学活性３−メチルベンゾオキサジン誘導体およびその製法
JP1649686 1986-01-28

Publications (1)

Publication Number Publication Date
DE19875012I2 true DE19875012I2 (de) 2006-06-29

Family

ID=27281433

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8686108442T Expired - Lifetime DE3687599T2 (de) 1985-06-20 1986-06-20 Optisch aktive pyridobenzoxazinderivate.
DE19863687599 Active DE19875012I2 (de) 1985-06-20 1986-06-20 Optisch aktive Pyridobenzoxazinderivate

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE8686108442T Expired - Lifetime DE3687599T2 (de) 1985-06-20 1986-06-20 Optisch aktive pyridobenzoxazinderivate.

Country Status (16)

Country Link
US (3) US5053407A (de)
EP (1) EP0206283B1 (de)
KR (2) KR920010048B1 (de)
AT (1) ATE85057T1 (de)
BG (1) BG60527B2 (de)
CA (1) CA1304080C (de)
DE (2) DE3687599T2 (de)
DK (1) DK170473B1 (de)
ES (1) ES8801251A1 (de)
FI (1) FI90241C (de)
GR (1) GR861625B (de)
HK (1) HK91793A (de)
IE (1) IE59463B1 (de)
NL (1) NL980016I2 (de)
NO (1) NO166131C (de)
YU (3) YU44918B (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0273399B1 (de) * 1986-12-25 1994-08-17 Daiichi Pharmaceutical Co., Ltd. Optisch aktive 2,3-Dihydrobenzoxazinderivate und Verfahren zu deren Herstellung
NO172846C (no) * 1987-12-25 1993-09-15 Daiichi Seiyaku Co Fremgangsmaate for fremstilling av 7,8-dihalogen-3-metyl-2,3-dihydro-2m-benzoksazinderivater og propoksybenzenderivater for utoevelse av fremgangsmaaten.
US5175160A (en) * 1988-08-09 1992-12-29 Daiichi Pharmaceutical Co., Ltd. Antimicrobial agent for animals
MY104139A (en) * 1988-08-09 1994-02-28 Daiichi Seiyaku Co Antimicrobial agent for animals
AU4376589A (en) * 1988-11-07 1990-05-10 Gist-Brocades N.V. Optically active benzoxazines and benzothiazines
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
FR2655545B1 (fr) * 1989-12-11 1994-06-10 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
TW208013B (de) * 1990-03-01 1993-06-21 Daiichi Co Ltd
NO179912C (no) * 1990-11-28 1997-01-08 Daiichi Seiyaku Co Analogifremgangsmåte for fremstilling av et terapeutisk virksomt optisk aktivt pyridobenzoksazinderivat
US5521310A (en) * 1992-10-07 1996-05-28 Derivados Del Etilo, S.A. Process to obtain benzoxazines to be used for the synthesis of ofloxazine, levofloxazine and derivatives
ES2055656B1 (es) * 1992-10-07 1995-11-16 Etilo Derivados Procedimiento para la obtencion de benzoxazinas utiles para sintesis de ofloxacina, levofloxacina y derivados.
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
ZA946853B (en) * 1993-09-10 1995-04-24 Daiichi Seiyaku Co Crystals of antimicrobial compound.
US5686095A (en) * 1995-10-23 1997-11-11 Price, Jr.; Francis W. Method of treating canker sores
KR100491282B1 (ko) 1996-07-24 2005-05-24 워너-램버트 캄파니 엘엘씨 통증 치료용 이소부틸가바 및 그의 유도체
US6248343B1 (en) 1998-01-20 2001-06-19 Ethicon, Inc. Therapeutic antimicrobial compositions
US5972358A (en) * 1998-01-20 1999-10-26 Ethicon, Inc. Low tack lotion, gels and creams
US5997893A (en) * 1998-01-20 1999-12-07 Ethicon, Inc. Alcohol based anti-microbial compositions with cosmetic appearance
US6022551A (en) * 1998-01-20 2000-02-08 Ethicon, Inc. Antimicrobial composition
KR100309871B1 (ko) 1999-02-24 2001-10-29 윤종용 (-)피리도벤즈옥사진 카르복실산 유도체의 제조방법
JP2003527308A (ja) 1998-12-04 2003-09-16 インフラックス，インコーポレイテッド 多剤輸送体の阻害剤
KR100617952B1 (ko) * 1999-03-04 2006-08-30 보령제약 주식회사 광학활성 피리도 벤즈옥사진 유도체의 제조방법
EP2360160B1 (de) * 1999-09-08 2013-07-24 Daiichi Sankyo Company, Limited Zwischenprodukte und deren Verwendung zur Herstellung vom Benzoxazinderivat
KR20010103346A (ko) * 2000-05-09 2001-11-23 이후근 패각 입자와 접착제 그리고 물감을 혼합하여 그림 밑칠용재료를 제조하는 방법
ATE319710T1 (de) 2000-12-21 2006-03-15 Pharmacia & Upjohn Co Llc Antimikrobielle chinolonderivate und ihre verwendung zur behandlung bakterieller infektionen
ES2329554T3 (es) 2001-03-07 2009-11-27 Daiichi Sankyo Company, Limited Procesos para producir derivados de propoxianilina opticamente activos.
KR100444248B1 (ko) 2001-04-27 2004-08-16 한국산업기술평가원 열간가공성이 우수한 고망간 듀플렉스 스텐레스강과 그제조방법
WO2003028665A2 (en) 2001-10-03 2003-04-10 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
US7425628B2 (en) * 2001-10-03 2008-09-16 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
KR100440192B1 (ko) * 2001-11-22 2004-07-12 이수화학 주식회사 광학 활성 퀴놀론카르복실산 유도체의 제조방법
AU2002365416A1 (en) * 2001-11-29 2003-06-10 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
EP2172192A1 (de) * 2001-12-24 2010-04-07 Teva Pharmaceutical Industries Ltd. Dosierform mit einer Kerntablette mit einem Wirkstoff, der in einem komprimierten Ringkörper aus Pulver- oder granulärem Material gehüllt ist, und Verfahren und Werkzeuge zu ihrer Herstellung
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
EP1478642A1 (de) 2002-08-14 2004-11-24 Teva Pharmaceutical Industries Ltd. Synthese von gatifloxacin
US20040152701A1 (en) * 2002-12-02 2004-08-05 Dr. Reddy's Laboratories Limited Novel anhydrous crystalline form of Levofloxacin and process for preparation there of
FR2859471B1 (fr) 2003-09-09 2006-02-03 Solvay Procede pour la fabrication d'un compose enantiopur
EP1852431A4 (de) 2005-02-07 2009-11-04 Mitsubishi Tanabe Pharma Corp Optisch aktives tetrahydronaphthalinderivat
US8546423B2 (en) 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US7838532B2 (en) * 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
WO2007097940A2 (en) * 2006-02-13 2007-08-30 Trustees Of Boston University Reca inhibitors with antibiotic activity, compositions and methods of use
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
US20070197548A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
WO2008019292A2 (en) * 2006-08-04 2008-02-14 Trustees Of Boston University Compositions and methods for potentiating antibiotic activity
WO2008077643A1 (en) * 2006-12-22 2008-07-03 Farmaprojects, S.A. Process for the preparation of an antibacterial quinolone compound
EP1939206A1 (de) * 2006-12-22 2008-07-02 Farmaprojects, S.A. Herstellungsverfahren für eine antibakterielle Quinolonverbindung
US7964723B2 (en) 2008-08-02 2011-06-21 Apeloa-Kangyu And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
NO2344129T3 (de) 2008-10-07 2018-07-21
PT2346509T (pt) 2008-10-07 2020-08-05 Horizon Orphan Llc Inalação de levofloxacina para redução da inflamação pulmonar
AU2010247141A1 (en) 2009-05-15 2011-12-15 Redx Pharma Plc Redox drug derivatives
SI2473170T1 (sl) 2009-09-04 2019-10-30 Horizon Orphan Llc Uporaba aerosoliziranega levofloksacina za zdravljenje cistične fibroze
CN101659669B (zh) * 2009-09-04 2011-07-20 诚达药业股份有限公司 左旋氧氟沙星的制备方法
CN102775424A (zh) * 2012-07-09 2012-11-14 浙江司太立制药股份有限公司 一种左氧氟沙星杂质的制备方法
CN106413713B (zh) * 2014-05-09 2020-07-14 特克尼梅德医疗技术股份公司 用作药物的吡吲哚对映异构体的药学上可接受的盐
CN105037388A (zh) * 2015-08-28 2015-11-11 安徽环球药业股份有限公司 一种安妥沙星的制备方法
CN105367585B (zh) * 2015-12-02 2017-11-17 山东齐都药业有限公司 左氧氟沙星杂质的制备方法
WO2021250482A1 (en) 2020-06-11 2021-12-16 Sentiss Pharma Private Limited Ophthalmic compositions comprising a combination of fluoroquinolone antibacterial agent and an anti-inflammatory agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
JPS5852290A (ja) * 1981-09-21 1983-03-28 Dai Ichi Seiyaku Co Ltd ピリドベンゾオキサジンカルボン酸誘導体
DE3543513A1 (de) * 1985-12-10 1987-06-11 Bayer Ag Enantiomerenreine 1,8-verbrueckte 4-chinolon-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel und ihre verwendung zur herstellung von arzneimitteln

