ATE174903T1 - Neues verfahren zur herstellung von 7- (substituierten)-9-((substistuierter - Google Patents

Neues verfahren zur herstellung von 7- (substituierten)-9-((substistuierter

Info

Publication number
ATE174903T1
ATE174903T1 AT93107719T AT93107719T ATE174903T1 AT E174903 T1 ATE174903 T1 AT E174903T1 AT 93107719 T AT93107719 T AT 93107719T AT 93107719 T AT93107719 T AT 93107719T AT E174903 T1 ATE174903 T1 AT E174903T1
Authority
AT
Austria
Prior art keywords
substituted
producing
new process
formula
compounds
Prior art date
Application number
AT93107719T
Other languages
English (en)
Inventor
Phaik-Eng Sum
Ving J Lee
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ATE174903T1 publication Critical patent/ATE174903T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT93107719T 1992-08-13 1993-05-12 Neues verfahren zur herstellung von 7- (substituierten)-9-((substistuierter ATE174903T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/928,588 US5284963A (en) 1992-08-13 1992-08-13 Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines

Publications (1)

Publication Number Publication Date
ATE174903T1 true ATE174903T1 (de) 1999-01-15

Family

ID=25456483

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93107719T ATE174903T1 (de) 1992-08-13 1993-05-12 Neues verfahren zur herstellung von 7- (substituierten)-9-((substistuierter

Country Status (27)

Country Link
US (1) US5284963A (de)
EP (1) EP0582790B1 (de)
JP (1) JP3590643B2 (de)
KR (1) KR100250603B1 (de)
CN (1) CN1037680C (de)
AT (1) ATE174903T1 (de)
AU (1) AU674689B2 (de)
CA (1) CA2103837C (de)
CZ (1) CZ286261B6 (de)
DE (1) DE69322708T2 (de)
DK (1) DK0582790T3 (de)
ES (1) ES2125927T3 (de)
FI (1) FI115722B (de)
GR (1) GR3029764T3 (de)
HU (1) HU222886B1 (de)
IL (3) IL119551A (de)
LV (1) LV12273B (de)
MX (1) MX9304649A (de)
NO (1) NO303574B1 (de)
NZ (1) NZ248358A (de)
PH (1) PH30150A (de)
PL (2) PL173923B1 (de)
RU (1) RU2111958C1 (de)
SG (1) SG68556A1 (de)
SK (1) SK281698B6 (de)
TW (1) TW221285B (de)
ZA (1) ZA935891B (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
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US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
EP1666453A1 (de) * 1999-09-14 2006-06-07 Trustees Of Tufts College Verfahren zur Herstellung von substituierten Tetracyclinen mit Hilfe von auf Übergangsmetalle basierten ChemienT
US6946118B1 (en) 1999-09-14 2005-09-20 Orapharma, Inc. Formulations for treating or preventing mucositis
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
AU2001268475A1 (en) * 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
EA006170B1 (ru) * 2000-07-07 2005-10-27 Трастис Оф Тафтс Коллидж Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния субъекта
SI1301467T1 (sl) 2000-07-07 2007-02-28 Tufts College 9-substituirane minociklinske spojine
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
US6683068B2 (en) * 2001-03-13 2004-01-27 Paratek Pharmaceuticals, Inc. 7, 9-substituted tetracycline compounds
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP1241160A1 (de) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracyclinderivate und ihre Verwendung als Antibiotica
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
US20040063674A1 (en) 2001-07-13 2004-04-01 Levy Stuart B. Tetracycline compounds having target therapeutic activities
AU2002365120A1 (en) 2001-08-02 2003-07-15 Paratek Pharmaceuticals, Inc. Medicaments
JP2005514410A (ja) * 2002-01-08 2005-05-19 パラテック ファーマシューティカルズ インコーポレイテッド ４−デジメチルアミノテトラサイクリン化合物
JP2005526754A (ja) * 2002-03-08 2005-09-08 パラテック ファーマシューティカルズ インコーポレイテッド アミノメチル置換されたテトラサイクリン化合物
JP2005520846A (ja) 2002-03-21 2005-07-14 パラテック ファーマシューティカルズ インコーポレイテッド 置換されたテトラサイクリン化合物。
US20040029843A1 (en) * 2002-06-20 2004-02-12 Orapharma, Inc. Rapidly disintegrating formulations for treating or preventing mucositis
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP2319828A3 (de) 2003-07-09 2011-07-06 Paratek Pharmaceuticals, Inc. Substituierte tetracyclinverbindungen
EP2287148A3 (de) 2004-10-25 2011-10-26 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclin-Verbindungen
PA8652001A1 (es) 2004-11-05 2006-10-13 Wyeth Corp Metabolitos glucuronidos de tigeciclina y epimeros de los mismos
JP2008530023A (ja) * 2005-02-04 2008-08-07 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物の１１ａ，１２−誘導体
US20060183758A1 (en) * 2005-02-17 2006-08-17 Cb Research And Development, Inc. Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057649A1 (es) 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR055336A1 (es) * 2005-06-16 2007-08-22 Wyeth Corp Proeso de elaboracion para la produccion de tigeciclina como un polvo reconstituible, polvo de tigeciclina liofilizado y producto hecho mediante el proceso
AU2006331685A1 (en) * 2005-12-22 2007-07-05 Wyeth Methods of treating gastrointestinal tract infections with tigecycline
WO2007120913A2 (en) * 2006-04-17 2007-10-25 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
CN101479235B (zh) * 2006-04-24 2013-09-18 特瓦制药工业有限公司 替加环素晶形及其制备方法
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
AU2007249695A1 (en) 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
US20070286818A1 (en) * 2006-06-07 2007-12-13 Wyeth Treating cystic fibrosis with antibiotics via an aerosol drug
US20070286817A1 (en) * 2006-06-07 2007-12-13 Wyeth Treating cystic fibrosis with antibiotics via a swirler delivery
US20080039433A1 (en) * 2006-06-15 2008-02-14 Smith Alexander D Stabilized Tetracycline Compositions
EP2236491A3 (de) 2006-11-29 2010-11-03 Teva Pharmaceutical Industries, Ltd. Kristalline Form von Tigecyclin und Verfahren zu deren Herstellung
BRPI0706517A2 (pt) * 2006-11-30 2011-03-29 Teva Pharma processos para preparação de f 9-haloacetamidominociclinas
EP2114865A1 (de) * 2007-03-01 2009-11-11 Teva Pharmaceutical Industries Ltd. Verfahren zur reinigung von tigecyclin
AT13157U1 (de) * 2007-04-24 2013-07-15 Teva Pharma Tigecyclin, kristalline Formen und Herstellungsverfahren dafür
US20090076153A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched tigecycline
AU2008331163B2 (en) 2007-11-29 2014-01-30 Viatris Asia Pacific Pte. Ltd. Phosphonic acid derivates and their use as P2Y12 receptor antagonists
CN103936645B (zh) 2008-08-08 2016-03-09 四相制药公司 C7-氟取代的四环素化合物
CA2761241C (en) 2009-05-08 2018-02-27 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
US9624166B2 (en) 2009-08-28 2017-04-18 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
HUE042600T2 (hu) 2012-08-31 2019-07-29 Tetraphase Pharmaceuticals Inc Tetraciklin vegyületek
EP3529236B1 (de) 2016-10-19 2024-02-07 Tetraphase Pharmaceuticals, Inc. Kristalline formen von eravacyclin
EP3976050B1 (de) 2019-05-24 2025-01-22 Stichting Radboud universitair medisch centrum Verbesserte verabreichung von glycylcyclinen durch inhalation zur behandlung von pulmonarinfektionen mit mycobacterium abscessus

