ZA855492B - Novel n-hydroxyl protecting groups and process for the preparation of 3-acylamino-1-hydroxy-2-azetidinones - Google Patents

Novel n-hydroxyl protecting groups and process for the preparation of 3-acylamino-1-hydroxy-2-azetidinones

Info

Publication number
ZA855492B
ZA855492B ZA855492A ZA855492A ZA855492B ZA 855492 B ZA855492 B ZA 855492B ZA 855492 A ZA855492 A ZA 855492A ZA 855492 A ZA855492 A ZA 855492A ZA 855492 B ZA855492 B ZA 855492B
Authority
ZA
South Africa
Prior art keywords
novel
azetidinones
acylamino
hydroxy
preparation
Prior art date
Application number
ZA855492A
Other languages
English (en)
Inventor
Richard Henry Mueller
Jakob-Matthias Drossard
Peter Hans Ermann
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of ZA855492B publication Critical patent/ZA855492B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Accommodation For Nursing Or Treatment Tables (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
ZA855492A 1984-08-03 1985-07-19 Novel n-hydroxyl protecting groups and process for the preparation of 3-acylamino-1-hydroxy-2-azetidinones ZA855492B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/637,260 US4581170A (en) 1984-08-03 1984-08-03 N-hydroxyl protecting groups and process and intermediates for the preparation of 3-acylamino-1-hydroxy-2-azetidinones

Publications (1)

Publication Number Publication Date
ZA855492B true ZA855492B (en) 1986-03-26

Family

ID=24555200

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA855492A ZA855492B (en) 1984-08-03 1985-07-19 Novel n-hydroxyl protecting groups and process for the preparation of 3-acylamino-1-hydroxy-2-azetidinones

Country Status (12)

Country Link
US (1) US4581170A (xx)
EP (2) EP0371004A1 (xx)
JP (2) JPH06732B2 (xx)
AT (1) ATE58896T1 (xx)
AU (2) AU589567B2 (xx)
CA (1) CA1268780C (xx)
DE (1) DE3580803D1 (xx)
DK (1) DK353385A (xx)
FI (1) FI852974L (xx)
IE (2) IE58758B1 (xx)
NZ (1) NZ212750A (xx)
ZA (1) ZA855492B (xx)

