TR200002671T2 - Bisiklo(2.2.1)Heptanlar ve ilgili bileşikler - Google Patents
Bisiklo(2.2.1)Heptanlar ve ilgili bileşiklerInfo
- Publication number
- TR200002671T2 TR200002671T2 TR2000/02671T TR200002671T TR200002671T2 TR 200002671 T2 TR200002671 T2 TR 200002671T2 TR 2000/02671 T TR2000/02671 T TR 2000/02671T TR 200002671 T TR200002671 T TR 200002671T TR 200002671 T2 TR200002671 T2 TR 200002671T2
- Authority
- TR
- Turkey
- Prior art keywords
- compounds
- bicyclo
- heptane
- related compounds
- heteroaryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- UMRZSTCPUPJPOJ-KNVOCYPGSA-N norbornane Chemical compound C1C[C@H]2CC[C@@H]1C2 UMRZSTCPUPJPOJ-KNVOCYPGSA-N 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 229910052760 oxygen Chemical group 0.000 abstract 2
- 239000001301 oxygen Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Abstract
Mevcut icat formül (I)'in bilesikleri ile ki, burada n 0-6'dir; X CH2, CH2CH2 ya da oksijendir; Z CHR2 ya da NR2 ya da NR2'dir; R1 ve R2 bagimsiz olarak hidrojenden, (C1-C6) alkilden, arilden ve heteroarilden seçilmektedir, burada söz konusu aril fenilden ve naftilden seçilmektedir ve söz konusu heteroaril bagimsiz olarak azottan, oksijenden ve kükürtten seçilen bir ile dört tane karisik atom içeren 5 ve 6 üyeli aromatik heterosiklik halkalardan seçilmektedir; bu gibi bilesikleri (I) içeren ilaç niteligindeki komposiyonlarla ve sinirsel ve psikiyatrik hastaliklari tedavi etmek için bu bilesiklerin (I) kullanimiyla ilgilidir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7834698P | 1998-03-17 | 1998-03-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200002671T2 true TR200002671T2 (tr) | 2000-12-21 |
Family
ID=22143450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/02671T TR200002671T2 (tr) | 1998-03-17 | 1999-03-04 | Bisiklo(2.2.1)Heptanlar ve ilgili bileşikler |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US6136861A (tr) |
| EP (1) | EP1064256B1 (tr) |
| JP (1) | JP3665567B2 (tr) |
| KR (1) | KR100372981B1 (tr) |
| CN (1) | CN1231461C (tr) |
| AP (1) | AP1116A (tr) |
| AR (1) | AR017236A1 (tr) |
| AT (1) | ATE272608T1 (tr) |
| AU (1) | AU753422B2 (tr) |
| BG (1) | BG104837A (tr) |
| BR (1) | BR9908850A (tr) |
| CA (1) | CA2321639C (tr) |
| CO (1) | CO5090835A1 (tr) |
| CZ (1) | CZ20003355A3 (tr) |
| DE (1) | DE69919142T2 (tr) |
| DZ (1) | DZ2745A1 (tr) |
| EA (1) | EA003946B1 (tr) |
| ES (1) | ES2224604T3 (tr) |
| GT (1) | GT199900040A (tr) |
| HR (1) | HRP20000611A2 (tr) |
| HU (1) | HUP0101031A3 (tr) |
| ID (1) | ID25651A (tr) |
| IL (1) | IL138342A0 (tr) |
| IS (1) | IS5592A (tr) |
| MA (1) | MA26614A1 (tr) |
| MY (1) | MY121047A (tr) |
| NO (1) | NO20004626L (tr) |
| NZ (1) | NZ506227A (tr) |
| OA (1) | OA11488A (tr) |
| PE (1) | PE20000339A1 (tr) |
| PL (1) | PL343278A1 (tr) |
| PT (1) | PT1064256E (tr) |
| SK (1) | SK13532000A3 (tr) |
| TN (1) | TNSN99039A1 (tr) |
| TR (1) | TR200002671T2 (tr) |
| TW (1) | TW509667B (tr) |
| UA (1) | UA53781C2 (tr) |
| WO (1) | WO1999047490A1 (tr) |
| YU (1) | YU53700A (tr) |
| ZA (1) | ZA992094B (tr) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000051590A2 (en) * | 1999-03-04 | 2000-09-08 | The Board Of Trustees Of The University Of Illinois | Neuropharmacological treatment of sleep-related breathing disorders |
| US6313159B1 (en) | 1999-08-20 | 2001-11-06 | Guilford Pharmaceuticals Inc. | Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors |
| UA73981C2 (en) * | 2000-03-10 | 2005-10-17 | Merck Patent Gmbh | (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit |