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USRE26271E (en) * 1967-09-26 Reductive alkylation process
US2482055A (en) * 1948-02-11 1949-09-13 American Cyanamid Co Aureomycin and preparation of same
US3007965A (en) * 1959-02-13 1961-11-07 American Cyanamid Co New tetracyclines produced by streptomyces aureofaciens
US3043875A (en) * 1959-10-22 1962-07-10 Pfizer & Co C Halogenated tetracycline derivatives and processes for their preparation
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US3360557A (en) * 1963-05-10 1967-12-26 American Cyanamid Co 9-hydroxytetracyclines and a process of preparing same
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US3341585A (en) * 1966-05-06 1967-09-12 American Cyanamid Co Substituted 7-and/or 9-amino-6-deoxytetracyclines
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US3518306A (en) * 1968-02-19 1970-06-30 American Cyanamid Co 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
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US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines

Also Published As

Publication number Publication date
LV12273B (en) 1999-11-20
EP0582790B1 (de) 1998-12-23
KR940003923A (ko) 1994-03-14
ZA935891B (en) 1994-03-09
CA2103837A1 (en) 1994-02-14
FI933566L (fi) 1994-02-14
RU2111958C1 (ru) 1998-05-27
CZ286261B6 (cs) 2000-02-16
NO932870D0 (no) 1993-08-12
HUT64941A (en) 1994-03-28
NZ248358A (en) 1996-04-26
US5284963A (en) 1994-02-08
ES2125927T3 (es) 1999-03-16
FI933566A0 (fi) 1993-08-12
JP3590643B2 (ja) 2004-11-17
CN1083047A (zh) 1994-03-02
SG68556A1 (en) 1999-11-16
PL300064A1 (en) 1994-02-21
AU674689B2 (en) 1997-01-09
PL173923B1 (pl) 1998-05-29
FI115722B (fi) 2005-06-30
CZ157793A3 (en) 1994-03-16
IL106674A0 (en) 1993-12-08
HU222886B1 (hu) 2003-12-29
DE69322708T2 (de) 1999-04-29
DE69322708D1 (de) 1999-02-04
HU9302331D0 (en) 1993-10-28
JPH06184075A (ja) 1994-07-05
MX9304649A (es) 1994-02-28
IL119551A0 (en) 1997-02-18
LV12273A (lv) 1999-05-20
KR100250603B1 (ko) 2000-04-01
IL106674A (en) 1998-07-15
TW221285B (de) 1994-02-21
CN1037680C (zh) 1998-03-11
PL173606B1 (pl) 1998-03-31
EP0582790A1 (de) 1994-02-16
AU4460393A (en) 1994-02-17
CA2103837C (en) 2004-10-05
GR3029764T3 (en) 1999-06-30
IL119551A (en) 2003-02-12
SK281698B6 (sk) 2001-07-10
DK0582790T3 (da) 1999-08-23
SK84993A3 (en) 1994-06-08
PH30150A (en) 1997-01-21
NO932870L (no) 1994-02-14
NO303574B1 (no) 1998-08-03

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee