FI862643A0 - Menetelmä terapeuttisesti aktiivisen S(-)-9-halogeeni-3-alkyyli-10-(4-alkyylipiperatsinyyli)-7-okso-2,3-dihydro-7H-pyrido/1,2,3-de//1,4/bentsoksatsiini-6-karboksyylihapon valmistamiseksi - Google Patents

Menetelmä terapeuttisesti aktiivisen S(-)-9-halogeeni-3-alkyyli-10-(4-alkyylipiperatsinyyli)-7-okso-2,3-dihydro-7H-pyrido/1,2,3-de//1,4/bentsoksatsiini-6-karboksyylihapon valmistamiseksi

Info

Publication number
FI862643A0
FI862643A0 FI862643A FI862643A FI862643A0 FI 862643 A0 FI862643 A0 FI 862643A0 FI 862643 A FI862643 A FI 862643A FI 862643 A FI862643 A FI 862643A FI 862643 A0 FI862643 A0 FI 862643A0
Authority
FI
Finland
Prior art keywords
alkylpiperazinyl
pyrido
dihydro
halo
oxo
Prior art date
Application number
FI862643A
Other languages
English (en)
Swedish (sv)
Other versions
FI90241C (fi
FI862643A (fi
FI90241B (fi
Inventor
Shohgo Atarashi
Shuichi Yokohama
Masazumi Imamura
Katsuichi Sakano
Nobuyuki Higashihashi
Masayuki Ohshima
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27281433&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI862643(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP60226499A external-priority patent/JPH0720946B2/ja
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of FI862643A0 publication Critical patent/FI862643A0/fi
Publication of FI862643A publication Critical patent/FI862643A/fi
Priority to FI884331A priority Critical patent/FI884331A/fi
Application granted granted Critical
Publication of FI90241B publication Critical patent/FI90241B/fi
Publication of FI90241C publication Critical patent/FI90241C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI862643A 1985-06-20 1986-06-19 Menetelmä terapeuttisesti aktiivisen S(-)-9-halogeeni-3-alkyyli-10-(4-alkyylipiperatsinyyli)-7-okso-2,3-dihydro-7H-pyrido/1,2,3-de//1,4/bentsoksatsiini-6-karboksyylihapon valmistamiseksi FI90241C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI884331A FI884331A (fi) 1985-06-20 1988-09-21 Optiskt aktiva bensoxazinderivat och foerfarande foer deras framstaellning.

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP13471285 1985-06-20
JP13471285 1985-06-20
JP22649985 1985-10-11
JP60226499A JPH0720946B2 (ja) 1985-10-11 1985-10-11 光学活性３−メチルベンゾオキサジン誘導体およびその製法
JP1649686 1986-01-28
JP1649686 1986-01-28

Publications (4)

Publication Number Publication Date
FI862643A0 true FI862643A0 (fi) 1986-06-19
FI862643A FI862643A (fi) 1986-12-21
FI90241B FI90241B (fi) 1993-09-30
FI90241C FI90241C (fi) 1994-01-10

Family

ID=27281433

Family Applications (1)

Application Number Title Priority Date Filing Date
FI862643A FI90241C (fi) 1985-06-20 1986-06-19 Menetelmä terapeuttisesti aktiivisen S(-)-9-halogeeni-3-alkyyli-10-(4-alkyylipiperatsinyyli)-7-okso-2,3-dihydro-7H-pyrido/1,2,3-de//1,4/bentsoksatsiini-6-karboksyylihapon valmistamiseksi

Country Status (16)

Country Link
US (3) US5053407A (fi)
EP (1) EP0206283B1 (fi)
KR (2) KR920010048B1 (fi)
AT (1) ATE85057T1 (fi)
BG (1) BG60527B2 (fi)
CA (1) CA1304080C (fi)
DE (2) DE3687599T2 (fi)
DK (1) DK170473B1 (fi)
ES (1) ES8801251A1 (fi)
FI (1) FI90241C (fi)
GR (1) GR861625B (fi)
HK (1) HK91793A (fi)
IE (1) IE59463B1 (fi)
NL (1) NL980016I2 (fi)
NO (1) NO166131C (fi)
YU (3) YU44918B (fi)

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FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
FR2655545B1 (fr) * 1989-12-11 1994-06-10 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
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US5521310A (en) * 1992-10-07 1996-05-28 Derivados Del Etilo, S.A. Process to obtain benzoxazines to be used for the synthesis of ofloxazine, levofloxazine and derivatives
ES2055656B1 (es) * 1992-10-07 1995-11-16 Etilo Derivados Procedimiento para la obtencion de benzoxazinas utiles para sintesis de ofloxacina, levofloxacina y derivados.
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
ZA946853B (en) * 1993-09-10 1995-04-24 Daiichi Seiyaku Co Crystals of antimicrobial compound.
US5686095A (en) * 1995-10-23 1997-11-11 Price, Jr.; Francis W. Method of treating canker sores
KR100491282B1 (ko) 1996-07-24 2005-05-24 워너-램버트 캄파니 엘엘씨 통증 치료용 이소부틸가바 및 그의 유도체
US6248343B1 (en) 1998-01-20 2001-06-19 Ethicon, Inc. Therapeutic antimicrobial compositions
US5972358A (en) * 1998-01-20 1999-10-26 Ethicon, Inc. Low tack lotion, gels and creams
US5997893A (en) * 1998-01-20 1999-12-07 Ethicon, Inc. Alcohol based anti-microbial compositions with cosmetic appearance
US6022551A (en) * 1998-01-20 2000-02-08 Ethicon, Inc. Antimicrobial composition
KR100309871B1 (ko) 1999-02-24 2001-10-29 윤종용 (-)피리도벤즈옥사진 카르복실산 유도체의 제조방법
JP2003527308A (ja) 1998-12-04 2003-09-16 インフラックス，インコーポレイテッド 多剤輸送体の阻害剤
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EP2360160B1 (en) * 1999-09-08 2013-07-24 Daiichi Sankyo Company, Limited Intermediates and their use for producing benzoxazine derivative
KR20010103346A (ko) * 2000-05-09 2001-11-23 이후근 패각 입자와 접착제 그리고 물감을 혼합하여 그림 밑칠용재료를 제조하는 방법
ATE319710T1 (de) 2000-12-21 2006-03-15 Pharmacia & Upjohn Co Llc Antimikrobielle chinolonderivate und ihre verwendung zur behandlung bakterieller infektionen
ES2329554T3 (es) 2001-03-07 2009-11-27 Daiichi Sankyo Company, Limited Procesos para producir derivados de propoxianilina opticamente activos.
KR100444248B1 (ko) 2001-04-27 2004-08-16 한국산업기술평가원 열간가공성이 우수한 고망간 듀플렉스 스텐레스강과 그제조방법
WO2003028665A2 (en) 2001-10-03 2003-04-10 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
US7425628B2 (en) * 2001-10-03 2008-09-16 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
KR100440192B1 (ko) * 2001-11-22 2004-07-12 이수화학 주식회사 광학 활성 퀴놀론카르복실산 유도체의 제조방법
AU2002365416A1 (en) * 2001-11-29 2003-06-10 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
EP2172192A1 (en) * 2001-12-24 2010-04-07 Teva Pharmaceutical Industries Ltd. Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder of granular material, and process and tooling for producing it
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
EP1478642A1 (en) 2002-08-14 2004-11-24 Teva Pharmaceutical Industries Ltd. Synthesis of gatifloxacin
US20040152701A1 (en) * 2002-12-02 2004-08-05 Dr. Reddy's Laboratories Limited Novel anhydrous crystalline form of Levofloxacin and process for preparation there of
FR2859471B1 (fr) 2003-09-09 2006-02-03 Solvay Procede pour la fabrication d'un compose enantiopur
EP1852431A4 (en) 2005-02-07 2009-11-04 Mitsubishi Tanabe Pharma Corp OPTICALLY ACTIVE TETRAHYDRONAPHTALENE DERIVATIVE
US8546423B2 (en) 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
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WO2007097940A2 (en) * 2006-02-13 2007-08-30 Trustees Of Boston University Reca inhibitors with antibiotic activity, compositions and methods of use
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
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WO2008019292A2 (en) * 2006-08-04 2008-02-14 Trustees Of Boston University Compositions and methods for potentiating antibiotic activity
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EP1939206A1 (en) * 2006-12-22 2008-07-02 Farmaprojects, S.A. Process for the preparation of an antibacterial quinolone compound
US7964723B2 (en) 2008-08-02 2011-06-21 Apeloa-Kangyu And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
NO2344129T3 (fi) 2008-10-07 2018-07-21
PT2346509T (pt) 2008-10-07 2020-08-05 Horizon Orphan Llc Inalação de levofloxacina para redução da inflamação pulmonar
AU2010247141A1 (en) 2009-05-15 2011-12-15 Redx Pharma Plc Redox drug derivatives
SI2473170T1 (sl) 2009-09-04 2019-10-30 Horizon Orphan Llc Uporaba aerosoliziranega levofloksacina za zdravljenje cistične fibroze
CN101659669B (zh) * 2009-09-04 2011-07-20 诚达药业股份有限公司 左旋氧氟沙星的制备方法
CN102775424A (zh) * 2012-07-09 2012-11-14 浙江司太立制药股份有限公司 一种左氧氟沙星杂质的制备方法
CN106413713B (zh) * 2014-05-09 2020-07-14 特克尼梅德医疗技术股份公司 用作药物的吡吲哚对映异构体的药学上可接受的盐
CN105037388A (zh) * 2015-08-28 2015-11-11 安徽环球药业股份有限公司 一种安妥沙星的制备方法
CN105367585B (zh) * 2015-12-02 2017-11-17 山东齐都药业有限公司 左氧氟沙星杂质的制备方法
WO2021250482A1 (en) 2020-06-11 2021-12-16 Sentiss Pharma Private Limited Ophthalmic compositions comprising a combination of fluoroquinolone antibacterial agent and an anti-inflammatory agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
JPS5852290A (ja) * 1981-09-21 1983-03-28 Dai Ichi Seiyaku Co Ltd ピリドベンゾオキサジンカルボン酸誘導体
DE3543513A1 (de) * 1985-12-10 1987-06-11 Bayer Ag Enantiomerenreine 1,8-verbrueckte 4-chinolon-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel und ihre verwendung zur herstellung von arzneimitteln

