RO115159B1 - Derivaţi de piperazină şi compoziţii farmaceutice care îi conţin - Google Patents

Derivaţi de piperazină şi compoziţii farmaceutice care îi conţin

Info

Publication number
RO115159B1
RO115159B1 RO96-01781A RO9601781A RO115159B1 RO 115159 B1 RO115159 B1 RO 115159B1 RO 9601781 A RO9601781 A RO 9601781A RO 115159 B1 RO115159 B1 RO 115159B1
Authority
RO
Romania
Prior art keywords
same
compositions containing
piperazine derivatives
nitrogen
oxygen
Prior art date
Application number
RO96-01781A
Other languages
English (en)
Inventor
Eui-Hwan Cho
Sun Gan Chung
Joong Young Kim
Sun Hwan Lee
Ho Seok Kwon
Byung Chul Kim
Jae Myeong Kong
Jae Eung Lee
Dong Wook Kang
Original Assignee
Samjin Pharmaceutical Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019950043607A external-priority patent/KR0162710B1/ko
Application filed by Samjin Pharmaceutical Co., Ltd filed Critical Samjin Pharmaceutical Co., Ltd
Publication of RO115159B1 publication Critical patent/RO115159B1/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Invenţia se referă la compuşi cu formula generală (I):la acizii şi la sărurile de adiţie ale acestora, în care Rşi Rsunt independent hidrogen, alchil C-Csau cicloalchil cu ciclu de C-C, opţional substituiţi, conţinând C-Cester inferior, C-Calchil inferior, C-Calcoxi inferior, aril, arilalcoxi sau amină nesaturată; l este un număr întreg, între 0 şi 7; m şi n sunt 0 sau 1; W este carbon sau azot; X este oxigen, sulf, opţional substituit cu imină; Y este azot sau oxigen; şi Z este hidrogen, alcoxi C-C, ariloxi, alchilamină C-C, cicloamină conţinând N-Nsau o grupare oxo, compuşii cu formula (I) de mai sus au activitate antitumorală puternică şi o toxicitate scăzută.
RO96-01781A 1995-01-11 1996-01-10 Derivaţi de piperazină şi compoziţii farmaceutice care îi conţin RO115159B1 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR19950000399 1995-01-11
KR1019950043607A KR0162710B1 (ko) 1995-01-10 1995-11-24 신규 피페라진 유도체 및 그 제조방법
PCT/KR1996/000005 WO1996021648A1 (en) 1995-01-11 1996-01-10 New piperazine derivatives and methods for the preparation thereof and compositions containing the same

Publications (1)

Publication Number Publication Date
RO115159B1 true RO115159B1 (ro) 1999-11-30

Family

ID=26630862

Family Applications (1)

Application Number Title Priority Date Filing Date
RO96-01781A RO115159B1 (ro) 1995-01-11 1996-01-10 Derivaţi de piperazină şi compoziţii farmaceutice care îi conţin

Country Status (16)