| CA2442717A1 (en) * | 2001-03-15 | 2002-09-26 | Saegis Pharmaceuticals, Inc. | Methods for restoring cognitive function following systemic stress |
| US6689904B2 (en) | 2001-06-29 | 2004-02-10 | Wyeth | Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine |
| US6750364B2 (en) | 2001-06-29 | 2004-06-15 | Wyeth | Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine as inhibitors of glutamate transport |
| US6689905B2 (en) | 2001-06-29 | 2004-02-10 | Wyeth | Stereoisomers of 3-aminotricyclo[2.2.1.0(2.6)]heptane-1,3-dicarboxylic acid |
| CA2458375A1 (en) | 2001-08-24 | 2003-03-06 | Pharmacia & Upjohn Company | Substituted-heteroaryl-7-aza¬2.2.1|bicycloheptanes for the treatment of disease |
| US7232798B2 (en) * | 2001-11-13 | 2007-06-19 | Tran Loi H | Neuroprotection and neuroegenisis by administering cyclic prolyl glycine |
| FR2872045B1 (fr) * | 2004-06-28 | 2006-09-29 | Centre Nat Rech Scient Cnrse | Medicaments pour le traitement specifique de symptomes de la maladie de parkinson |
| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| US8822498B2 (en) | 2007-09-13 | 2014-09-02 | Concert Pharmaceuticals, Inc. | Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof |
| ES2409215T3 (es) * | 2007-09-14 | 2013-06-25 | Janssen Pharmaceuticals, Inc. | 4-fenil-1H-piridin-2-onas 1-3-disustituidas |
| SI2203439T1 (sl) | 2007-09-14 | 2011-05-31 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni |
| EA019085B1 (ru) | 2007-09-14 | 2014-01-30 | Янссен Фармасьютикалз, Инк. | 1',3-двузамещенные 4-(арил-х-фенил)-1н-пиридин-2-оны |
| RU2492170C9 (ru) * | 2007-11-14 | 2013-12-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2 |
| BRPI0918055A2 (pt) | 2008-09-02 | 2015-12-01 | Addex Pharmaceuticals Sa | derivados de 3-azabiciclo[3,1,0]hexila como moduladores de receptores metabotrópicos de glutamato. |
| WO2010043396A1 (en) | 2008-10-16 | 2010-04-22 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| CN102232074B (zh) | 2008-11-28 | 2014-12-03 | 奥梅-杨森制药有限公司 | 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物 |
| BRPI1010831A2 (pt) | 2009-05-12 | 2016-04-05 | Addex Pharmaceuticals Sa | derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| ME01573B (me) | 2009-05-12 | 2014-09-20 | Addex Pharma Sa | DERIVATI 1,2,4-TRIAZOLO[4,3-a]PIRIDINA I NJIHOVA UPOTREBA U TRETMANU ILI PREVENCIJI NEUROLOŠKIH I PSIHIJATRIJSKIH POREMEĆAJA |
| US8993591B2 (en) | 2010-11-08 | 2015-03-31 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a] pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
| WO2012062751A1 (en) | 2010-11-08 | 2012-05-18 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| JP5852664B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
| AR083845A1 (es) * | 2010-11-18 | 2013-03-27 | Lilly Co Eli | COMPUESTOS 3-FENILSULFANILMETIL-BICICLO[3.1.0]HEXANO 4-SUSTITUIDOS COMO ANTAGONISTAS DE mGluR2/3 |
| CA2818118C (en) | 2010-11-18 | 2016-03-29 | Eli Lilly And Company | 4-substituted-3-benzyloxy-bicyclo[3.1.0]hexane compounds as mglur 2/3 antagonists |
| KR102243637B1 (ko) | 2013-03-14 | 2021-04-26 | 리커리엄 아이피 홀딩스, 엘엘씨 | 바이사이클릭 진통 화합물 |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| CN108947867A (zh) | 2013-12-12 | 2018-12-07 | 卡利拉制药公司 | 双环烷基化合物及合成 |
| LT3096790T (lt) | 2014-01-21 | 2019-10-10 | Janssen Pharmaceutica, N.V. | Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas |
| SI3431106T1 (sl) | 2014-01-21 | 2021-03-31 | Janssen Pharmaceutica Nv | Kombinacije, ki vsebujejo pozitivne alosterične modulatorje metabotropnega glutamatergičnega receptorja podtipa 2 in njihova uporaba |
| EP3114107B1 (en) | 2014-03-07 | 2020-07-22 | Recurium IP Holdings, LLC | Propellane derivates and synthesis |
| US10308609B2 (en) | 2014-09-17 | 2019-06-04 | Zeno Royalties & Milestones, LLC | Bicyclic compounds |
| US20190060257A1 (en) * | 2016-03-16 | 2019-02-28 | Zeno Royalties & Milestones, LLC | Analgesic compounds |
| AU2018269755B2 (en) | 2017-05-15 | 2022-06-16 | Recurium Ip Holdings, Llc | Analgesic compounds |
| JP2021524864A (ja) | 2018-05-15 | 2021-09-16 | ロイド ハン ロイ トランＬｌｏｙｄ Ｈｕｎｇ Ｌｏｉ Ｔｒａｎ | 軽度の認知障害、抑うつ、および精神障害の治療のための治療薬組成物およびその使用方法 |
| KR102157141B1 (ko) | 2018-11-27 | 2020-09-17 | 주식회사 파미니티 | 으아리 추출물을 유효 성분으로 포함하는 인지 기능 개선용 조성물 |
| KR102172916B1 (ko) | 2018-12-07 | 2020-11-02 | 주식회사 파미니티 | 실크 펩타이드 및 천연 추출물을 포함하는 인지 기능 개선용 조성물 |
| US10844380B1 (en) | 2019-06-17 | 2020-11-24 | Biorchestra Co., Ltd. | Uses for prevention or treatment of brain diseases using microrna |
| US11198908B2 (en) | 2019-06-17 | 2021-12-14 | Biorchestra Co., Ltd. | Method for diagnosis of Alzheimer's disease using microRNA |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE199829T1 (de) * | 1994-06-03 | 2001-04-15 | Thejmde Trust | Meta substituierte arylalkylamine und therapeutische und diagnostische verwendung davon |
| PL182285B1 (pl) * | 1994-08-12 | 2001-12-31 | Lilly Co Eli | Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL |
| GB9605429D0 (en) * | 1995-11-16 | 1996-05-15 | Lilly Co Eli | Excitatory amino acid receptor antagonists |
| BR9611521A (pt) * | 1995-11-16 | 1999-06-29 | Lilly Co Eli | Antagonistas de receptor de aminoácido excitador |
-
1999
- 1999-03-04 WO PCT/IB1999/000376 patent/WO1999047490A1/en not_active Application Discontinuation
- 1999-03-04 EP EP99905122A patent/EP1064256B1/en not_active Expired - Lifetime
- 1999-03-04 TR TR2000/02671T patent/TR200002671T2/tr unknown
- 1999-03-04 BR BR9908850-9A patent/BR9908850A/pt not_active Application Discontinuation
- 1999-03-04 DE DE69919142T patent/DE69919142T2/de not_active Expired - Fee Related
- 1999-03-04 ES ES99905122T patent/ES2224604T3/es not_active Expired - Lifetime
- 1999-03-04 CN CNB998040401A patent/CN1231461C/zh not_active Expired - Fee Related
- 1999-03-04 HU HU0101031A patent/HUP0101031A3/hu unknown
- 1999-03-04 JP JP2000536687A patent/JP3665567B2/ja not_active Expired - Fee Related
- 1999-03-04 CZ CZ20003355A patent/CZ20003355A3/cs unknown
- 1999-03-04 EA EA200000842A patent/EA003946B1/ru not_active IP Right Cessation
- 1999-03-04 SK SK1353-2000A patent/SK13532000A3/sk unknown
- 1999-03-04 IL IL13834299A patent/IL138342A0/xx unknown
- 1999-03-04 CA CA002321639A patent/CA2321639C/en not_active Expired - Fee Related
- 1999-03-04 PT PT99905122T patent/PT1064256E/pt unknown
- 1999-03-04 AT AT99905122T patent/ATE272608T1/de not_active IP Right Cessation
- 1999-03-04 PL PL99343278A patent/PL343278A1/xx unknown
- 1999-03-04 US US09/380,727 patent/US6136861A/en not_active Expired - Fee Related
- 1999-03-04 AU AU25409/99A patent/AU753422B2/en not_active Ceased
- 1999-03-04 YU YU53700A patent/YU53700A/sh unknown
- 1999-03-04 ID IDW20001811A patent/ID25651A/id unknown
- 1999-03-04 NZ NZ506227A patent/NZ506227A/xx unknown
- 1999-03-04 KR KR10-2000-7010264A patent/KR100372981B1/ko not_active IP Right Cessation
- 1999-03-10 AP APAP/P/1999/001482A patent/AP1116A/en active
- 1999-03-12 PE PE1999000198A patent/PE20000339A1/es not_active Application Discontinuation
