ATE234288T1 - Verfahren zur herstellung eines buthylthuio- isochinolinderivates und zwischenprodukte dafür - Google Patents
Verfahren zur herstellung eines buthylthuio- isochinolinderivates und zwischenprodukte dafürInfo
- Publication number
- ATE234288T1 ATE234288T1 AT98919219T AT98919219T ATE234288T1 AT E234288 T1 ATE234288 T1 AT E234288T1 AT 98919219 T AT98919219 T AT 98919219T AT 98919219 T AT98919219 T AT 98919219T AT E234288 T1 ATE234288 T1 AT E234288T1
- Authority
- AT
- Austria
- Prior art keywords
- buthylthuio
- producing
- intermediate products
- isoquinoline derivative
- products therefor
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title 1
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical class C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title 1
- GKVJSYYVNPXJRL-UHFFFAOYSA-N 1-(4-phenylsulfanylbutyl)isoquinoline Chemical compound N=1C=CC2=CC=CC=C2C=1CCCCSC1=CC=CC=C1 GKVJSYYVNPXJRL-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- General Health & Medical Sciences (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97810212 | 1997-04-10 | ||
EP97810240 | 1997-04-18 | ||
PCT/EP1998/001959 WO1998045271A1 (en) | 1997-04-10 | 1998-04-03 | Process for making a butylthio-isoquinoline and intermediates therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE234288T1 true ATE234288T1 (de) | 2003-03-15 |
Family
ID=27222866
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98919219T ATE234288T1 (de) | 1997-04-10 | 1998-04-03 | Verfahren zur herstellung eines buthylthuio- isochinolinderivates und zwischenprodukte dafür |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0975601B1 (de) |
JP (1) | JP3467043B2 (de) |
AT (1) | ATE234288T1 (de) |
AU (1) | AU7214298A (de) |
CA (1) | CA2286013C (de) |
DE (1) | DE69812079T2 (de) |
DK (1) | DK0975601T3 (de) |
WO (1) | WO1998045271A1 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2273643A1 (en) * | 1998-06-09 | 1999-12-09 | F. Hoffmann-La Roche Ag | Stereoselective reduction of carbonyl compounds |
EP1236715B1 (de) * | 1998-06-29 | 2008-10-15 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von S-Aryl-Cystein |
US6765109B1 (en) | 1998-06-29 | 2004-07-20 | Roche Colorado Corporation | Preparation of S-aryl-cysteine and its derivatives |
CA2361475A1 (en) | 1999-01-28 | 2000-08-03 | Ajinomoto Co., Inc. | Process for the preparation of .alpha.-aminoketones |
US6225307B1 (en) | 1999-03-31 | 2001-05-01 | The Procter & Gamble Company | Viral treatment |
WO2002064553A1 (fr) * | 2001-02-14 | 2002-08-22 | Kureha Chemical Industry Company, Limited | Procede de preparation de derives d'alcools halogenes |
CN1329373C (zh) * | 2003-12-11 | 2007-08-01 | 上海安基生物科技股份有限公司 | (2s.3r)-n-苄氧羰基-3-氨基-1-氯-4-苯硫基-2-丁醇的生产方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
ATE416158T1 (de) * | 1995-09-26 | 2008-12-15 | Japan Tobacco Inc | Verfahren zur herstellung von amidderivaten und ihren zwischenverbindungen |
US5705647A (en) * | 1996-09-05 | 1998-01-06 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
-
1998
- 1998-04-03 JP JP54236098A patent/JP3467043B2/ja not_active Expired - Fee Related
- 1998-04-03 CA CA002286013A patent/CA2286013C/en not_active Expired - Fee Related
- 1998-04-03 EP EP98919219A patent/EP0975601B1/de not_active Expired - Lifetime
- 1998-04-03 AU AU72142/98A patent/AU7214298A/en not_active Abandoned
- 1998-04-03 AT AT98919219T patent/ATE234288T1/de active
- 1998-04-03 DE DE69812079T patent/DE69812079T2/de not_active Expired - Lifetime
- 1998-04-03 DK DK98919219T patent/DK0975601T3/da active
- 1998-04-03 WO PCT/EP1998/001959 patent/WO1998045271A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CA2286013C (en) | 2003-07-15 |
EP0975601A1 (de) | 2000-02-02 |
EP0975601B1 (de) | 2003-03-12 |
DE69812079T2 (de) | 2003-12-18 |
JP2000510479A (ja) | 2000-08-15 |
CA2286013A1 (en) | 1998-10-15 |
DE69812079D1 (de) | 2003-04-17 |
WO1998045271A1 (en) | 1998-10-15 |
JP3467043B2 (ja) | 2003-11-17 |
DK0975601T3 (da) | 2003-06-16 |
AU7214298A (en) | 1998-10-30 |
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