Also Published As

Publication number Publication date
ATE85057T1 (de) 1993-02-15
NO862426D0 (no) 1986-06-18
NO862426L (no) 1986-12-22
EP0206283A3 (en) 1988-08-10
ES556292A0 (es) 1988-01-01
ES8801251A1 (es) 1988-01-01
DE19875012I2 (de) 2006-06-29
CA1304080C (en) 1992-06-23
YU45512B (en) 1992-05-28
NO166131C (no) 1991-06-05
IE861631L (en) 1986-12-20
YU209889A (en) 1990-04-30
YU107386A (en) 1988-02-29
DE3687599T2 (de) 1993-05-19
NL980016I1 (nl) 1998-07-01
NO166131B (no) 1991-02-25
KR940003757B1 (ko) 1994-04-30
YU186788A (en) 1989-04-30
US4985557A (en) 1991-01-15
IE59463B1 (en) 1994-02-23
US5142046A (en) 1992-08-25
KR920010048B1 (ko) 1992-11-13
FI90241C (fi) 1994-01-10
DK285086D0 (da) 1986-06-18
YU45524B (en) 1992-05-28
EP0206283A2 (en) 1986-12-30
DK170473B1 (da) 1995-09-11
DE3687599D1 (de) 1993-03-11
BG60527B2 (bg) 1995-07-28
KR870000340A (ko) 1987-02-17
FI862643A (fi) 1986-12-21
FI90241B (fi) 1993-09-30
YU44918B (en) 1991-04-30
NL980016I2 (nl) 1998-08-03
GR861625B (en) 1986-10-21
US5053407A (en) 1991-10-01
KR920009279A (ko) 1992-05-28
EP0206283B1 (en) 1993-01-27
HK91793A (en) 1993-09-10
DK285086A (da) 1986-12-21

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Legal Events

Date Code Title Description
BB Publication of examined application
TC Name/ company changed in patent

Owner name: DAIICHI PHARMACEUTICAL CO., LTD.

SPCG Supplementary protection certificate granted

Spc suppl protection certif: L128

Extension date: 20110618

FG Patent granted

Owner name: DAIICHI PHARMACEUTICAL CO., LTD.

MA Patent expired
PC Transfer of assignment of patent

Owner name: DAIICHI SANKYO COMPANY , LIMITED

Free format text: DAIICHI SANKYO COMPANY , LIMITED