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EP0233607B1 (en) * 1986-02-18 1991-03-13 E.R. Squibb & Sons, Inc. [(2,2,2-Trichloroethoxy) methoxy]amine
US5037974A (en) * 1988-05-23 1991-08-06 Merck & Co., Inc. Cyclization process for synthesis of a beta-lactam carbapenem intermediate
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US6068993A (en) * 1997-07-02 2000-05-30 Biobras Sa Vector for expression of heterologous protein and methods for extracting recombinant protein and for purifying isolated recombinant insulin
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
NZ526532A (en) * 2001-01-26 2005-01-28 Schering Corp The use of substituted azetidinone compounds for the treatment of sitosterolemia
EP1785144A3 (en) * 2001-01-26 2007-05-23 Shering Corporation Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications
WO2002058685A2 (en) * 2001-01-26 2002-08-01 Schering Corporation Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
CZ20032031A3 (cs) * 2001-01-26 2003-12-17 Schering Corporation Farmaceutický prostředek
CN100509058C (zh) * 2001-01-26 2009-07-08 先灵公司 过氧化物酶体增殖物激活受体(ppar)活化剂和甾醇吸收抑制剂的组合药以及对于血管适应症的治疗
WO2002058734A2 (en) * 2001-01-26 2002-08-01 Schering Corporation Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
WO2002096415A2 (en) * 2001-05-25 2002-12-05 Schering Corporation Use of azetidinone substituted derivatives in the treatment of alzheimer's disease
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
MXPA04002573A (es) * 2001-09-21 2004-06-18 Schering Corp Tratamiento de xantoma con derivados de azetidinona como inhibidores de la absorcion de esterol.
HUP0401501A3 (en) * 2001-09-21 2012-02-28 Schering Corp Treating or preventing vascular inflammation using pharmaceutical compositions containing sterol absorption inhibitor(s)
CA2504878A1 (en) * 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorption inhibitors for the treatment of demyelination
CA2517573C (en) * 2003-03-07 2011-12-06 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP4589919B2 (ja) * 2003-03-07 2010-12-01 シェーリング コーポレイション 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
US7235543B2 (en) 2003-03-07 2007-06-26 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
EP1680189A2 (en) * 2003-11-05 2006-07-19 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
US9436903B2 (en) 2013-03-04 2016-09-06 Hello Inc. Wearable device with magnets with a defined distance between adjacent magnets
US9526422B2 (en) 2013-03-04 2016-12-27 Hello Inc. System for monitoring individuals with a monitoring device, telemetry system, activity manager and a feedback system
US9204798B2 (en) 2013-03-04 2015-12-08 Hello, Inc. System for monitoring health, wellness and fitness with feedback
US9159223B2 (en) 2013-03-04 2015-10-13 Hello, Inc. User monitoring device configured to be in communication with an emergency response system or team
US9634921B2 (en) 2013-03-04 2017-04-25 Hello Inc. Wearable device coupled by magnets positioned in a frame in an interior of the wearable device with at least one electronic circuit
US9427189B2 (en) 2013-03-04 2016-08-30 Hello Inc. Monitoring system and device with sensors that are responsive to skin pigmentation
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US9367793B2 (en) 2013-03-04 2016-06-14 Hello Inc. Wearable device with magnets distanced from exterior surfaces of the wearable device
US9406220B2 (en) 2013-03-04 2016-08-02 Hello Inc. Telemetry system with tracking receiver devices
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US9339188B2 (en) 2013-03-04 2016-05-17 James Proud Methods from monitoring health, wellness and fitness with feedback
US9438044B2 (en) 2013-03-04 2016-09-06 Hello Inc. Method using wearable device with unique user ID and telemetry system in communication with one or more social networks
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US9424508B2 (en) 2013-03-04 2016-08-23 Hello Inc. Wearable device with magnets having first and second polarities
US9553486B2 (en) 2013-03-04 2017-01-24 Hello Inc. Monitoring system and device with sensors that is remotely powered
US9320434B2 (en) 2013-03-04 2016-04-26 Hello Inc. Patient monitoring systems and messages that send alerts to patients only when the patient is awake
US9149189B2 (en) 2013-03-04 2015-10-06 Hello, Inc. User or patient monitoring methods using one or more analysis tools
US9361572B2 (en) 2013-03-04 2016-06-07 Hello Inc. Wearable device with magnets positioned at opposing ends and overlapped from one side to another
US9445651B2 (en) 2013-03-04 2016-09-20 Hello Inc. Wearable device with overlapping ends coupled by magnets
US9420857B2 (en) 2013-03-04 2016-08-23 Hello Inc. Wearable device with interior frame
US9582748B2 (en) 2013-03-04 2017-02-28 Hello Inc. Base charging station for monitoring device
US9848776B2 (en) 2013-03-04 2017-12-26 Hello Inc. Methods using activity manager for monitoring user activity
US9392939B2 (en) 2013-03-04 2016-07-19 Hello Inc. Methods using a monitoring device to monitor individual activities, behaviors or habit information and communicate with a database with corresponding individual base information for comparison
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US9330561B2 (en) 2013-03-04 2016-05-03 Hello Inc. Remote communication systems and methods for communicating with a building gateway control to control building systems and elements
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Also Published As

Publication number Publication date
EP0371004A1 (en) 1990-05-30
DE3580803D1 (de) 1991-01-17
ATE58896T1 (de) 1990-12-15
JPH0662532B2 (ja) 1994-08-17
DK353385A (da) 1986-02-04
JPH069528A (ja) 1994-01-18
NZ212750A (en) 1989-04-26
CA1268780C (en) 1990-05-08
FI852974L (fi) 1986-02-04
EP0170280A1 (en) 1986-02-05
IE58771B1 (en) 1993-11-03
AU4535685A (en) 1986-02-06
EP0170280B1 (en) 1990-12-05
CA1262357A (en) 1989-10-17
FI852974A0 (fi) 1985-08-01
US4581170A (en) 1986-04-08
AU4083589A (en) 1990-02-08
IE851917L (en) 1986-02-03
AU589567B2 (en) 1989-10-19
JPS6147445A (ja) 1986-03-07
AU614663B2 (en) 1991-09-05
DK353385D0 (da) 1985-08-02
JPH06732B2 (ja) 1994-01-05
IE58758B1 (en) 1993-11-03

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