ES475587A1 - Procedimiento para preparar derivados de isoquinolina - Google Patents
Procedimiento para preparar derivados de isoquinolinaInfo
- Publication number
- ES475587A1 ES475587A1 ES475587A ES475587A ES475587A1 ES 475587 A1 ES475587 A1 ES 475587A1 ES 475587 A ES475587 A ES 475587A ES 475587 A ES475587 A ES 475587A ES 475587 A1 ES475587 A1 ES 475587A1
- Authority
- ES
- Spain
- Prior art keywords
- isouqinolines
- benz
- hexahydro
- formula
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Procedimiento para preparar derivados de isoquinolina, de fórmula I **fórmula** en donde R1 es hidrógeno, halógeno con número atómico de 9 a 35 o un grupo alquilo o alcoxi conteniendo de 1 a 4 átomos de carbono, R2 es hidrógeno, alquilo conteniendo de 1 a 4 átomos de carbono, un grupo fenilo o un grupo fenilo mono-sustituido o di-sustituido por halógeno con número, atómico de 9 a 35, alquilo conteniendo de 1 a 4 átomos de carbno o alcoxi conteniendo de 1 a 4 átomos de carbono, y R3III es alquilo conteniendo de 1 a 4 átomos de carbono, un grupo alquenilo o alquinilo conteniendo de 3 a 6 átomos de carbono, cuyo enlace múltiple no se encuentra adyacente al átomo de nitrógeno de la estructura de anillo tri-cíclica, un grupo cicloalquilalquilo conteniendo de 4 a 10 átomos de carbono, un grupo cicloalquilo conteniendo de 3 a 7 átomos de carbono, un grupo fenilalquilo de 7 a 10 átomos de carbono que puede ser mono-sustituido o di-sustituido en el anillo fenílico por halógeno con número atómico de9 a 35, alquilo de 1 a 4 átomos de carbono o alcoxi de 1 a 4 átomos de carbono, o un grupo alcanoilalquilo conteniendo de 3 a 5 átomos de carbono, cuyo átomo de oxígeno está separado del átomo de nitrógeno de la estructura de anillo tri-cíclica por a lo menos 2 átomos de carbono y sus sales de adición de ácido, caracterizado porque comprende introducir el grupo R3IIIen compuestos de fórmula**fórmula** en donde R1 y R2 tienen los significados previamente indicados, preferentemente por reacción de los compuestos de fórmula Ib con compuestos de fórmula R3III-x en donde R3III se define como anteriormente y X es el radical ácido de un éster reactivo, y si se desea, se convierten los compuestos de fórmula Id resultantes en sus sales de adición de ácido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH82077A CH630902A5 (en) | 1977-01-24 | 1977-01-24 | Process for preparing novel derivatives of 1,2,3,4,4a,10b-hexahydrobenzo(f)isoquinoline. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES475587A1 true ES475587A1 (es) | 1980-02-16 |
Family
ID=4195950
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES466245A Expired ES466245A1 (es) | 1977-01-24 | 1978-01-23 | Procedimiento para preparar derivados de isoquinolina |
| ES475587A Expired ES475587A1 (es) | 1977-01-24 | 1978-11-30 | Procedimiento para preparar derivados de isoquinolina |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES466245A Expired ES466245A1 (es) | 1977-01-24 | 1978-01-23 | Procedimiento para preparar derivados de isoquinolina |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5392778A (es) |
| AT (1) | AT367405B (es) |
| BE (1) | BE863215A (es) |
| CA (1) | CA1105468A (es) |
| CH (3) | CH630902A5 (es) |
| DE (1) | DE2801576A1 (es) |
| DK (1) | DK19278A (es) |
| ES (2) | ES466245A1 (es) |
| FI (1) | FI780130A (es) |
| FR (1) | FR2378015A1 (es) |
| GB (1) | GB1596170A (es) |
| IE (1) | IE46381B1 (es) |
| IL (1) | IL53869A (es) |
| IT (1) | IT7847687A0 (es) |
| NL (1) | NL7800719A (es) |
| NZ (1) | NZ186279A (es) |
| PH (1) | PH14194A (es) |
| PT (1) | PT67562B (es) |
