DE3687599D1 - Optisch aktive pyridobenzoxazinderivate. - Google Patents

Optisch aktive pyridobenzoxazinderivate.

Info

Publication number
DE3687599D1
DE3687599D1 DE8686108442T DE3687599T DE3687599D1 DE 3687599 D1 DE3687599 D1 DE 3687599D1 DE 8686108442 T DE8686108442 T DE 8686108442T DE 3687599 T DE3687599 T DE 3687599T DE 3687599 D1 DE3687599 D1 DE 3687599D1
Authority
DE
Germany
Prior art keywords
optically active
preparing
active pyridobenzoxazine
derivatives
pyridobenzoxazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686108442T
Other languages
English (en)
Other versions
DE19875012I2 (de
DE3687599T2 (de
Inventor
Isao C O Daiichi Seiy Hayakawa
Shohgo C O Daiichi Se Atarashi
Shuichi C O Daiichi S Yokohama
Masazumi C O Daiichi S Imamura
Katsuichi C O Daiichi S Sakano
Nobuyuki C O Daii Higashihashi
Masayuki C O Daiichi S Ohshima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27281433&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3687599(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP60226499A external-priority patent/JPH0720946B2/ja
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Publication of DE3687599D1 publication Critical patent/DE3687599D1/de
Application granted granted Critical
Publication of DE3687599T2 publication Critical patent/DE3687599T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8686108442T 1985-06-20 1986-06-20 Optisch aktive pyridobenzoxazinderivate. Expired - Lifetime DE3687599T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP13471285 1985-06-20
JP60226499A JPH0720946B2 (ja) 1985-10-11 1985-10-11 光学活性３−メチルベンゾオキサジン誘導体およびその製法
JP1649686 1986-01-28

Publications (2)

Publication Number Publication Date
DE3687599D1 true DE3687599D1 (de) 1993-03-11
DE3687599T2 DE3687599T2 (de) 1993-05-19

Family

ID=27281433

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19863687599 Active DE19875012I2 (de) 1985-06-20 1986-06-20 Optisch aktive Pyridobenzoxazinderivate
DE8686108442T Expired - Lifetime DE3687599T2 (de) 1985-06-20 1986-06-20 Optisch aktive pyridobenzoxazinderivate.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19863687599 Active DE19875012I2 (de) 1985-06-20 1986-06-20 Optisch aktive Pyridobenzoxazinderivate

Country Status (16)

Country Link
US (3) US5053407A (de)
EP (1) EP0206283B1 (de)
KR (2) KR920010048B1 (de)
AT (1) ATE85057T1 (de)
BG (1) BG60527B2 (de)
CA (1) CA1304080C (de)
DE (2) DE19875012I2 (de)
DK (1) DK170473B1 (de)
ES (1) ES8801251A1 (de)
FI (1) FI90241C (de)
GR (1) GR861625B (de)
HK (1) HK91793A (de)
IE (1) IE59463B1 (de)
NL (1) NL980016I2 (de)
NO (1) NO166131C (de)
YU (3) YU44918B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7629458B2 (en) 2001-10-03 2009-12-08 Teva Pharmaceutical Industries Ltd. Preparation of levofloxacin and hemihydrate thereof

