DE69322708D1 - Neues Verfahren zur Herstellung von 7-(substituierten)-9-[(substistuierter Glycyl)amido]-6-demethyl-6-deoxytetracyclinen - Google Patents

Neues Verfahren zur Herstellung von 7-(substituierten)-9-[(substistuierter Glycyl)amido]-6-demethyl-6-deoxytetracyclinen

Info

Publication number
DE69322708D1
DE69322708D1 DE69322708T DE69322708T DE69322708D1 DE 69322708 D1 DE69322708 D1 DE 69322708D1 DE 69322708 T DE69322708 T DE 69322708T DE 69322708 T DE69322708 T DE 69322708T DE 69322708 D1 DE69322708 D1 DE 69322708D1
Authority
DE
Germany
Prior art keywords
substituted
deoxytetracyclines
demethyl
amido
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69322708T
Other languages
English (en)
Other versions
DE69322708T2 (de
Inventor
Phaik-Eng Sum
Ving J Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DE69322708D1 publication Critical patent/DE69322708D1/de
Application granted granted Critical
Publication of DE69322708T2 publication Critical patent/DE69322708T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
DE69322708T 1992-08-13 1993-05-12 Neues Verfahren zur Herstellung von 7-(substituierten)-9-[(substistuierter Glycyl)amido]-6-demethyl-6-deoxytetracyclinen Expired - Lifetime DE69322708T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/928,588 US5284963A (en) 1992-08-13 1992-08-13 Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines

Publications (2)

Publication Number Publication Date
DE69322708D1 true DE69322708D1 (de) 1999-02-04
DE69322708T2 DE69322708T2 (de) 1999-04-29

Family

ID=25456483

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69322708T Expired - Lifetime DE69322708T2 (de) 1992-08-13 1993-05-12 Neues Verfahren zur Herstellung von 7-(substituierten)-9-[(substistuierter Glycyl)amido]-6-demethyl-6-deoxytetracyclinen

Country Status (27)

Country Link
US (1) US5284963A (de)
EP (1) EP0582790B1 (de)
JP (1) JP3590643B2 (de)
KR (1) KR100250603B1 (de)
CN (1) CN1037680C (de)
AT (1) ATE174903T1 (de)
AU (1) AU674689B2 (de)
CA (1) CA2103837C (de)
CZ (1) CZ286261B6 (de)
DE (1) DE69322708T2 (de)
DK (1) DK0582790T3 (de)
ES (1) ES2125927T3 (de)
FI (1) FI115722B (de)
GR (1) GR3029764T3 (de)
HU (1) HU222886B1 (de)
IL (3) IL119551A (de)
LV (1) LV12273B (de)
MX (1) MX9304649A (de)
NO (1) NO303574B1 (de)
NZ (1) NZ248358A (de)
PH (1) PH30150A (de)
PL (2) PL173923B1 (de)
RU (1) RU2111958C1 (de)
SG (1) SG68556A1 (de)
SK (1) SK281698B6 (de)
TW (1) TW221285B (de)
ZA (1) ZA935891B (de)