- 1999-03-12 TW TW088103874A patent/TW509667B/zh not_active IP Right Cessation
- 1999-03-15 AR ARP990101118A patent/AR017236A1/es unknown
- 1999-03-15 MY MYPI99000966A patent/MY121047A/en unknown
- 1999-03-16 TN TNTNSN99039A patent/TNSN99039A1/fr unknown
- 1999-03-16 DZ DZ990046A patent/DZ2745A1/xx active
- 1999-03-16 GT GT199900040A patent/GT199900040A/es unknown
- 1999-03-16 MA MA25498A patent/MA26614A1/fr unknown
- 1999-03-16 ZA ZA9902094A patent/ZA992094B/xx unknown
- 1999-03-17 CO CO99016567A patent/CO5090835A1/es unknown
- 1999-04-03 UA UA2000095327A patent/UA53781C2/uk unknown
-
2000
- 2000-08-18 IS IS5592A patent/IS5592A/is unknown
- 2000-09-15 NO NO20004626A patent/NO20004626L/no not_active Application Discontinuation
- 2000-09-15 HR HR20000611A patent/HRP20000611A2/hr not_active Application Discontinuation
- 2000-09-18 OA OA1200000258A patent/OA11488A/en unknown
- 2000-10-11 BG BG104837A patent/BG104837A/bg unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TR200002671T2 (tr) | Bisiklo(2.2.1)Heptanlar ve ilgili bileşikler | |
| DE60119894D1 (de) | Piperidinverbindungen und diese enthaltenden medikamente | |
| HUP0000735A2 (hu) | Az Xa faktort gátló nitrogéntartalmú heteroaromás vegyületek | |
| ATE396728T1 (de) | Verwendung von oestrogen antagonisten und oestrogen agonisten zur behandlung von pathologischen zuständen | |
| HUP0000942A2 (hu) | Kinolin- és kinazolinszármazékok, e vegyületeket tartalmazó gyógyászati készítmények, valamint e vegyületek előállítása és alkalmazása | |
| HUP9903707A2 (hu) | 17Béta-karboxi-,-tio-karboxi-vagy -amido-androsztánszármazékok laktonszármazékai, előállításuk, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények | |
| NO980856L (no) | Piperazinderivater og fremgangsmÕte for fremstilling derav | |
| ATE381554T1 (de) | Aroylfurane und aroylthiophene, die sich für die behandlung von krebs eignen | |
| MY100115A (en) | Nitrogen containing heterocyclic compounds, and their production and use. | |
| ES2126693T3 (es) | Derivado de triazina, su produccion y su uso. | |
| NO930244D0 (no) | Umettede 17beta-substituerte 3-karboksysteroider | |
| DK183789D0 (da) | 2-alkyl-3-benzoylbenzofuraner og laegemidler indeholdende disse | |
| CO4910142A1 (es) | Compuestos de furano nitrona | |
| BG105123A (en) | Tetrahydroquinaline derivatives as glycine antagonists | |
| ATE83234T1 (de) | Oxadiazol-pyrimidinone, ihre herstellung und ihre kosmetische und dermopharmazeutische verwendung. | |
| ATE247660T1 (de) | Furopyridinderivate und ihre therapeutische verwendung | |
| SE8303913D0 (sv) | Heterocykliska foreningar | |
| DK1161424T3 (da) | Hidtil ukendte diazolderivater som serotonerge midler | |
| DE69808326T2 (de) | Azetidinonderivate zur behandlung von hcmv entzündungen | |
| EA200000929A3 (ru) | Новые цианоиндольные соединения-ингибиторы повторного захвата серотонина, способ их получения и содержащие их фармацевтические композиции | |
| FI811266L (fi) | Antihypertensiva laktamer | |
| ATE208761T1 (de) | Quinolin-derivate und diese enthaltende pharmazeutische zusammensetzungen | |
| HUP0104151A2 (hu) | Nitrogén-monoxid-szintetáz inhibitor tulajdonsággal rendelkező amino-alkil-3,4-dihidro-kinolin-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| RU94016363A (ru) | Производные 2-аминопиразин 5-карбоксамида, их получение и применение в терапии | |
| HUP0400531A2 (hu) | Gyulladásgátló szerekként alkalmazható hidantoinvegyületek és ezeket tartalmazó gyógyszerkészítmények |