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DE3750396T2 (de) * 1986-12-25 1995-01-05 Daiichi Seiyaku Co Optisch aktive 2,3-Dihydrobenzoxazinderivate und Verfahren zu deren Herstellung.
IE75342B1 (en) * 1987-12-25 1997-08-27 Daiichi Seiyaku Co Propoxybenzene derivatives and process for preparing the same
US5175160A (en) * 1988-08-09 1992-12-29 Daiichi Pharmaceutical Co., Ltd. Antimicrobial agent for animals
MY104139A (en) * 1988-08-09 1994-02-28 Daiichi Seiyaku Co Antimicrobial agent for animals
AU4376589A (en) * 1988-11-07 1990-05-10 Gist-Brocades N.V. Optically active benzoxazines and benzothiazines
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
FR2655545B1 (fr) * 1989-12-11 1994-06-10 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
TW208013B (de) * 1990-03-01 1993-06-21 Daiichi Co Ltd
NO179912C (no) * 1990-11-28 1997-01-08 Daiichi Seiyaku Co Analogifremgangsmåte for fremstilling av et terapeutisk virksomt optisk aktivt pyridobenzoksazinderivat
KR0131914B1 (ko) * 1992-10-07 1998-04-17 조아퀸 가리데 센트멘나트 오플로옥사진, 레보플로옥사진과 이 유도체의 합성에 이용될 수 있는 벤조옥사진의 수득과정
ES2055656B1 (es) * 1992-10-07 1995-11-16 Etilo Derivados Procedimiento para la obtencion de benzoxazinas utiles para sintesis de ofloxacina, levofloxacina y derivados.
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
ZA946853B (en) * 1993-09-10 1995-04-24 Daiichi Seiyaku Co Crystals of antimicrobial compound.
US5686095A (en) * 1995-10-23 1997-11-11 Price, Jr.; Francis W. Method of treating canker sores
BR9710536A (pt) 1996-07-24 1999-08-17 Warner Lambert Co Isobutilgaba e seus derivados para o tratamento da dor
US6022551A (en) * 1998-01-20 2000-02-08 Ethicon, Inc. Antimicrobial composition
US6248343B1 (en) 1998-01-20 2001-06-19 Ethicon, Inc. Therapeutic antimicrobial compositions
US5972358A (en) * 1998-01-20 1999-10-26 Ethicon, Inc. Low tack lotion, gels and creams
US5997893A (en) * 1998-01-20 1999-12-07 Ethicon, Inc. Alcohol based anti-microbial compositions with cosmetic appearance
KR100309871B1 (ko) 1999-02-24 2001-10-29 윤종용 (-)피리도벤즈옥사진 카르복실산 유도체의 제조방법
IL143535A0 (en) 1998-12-04 2002-04-21 Influx Inc Inhibitors of multidrug transporters
KR100617952B1 (ko) * 1999-03-04 2006-08-30 보령제약 주식회사 광학활성 피리도 벤즈옥사진 유도체의 제조방법
ES2472240T3 (es) * 1999-09-08 2014-06-30 Daiichi Sankyo Company, Limited Procedimiento para la preparación de derivados de benzoxazina y de sus intermedios
KR20010103346A (ko) * 2000-05-09 2001-11-23 이후근 패각 입자와 접착제 그리고 물감을 혼합하여 그림 밑칠용재료를 제조하는 방법
WO2002059116A2 (en) 2000-12-21 2002-08-01 Pharmacia & Upjohn Company Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
US7217560B2 (en) 2001-03-07 2007-05-15 Daiichi Pharmaceutical Co., Ltd. Process for preparation of optically active propoxyaniline derivatives
JP4031992B2 (ja) 2001-04-27 2008-01-09 リサーチ インスティチュート オブ インダストリアル サイエンス アンド テクノロジー 優れた熱間加工性を持つ高マンガン二相ステンレス鋼及びその製造方法
US7425628B2 (en) * 2001-10-03 2008-09-16 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
KR100440192B1 (ko) * 2001-11-22 2004-07-12 이수화학 주식회사 광학 활성 퀴놀론카르복실산 유도체의 제조방법
AU2002365416A1 (en) * 2001-11-29 2003-06-10 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
NZ534104A (en) * 2001-12-24 2007-03-30 Teva Pharma Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
PL375437A1 (en) * 2002-08-14 2005-11-28 Teva Pharmaceutical Industries Ltd. Synthesis of gatifloxacin
US20040152701A1 (en) * 2002-12-02 2004-08-05 Dr. Reddy's Laboratories Limited Novel anhydrous crystalline form of Levofloxacin and process for preparation there of
FR2859471B1 (fr) 2003-09-09 2006-02-03 Solvay Procede pour la fabrication d'un compose enantiopur
CN101119986B (zh) 2005-02-07 2011-07-06 田边三菱制药株式会社 光学活性四氢萘衍生物
US8524735B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US7838532B2 (en) * 2005-05-18 2010-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
CA2642264A1 (en) * 2006-02-13 2007-08-30 Trustees Of Boston University Reca inhibitors with antibiotic activity, compositions and methods of use
US20070197548A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
US20100234348A1 (en) * 2006-08-04 2010-09-16 Trustees Of Boston University Compositions and methods for potentiating antibiotic activity
WO2008077643A1 (en) * 2006-12-22 2008-07-03 Farmaprojects, S.A. Process for the preparation of an antibacterial quinolone compound
EP1939206A1 (de) * 2006-12-22 2008-07-02 Farmaprojects, S.A. Herstellungsverfahren für eine antibakterielle Quinolonverbindung
US7964723B2 (en) 2008-08-02 2011-06-21 Apeloa-Kangyu And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
HUE038428T2 (hu) 2008-10-07 2018-10-29 Horizon Orphan Llc Aeroszol fluorokinolon készítmények javított farmakokinetika érdekében
WO2010042549A1 (en) 2008-10-07 2010-04-15 Mpex Pharmaceuticals, Inc. Inhalation of levofloxacin for reducing lung inflammation
EP2429991B1 (de) 2009-05-15 2014-09-10 Redx Pharma Limited Redox-wirkstoffderivate
PT2473170T (pt) 2009-09-04 2019-08-23 Horizon Orphan Llc Utilização de levofloxacina em aerossol para tratamento de fibrose cística
CN101659669B (zh) * 2009-09-04 2011-07-20 诚达药业股份有限公司 左旋氧氟沙星的制备方法
CN102775424A (zh) * 2012-07-09 2012-11-14 浙江司太立制药股份有限公司 一种左氧氟沙星杂质的制备方法
EP2969004A4 (de) 2013-03-15 2016-09-21 Melinta Therapeutics Inc Verfahren zur behandlung von infektionen bei übergewichtigen und adipösen patienten mithilfe von antibiotika
FI3831385T3 (fi) * 2014-05-09 2024-09-04 Tecnimede Sociedade Tecnico Medicinal S Pirlindolienantiomeerien mandelaattisuoloja käytettäviksi lääkinnässä
CN105037388A (zh) * 2015-08-28 2015-11-11 安徽环球药业股份有限公司 一种安妥沙星的制备方法
CN105367585B (zh) * 2015-12-02 2017-11-17 山东齐都药业有限公司 左氧氟沙星杂质的制备方法
EP4149427A1 (de) 2020-06-11 2023-03-22 Sentiss Pharma Private Limited Ophthalmische zusammensetzungen mit einer kombination aus einem antibakteriellen fluorchinolonmittel und einem entzündungshemmenden mittel

Family Cites Families (3)

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JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
JPS5852290A (ja) * 1981-09-21 1983-03-28 Dai Ichi Seiyaku Co Ltd ピリドベンゾオキサジンカルボン酸誘導体
DE3543513A1 (de) * 1985-12-10 1987-06-11 Bayer Ag Enantiomerenreine 1,8-verbrueckte 4-chinolon-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel und ihre verwendung zur herstellung von arzneimitteln

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7629458B2 (en) 2001-10-03 2009-12-08 Teva Pharmaceutical Industries Ltd. Preparation of levofloxacin and hemihydrate thereof

Also Published As

Publication number Publication date
KR870000340A (ko) 1987-02-17
EP0206283B1 (de) 1993-01-27
NO862426D0 (no) 1986-06-18
NO862426L (no) 1986-12-22
BG60527B2 (bg) 1995-07-28
YU186788A (en) 1989-04-30
US5142046A (en) 1992-08-25
DK285086D0 (da) 1986-06-18
DK170473B1 (da) 1995-09-11
KR920010048B1 (ko) 1992-11-13
YU45512B (en) 1992-05-28
NL980016I2 (nl) 1998-08-03
YU45524B (en) 1992-05-28
FI90241C (fi) 1994-01-10
ES8801251A1 (es) 1988-01-01
YU209889A (en) 1990-04-30
US5053407A (en) 1991-10-01
ATE85057T1 (de) 1993-02-15
DE19875012I2 (de) 2006-06-29
IE59463B1 (en) 1994-02-23
YU44918B (en) 1991-04-30
EP0206283A2 (de) 1986-12-30
US4985557A (en) 1991-01-15
ES556292A0 (es) 1988-01-01
FI90241B (fi) 1993-09-30
DE3687599T2 (de) 1993-05-19
NO166131C (no) 1991-06-05
NL980016I1 (nl) 1998-07-01
IE861631L (en) 1986-12-20
FI862643A (fi) 1986-12-21
FI862643A0 (fi) 1986-06-19
YU107386A (en) 1988-02-29
HK91793A (en) 1993-09-10
EP0206283A3 (en) 1988-08-10
KR920009279A (ko) 1992-05-28
NO166131B (no) 1991-02-25
DK285086A (da) 1986-12-21
KR940003757B1 (ko) 1994-04-30
CA1304080C (en) 1992-06-23
GR861625B (en) 1986-10-21

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Legal Events

Date Code Title Description
R040 Withdrawal/refusal of revocation action now final

Free format text: PRODUCT NAME: LEVOFLOXACIN, EINSCHLIESSLICH LEVOFLOXACIN 0,5 H 2 O; NAT. REGISTRATION NO/DATE: 41382.00.00 41382.01.00 41384.00.00 19980122 FIRST REGISTRATION: GROSSBRITANNIEN 13402/0011 13402/0012 13402/0013 19970606

Spc suppl protection certif: 19875012

Filing date: 19980401

Expiry date: 20060621

Extension date: 20110620

R071 Expiry of right

Free format text: PRODUCT NAME: LEVOFLOXACIN, EINSCHLIESSLICH LEVOFLOXACIN 0,5 H 2 O; NAT. REGISTRATION NO/DATE: 41382.00.00 41382.01.00 41384.00.00 19980122 FIRST REGISTRATION: GROSSBRITANNIEN 13402/0011 13402/0012 13402/0013 19970606

Spc suppl protection certif: 19875012

Filing date: 19980401

Expiry date: 20060621

Extension date: 20110620

Effective date: 20110621