ATE201201T1 - Verfahren zur herstellung von pyrimidinderivaten - Google Patents
Verfahren zur herstellung von pyrimidinderivatenInfo
- Publication number
- ATE201201T1 ATE201201T1 AT97119003T AT97119003T ATE201201T1 AT E201201 T1 ATE201201 T1 AT E201201T1 AT 97119003 T AT97119003 T AT 97119003T AT 97119003 T AT97119003 T AT 97119003T AT E201201 T1 ATE201201 T1 AT E201201T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- pyrimidine derivatives
- carbanionic
- chem
- independently represent
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 150000002690 malonic acid derivatives Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH275796 | 1996-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE201201T1 true ATE201201T1 (de) | 2001-06-15 |
Family
ID=4240937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97119003T ATE201201T1 (de) | 1996-11-08 | 1997-10-31 | Verfahren zur herstellung von pyrimidinderivaten |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US5883254A (de) |
| EP (1) | EP0841326B1 (de) |
| JP (1) | JP3805502B2 (de) |
| KR (1) | KR100535450B1 (de) |
| CN (1) | CN1109023C (de) |
| AT (1) | ATE201201T1 (de) |
| DE (1) | DE69704832T2 (de) |
| DK (1) | DK0841326T3 (de) |
| ES (1) | ES2158425T3 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ542136A (en) | 2003-03-07 | 2008-07-31 | Sanofi Aventis | Substituted 2-(diaza-bicyclo-alkyl)-pyrimidone derivatives |
| EP1454908B1 (de) * | 2003-03-07 | 2008-02-27 | Sanofi-Aventis | Substituierte Pyridinyl-2-(diaza-bicyclo-alkyl)-pyrimidinonderivate |
| EP1454910A1 (de) * | 2003-03-07 | 2004-09-08 | Sanofi-Synthelabo | Substitutierte Pyrimidinyl-2-(diaza-bicyclo-alkyl)-pyrimidonederivate |
| CL2004000545A1 (es) * | 2003-03-18 | 2005-01-28 | Pharmacia Corp Sa Organizada B | Uso de un antagonista de los receptores de aldosterona y un antagonista de receptores de endotelina para el tratamiento o profilaxis de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopatia y enfermedades cardiovascul |
| DE102004022897A1 (de) * | 2004-05-10 | 2005-12-08 | Bayer Cropscience Ag | Azinyl-imidazoazine |
| US20100022568A1 (en) * | 2006-04-13 | 2010-01-28 | Actelion Pharmaceeuticals Ltd. | Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis |
| EP2072503B1 (de) * | 2007-12-18 | 2011-10-26 | Dipharma Francis S.r.l. | Verfahren zur Herstellung von Bosentan |
| EP2251001A4 (de) * | 2008-02-08 | 2013-01-09 | Shiseido Co Ltd | Hautbleichmittel und externes präparat für die haut |
| WO2010118992A1 (en) | 2009-04-13 | 2010-10-21 | Sandoz Ag | Process for preparation of endothelial receptor antagonist (bosentan) |
| EP2509594A1 (de) | 2009-12-09 | 2012-10-17 | INSERM - Institut National de la Santé et de la Recherche Médicale | Endothelin-hemmer zur behandlung von rasch progressiver glomerulonephritis |
| KR102004422B1 (ko) * | 2012-12-20 | 2019-07-26 | 제일약품주식회사 | 보센탄 일수화물의 제조방법, 이에 사용되는 신규 중간체 및 이의 제조방법 |
| WO2018185516A1 (en) | 2017-04-05 | 2018-10-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cardiovascular toxicity induced by anti-cancer therapy |
| CN116410141A (zh) * | 2021-12-31 | 2023-07-11 | 南京艾德凯腾生物医药有限责任公司 | 一种阿伐那非中间体的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH423708A (de) * | 1961-12-08 | 1966-06-30 | Ciba Geigy | Verfahren zum Färben und Bedrucken von Textilmaterialien |
| BE625803A (de) * | 1961-12-08 | |||
| RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| EP0726708A1 (de) * | 1993-11-05 | 1996-08-21 | Pathogenesis Corporation | Virusassoziierte multiple sklerose : behandlung, vorbeugung und ihre diagnose |
-
1997
- 1997-10-16 US US08/951,700 patent/US5883254A/en not_active Expired - Lifetime
- 1997-10-28 KR KR1019970055491A patent/KR100535450B1/ko not_active Expired - Lifetime
- 1997-10-31 EP EP97119003A patent/EP0841326B1/de not_active Expired - Lifetime
- 1997-10-31 DE DE69704832T patent/DE69704832T2/de not_active Expired - Lifetime
- 1997-10-31 AT AT97119003T patent/ATE201201T1/de active
- 1997-10-31 DK DK97119003T patent/DK0841326T3/da active
- 1997-10-31 ES ES97119003T patent/ES2158425T3/es not_active Expired - Lifetime
- 1997-11-04 JP JP30148197A patent/JP3805502B2/ja not_active Expired - Lifetime
- 1997-11-07 CN CN97122238A patent/CN1109023C/zh not_active Expired - Lifetime
-
1998
- 1998-09-25 US US09/161,086 patent/US6121447A/en not_active Expired - Lifetime
-
2000
- 2000-03-16 US US09/526,252 patent/US6274734B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1109023C (zh) | 2003-05-21 |
| JP3805502B2 (ja) | 2006-08-02 |
| DK0841326T3 (da) | 2001-07-23 |
| EP0841326B1 (de) | 2001-05-16 |
| US6121447A (en) | 2000-09-19 |
| US6274734B1 (en) | 2001-08-14 |
| KR19980041968A (ko) | 1998-08-17 |
| JPH10139765A (ja) | 1998-05-26 |
| EP0841326A1 (de) | 1998-05-13 |
| DE69704832D1 (de) | 2001-06-21 |
| ES2158425T3 (es) | 2001-09-01 |
| US5883254A (en) | 1999-03-16 |
| KR100535450B1 (ko) | 2006-03-30 |
| DE69704832T2 (de) | 2001-11-29 |
| CN1182082A (zh) | 1998-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |