ES8201582A1 - Un procedimiento para la preparacion de derivados de triazo-lopiridazina - Google Patents

Un procedimiento para la preparacion de derivados de triazo-lopiridazina

Info

Publication number
ES8201582A1
ES8201582A1 ES500384A ES500384A ES8201582A1 ES 8201582 A1 ES8201582 A1 ES 8201582A1 ES 500384 A ES500384 A ES 500384A ES 500384 A ES500384 A ES 500384A ES 8201582 A1 ES8201582 A1 ES 8201582A1
Authority
ES
Spain
Prior art keywords
intermediates
preparation
triazolopyridazine derivatives
medicaments containing
triazolopyridazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500384A
Other languages
English (en)
Other versions
ES500384A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8201582A1 publication Critical patent/ES8201582A1/es
Publication of ES500384A0 publication Critical patent/ES500384A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE TRIAZOLOPIRIDAZINA, ASI COMO DE SUS SALES DE ACIDO FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE A, R1, R2 Y R5 PUEDEN SER VARIOS TIPOS DE RADICALES, R3 ES HIDROGENO, O HALOGENO; R4 ES HIDROGENO, HALOGENO, O HIDROXILO; Y LA LINEA DE TRAZOS SIGNIFICA UN ENLACE CARBONO-CARBONO OPCIONAL. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA Y-NH2, EN LAS QUE A, R2, R3, R4 Y R5 Y LA LINEA DE TRAZOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I); R6 ES UN GRUPO ALCOXICARBONILO INFERIOR; E Y ES HIDROGENO, HIDROXILO O AMINO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, TAL COMO METANOL A LA TEMPERATURA AMBIENTE.
ES500384A 1979-07-23 1981-03-16 Un procedimiento para la preparacion de derivados de triazo-lopiridazina Granted ES500384A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7925576 1979-07-23
GB8013203 1980-04-22

Publications (2)

Publication Number Publication Date
ES8201582A1 true ES8201582A1 (es) 1982-01-01
ES500384A0 ES500384A0 (es) 1982-01-01

Family

ID=26272284

Family Applications (5)

Application Number Title Priority Date Filing Date
ES493579A Granted ES493579A0 (es) 1979-07-23 1980-07-22 Un procedimiento para la preparacion de derivados de triazo-lopiridazina
ES500385A Expired ES8201583A1 (es) 1979-07-23 1981-03-16 Un procedimiento para la preparacion de derivados de triazo-lopiridazina
ES500384A Granted ES500384A0 (es) 1979-07-23 1981-03-16 Un procedimiento para la preparacion de derivados de triazo-lopiridazina
ES500383A Expired ES8201581A1 (es) 1979-07-23 1981-03-16 Un procedimiento para la preparacion de derivados de triazo-lopiridazina
ES500382A Granted ES500382A0 (es) 1979-07-23 1981-03-16 Un procedimiento para la preparacion de derivados de triazo-lopiridazina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES493579A Granted ES493579A0 (es) 1979-07-23 1980-07-22 Un procedimiento para la preparacion de derivados de triazo-lopiridazina
ES500385A Expired ES8201583A1 (es) 1979-07-23 1981-03-16 Un procedimiento para la preparacion de derivados de triazo-lopiridazina

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES500383A Expired ES8201581A1 (es) 1979-07-23 1981-03-16 Un procedimiento para la preparacion de derivados de triazo-lopiridazina
ES500382A Granted ES500382A0 (es) 1979-07-23 1981-03-16 Un procedimiento para la preparacion de derivados de triazo-lopiridazina

Country Status (15)

Country Link
US (1) US4307094A (es)
EP (1) EP0024309A3 (es)
AR (1) AR229089A1 (es)
AU (1) AU6044380A (es)
CA (1) CA1137087A (es)
DK (1) DK316480A (es)
ES (5) ES493579A0 (es)
FI (1) FI802308A (es)
GR (1) GR69719B (es)
HU (1) HU180159B (es)
IL (1) IL60617A0 (es)
MC (1) MC1334A1 (es)
NO (1) NO802206L (es)
PH (1) PH16228A (es)
PT (1) PT71587B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
NZ204130A (en) * 1982-05-12 1986-03-14 Hoffmann La Roche Bicyclic heterocyclic compounds and pharmaceutical compositions
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
US4619687A (en) * 1984-09-27 1986-10-28 Sumitomo Chemical Company, Limited Triazolopyridazines and their use as herbicides
ZW11586A1 (en) * 1985-07-01 1987-12-30 Hoffmann La Roche Bicyclic compounds
EP0440119A1 (en) * 1990-01-31 1991-08-07 Takeda Chemical Industries, Ltd. Imidazopyridazine compounds, their production and use
WO1993012076A1 (en) * 1991-12-13 1993-06-24 Corvas International Inc. Reagents for automated synthesis of peptide analogs
US6020331A (en) * 1995-03-24 2000-02-01 Molecumetics, Ltd. β-sheet mimetics and use thereof as protease inhibitors
US6245764B1 (en) 1995-03-24 2001-06-12 Molecumetics Ltd. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6699869B1 (en) 1995-03-24 2004-03-02 Myriad Genetics Inc. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
EP1661566A3 (en) * 1996-08-05 2008-04-16 Myriad Genetics, Inc. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
DE69735545T2 (de) * 1996-08-05 2006-08-10 Myriad Genetics, Inc., Salt Lake City Verwendung von beta-blatt mimetika als protease und kinase hemmer und alshemmer eines transkriptionsfaktors
US6117896A (en) * 1997-02-10 2000-09-12 Molecumetics Ltd. Methods for regulating transcription factors
US6069248A (en) * 1998-08-21 2000-05-30 Axys Pharmaceuticals, Inc. Process for the synthesis of triazolopyridazine compounds
JP2005526722A (ja) * 2002-02-14 2005-09-08 ミリアド・ジェネティックス・インコーポレイテッド β−シートミメティックならびにそれに関連する組成物および方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663564A (en) * 1958-06-19 1972-05-16 Knoll Pharmaceutical Co Urazoles and their production
US3621099A (en) * 1969-03-05 1971-11-16 Charles R Jacobson Therapeutic compositions and methods for stimulating the central nervous system
DE2526358A1 (de) * 1974-06-19 1976-01-08 Mitsubishi Chem Ind 1,2-alkylenurazolderivate, ihre herstellung und verwendung als herbizid

