RO115159B1 - Derivaţi de piperazină şi compoziţii farmaceutice care îi conţin - Google Patents

Derivaţi de piperazină şi compoziţii farmaceutice care îi conţin

Info

Publication number
RO115159B1
RO115159B1 RO96-01781A RO9601781A RO115159B1 RO 115159 B1 RO115159 B1 RO 115159B1 RO 9601781 A RO9601781 A RO 9601781A RO 115159 B1 RO115159 B1 RO 115159B1
Authority
RO
Romania
Prior art keywords
same
compositions containing
piperazine derivatives
nitrogen
oxygen
Prior art date
Application number
RO96-01781A
Other languages
English (en)
Inventor
Eui-Hwan Cho
Sun Gan Chung
Joong Young Kim
Sun Hwan Lee
Ho Seok Kwon
Byung Chul Kim
Jae Myeong Kong
Jae Eung Lee
Dong Wook Kang
Original Assignee
Samjin Pharmaceutical Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019950043607A external-priority patent/KR0162710B1/ko
Application filed by Samjin Pharmaceutical Co., Ltd filed Critical Samjin Pharmaceutical Co., Ltd
Publication of RO115159B1 publication Critical patent/RO115159B1/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Invenţia se referă la compuşi cu formula generală (I):la acizii şi la sărurile de adiţie ale acestora, în care Rşi Rsunt independent hidrogen, alchil C-Csau cicloalchil cu ciclu de C-C, opţional substituiţi, conţinând C-Cester inferior, C-Calchil inferior, C-Calcoxi inferior, aril, arilalcoxi sau amină nesaturată; l este un număr întreg, între 0 şi 7; m şi n sunt 0 sau 1; W este carbon sau azot; X este oxigen, sulf, opţional substituit cu imină; Y este azot sau oxigen; şi Z este hidrogen, alcoxi C-C, ariloxi, alchilamină C-C, cicloamină conţinând N-Nsau o grupare oxo, compuşii cu formula (I) de mai sus au activitate antitumorală puternică şi o toxicitate scăzută.
RO96-01781A 1995-01-11 1996-01-10 Derivaţi de piperazină şi compoziţii farmaceutice care îi conţin RO115159B1 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR19950000399 1995-01-11
KR1019950043607A KR0162710B1 (ko) 1995-01-10 1995-11-24 신규 피페라진 유도체 및 그 제조방법
PCT/KR1996/000005 WO1996021648A1 (en) 1995-01-11 1996-01-10 New piperazine derivatives and methods for the preparation thereof and compositions containing the same

Publications (1)

Publication Number Publication Date
RO115159B1 true RO115159B1 (ro) 1999-11-30

Family

ID=26630862

Family Applications (1)

Application Number Title Priority Date Filing Date
RO96-01781A RO115159B1 (ro) 1995-01-11 1996-01-10 Derivaţi de piperazină şi compoziţii farmaceutice care îi conţin

Country Status (16)

Country Link
US (1) US5780472A (ro)
EP (1) EP0749425A1 (ro)
JP (1) JP2978967B2 (ro)
CN (1) CN1128139C (ro)
AU (1) AU699619B2 (ro)
BR (1) BR9605309A (ro)
CA (1) CA2184919C (ro)
CZ (1) CZ288002B6 (ro)
FI (1) FI963566A7 (ro)
HU (1) HUP9602489A3 (ro)
NO (1) NO307459B1 (ro)
NZ (1) NZ298499A (ro)
PL (1) PL183865B1 (ro)
RO (1) RO115159B1 (ro)
SK (1) SK282252B6 (ro)
WO (1) WO1996021648A1 (ro)

