ATE58896T1 - Neue zwischenprodukte und verfahren zur herstellung von 3-acylamino-1-hydroxy-2azetidinonen. - Google Patents

Neue zwischenprodukte und verfahren zur herstellung von 3-acylamino-1-hydroxy-2azetidinonen.

Info

Publication number
ATE58896T1
ATE58896T1 AT85109655T AT85109655T ATE58896T1 AT E58896 T1 ATE58896 T1 AT E58896T1 AT 85109655 T AT85109655 T AT 85109655T AT 85109655 T AT85109655 T AT 85109655T AT E58896 T1 ATE58896 T1 AT E58896T1
Authority
AT
Austria
Prior art keywords
processes
acylamino
hydroxy
production
intermediate products
Prior art date
Application number
AT85109655T
Other languages
English (en)
Inventor
Richard H Mueller
Jakob-Matthias Drossard
Peter H Ermann
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Application granted granted Critical
Publication of ATE58896T1 publication Critical patent/ATE58896T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Accommodation For Nursing Or Treatment Tables (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
AT85109655T 1984-08-03 1985-08-01 Neue zwischenprodukte und verfahren zur herstellung von 3-acylamino-1-hydroxy-2azetidinonen. ATE58896T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/637,260 US4581170A (en) 1984-08-03 1984-08-03 N-hydroxyl protecting groups and process and intermediates for the preparation of 3-acylamino-1-hydroxy-2-azetidinones
EP85109655A EP0170280B1 (de) 1984-08-03 1985-08-01 Neue Zwischenprodukte und Verfahren zur Herstellung von 3-Acylamino-1-hydroxy-2-azetidinonen

Publications (1)

Publication Number Publication Date
ATE58896T1 true ATE58896T1 (de) 1990-12-15

Family

ID=24555200

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85109655T ATE58896T1 (de) 1984-08-03 1985-08-01 Neue zwischenprodukte und verfahren zur herstellung von 3-acylamino-1-hydroxy-2azetidinonen.

Country Status (12)

Country Link
US (1) US4581170A (de)
EP (2) EP0170280B1 (de)
JP (2) JPH06732B2 (de)
AT (1) ATE58896T1 (de)
AU (2) AU589567B2 (de)
CA (1) CA1268780C (de)
DE (1) DE3580803D1 (de)
DK (1) DK353385A (de)
FI (1) FI852974A7 (de)
IE (2) IE58758B1 (de)
NZ (1) NZ212750A (de)
ZA (1) ZA855492B (de)