Also Published As

Publication number Publication date
ATE85057T1 (de) 1993-02-15
NO862426D0 (no) 1986-06-18
NO862426L (no) 1986-12-22
EP0206283A3 (en) 1988-08-10
ES556292A0 (es) 1988-01-01
ES8801251A1 (es) 1988-01-01
CA1304080C (en) 1992-06-23
YU45512B (en) 1992-05-28
NO166131C (no) 1991-06-05
IE861631L (en) 1986-12-20
YU209889A (en) 1990-04-30
YU107386A (en) 1988-02-29
DE3687599T2 (de) 1993-05-19
NL980016I1 (nl) 1998-07-01
NO166131B (no) 1991-02-25
KR940003757B1 (ko) 1994-04-30
YU186788A (en) 1989-04-30
FI862643A0 (fi) 1986-06-19
US4985557A (en) 1991-01-15
IE59463B1 (en) 1994-02-23
US5142046A (en) 1992-08-25
KR920010048B1 (ko) 1992-11-13
FI90241C (fi) 1994-01-10
DK285086D0 (da) 1986-06-18
YU45524B (en) 1992-05-28
EP0206283A2 (de) 1986-12-30
DK170473B1 (da) 1995-09-11
DE3687599D1 (de) 1993-03-11
BG60527B2 (bg) 1995-07-28
KR870000340A (ko) 1987-02-17
FI862643A (fi) 1986-12-21
FI90241B (fi) 1993-09-30
YU44918B (en) 1991-04-30
NL980016I2 (nl) 1998-08-03
GR861625B (en) 1986-10-21
US5053407A (en) 1991-10-01
KR920009279A (ko) 1992-05-28
EP0206283B1 (de) 1993-01-27
HK91793A (en) 1993-09-10
DK285086A (da) 1986-12-21

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