DK0975601T3 - Fremgangsmåde til fremstilling af butylthio-isoquinolin og mellemprodukter derfor - Google Patents
Fremgangsmåde til fremstilling af butylthio-isoquinolin og mellemprodukter derforInfo
- Publication number
- DK0975601T3 DK0975601T3 DK98919219T DK98919219T DK0975601T3 DK 0975601 T3 DK0975601 T3 DK 0975601T3 DK 98919219 T DK98919219 T DK 98919219T DK 98919219 T DK98919219 T DK 98919219T DK 0975601 T3 DK0975601 T3 DK 0975601T3
- Authority
- DK
- Denmark
- Prior art keywords
- butylthioisoquinoline
- preparation
- intermediates therefor
- therefor
- intermediates
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- MLNGFEYPIIEVKG-UHFFFAOYSA-N 1-butylsulfanylisoquinoline Chemical compound C1=CC=C2C(SCCCC)=NC=CC2=C1 MLNGFEYPIIEVKG-UHFFFAOYSA-N 0.000 title 1
- GKVJSYYVNPXJRL-UHFFFAOYSA-N 1-(4-phenylsulfanylbutyl)isoquinoline Chemical compound N=1C=CC2=CC=CC=C2C=1CCCCSC1=CC=CC=C1 GKVJSYYVNPXJRL-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97810212 | 1997-04-10 | ||
| EP97810240 | 1997-04-18 | ||
| PCT/EP1998/001959 WO1998045271A1 (en) | 1997-04-10 | 1998-04-03 | Process for making a butylthio-isoquinoline and intermediates therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0975601T3 true DK0975601T3 (da) | 2003-06-16 |
Family
ID=27222866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98919219T DK0975601T3 (da) | 1997-04-10 | 1998-04-03 | Fremgangsmåde til fremstilling af butylthio-isoquinolin og mellemprodukter derfor |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0975601B1 (de) |
| JP (1) | JP3467043B2 (de) |
| AT (1) | ATE234288T1 (de) |
| AU (1) | AU7214298A (de) |
| CA (1) | CA2286013C (de) |
| DE (1) | DE69812079T2 (de) |
| DK (1) | DK0975601T3 (de) |
| WO (1) | WO1998045271A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2273643A1 (en) * | 1998-06-09 | 1999-12-09 | F. Hoffmann-La Roche Ag | Stereoselective reduction of carbonyl compounds |
| US6765109B1 (en) | 1998-06-29 | 2004-07-20 | Roche Colorado Corporation | Preparation of S-aryl-cysteine and its derivatives |
| EP1236715B1 (de) * | 1998-06-29 | 2008-10-15 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von S-Aryl-Cystein |
| ATE411978T1 (de) | 1999-01-28 | 2008-11-15 | Ajinomoto Kk | Verfahren zur herstellung von alpha-aminoketonen |
| JP2002540149A (ja) | 1999-03-31 | 2002-11-26 | ザ プロクター アンド ギャンブル カンパニー | ウイルス感染治療のためのカルバミン酸エステル誘導体の使用法 |
| JPWO2002064553A1 (ja) * | 2001-02-14 | 2004-06-10 | 呉羽化学工業株式会社 | ハロゲノアルコール誘導体の製造方法 |
| CN1329373C (zh) * | 2003-12-11 | 2007-08-01 | 上海安基生物科技股份有限公司 | （2s.3r）－n－苄氧羰基－3－氨基－1－氯－4－苯硫基－2－丁醇的生产方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| PT984000E (pt) * | 1995-09-26 | 2009-02-06 | Agouron Pharma | Processo para a produção de derivados amina e compostos intermediários |
| US5705647A (en) * | 1996-09-05 | 1998-01-06 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
-
1998
- 1998-04-03 AT AT98919219T patent/ATE234288T1/de active
- 1998-04-03 CA CA002286013A patent/CA2286013C/en not_active Expired - Fee Related
- 1998-04-03 DE DE69812079T patent/DE69812079T2/de not_active Expired - Lifetime
- 1998-04-03 AU AU72142/98A patent/AU7214298A/en not_active Abandoned
- 1998-04-03 EP EP98919219A patent/EP0975601B1/de not_active Expired - Lifetime
- 1998-04-03 DK DK98919219T patent/DK0975601T3/da active
- 1998-04-03 JP JP54236098A patent/JP3467043B2/ja not_active Expired - Fee Related
- 1998-04-03 WO PCT/EP1998/001959 patent/WO1998045271A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2286013C (en) | 2003-07-15 |
| EP0975601A1 (de) | 2000-02-02 |
| DE69812079T2 (de) | 2003-12-18 |
| AU7214298A (en) | 1998-10-30 |
| JP3467043B2 (ja) | 2003-11-17 |
| ATE234288T1 (de) | 2003-03-15 |
| DE69812079D1 (de) | 2003-04-17 |
| CA2286013A1 (en) | 1998-10-15 |
| EP0975601B1 (de) | 2003-03-12 |
| WO1998045271A1 (en) | 1998-10-15 |
| JP2000510479A (ja) | 2000-08-15 |
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