| SE (1) | SE7800452L (es) |
| SU (1) | SU852172A3 (es) |
| ZA (1) | ZA78430B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8302361D0 (sv) * | 1983-04-27 | 1983-04-27 | Astra Laekemedel Ab | New tricyclic amines |
| US5294618A (en) * | 1989-07-28 | 1994-03-15 | Merck Sharp & Dohme Limited | Octahydrobenzisoquinoline derivatives as antipsychotic agents |
| GB8917333D0 (en) * | 1989-07-28 | 1989-09-13 | Merck Sharp & Dohme | Therapeutic agents |
| EP0539209A1 (en) * | 1991-10-24 | 1993-04-28 | The Upjohn Company | Benzo-isoquinoline derivatives and analogs and their use in therapeutics |
| WO1993008166A1 (en) * | 1991-10-24 | 1993-04-29 | The Upjohn Company | Benzo-isoquinoline derivatives and analogs and their use in therapeutics |
| AT407636B (de) * | 1999-07-09 | 2001-05-25 | Martin Dr Kratzel | Diels-alder-produkte von tetrahydropyridin-dienen mit naphthochinonen und deren oxidationsprodukte, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von arzneimitteln |
-
1977
- 1977-01-24 CH CH82077A patent/CH630902A5/de not_active IP Right Cessation
-
1978
- 1978-01-14 DE DE19782801576 patent/DE2801576A1/de not_active Withdrawn
- 1978-01-16 SE SE7800452A patent/SE7800452L/xx unknown
- 1978-01-16 DK DK19278A patent/DK19278A/da not_active Application Discontinuation
- 1978-01-16 FI FI780130A patent/FI780130A/fi not_active Application Discontinuation
- 1978-01-18 IT IT7847687A patent/IT7847687A0/it unknown
- 1978-01-20 NL NL7800719A patent/NL7800719A/xx not_active Application Discontinuation
- 1978-01-20 NZ NZ186279A patent/NZ186279A/xx unknown
- 1978-01-23 BE BE184555A patent/BE863215A/xx not_active IP Right Cessation
- 1978-01-23 CA CA295,458A patent/CA1105468A/en not_active Expired
- 1978-01-23 ES ES466245A patent/ES466245A1/es not_active Expired
- 1978-01-23 AT AT0045478A patent/AT367405B/de not_active IP Right Cessation
- 1978-01-23 SU SU782571448A patent/SU852172A3/ru active
- 1978-01-23 GB GB2603/78A patent/GB1596170A/en not_active Expired
- 1978-01-23 JP JP534678A patent/JPS5392778A/ja active Pending
- 1978-01-23 IE IE151/78A patent/IE46381B1/en unknown
- 1978-01-23 IL IL53869A patent/IL53869A/xx unknown
- 1978-01-23 PH PH20696A patent/PH14194A/en unknown
- 1978-01-23 PT PT67562A patent/PT67562B/pt unknown
- 1978-01-24 ZA ZA00780430A patent/ZA78430B/xx unknown
- 1978-01-24 FR FR7801860A patent/FR2378015A1/fr active Granted
- 1978-11-30 ES ES475587A patent/ES475587A1/es not_active Expired
-
1981
- 1981-03-20 CH CH190981A patent/CH630904A5/de not_active IP Right Cessation
- 1981-03-20 CH CH190881A patent/CH630903A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2378015B1 (es) | 1980-08-22 |
| NL7800719A (nl) | 1978-07-26 |
| SE7800452L (sv) | 1978-07-25 |
| IL53869A0 (en) | 1978-04-30 |
| NZ186279A (en) | 1980-05-27 |
| GB1596170A (en) | 1981-08-19 |
| SU852172A3 (ru) | 1981-07-30 |
| CA1105468A (en) | 1981-07-21 |
| AT367405B (de) | 1982-07-12 |
| CH630903A5 (en) | 1982-07-15 |
| FR2378015A1 (fr) | 1978-08-18 |
| PT67562A (fr) | 1978-02-01 |
| IE46381B1 (en) | 1983-05-18 |
| BE863215A (fr) | 1978-07-24 |
| IL53869A (en) | 1981-05-20 |
| IT7847687A0 (it) | 1978-01-18 |
| PT67562B (fr) | 1980-11-03 |
| JPS5392778A (en) | 1978-08-15 |
| DK19278A (da) | 1978-07-25 |
| DE2801576A1 (de) | 1978-07-27 |
| FI780130A (fi) | 1978-07-25 |
| ES466245A1 (es) | 1980-12-16 |
| IE780151L (en) | 1978-07-24 |
| AU3265478A (en) | 1979-08-02 |
| CH630902A5 (en) | 1982-07-15 |
| PH14194A (en) | 1981-03-26 |
| ZA78430B (en) | 1979-09-26 |
| CH630904A5 (en) | 1982-07-15 |
| ATA45478A (de) | 1981-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19990405 |