AR057033A1 - Tigeciclina y metodos para preparar 9-nitrominociclina - Google Patents

Tigeciclina y metodos para preparar 9-nitrominociclina

Info

Publication number
AR057033A1
AR057033A1 ARP060102155A ARP060102155A AR057033A1 AR 057033 A1 AR057033 A1 AR 057033A1 AR P060102155 A ARP060102155 A AR P060102155A AR P060102155 A ARP060102155 A AR P060102155A AR 057033 A1 AR057033 A1 AR 057033A1
Authority
AR
Argentina
Prior art keywords
methods
compound
formula
tigecicline
nitrominocicline
Prior art date
Application number
ARP060102155A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR057033A1 publication Critical patent/AR057033A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Abstract

Se revelan métodos para preparar y purificar tetraciclinas, tales como tigeciclina. Tales se revelan composiciones de tetraciclinas, tales como composiciones de tigeciclina, preparadas por estos métodos. Reivindicacion 1: Un método para preparar al menos un compuesto de formula (1), o una sal aceptable para uso farmacéutico del mismo, donde R1 y R2 se selecciona cada uno en forma independiente de hidrogeno, alquilo (C1-6) de cadena recta y ramificada y cicloalquilo, o R1 y R2, junto con N, forman un heterociclo; R es -NR3R4, donde R3 y R4 se selecciona cada uno en forma independiente de hidrogeno, y alquilo (C1-6) de cadena recta y ramificada; y n oscila entre 1-4, que comprende: (a) hacer reaccionar al menos un agente nitrante con al menos un compuesto de formula (2), o una sal del mismo, para producir una mezcla de reaccion que comprende un intermediario; y (b) hacer además reaccionar el intermediario para formar el al menos un compuesto de formula 1, donde el intermediario no se aísla de la mezcla de reaccion.
ARP060102155A 2005-05-27 2006-05-24 Tigeciclina y metodos para preparar 9-nitrominociclina AR057033A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68529105P 2005-05-27 2005-05-27

Publications (1)

Publication Number Publication Date
AR057033A1 true AR057033A1 (es) 2007-11-14

Family

ID=36933528

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102155A AR057033A1 (es) 2005-05-27 2006-05-24 Tigeciclina y metodos para preparar 9-nitrominociclina

Country Status (20)

Country Link
US (1) US20070049560A1 (es)
EP (1) EP1885687A2 (es)
JP (1) JP2008545708A (es)
KR (1) KR20080016893A (es)
CN (1) CN101228111A (es)
AR (1) AR057033A1 (es)
AU (1) AU2006252687A1 (es)
BR (1) BRPI0610268A2 (es)
CA (1) CA2609264A1 (es)
CR (1) CR9543A (es)
EC (1) ECSP078042A (es)
GT (1) GT200600223A (es)
IL (1) IL187539A0 (es)
MX (1) MX2007014718A (es)
NO (1) NO20076072L (es)
PE (1) PE20061422A1 (es)
RU (1) RU2007143164A (es)
TW (1) TW200716514A (es)
WO (1) WO2006130501A2 (es)
ZA (1) ZA200710173B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
CN101489987A (zh) * 2006-04-17 2009-07-22 特瓦制药工业有限公司 四环素衍生物的分离
TW200812943A (en) * 2006-04-24 2008-03-16 Teva Pharma Processes for preparation of tigecycline crystalline forms I and II
US8198470B2 (en) 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
WO2008066935A2 (en) * 2006-11-29 2008-06-05 Teva Pharmaceutical Industries Ltd. Crystalline forms of tigecycline and processes for preparation thereof
BRPI0706517A2 (pt) * 2006-11-30 2011-03-29 Teva Pharma processos para preparação de f 9-haloacetamidominociclinas
WO2008106234A1 (en) * 2007-03-01 2008-09-04 Teva Pharmaceutical Industries Ltd. Processes for purification of tigecycline
WO2009052152A2 (en) * 2007-10-16 2009-04-23 Wyeth Tigecycline and methods of preparing intermediates
EP2220033B1 (en) * 2007-11-14 2014-12-17 Sandoz AG Crystalline forms of tigecycline hydrochloride
EP2376433B1 (en) 2008-12-18 2014-10-29 Sandoz AG Crystalline form c of tigecycline dihydrochloride and methods for its preparation
EP2406213A1 (en) 2009-03-12 2012-01-18 Wyeth LLC Nitration of tetracyclines
EP2327676B1 (en) * 2009-11-26 2014-03-05 Sandoz Ag Reaction of organic compounds with low amounts of hydrogen
EP2568987B1 (en) 2010-05-12 2016-11-16 Rempex Pharmaceuticals, Inc. Tetracycline compositions
CN102391148B (zh) * 2011-10-24 2014-01-08 江苏奥赛康药业股份有限公司 一种高纯度替加环素的合成方法
CN103044281A (zh) * 2013-01-02 2013-04-17 湖南赛隆药业有限公司 高纯度替加环素的制法
CN104418766B (zh) * 2013-08-26 2018-09-07 江苏豪森药业集团有限公司 替加环素的纯化方法
EP3068370A2 (en) 2013-11-12 2016-09-21 Galenicum Health S.L. Stable pharmaceutical compositions
CN104211617A (zh) * 2014-08-29 2014-12-17 重庆康乐制药有限公司 一种替加环素的制备方法
CN111362829B (zh) * 2018-12-26 2021-11-30 浙江昌海制药有限公司 一种米诺环素二对氯苯磺酸盐晶型及其制备方法和应用
CN111060641B (zh) * 2019-12-27 2020-10-23 瀚晖制药有限公司 一种注射用替加环素中9-硝基米诺环素的检测方法
CN114957031A (zh) * 2022-05-17 2022-08-30 河北圣雪大成制药有限责任公司 一种合成9-氨基米诺环素硫酸盐的新方法

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3026248A (en) * 1959-09-11 1962-03-20 Pfizer & Co C Thioglycerol and formaldehyde sulfoxylate stabilized tetracycline antibiotics in polyhydric alcohol solvents
US3043875A (en) * 1959-10-22 1962-07-10 Pfizer & Co C Halogenated tetracycline derivatives and processes for their preparation
FR1430859A (es) * 1960-05-23 1966-05-25
US3338963A (en) * 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3239499A (en) * 1961-05-19 1966-03-08 Pfizer & Co C Tetracycline derivative
US3502696A (en) * 1961-08-18 1970-03-24 Pfizer & Co C Antibacterial agents
US3148212A (en) * 1961-12-22 1964-09-08 American Cyanamid Co Reductive alkylation process
USRE26171E (en) * 1962-03-02 1967-03-07 Multiprocessing computer system
US3250810A (en) * 1962-09-06 1966-05-10 Pfizer & Co C 6-hydroxy-6-halomethyl tetracyclines
US3145228A (en) * 1962-09-06 1964-08-18 Pfizer & Co C 5-alkoxy-and 5-benzyloxy-tetracycline, derivatives and analogues thereof
US3250809A (en) * 1962-09-06 1966-05-10 Pfizer & Co C 6-deoxy-6-demethyl-6-halomethylene tetracyclines and their 11a-chloro and fluoro derivatives
US3219529A (en) * 1962-10-04 1965-11-23 American Cyanamid Co Stable tetracycline solutions
USRE26253E (en) * 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3397230A (en) * 1966-03-14 1968-08-13 American Cyanamid Co Nitration of tetracyclines
US3433834A (en) * 1966-03-14 1969-03-18 American Cyanamid Co Nitration of 11a-chloro tetracyclines
US3341585A (en) * 1966-05-06 1967-09-12 American Cyanamid Co Substituted 7-and/or 9-amino-6-deoxytetracyclines
US3849493A (en) * 1966-08-01 1974-11-19 Pfizer D-ring substituted 6-deoxytetracyclines
US3345410A (en) * 1966-12-01 1967-10-03 American Cyanamid Co Substituted 7- and/or 9-amino tetracyclines
US3373196A (en) * 1967-03-21 1968-03-12 American Cyanamid Co 7-and/or 9-(lower alkyl) amino-5a, 6-anhydrotetracyclines
US3373197A (en) * 1967-04-27 1968-03-12 American Cyanamid Co Substituted 6-epitetracyclines and 5a-epi-6-epitetracyclines
US3373198A (en) * 1967-04-27 1968-03-12 American Cyanamid Co Substituted 5a, 11a-dehydro-6-epitetracyclines
US3360561A (en) * 1967-06-19 1967-12-26 American Cyanamid Co Nitration of tetracyclines
US3518306A (en) * 1968-02-19 1970-06-30 American Cyanamid Co 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines
US4038315A (en) * 1972-05-11 1977-07-26 American Cyanamid Company Isolation and recovery of calcium chloride complex of 7-dimethylamino-6-dimethyl l-6-deoxytetracycline hydrochloride
US5202449A (en) * 1987-07-28 1993-04-13 Nippon Kayaku Kabushiki Kaisha Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline
US5141960A (en) * 1991-06-25 1992-08-25 G. D. Searle & Co. Tricyclic glycinamide derivatives as anti-convulsants
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5281628A (en) * 1991-10-04 1994-01-25 American Cyanamid Company 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
MX9603508A (es) * 1994-02-17 1997-03-29 Pfizer Analogos de la doxiciclina.
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
US5843925A (en) * 1994-12-13 1998-12-01 American Cyanamid Company Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US6946453B2 (en) * 1998-11-18 2005-09-20 Collagenex Pharmaceuticals, Inc. 4-dedimethylaminotracycline derivatives
US6506740B1 (en) * 1998-11-18 2003-01-14 Robert A. Ashley 4-dedimethylaminotetracycline derivatives
WO2001052858A1 (en) * 2000-01-24 2001-07-26 Trustees Of Tufts College Tetracycline compounds for treatment of cryptosporidium parvum related disorders
IL151971A0 (en) * 2000-03-31 2003-04-10 Tufts College 7-and 9-carbamate, urea, thiourea, thiocarbabamate, and heteroaryl-amino substituted tetracycline compounds
ATE504562T1 (de) * 2000-07-07 2011-04-15 Tufts College 7-, 8- und 9-substitutierte tetracyclinverbindungen
MXPA03000055A (es) * 2000-07-07 2003-07-14 Tufts College Compuestos de monociclina sustituidos en posicion 9..
KR100997596B1 (ko) * 2000-07-07 2010-11-30 파라테크 파마슈티컬스, 인크. 7-치환 테트라사이클린 화합물
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
RU2300380C2 (ru) * 2001-10-05 2007-06-10 Тетрадженекс Фармасьютикалс, Инк. Производные тетрациклина и способы их применения
EP2995610A1 (en) * 2002-01-08 2016-03-16 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
UA83266C2 (en) * 2003-12-08 2008-06-25 Уайет Oxazole derivatives of tetracyclines