Also Published As

Publication number Publication date
EP0024309A3 (de) 1981-07-22
ES500385A0 (es) 1982-01-01
ES8201583A1 (es) 1982-01-01
PT71587B (en) 1981-12-17
US4307094A (en) 1981-12-22
GR69719B (es) 1982-07-09
FI802308A (fi) 1981-01-24
ES8201580A1 (es) 1982-01-01
HU180159B (en) 1983-02-28
ES500382A0 (es) 1982-01-01
ES8106306A1 (es) 1981-06-16
AR229089A1 (es) 1983-06-15
CA1137087A (en) 1982-12-07
EP0024309A2 (de) 1981-03-04
PT71587A (en) 1980-08-01
AU6044380A (en) 1981-01-29
ES500383A0 (es) 1982-01-01
NO802206L (no) 1981-01-26
MC1334A1 (fr) 1981-04-21
IL60617A0 (en) 1980-09-16
ES8201581A1 (es) 1982-01-01
DK316480A (da) 1981-01-24
PH16228A (en) 1983-08-09
ES493579A0 (es) 1981-06-16
ES500384A0 (es) 1982-01-01

Similar Documents

Publication Publication Date Title
ES8106306A1 (es) Un procedimiento para la preparacion de derivados de triazo-lopiridazina
ATE141166T1 (de) Guanidinaminoglycosid enthaltende liposome
NO862426D0 (no) Fremgangsmaate for fremstilling av pyridobenzoksazinderivater.
FR2432511A1 (fr) Derives triazoliques, leur preparation et leur application en tant que medicaments
FR2375231A1 (fr) Derives de di- et tetrahydrobenzo-(5,6)cyclohepta(1,2-b)pyrazolo(4,3-a)pyridine, et leur utilisation comme medicaments
PT77370B (en) Process for preparing new pyrazolo <3,4-b> piridine derivatives and pharmaceutical preparations containing the same
ES2093666T3 (es) Derivados de los acidos 7-(2,7-diazabiciclo(3,3.0)octil)-3-quinolon- y -naftiridon carboxilicos.
GB1531963A (en) Pyrido(1,2alpha)pyrimidine derivatives
GR1000156B (el) ΜΕΘΟΔΟΣ ΠΑΡΑΣΚΕΥΗΣ ΝΕΩΝ ΠΑΡΑΓΩΓΩΝ ΤΡΙΚΥΚΛΙΚΩΝ ΑΜΙΝΩΝ ΤΗΣ ΤΕΤΡΑΥΔΡΟ-5,6,7,8ΝΑΦΘΟ[2,3b] ΔΙΥΔΡΟ-2,3 ΦΟΥΡΑΝΗΣ & ΤΗΣ ΤΕΤΡΑΥΔΡΟ-6,7,8,9 5Η-ΒΕΝΖΟΚΥΚΛΟΕΠΤΑ[2,3Β] ΔΙΥΔΡΟ-2,3 ΦΟΥΡΑΝΗΣ.
ES450799A1 (es) Un procedimiento para la preparacion de nuevas 3-fenilespino(esobenzofuran-1,4'-piperidemo) sulfenamidas y derivados.
FI834661A0 (fi) Nya farmakologiskt aktiva pyrazolopyridiner
ES8305783A1 (es) Procedimiento para la obtencion de derivados de aminociclitol saturados.
SE8803765L (sv) Nya isopolypeptider samt foerfarande foer framstaellning av desamma
FR2405261A1 (fr) Nouveaux derives pyrroliques de la cephalosporine, utiles notamment comme antibiotiques, et leur procede de preparation
FR2373541A1 (fr) Nouveaux derives sulfamoyl de la 8b-aminomethylergoline utiles notamment comme antagonistes de la serotonine et leur procede de preparation
SE9002508D0 (sv) Asymmetric synthesis of furo (3,4-c) pyridine derivatives
FR2381769A1 (fr) Nouveaux derives de l'ajmalicine, leurs sels, leur preparation et les medicaments qui les renferment
JPS52106838A (en) Preparation of allyl alcohol derivatives
FR2368484A2 (fr) Nouveaux derives de la benzol(5,6)gamma-pyrone, leur procede de preparation et leur utilisation therapeutique
FR2437399A1 (fr) Polypeptides, ou sels d'addition d'acides de ceux-ci, therapeutiquement actifs et procede de preparation de ces composes
FI850401A0 (fi) Maettade tricykliska kvaevehaltiga dioner saosom medel foer aktivering av fattningsfoeremaogan.