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ATE294778T1 (de) * 1995-01-23 2005-05-15 Daiichi Suntory Pharma Co Ltd Verbesserung oder heilung von durch ischämischen krankheiten hervorgerufenen symtomen und dafür verwendbare phenylpiperidinverbingungen
SK27598A3 (en) * 1996-06-29 1998-11-04 Samjin Pharm Co Ltd Piperazine derivatives and process for the preparation thereof
US6794392B1 (en) 1996-09-30 2004-09-21 Schering Aktiengesellschaft Cell differentiation inducer
US6174905B1 (en) * 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
KR100420616B1 (ko) * 1996-12-26 2004-05-17 동화약품공업주식회사 신규테레프탈산아미드유도체
CN1129581C (zh) 1998-09-22 2003-12-03 山之内制药株式会社 氰基苯基衍生物
EP1424072A1 (en) * 1999-03-03 2004-06-02 Samjin Pharmaceutical Co., Ltd. N'-(pyridin-3-yl)-(4-phenylpiperazin-1-yl)-carboxyimidamide and -iminothiolate derivatives for the treatment of tumors
EP1301484A2 (en) 2000-07-20 2003-04-16 Neurogen Corporation Capsaicin receptor ligands
DE10035908A1 (de) 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
US6432957B1 (en) * 2001-06-29 2002-08-13 Kowa Co., Ltd. Piperazine derivative
ATE449090T1 (de) * 2001-07-02 2009-12-15 High Point Pharmaceuticals Llc Substituierte piperazin- und diazepanderivate zur verwendung als histamin h3 rezeptormodulatoren
OA12670A (en) * 2001-10-22 2006-06-20 Pfizer Prod Inc Piperazine derivatives with ccr1 receptor antagonist activity.
EP1458374A2 (en) * 2001-12-14 2004-09-22 Novo Nordisk A/S Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
US7071335B2 (en) 2002-02-01 2006-07-04 Euro-Celtique S.A. 2-pyridinyl-1-piperazine therapeutic agents useful for treating pain
EA200500114A1 (ru) 2002-06-28 2005-06-30 Еуро-Селтик, С. А. Терапевтические агенты, используемые для лечения боли
US7262194B2 (en) 2002-07-26 2007-08-28 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US7157462B2 (en) * 2002-09-24 2007-01-02 Euro-Celtique S.A. Therapeutic agents useful for treating pain
WO2004083235A2 (en) * 2003-03-19 2004-09-30 Exelixis Inc. Tie-2 modulators and methods of use
NZ590148A (en) 2004-12-30 2012-04-27 Janssen Pharmaceutica Nv Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase
TWI385164B (zh) * 2005-02-17 2013-02-11 Astellas Pharma Inc Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivatives (II)
US7541359B2 (en) 2005-06-30 2009-06-02 Janssen Pharmaceutica N.V. N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase
JPWO2007020888A1 (ja) 2005-08-12 2009-02-26 武田薬品工業株式会社 脳・神経細胞保護剤および睡眠障害治療薬
DE602007011793D1 (de) 2006-10-18 2011-02-17 Pfizer Prod Inc Biaryl-ether-harnstoffverbindungen
ES2536406T3 (es) 2007-06-08 2015-05-25 Janssen Pharmaceutica, N.V. Derivados de piperidina/piperazina
JP5464709B2 (ja) 2007-06-08 2014-04-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ピペリジン／ピペラジン誘導体
EP2152271B1 (en) 2007-06-08 2015-10-21 Janssen Pharmaceutica, N.V. Piperidine/piperazine derivatives
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
WO2009048101A1 (ja) * 2007-10-10 2009-04-16 Takeda Pharmaceutical Company Limited アミド化合物
PE20100083A1 (es) 2008-06-05 2010-02-17 Janssen Pharmaceutica Nv Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar
US20120225097A1 (en) 2009-11-12 2012-09-06 Hawryluk Natalie A Piperazinecarboxamide derivative useful as a modulator of fatty acid amide hydrolase (faah)
UA108233C2 (uk) 2010-05-03 2015-04-10 Модулятори активності гідролази амідів жирних кислот
EP3373935B1 (en) 2015-11-12 2021-09-01 Merck Sharp & Dohme Corp. Cyanopyridine derivatives as liver x receptor beta agonists, compositions, and their use
JP2019533022A (ja) * 2016-10-24 2019-11-14 ユマニティ セラピューティクス，インコーポレーテッド 化合物及びその使用
EP3566055B1 (en) 2017-01-06 2025-03-12 Janssen Pharmaceutica NV Scd inhibitor for the treatment of neurological disorders
CA3083000A1 (en) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. Compounds and uses thereof
WO2019183587A1 (en) 2018-03-23 2019-09-26 Yumanity Therapeutics, Inc. Compounds and uses thereof
WO2020154571A1 (en) 2019-01-24 2020-07-30 Yumanity Therapeutics, Inc. Compounds and uses thereof
EA202192047A1 (ru) 2019-11-13 2021-12-08 Юманити Терапьютикс, Инк. Соединения и их применение
WO2022118966A1 (ja) * 2020-12-04 2022-06-09 国立大学法人京都大学 細胞内への核酸分子取り込み促進剤、医薬組成物、及び新規化合物

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OA04700A (fr) * 1973-05-15 1980-07-31 Rhone Poulenc Sa Nouveaux dérivés de la naphtyridine et leur procédé de préparation.
AU7580187A (en) * 1986-06-23 1988-01-12 Upjohn Company, The Androstane-type and cortical aminoesters
US4960776A (en) * 1987-01-28 1990-10-02 A. H. Robins Company, Inc. 4-aryl-N-(alkylaminoalkyl, heterocyclicamino and heterocyclicamino)alkyl)-1-piperazinecarboxamides
JPH02142770A (ja) * 1988-11-25 1990-05-31 Shigeki Shin ピペラジン系誘導体
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US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas

Also Published As

Publication number Publication date
PL316613A1 (en) 1997-01-20
NO307459B1 (no) 2000-04-10
CA2184919C (en) 2000-03-14
BR9605309A (pt) 1997-10-14
US5780472A (en) 1998-07-14
FI963566A0 (fi) 1996-09-10
SK88996A3 (en) 1997-05-07
HU9602489D0 (en) 1996-11-28
CZ296096A3 (en) 1997-02-12
JPH09511764A (ja) 1997-11-25
NZ298499A (en) 1998-01-26
HUP9602489A3 (en) 1998-01-28
CA2184919A1 (en) 1996-07-18
NO963792D0 (no) 1996-09-10
SK282252B6 (sk) 2001-12-03
AU4400796A (en) 1996-07-31
CN1145620A (zh) 1997-03-19
NO963792L (no) 1996-11-11
PL183865B1 (pl) 2002-07-31
FI963566A7 (fi) 1996-09-10
WO1996021648A1 (en) 1996-07-18
EP0749425A1 (en) 1996-12-27
JP2978967B2 (ja) 1999-11-15
CN1128139C (zh) 2003-11-19
HUP9602489A2 (en) 1997-08-28
AU699619B2 (en) 1998-12-10
CZ288002B6 (cs) 2001-03-14

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