Also Published As

Publication number Publication date
KR20080016893A (ko) 2008-02-22
MX2007014718A (es) 2008-02-15
IL187539A0 (en) 2008-03-20
CR9543A (es) 2008-02-20
WO2006130501A3 (en) 2007-03-29
WO2006130501A2 (en) 2006-12-07
TW200716514A (en) 2007-05-01
ZA200710173B (en) 2009-09-30
RU2007143164A (ru) 2009-07-10
JP2008545708A (ja) 2008-12-18
BRPI0610268A2 (pt) 2010-06-08
EP1885687A2 (en) 2008-02-13
PE20061422A1 (es) 2007-01-29
CN101228111A (zh) 2008-07-23
NO20076072L (no) 2008-02-19
GT200600223A (es) 2007-05-08
AU2006252687A1 (en) 2006-12-07
CA2609264A1 (en) 2006-12-07
ECSP078042A (es) 2008-01-23
US20070049560A1 (en) 2007-03-01

Similar Documents

Publication Publication Date Title
AR057033A1 (es) Tigeciclina y metodos para preparar 9-nitrominociclina
AR057034A1 (es) Metodos para purificar tigeciclina
AR057032A1 (es) Tigeciclina y metodos de preparacion
AR057324A1 (es) Tigeciclina y metodos para preparar 9-aminominociclina
AR063706A1 (es) Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden.
CL2021000737A1 (es) Fabricación de compuestos y composiciones para inhibir la actividad de shp2
AR063707A1 (es) Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmacéuticas que las comprenden.
CO5580815A2 (es) Derivados de adamantana, procesos para su preparacion y composiciones farmaceuticas que los contienen
AR083849A1 (es) Antagonistas de mdm2 de espiro-oxindol
EA201270550A1 (ru) Процесс получения соединений для применения в качестве ингибиторов sglt2
BRPI0516911A (pt) método para a preparação de um composto e composto de anilina
EA200870362A1 (ru) Способ получения производных лактамида, новые производные лактамида и препараты, содержащие производные лактамида
PE20040164A1 (es) Mimeticos de glucocorticoides, procedimientos para su preparacion y composiciones farmaceuticas
CO6290658A2 (es) Derivados de azetidina y ciclobutano como inhibidores de jack
PE20081838A1 (es) Derivados de ester o amida de imidazolilo como moduladores del receptor glucocorticoide
CO6241101A2 (es) Derivados de quinolina como inhibidores de la p13 quinasa
AR086357A1 (es) Derivados de indazol sustituidos activos como inhibidores de quinasas
PE20060583A1 (es) Tiazolil-dihidro-indazoles como inhibidores de pi3-quinasas
AR049401A1 (es) Aza-biciclononanos
UY29002A1 (es) Nuevos derivados de hidantoína, procesos parasu preparación, composiciones farmacéuticas que los contienen y su uso en terapia
BRPI0817096A8 (pt) Análogo de tiazolidinodiona e composição farmacêutica que o compreende
MX340573B (es) Proceso para la fabricacion de compuestos farmaceuticamente activos.
AR068045A1 (es) Derivados de catecolamina y prodrogas de los mismos
PE20100487A1 (es) Nuevo procedimiento de sintesis de la ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable
AR089429A1 (es) Composicion para el cuidado personal solida

Legal Events

Date Code Title Description
FB Suspension of granting procedure