ES8201581A1 - Un procedimiento para la preparacion de derivados de triazo-lopiridazina - Google Patents

Un procedimiento para la preparacion de derivados de triazo-lopiridazina

Info

Publication number
ES8201581A1
ES8201581A1 ES500383A ES500383A ES8201581A1 ES 8201581 A1 ES8201581 A1 ES 8201581A1 ES 500383 A ES500383 A ES 500383A ES 500383 A ES500383 A ES 500383A ES 8201581 A1 ES8201581 A1 ES 8201581A1
Authority
ES
Spain
Prior art keywords
intermediates
preparation
triazolopyridazine derivatives
medicaments containing
triazolopyridazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500383A
Other languages
English (en)
Other versions
ES500383A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES500383A0 publication Critical patent/ES500383A0/es
Publication of ES8201581A1 publication Critical patent/ES8201581A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE TRIAZOLOPIRIDAZINA, ASI COMO DE SUS SALES DE ACIDOS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE A, R2 Y R5 PUEDEN SER VAROS TIPOS DE RADICALES; R1 ES UN GRUPO MERCAPTO; R3 ES UN HIDROGENO O HALOGENO; R4 ES HIDROGENO, HALOGENO O HIDROXILO; Y LA LINEA DE TRAZOS SIGNIFICA UN ENLACE CARBONO-CARBONO OPCIONAL. CONSISTE EN LA REACCION DE DISOCIACION DEL GRUPO R6 DEL COMPUESTO DE FORMULA (II), EN LA QUE R6 ES UN GRUPO ALCANOILO INFERIOR O ARIL-(ALQUILO INFERIOR), Y A, R2, R3, R4 Y R5 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO SIGUIENDO METODOS CONVENCIONALES, QUE DEPENDEN DE LA NATURALEZA DEL GRUPO R6.
ES500383A 1979-07-23 1981-03-16 Un procedimiento para la preparacion de derivados de triazo-lopiridazina Expired ES8201581A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7925576 1979-07-23
GB8013203 1980-04-22

Publications (2)

Publication Number Publication Date
ES500383A0 ES500383A0 (es) 1982-01-01
ES8201581A1 true ES8201581A1 (es) 1982-01-01

Family

ID=26272284

Family Applications (5)

Application Number Title Priority Date Filing Date
ES493579A Granted ES493579A0 (es) 1979-07-23 1980-07-22 Un procedimiento para la preparacion de derivados de triazo-lopiridazina
ES500384A Granted ES500384A0 (es) 1979-07-23 1981-03-16 Un procedimiento para la preparacion de derivados de triazo-lopiridazina
ES500382A Granted ES500382A0 (es) 1979-07-23 1981-03-16 Un procedimiento para la preparacion de derivados de triazo-lopiridazina
ES500383A Expired ES8201581A1 (es) 1979-07-23 1981-03-16 Un procedimiento para la preparacion de derivados de triazo-lopiridazina
ES500385A Expired ES8201583A1 (es) 1979-07-23 1981-03-16 Un procedimiento para la preparacion de derivados de triazo-lopiridazina

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES493579A Granted ES493579A0 (es) 1979-07-23 1980-07-22 Un procedimiento para la preparacion de derivados de triazo-lopiridazina
ES500384A Granted ES500384A0 (es) 1979-07-23 1981-03-16 Un procedimiento para la preparacion de derivados de triazo-lopiridazina
ES500382A Granted ES500382A0 (es) 1979-07-23 1981-03-16 Un procedimiento para la preparacion de derivados de triazo-lopiridazina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES500385A Expired ES8201583A1 (es) 1979-07-23 1981-03-16 Un procedimiento para la preparacion de derivados de triazo-lopiridazina

Country Status (15)

Country Link
US (1) US4307094A (es)
EP (1) EP0024309A3 (es)
AR (1) AR229089A1 (es)
AU (1) AU6044380A (es)
CA (1) CA1137087A (es)
DK (1) DK316480A (es)
ES (5) ES493579A0 (es)
FI (1) FI802308A (es)
GR (1) GR69719B (es)
HU (1) HU180159B (es)
IL (1) IL60617A0 (es)
MC (1) MC1334A1 (es)
NO (1) NO802206L (es)
PH (1) PH16228A (es)
PT (1) PT71587B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
NZ204130A (en) * 1982-05-12 1986-03-14 Hoffmann La Roche Bicyclic heterocyclic compounds and pharmaceutical compositions
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
US4619687A (en) * 1984-09-27 1986-10-28 Sumitomo Chemical Company, Limited Triazolopyridazines and their use as herbicides
ZW11586A1 (en) * 1985-07-01 1987-12-30 Hoffmann La Roche Bicyclic compounds
EP0440119A1 (en) * 1990-01-31 1991-08-07 Takeda Chemical Industries, Ltd. Imidazopyridazine compounds, their production and use
WO1993012076A1 (en) * 1991-12-13 1993-06-24 Corvas International Inc. Reagents for automated synthesis of peptide analogs
US6245764B1 (en) 1995-03-24 2001-06-12 Molecumetics Ltd. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6699869B1 (en) 1995-03-24 2004-03-02 Myriad Genetics Inc. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6020331A (en) 1995-03-24 2000-02-01 Molecumetics, Ltd. β-sheet mimetics and use thereof as protease inhibitors
KR20000029838A (ko) * 1996-08-05 2000-05-25 몰레큐메틱스 리미티드 프로테아제및키나제억제제로서그리고전사인자억제제로서의베타-시트유사체의용도
US6117896A (en) * 1997-02-10 2000-09-12 Molecumetics Ltd. Methods for regulating transcription factors
EP1661566A3 (en) * 1996-08-05 2008-04-16 Myriad Genetics, Inc. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
WO2000011005A1 (en) * 1998-08-21 2000-03-02 Axys Pharmaceuticals, Inc. Process for the synthesis of triazolopyridazine compounds
US7053214B2 (en) 2002-02-14 2006-05-30 Myriad Genetics, Inc. β-sheet mimetics and composition and methods relating thereto

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663564A (en) * 1958-06-19 1972-05-16 Knoll Pharmaceutical Co Urazoles and their production
US3621099A (en) * 1969-03-05 1971-11-16 Charles R Jacobson Therapeutic compositions and methods for stimulating the central nervous system
DE2526358A1 (de) 1974-06-19 1976-01-08 Mitsubishi Chem Ind 1,2-alkylenurazolderivate, ihre herstellung und verwendung als herbizid

Also Published As

Publication number Publication date
MC1334A1 (fr) 1981-04-21
PH16228A (en) 1983-08-09
AU6044380A (en) 1981-01-29
ES500383A0 (es) 1982-01-01
IL60617A0 (en) 1980-09-16
US4307094A (en) 1981-12-22
PT71587A (en) 1980-08-01
ES8106306A1 (es) 1981-06-16
EP0024309A3 (de) 1981-07-22
EP0024309A2 (de) 1981-03-04
ES500385A0 (es) 1982-01-01
CA1137087A (en) 1982-12-07
DK316480A (da) 1981-01-24
NO802206L (no) 1981-01-26
ES493579A0 (es) 1981-06-16
ES8201582A1 (es) 1982-01-01
HU180159B (en) 1983-02-28
GR69719B (es) 1982-07-09
ES8201580A1 (es) 1982-01-01
AR229089A1 (es) 1983-06-15
ES500384A0 (es) 1982-01-01
ES500382A0 (es) 1982-01-01
ES8201583A1 (es) 1982-01-01
FI802308A (fi) 1981-01-24
PT71587B (en) 1981-12-17

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