Country Link
US (1) US5780472A (ro)
EP (1) EP0749425A1 (ro)
JP (1) JP2978967B2 (ro)
CN (1) CN1128139C (ro)
AU (1) AU699619B2 (ro)
BR (1) BR9605309A (ro)
CA (1) CA2184919C (ro)
CZ (1) CZ288002B6 (ro)
FI (1) FI963566A7 (ro)
HU (1) HUP9602489A3 (ro)
NO (1) NO307459B1 (ro)
NZ (1) NZ298499A (ro)
PL (1) PL183865B1 (ro)
RO (1) RO115159B1 (ro)
SK (1) SK282252B6 (ro)
WO (1) WO1996021648A1 (ro)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0755923B1 (en) * 1995-01-23 2005-05-04 Daiichi Suntory Pharma Co., Ltd. Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor
CN1152015C (zh) * 1996-06-29 2004-06-02 三进制药株式会社 新哌嗪衍生物及其制造方法
US6174905B1 (en) * 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
US6794392B1 (en) 1996-09-30 2004-09-21 Schering Aktiengesellschaft Cell differentiation inducer
KR100420616B1 (ko) * 1996-12-26 2004-05-17 동화약품공업주식회사 신규테레프탈산아미드유도체
BR9914018A (pt) 1998-09-22 2001-07-03 Yamanouchi Pharmaceuticals Co Derivado de cianofenila
EP1075469B1 (en) * 1999-03-03 2004-05-26 Samjin Pharmaceutical Co., Ltd. Piperazine derivatives and process for the preparation thereof
KR20030024799A (ko) 2000-07-20 2003-03-26 뉴로젠 코포레이션 캡사이신 수용체 리간드
DE10035908A1 (de) * 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
US6432957B1 (en) * 2001-06-29 2002-08-13 Kowa Co., Ltd. Piperazine derivative
ATE449090T1 (de) * 2001-07-02 2009-12-15 High Point Pharmaceuticals Llc Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren
OA12670A (en) * 2001-10-22 2006-06-20 Pfizer Prod Inc Piperazine derivatives with ccr1 receptor antagonist activity.
JP2005518377A (ja) * 2001-12-14 2005-06-23 ノボ　ノルディスク　アクティーゼルスカブ ホルモン感受性リパーゼの活性を低下させるための化合物の使用
DK1472225T3 (da) 2002-02-01 2010-08-09 Euro Celtique Sa 2-Piperazinpyridiner, som er anvendelige til behandling af smerte
DK1556354T3 (da) 2002-06-28 2008-06-02 Euro Celtique Sa Terapeutiske piperazinderivater, der er egnede til behandling af smerter
US7262194B2 (en) 2002-07-26 2007-08-28 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US7157462B2 (en) 2002-09-24 2007-01-02 Euro-Celtique S.A. Therapeutic agents useful for treating pain
EP1608373A4 (en) * 2003-03-19 2010-09-29 Exelixis Inc TIE-2 MODULATORS AND USE METHOD
DK1836179T3 (en) * 2004-12-30 2015-05-26 Janssen Pharmaceutica Nv PIPERIDINE AND PIPERAZINE-1-CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF FAT ACID AMIDE HYDRALASE (FAAH) FOR THE TREATMENT OF ANCIENT, PAIN AND OTHER CONDITIONS
EP1849773B1 (en) 2005-02-17 2013-10-16 Astellas Pharma Inc. Piperazine derivatives for the treatment of urinary incontinence and pain
US7541359B2 (en) 2005-06-30 2009-06-02 Janssen Pharmaceutica N.V. N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase
CA2618653A1 (en) 2005-08-12 2007-02-22 Takeda Pharmaceutical Company Limited Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder
AP2780A (en) 2006-10-18 2013-09-30 Pfizer Prod Inc Biaryl ether urea compounds
CA2687918C (en) 2007-06-08 2016-11-08 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
RU2470017C2 (ru) * 2007-06-08 2012-12-20 Янссен Фармацевтика Н.В. Производные пиперидина/пиперазина
JP5443342B2 (ja) 2007-06-08 2014-03-19 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ピペリジン／ピペラジン誘導体
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
CL2008002998A1 (es) * 2007-10-10 2009-11-20 Takeda Pharmaceuticals Co Compuestos derivados de piperazina-1-carboxamida, inhibidor de faah; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del dolor inflamatorio o neuropatico, ansiedad y depresion.
ES2617619T3 (es) 2008-06-05 2017-06-19 Janssen Pharmaceutica, N.V. Combinaciones de fármacos que comprenden un inhibidor de DGAT y un agonista de PPAR
WO2011060026A1 (en) 2009-11-12 2011-05-19 Jansen Pharmaceutica Nv Piperazinecarboxamide derivative useful as a modulator of fatty acid amide hydrolase (faah)
UA108233C2 (uk) 2010-05-03 2015-04-10 Модулятори активності гідролази амідів жирних кислот
WO2017083216A1 (en) * 2015-11-12 2017-05-18 Merck Sharp & Dohme Corp. Cyanopyridine derivatives as liver x receptor beta agonists, compositions, and their use
CN117777121A (zh) * 2016-10-24 2024-03-29 詹森药业有限公司 化合物及其用途
EA201991650A1 (ru) 2017-01-06 2020-01-20 Юманити Терапьютикс, Инк. Способы лечения неврологических расстройств
WO2019084157A1 (en) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. COMPOUNDS AND USES THEREOF
AU2019238326B2 (en) 2018-03-23 2025-03-06 Janssen Pharmaceutica Nv Compounds and uses thereof
JP7742775B2 (ja) 2019-01-24 2025-09-22 ヤンセン ファーマシューティカ エヌ．ベー． 化合物及びその使用
EA202192047A1 (ru) 2019-11-13 2021-12-08 Юманити Терапьютикс, Инк. Соединения и их применение
JPWO2022118966A1 (ro) * 2020-12-04 2022-06-09

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA04700A (fr) * 1973-05-15 1980-07-31 Rhone Poulenc Sa Nouveaux dérivés de la naphtyridine et leur procédé de préparation.
AU7580187A (en) * 1986-06-23 1988-01-12 Upjohn Company, The Androstane-type and cortical aminoesters
US4960776A (en) * 1987-01-28 1990-10-02 A. H. Robins Company, Inc. 4-aryl-N-(alkylaminoalkyl, heterocyclicamino and heterocyclicamino)alkyl)-1-piperazinecarboxamides
JPH02142770A (ja) * 1988-11-25 1990-05-31 Shigeki Shin ピペラジン系誘導体
JPH03141258A (ja) * 1989-10-25 1991-06-17 Kowa Co 新規なピペラジン誘導体
DE4216364A1 (de) * 1991-12-14 1993-11-25 Thomae Gmbh Dr K Neue Pyridylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas

Also Published As

Publication number Publication date
CN1145620A (zh) 1997-03-19
SK282252B6 (sk) 2001-12-03
US5780472A (en) 1998-07-14
PL316613A1 (en) 1997-01-20
SK88996A3 (en) 1997-05-07
BR9605309A (pt) 1997-10-14
AU699619B2 (en) 1998-12-10
NO963792L (no) 1996-11-11
NO307459B1 (no) 2000-04-10
HU9602489D0 (en) 1996-11-28
FI963566A0 (fi) 1996-09-10
CA2184919A1 (en) 1996-07-18
NO963792D0 (no) 1996-09-10
FI963566A7 (fi) 1996-09-10
CZ296096A3 (en) 1997-02-12
JP2978967B2 (ja) 1999-11-15
JPH09511764A (ja) 1997-11-25
HUP9602489A3 (en) 1998-01-28
HUP9602489A2 (en) 1997-08-28
PL183865B1 (pl) 2002-07-31
AU4400796A (en) 1996-07-31
CA2184919C (en) 2000-03-14
EP0749425A1 (en) 1996-12-27
NZ298499A (en) 1998-01-26
CN1128139C (zh) 2003-11-19
CZ288002B6 (cs) 2001-03-14
WO1996021648A1 (en) 1996-07-18

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