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USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US6946118B1 (en) 1999-09-14 2005-09-20 Orapharma, Inc. Formulations for treating or preventing mucositis
ES2260051T3 (es) * 1999-09-14 2006-11-01 Trustees Of Tufts College Metodo para preparar tetraciclinas substituidas con quimicas basadas en metales de transicion.
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
AU2001268475A1 (en) * 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
AU8638801A (en) * 2000-07-07 2002-01-21 Tufts College 9-substituted minocycline compounds
IL153672A0 (en) * 2000-07-07 2003-07-06 Tufts College 7-substituted tetracycline compounds
WO2002072532A1 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7, 9-substituted tetracycline compounds
EP1241160A1 (de) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracyclinderivate und ihre Verwendung als Antibiotica
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP2329826A1 (de) 2001-07-13 2011-06-08 Paratek Pharmaceuticals, Inc. Tetracycline zur Behandlung der multiplen Sklerose
AU2002365120A1 (en) * 2001-08-02 2003-07-15 Paratek Pharmaceuticals, Inc. Medicaments
EP2311799A1 (de) 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-Dedimethylamin-Tetracyclinverbindungen
EP2301534A1 (de) * 2002-03-08 2011-03-30 Paratek Pharmaceuticals, Inc. Aminomethyl-substituierte Tetracyclin-Verbindungen
EP2481723A3 (de) 2002-03-21 2013-02-13 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclin-Verbindungen
US20040029843A1 (en) * 2002-06-20 2004-02-12 Orapharma, Inc. Rapidly disintegrating formulations for treating or preventing mucositis
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
US20050143352A1 (en) 2003-07-09 2005-06-30 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP2284152A3 (de) 2004-10-25 2011-10-05 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclin-Verbindungen
US7534766B2 (en) 2004-11-05 2009-05-19 Wyeth Glucuronide metabolites and epimers thereof of tigecycline
EP1848685A1 (de) 2005-02-04 2007-10-31 Paratek Pharmaceuticals, Inc. 11a,12-derivate von tetracyclinverbindungen
US20060183758A1 (en) * 2005-02-17 2006-08-17 Cb Research And Development, Inc. Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057649A1 (es) 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
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PE20070072A1 (es) * 2005-06-16 2007-02-25 Wyeth Corp Proceso de manufactura para tigeciclina como polvo reconstituible
KR20080085184A (ko) * 2005-12-22 2008-09-23 와이어쓰 티게사이클린을 사용한 위장관 감염의 치료방법
CA2649221A1 (en) * 2006-04-17 2007-10-25 Evgeny Tsiperman Isolation of tetracycline derivatives
ES2528202T3 (es) * 2006-04-24 2015-02-05 Teva Pharmaceutical Industries Ltd. Una forma cristalina de tigeciclina y procesos para su preparación
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
EP2218785A3 (de) 2006-05-15 2010-12-29 Paratek Pharmaceuticals, Inc. Verfahren zur Regelung der Genexpression oder von Genprodukten mit substituierten Tetracyclinverbindungen
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US20070286818A1 (en) * 2006-06-07 2007-12-13 Wyeth Treating cystic fibrosis with antibiotics via an aerosol drug
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US8198469B2 (en) * 2006-11-29 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline forms of tigecycline and processes for preparation thereof
BRPI0706517A2 (pt) * 2006-11-30 2011-03-29 Teva Pharma processos para preparação de f 9-haloacetamidominociclinas
EP2114865A1 (de) * 2007-03-01 2009-11-11 Teva Pharmaceutical Industries Ltd. Verfahren zur reinigung von tigecyclin
AT13157U1 (de) * 2007-04-24 2013-07-15 Teva Pharma Tigecyclin, kristalline Formen und Herstellungsverfahren dafür
US20090076153A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched tigecycline
CN101868469B (zh) 2007-11-29 2014-04-02 埃科特莱茵药品有限公司 膦酸衍生物及其作为p2y12受体拮抗剂
HUE026562T2 (hu) 2008-08-08 2016-06-28 Tetraphase Pharmaceuticals Inc C7-fluor-helyettesített tetraciklin vegyületek
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US9624166B2 (en) 2009-08-28 2017-04-18 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
LT2890673T (lt) 2012-08-31 2019-04-10 Tetraphase Pharmaceuticals, Inc. Tetraciklino junginiai
SG11201903327PA (en) 2016-10-19 2019-05-30 Tetraphase Pharmaceuticals Inc Crystalline forms of eravacycline
US20220233555A1 (en) 2019-05-24 2022-07-28 Stichting Radboud Universitair Medisch Centrum Improved administration of glycylcyclines by inhalation

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Also Published As

Publication number Publication date
ATE174903T1 (de) 1999-01-15
TW221285B (de) 1994-02-21
EP0582790A1 (de) 1994-02-16
AU4460393A (en) 1994-02-17
IL106674A (en) 1998-07-15
CN1083047A (zh) 1994-03-02
SG68556A1 (en) 1999-11-16
NO932870L (no) 1994-02-14
FI933566A (fi) 1994-02-14
DK0582790T3 (da) 1999-08-23
GR3029764T3 (en) 1999-06-30
CZ157793A3 (en) 1994-03-16
SK281698B6 (sk) 2001-07-10
ES2125927T3 (es) 1999-03-16
US5284963A (en) 1994-02-08
KR100250603B1 (ko) 2000-04-01
HU222886B1 (hu) 2003-12-29
KR940003923A (ko) 1994-03-14
LV12273A (lv) 1999-05-20
DE69322708T2 (de) 1999-04-29
MX9304649A (es) 1994-02-28
EP0582790B1 (de) 1998-12-23
ZA935891B (en) 1994-03-09
FI115722B (fi) 2005-06-30
CA2103837C (en) 2004-10-05
PL173606B1 (pl) 1998-03-31
NO932870D0 (no) 1993-08-12
CN1037680C (zh) 1998-03-11
NZ248358A (en) 1996-04-26
FI933566A0 (fi) 1993-08-12
HU9302331D0 (en) 1993-10-28
CA2103837A1 (en) 1994-02-14
IL119551A (en) 2003-02-12
RU2111958C1 (ru) 1998-05-27
SK84993A3 (en) 1994-06-08
PH30150A (en) 1997-01-21
PL300064A1 (en) 1994-02-21
JP3590643B2 (ja) 2004-11-17
IL106674A0 (en) 1993-12-08
PL173923B1 (pl) 1998-05-29
NO303574B1 (no) 1998-08-03
CZ286261B6 (cs) 2000-02-16
IL119551A0 (en) 1997-02-18
LV12273B (en) 1999-11-20
HUT64941A (en) 1994-03-28
JPH06184075A (ja) 1994-07-05
AU674689B2 (en) 1997-01-09

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Owner name: WYETH HOLDINGS CORP., MADISON, N.J., US