RO115159B1 - Derivaţi de piperazină şi compoziţii farmaceutice care îi conţin - Google Patents
Derivaţi de piperazină şi compoziţii farmaceutice care îi conţinInfo
- Publication number
- RO115159B1 RO115159B1 RO96-01781A RO9601781A RO115159B1 RO 115159 B1 RO115159 B1 RO 115159B1 RO 9601781 A RO9601781 A RO 9601781A RO 115159 B1 RO115159 B1 RO 115159B1
- Authority
- RO
- Romania
- Prior art keywords
- same
- compositions containing
- piperazine derivatives
- nitrogen
- oxygen
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 150000004885 piperazines Chemical class 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052757 nitrogen Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000002466 imines Chemical group 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
Invenţia se referă la compuşi cu formula generală (I):la acizii şi la sărurile de adiţie ale acestora, în care Rşi Rsunt independent hidrogen, alchil C-Csau cicloalchil cu ciclu de C-C, opţional substituiţi, conţinând C-Cester inferior, C-Calchil inferior, C-Calcoxi inferior, aril, arilalcoxi sau amină nesaturată; l este un număr întreg, între 0 şi 7; m şi n sunt 0 sau 1; W este carbon sau azot; X este oxigen, sulf, opţional substituit cu imină; Y este azot sau oxigen; şi Z este hidrogen, alcoxi C-C, ariloxi, alchilamină C-C, cicloamină conţinând N-Nsau o grupare oxo, compuşii cu formula (I) de mai sus au activitate antitumorală puternică şi o toxicitate scăzută.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR19950000399 | 1995-01-11 | ||
| KR1019950043607A KR0162710B1 (ko) | 1995-01-10 | 1995-11-24 | 신규 피페라진 유도체 및 그 제조방법 |
| PCT/KR1996/000005 WO1996021648A1 (en) | 1995-01-11 | 1996-01-10 | New piperazine derivatives and methods for the preparation thereof and compositions containing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO115159B1 true RO115159B1 (ro) | 1999-11-30 |
Family
ID=26630862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO96-01781A RO115159B1 (ro) | 1995-01-11 | 1996-01-10 | Derivaţi de piperazină şi compoziţii farmaceutice care îi conţin |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5780472A (ro) |
| EP (1) | EP0749425A1 (ro) |
| JP (1) | JP2978967B2 (ro) |
| CN (1) | CN1128139C (ro) |
| AU (1) | AU699619B2 (ro) |
| BR (1) | BR9605309A (ro) |
| CA (1) | CA2184919C (ro) |
| CZ (1) | CZ288002B6 (ro) |
| FI (1) | FI963566A0 (ro) |
| HU (1) | HUP9602489A3 (ro) |
| NO (1) | NO307459B1 (ro) |
| NZ (1) | NZ298499A (ro) |
| PL (1) | PL183865B1 (ro) |
| RO (1) | RO115159B1 (ro) |
| SK (1) | SK282252B6 (ro) |
| WO (1) | WO1996021648A1 (ro) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996022977A1 (en) * | 1995-01-23 | 1996-08-01 | Suntory Limited | Ameliorant or remedy for symptoms caused by ischemic diseases and compounds useful therefor |
| CA2230960C (en) | 1996-06-29 | 2007-08-28 | Samjin Pharmaceutical Co., Ltd. | Piperazine derivatives and process for the preparation thereof |
| US6794392B1 (en) | 1996-09-30 | 2004-09-21 | Schering Aktiengesellschaft | Cell differentiation inducer |
| US6174905B1 (en) | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
| KR100420616B1 (ko) * | 1996-12-26 | 2004-05-17 | 동화약품공업주식회사 | 신규테레프탈산아미드유도체 |
| CN1129581C (zh) | 1998-09-22 | 2003-12-03 | 山之内制药株式会社 | 氰基苯基衍生物 |
| DE60010988T2 (de) * | 1999-03-03 | 2005-06-09 | Samjin Pharmaceutical Co., Ltd. | Piperazinderivate und verfahren zu ihrer herstellung |
| AU8066701A (en) | 2000-07-20 | 2002-02-05 | Neurogen Corp | Capsaicin receptor ligands |
| DE10035908A1 (de) | 2000-07-21 | 2002-03-07 | Asta Medica Ag | Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel |
| US6432957B1 (en) * | 2001-06-29 | 2002-08-13 | Kowa Co., Ltd. | Piperazine derivative |
| AU2002344951A1 (en) * | 2001-07-02 | 2003-01-21 | Boehringer Ingelheim International Gmbh | Substituted piperazine and diazepanes as histamine h3 receptor agonists |
| DE60235249D1 (de) * | 2001-10-22 | 2010-03-18 | Pfizer Prod Inc | Piperazinderivate mit ccr1-rezeptor-antagonistischer wirkung |
| AU2002351732A1 (en) * | 2001-12-14 | 2003-06-30 | Novo Nordisk A/S | Compositions decreasing activity of hormone-sensitive lipase |
| EP2033951A3 (en) | 2002-02-01 | 2009-12-23 | Euro-Celtique S.A. | 2-Piperazine-pyridines useful for treating pain |
| DK1556354T3 (da) | 2002-06-28 | 2008-06-02 | Euro Celtique Sa | Terapeutiske piperazinderivater, der er egnede til behandling af smerter |
| US7262194B2 (en) | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| US7157462B2 (en) | 2002-09-24 | 2007-01-02 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| EP1608373A4 (en) * | 2003-03-19 | 2010-09-29 | Exelixis Inc | TIE-2 MODULATORS AND USE METHOD |
| ME02929B (me) | 2004-12-30 | 2018-04-20 | Janssen Pharmaceutica Nv | DERIVATIVI FENILAMIDA 4-(BENZIL)-PIPERAZIN-1-KARBOKSILNE KISELINE l SLIĆNA JEDINJENJA KAO MODULATORI HIDROLAZE AMIDA MASNIH KISELINA (FAAH) ZA LEĆENJE ANKSIOZNOSTI, BOLA l OSTALIH STANJA |
| CN101160287B (zh) * | 2005-02-17 | 2011-08-03 | 安斯泰来制药株式会社 | 吡啶基非芳香族含氮杂环-1-羧酸酯衍生物 |
| PE20070099A1 (es) | 2005-06-30 | 2007-02-06 | Janssen Pharmaceutica Nv | N-heteroarilpiperazinil ureas como moduladores de la amida hidrolasa del acido graso |
| JPWO2007020888A1 (ja) | 2005-08-12 | 2009-02-26 | 武田薬品工業株式会社 | 脳・神経細胞保護剤および睡眠障害治療薬 |
| RS51647B (sr) | 2006-10-18 | 2011-10-31 | Pfizer Products Inc. | Jedinjenja biaril etar uree |
| BRPI0813331A2 (pt) | 2007-06-08 | 2014-12-23 | Janssen Pharmaceutica Nv | Derivados de piperidina/piperazina |
| CA2687918C (en) | 2007-06-08 | 2016-11-08 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| AU2008258549B2 (en) | 2007-06-08 | 2013-11-14 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
| AU2008311727A1 (en) * | 2007-10-10 | 2009-04-16 | Takeda Pharmaceutical Company Limited | Amide compound |
| PE20140572A1 (es) | 2008-06-05 | 2014-05-16 | Janssen Pharmaceutica Nv | Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar |
| WO2011060026A1 (en) | 2009-11-12 | 2011-05-19 | Jansen Pharmaceutica Nv | Piperazinecarboxamide derivative useful as a modulator of fatty acid amide hydrolase (faah) |
| UA108233C2 (uk) * | 2010-05-03 | 2015-04-10 | Модулятори активності гідролази амідів жирних кислот | |
| EP3373935B1 (en) | 2015-11-12 | 2021-09-01 | Merck Sharp & Dohme Corp. | Cyanopyridine derivatives as liver x receptor beta agonists, compositions, and their use |
| CN110099898B (zh) * | 2016-10-24 | 2023-07-25 | 优曼尼蒂治疗公司 | 化合物及其用途 |
| CA3049010A1 (en) | 2017-01-06 | 2018-07-12 | Yumanity Therapeutics, Inc. | Methods for the treatment of neurological disorders |
| CA3083000A1 (en) | 2017-10-24 | 2019-05-02 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| BR112020019191A2 (pt) | 2018-03-23 | 2021-01-05 | Yumanity Therapeutics, Inc. | Compostos e seus usos |
| KR20220007845A (ko) | 2019-01-24 | 2022-01-19 | 유마니티 테라퓨틱스, 인크. | 화합물 및 이의 용도 |
| EA202192047A1 (ru) | 2019-11-13 | 2021-12-08 | Юманити Терапьютикс, Инк. | Соединения и их применение |
| WO2022118966A1 (ja) * | 2020-12-04 | 2022-06-09 | 国立大学法人京都大学 | 細胞内への核酸分子取り込み促進剤、医薬組成物、及び新規化合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| OA04700A (fr) * | 1973-05-15 | 1980-07-31 | Rhone Poulenc Sa | Nouveaux dérivés de la naphtyridine et leur procédé de préparation. |
| AU7580187A (en) * | 1986-06-23 | 1988-01-12 | Upjohn Company, The | Androstane-type and cortical aminoesters |
| US4960776A (en) * | 1987-01-28 | 1990-10-02 | A. H. Robins Company, Inc. | 4-aryl-N-(alkylaminoalkyl, heterocyclicamino and heterocyclicamino)alkyl)-1-piperazinecarboxamides |
| JPH02142770A (ja) * | 1988-11-25 | 1990-05-31 | Shigeki Shin | ピペラジン系誘導体 |
| JPH03141258A (ja) * | 1989-10-25 | 1991-06-17 | Kowa Co | 新規なピペラジン誘導体 |
| DE4216364A1 (de) * | 1991-12-14 | 1993-11-25 | Thomae Gmbh Dr K | Neue Pyridylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5196428A (en) * | 1992-04-03 | 1993-03-23 | Bristol-Myers Squibb Company | Imidazo[4,5-b]qinolinyl oxy alkyl ureas |
-
1996
- 1996-01-10 CN CN96190006A patent/CN1128139C/zh not_active Expired - Lifetime
- 1996-01-10 AU AU44007/96A patent/AU699619B2/en not_active Expired
- 1996-01-10 EP EP96900459A patent/EP0749425A1/en not_active Withdrawn
- 1996-01-10 BR BR9605309A patent/BR9605309A/pt unknown
- 1996-01-10 CA CA002184919A patent/CA2184919C/en not_active Expired - Lifetime
- 1996-01-10 NZ NZ298499A patent/NZ298499A/en not_active IP Right Cessation
- 1996-01-10 CZ CZ19962960A patent/CZ288002B6/cs not_active IP Right Cessation
- 1996-01-10 US US08/676,174 patent/US5780472A/en not_active Expired - Lifetime
- 1996-01-10 HU HU9602489A patent/HUP9602489A3/hu unknown
- 1996-01-10 WO PCT/KR1996/000005 patent/WO1996021648A1/en not_active Ceased
- 1996-01-10 RO RO96-01781A patent/RO115159B1/ro unknown
- 1996-01-10 PL PL96316613A patent/PL183865B1/pl unknown
- 1996-01-10 SK SK889-96A patent/SK282252B6/sk unknown
- 1996-01-10 JP JP8521570A patent/JP2978967B2/ja not_active Expired - Lifetime
- 1996-09-10 NO NO963792A patent/NO307459B1/no unknown
- 1996-09-10 FI FI963566A patent/FI963566A0/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK282252B6 (sk) | 2001-12-03 |
| CZ288002B6 (cs) | 2001-03-14 |
| EP0749425A1 (en) | 1996-12-27 |
| HUP9602489A3 (en) | 1998-01-28 |
| CZ296096A3 (en) | 1997-02-12 |
| US5780472A (en) | 1998-07-14 |
| CA2184919C (en) | 2000-03-14 |
| JP2978967B2 (ja) | 1999-11-15 |
| CN1145620A (zh) | 1997-03-19 |
| NO307459B1 (no) | 2000-04-10 |
| FI963566A7 (fi) | 1996-09-10 |
| HU9602489D0 (en) | 1996-11-28 |
| NO963792D0 (no) | 1996-09-10 |
| HUP9602489A2 (en) | 1997-08-28 |
| CA2184919A1 (en) | 1996-07-18 |
| PL316613A1 (en) | 1997-01-20 |
| NZ298499A (en) | 1998-01-26 |
| SK88996A3 (en) | 1997-05-07 |
| JPH09511764A (ja) | 1997-11-25 |
| CN1128139C (zh) | 2003-11-19 |
| AU4400796A (en) | 1996-07-31 |
| BR9605309A (pt) | 1997-10-14 |
| FI963566A0 (fi) | 1996-09-10 |
| WO1996021648A1 (en) | 1996-07-18 |
| NO963792L (no) | 1996-11-11 |
| PL183865B1 (pl) | 2002-07-31 |
| AU699619B2 (en) | 1998-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RO115159B1 (ro) | Derivaţi de piperazină şi compoziţii farmaceutice care îi conţin | |
| MD663G2 (ro) | Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente | |
| NO980856L (no) | Piperazinderivater og fremgangsmÕte for fremstilling derav | |
| EP0272110A3 (en) | Erythromycin a derivatives and method for the preparation of the same | |
| NO951813L (no) | Bicyklisk heterocyklisk sulfonamid og sulfonester-derivater | |
| TR200002671T2 (tr) | Bisiklo(2.2.1)Heptanlar ve ilgili bileşikler | |
| EP1031563A4 (en) | SULFONYL DERIVATIVES | |
| NO307255B1 (no) | Nye forbindelser og antitumormidler | |
| RO82962B (ro) | Procedeu pentru prepararea unor derivati de cefalosporina | |
| PT1447400E (pt) | Composto bicíclico | |
| NO990578L (no) | Diesel-brennstoff inneholdende oksygenerte forbindelser | |
| EA200100059A2 (ru) | Новые бензолсульфонамидные производные, способ их получения и содержащие их фармацевтические композиции | |
| MY125037A (en) | 1,2,3,4 tetrahydroquinoline derivatives | |
| RO93388B (ro) | Procedeu pentru prepararea unor derivati de aminoalcooli | |
| MX170732B (es) | Composicion de derivados de succinimida y su uso | |
| AU695633B2 (en) | Arylpiperidine and arylpiperazine derivatives and medicament containing the same | |
| TW222268B (ro) | ||
| ATE477263T1 (de) | Zusammensetzung enthaltend ferrocen-derivate und treibstoff diese enthaltend | |
| ATE148128T1 (de) | Anthracyclinglycosid-derivate und verfahren zu ihrer herstellung | |
| DK0601191T3 (da) | Hidtil ukendt tetracyklisk forbindelse | |
| ZA974886B (en) | Novel dibenzo-oxazepine and -dioxepine derivatives. | |
| DE59703603D1 (de) | Pteridinderivate als NO Synthase-Hemmer | |
| BG100704A (en) | New piperazine derivatives and methods for their preparation as well as of the compounds containing them | |
| TR199901301T2 (xx) | Yeni eritromisin t�revleri ve bunlar�n haz�rlanma y�ntemi. | |
| ATE133677T1 (de) | Bisphosphonsäurederivate, ihre produktion und ihre verwendung |