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EP0233607B1 (de) * 1986-02-18 1991-03-13 E.R. Squibb & Sons, Inc. [(2,2,2-Trichloroethoxy)methoxy]amin
US5037974A (en) * 1988-05-23 1991-08-06 Merck & Co., Inc. Cyclization process for synthesis of a beta-lactam carbapenem intermediate
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US6068993A (en) * 1997-07-02 2000-05-30 Biobras Sa Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
KR20040025890A (ko) * 2001-01-26 2004-03-26 쉐링 코포레이션 혈관성 질환을 치료하기 위한 스테롤 흡수 억제제와 혈액조절제의 조합물
ES2290562T3 (es) * 2001-01-26 2008-02-16 Schering Corporation Combinaciones del activador del receptor activado por el proliferador de los peroxisomas (ppar) fenofibrato con el inhibidor de la absorcion de esteroles ezetimiba para indicaciones vasculares.
CA2434033A1 (en) * 2001-01-26 2002-08-01 Schering Corporation Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
IL156585A0 (en) * 2001-01-26 2004-01-04 Schering Corp Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions
CA2434488A1 (en) * 2001-01-26 2002-08-01 Harry R. Davis Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications
KR20070120617A (ko) * 2001-01-26 2007-12-24 쉐링 코포레이션 치환된 아제티딘온 화합물을 포함하는 약제학적 조성물
US20030013699A1 (en) * 2001-05-25 2003-01-16 Davis Harry R. Methods for treating alzheimer's disease and/or regulating levels of amyloid beta peptides in a subject
ES2312624T3 (es) * 2001-09-21 2009-03-01 Schering Corporation Metodos para tratar o prevenir la inflamacion vascular usando un inhibidor (inhibidores) de la absorcion de esterol.
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7132415B2 (en) * 2001-09-21 2006-11-07 Schering Corporation Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
MXPA05004810A (es) * 2002-11-06 2005-07-22 Schering Corp Inhibidores de la absorcion del colesterol para el tratamiento de la desmielinizacion.
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
EP1601669B1 (de) * 2003-03-07 2008-12-24 Schering Corporation Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
WO2004081004A1 (en) * 2003-03-07 2004-09-23 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
ATE406364T1 (de) * 2003-03-07 2008-09-15 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
EP1680189A2 (de) * 2003-11-05 2006-07-19 Schering Corporation Kombinationen von lipidmodulierenden mitteln mit substituierten azetidinonen zur behandlung von vaskularen erkrankungen
US9361572B2 (en) 2013-03-04 2016-06-07 Hello Inc. Wearable device with magnets positioned at opposing ends and overlapped from one side to another
US9582748B2 (en) 2013-03-04 2017-02-28 Hello Inc. Base charging station for monitoring device
US9634921B2 (en) 2013-03-04 2017-04-25 Hello Inc. Wearable device coupled by magnets positioned in a frame in an interior of the wearable device with at least one electronic circuit
US9406220B2 (en) 2013-03-04 2016-08-02 Hello Inc. Telemetry system with tracking receiver devices
US9159223B2 (en) 2013-03-04 2015-10-13 Hello, Inc. User monitoring device configured to be in communication with an emergency response system or team
US8810430B2 (en) 2013-03-04 2014-08-19 Hello Inc. System using wearable device with unique user ID and telemetry system
US9532716B2 (en) 2013-03-04 2017-01-03 Hello Inc. Systems using lifestyle database analysis to provide feedback
US9320434B2 (en) 2013-03-04 2016-04-26 Hello Inc. Patient monitoring systems and messages that send alerts to patients only when the patient is awake
US9392939B2 (en) 2013-03-04 2016-07-19 Hello Inc. Methods using a monitoring device to monitor individual activities, behaviors or habit information and communicate with a database with corresponding individual base information for comparison
US9149189B2 (en) 2013-03-04 2015-10-06 Hello, Inc. User or patient monitoring methods using one or more analysis tools
US9330561B2 (en) 2013-03-04 2016-05-03 Hello Inc. Remote communication systems and methods for communicating with a building gateway control to control building systems and elements
US9430938B2 (en) 2013-03-04 2016-08-30 Hello Inc. Monitoring device with selectable wireless communication
US9398854B2 (en) 2013-03-04 2016-07-26 Hello Inc. System with a monitoring device that monitors individual activities, behaviors or habit information and communicates with a database with corresponding individual base information for comparison
US9553486B2 (en) 2013-03-04 2017-01-24 Hello Inc. Monitoring system and device with sensors that is remotely powered
US9462856B2 (en) 2013-03-04 2016-10-11 Hello Inc. Wearable device with magnets sealed in a wearable device structure
US9530089B2 (en) 2013-03-04 2016-12-27 Hello Inc. Wearable device with overlapping ends coupled by magnets of a selected width, length and depth
US9526422B2 (en) 2013-03-04 2016-12-27 Hello Inc. System for monitoring individuals with a monitoring device, telemetry system, activity manager and a feedback system
US9424508B2 (en) 2013-03-04 2016-08-23 Hello Inc. Wearable device with magnets having first and second polarities
US9357922B2 (en) 2013-03-04 2016-06-07 Hello Inc. User or patient monitoring systems with one or more analysis tools
US9436903B2 (en) 2013-03-04 2016-09-06 Hello Inc. Wearable device with magnets with a defined distance between adjacent magnets
US9737214B2 (en) 2013-03-04 2017-08-22 Hello Inc. Wireless monitoring of patient exercise and lifestyle
US9345404B2 (en) 2013-03-04 2016-05-24 Hello Inc. Mobile device that monitors an individuals activities, behaviors, habits or health parameters
US9339188B2 (en) 2013-03-04 2016-05-17 James Proud Methods from monitoring health, wellness and fitness with feedback
US9427160B2 (en) 2013-03-04 2016-08-30 Hello Inc. Wearable device with overlapping ends coupled by magnets positioned in the wearable device by an undercut
US9848776B2 (en) 2013-03-04 2017-12-26 Hello Inc. Methods using activity manager for monitoring user activity
US9420856B2 (en) 2013-03-04 2016-08-23 Hello Inc. Wearable device with adjacent magnets magnetized in different directions
US9298882B2 (en) 2013-03-04 2016-03-29 Hello Inc. Methods using patient monitoring devices with unique patient IDs and a telemetry system
US9662015B2 (en) 2013-03-04 2017-05-30 Hello Inc. System or device with wearable devices having one or more sensors with assignment of a wearable device user identifier to a wearable device user
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Also Published As

Publication number Publication date
FI852974L (fi) 1986-02-04
FI852974A7 (fi) 1986-02-04
ZA855492B (en) 1986-03-26
US4581170A (en) 1986-04-08
CA1268780C (fr) 1990-05-08
DE3580803D1 (de) 1991-01-17
JPH0662532B2 (ja) 1994-08-17
IE58758B1 (en) 1993-11-03
IE851917L (en) 1986-02-03
DK353385D0 (da) 1985-08-02
AU4083589A (en) 1990-02-08
AU589567B2 (en) 1989-10-19
EP0170280A1 (de) 1986-02-05
NZ212750A (en) 1989-04-26
AU4535685A (en) 1986-02-06
CA1262357A (en) 1989-10-17
EP0371004A1 (de) 1990-05-30
FI852974A0 (fi) 1985-08-01
AU614663B2 (en) 1991-09-05
JPH069528A (ja) 1994-01-18
DK353385A (da) 1986-02-04
JPS6147445A (ja) 1986-03-07
IE58771B1 (en) 1993-11-03
JPH06732B2 (ja) 1994-01-05
EP0170280B1 (de) 1990-12-05

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee