DE69808326T2 - Azetidinonderivate zur behandlung von hcmv entzündungen - Google Patents
Azetidinonderivate zur behandlung von hcmv entzündungenInfo
- Publication number
- DE69808326T2 DE69808326T2 DE69808326T DE69808326T DE69808326T2 DE 69808326 T2 DE69808326 T2 DE 69808326T2 DE 69808326 T DE69808326 T DE 69808326T DE 69808326 T DE69808326 T DE 69808326T DE 69808326 T2 DE69808326 T2 DE 69808326T2
- Authority
- DE
- Germany
- Prior art keywords
- lower alkyl
- het
- hydrogen
- optionally substituted
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6154497P | 1997-10-07 | 1997-10-07 | |
PCT/CA1998/000953 WO1999018072A1 (en) | 1997-10-07 | 1998-10-06 | Azetidinone derivatives for the treatment of hcmv infections |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69808326D1 DE69808326D1 (de) | 2002-10-31 |
DE69808326T2 true DE69808326T2 (de) | 2003-05-22 |
Family
ID=22036448
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69808326T Expired - Lifetime DE69808326T2 (de) | 1997-10-07 | 1998-10-06 | Azetidinonderivate zur behandlung von hcmv entzündungen |
Country Status (11)
Country | Link |
---|---|
US (1) | US6242439B1 (de) |
EP (1) | EP1021405B1 (de) |
JP (1) | JP2001519329A (de) |
AT (1) | ATE224872T1 (de) |
AU (1) | AU9426098A (de) |
CA (1) | CA2301543C (de) |
DE (1) | DE69808326T2 (de) |
DK (1) | DK1021405T3 (de) |
ES (1) | ES2180201T3 (de) |
PT (1) | PT1021405E (de) |
WO (1) | WO1999018072A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS50386B (sr) | 2001-03-28 | 2009-12-31 | Schering Corporation, | Enantioselektivna sinteza intermedijarnih jedinjenja azetidinona |
DE10134478B4 (de) * | 2001-07-16 | 2007-10-31 | Priaton Gmbh | Verfahren zur Darstellung von thiazolsubstituierten β-Lactamen |
AU2005329094A1 (en) * | 2005-03-09 | 2006-09-21 | Carrier Commercial Refrigeration, Inc. | Cold room with roof-top support platform |
US8673288B2 (en) * | 2008-09-02 | 2014-03-18 | The Board Of Trustees Of The University Of Illinois | Compositions and methods for inhibiting entry of a hepatic virus |
WO2020053654A1 (en) | 2018-09-12 | 2020-03-19 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
AU2020353055B2 (en) | 2019-09-26 | 2024-03-07 | Gilead Sciences, Inc. | Antiviral pyrazolopyridinone compounds |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5229381A (en) * | 1983-12-01 | 1993-07-20 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
US4680391A (en) | 1983-12-01 | 1987-07-14 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
NZ228600A (en) * | 1988-04-11 | 1992-02-25 | Merck & Co Inc | 1-(benzylaminocarbonyl)-4-phenoxy-azetidin-2-one derivatives |
DE377549T1 (de) | 1989-01-03 | 1990-11-08 | Marcos Y. Southbridge Mass. Us Kleinerman | Fernmessung physikalischer variablen mit faseroptischen systemen. |
US5100880A (en) * | 1991-03-20 | 1992-03-31 | Merck & Co., Inc. | Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone |
US5104862A (en) * | 1991-03-20 | 1992-04-14 | Merck & Co., Inc. | Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone |
US5229831A (en) | 1991-09-20 | 1993-07-20 | The Charles Stark Draper Laboratory, Inc. | Ultraminiature tactical grade cryogenic RFOG |
GB2266527A (en) * | 1992-03-17 | 1993-11-03 | Merck & Co Inc | Substituted azetidinones useful in the treatment of leukemia |
GB9314350D0 (en) * | 1993-07-12 | 1993-08-25 | Zeneca Ltd | Armide derivatives |
CZ265896A3 (en) * | 1994-03-23 | 1997-06-11 | Tokyo Tanabe Co | Tryptase inhibitor, its use and pharmaceutical compositions containing thereof |
-
1998
- 1998-10-06 DE DE69808326T patent/DE69808326T2/de not_active Expired - Lifetime
- 1998-10-06 PT PT98947256T patent/PT1021405E/pt unknown
- 1998-10-06 US US09/167,143 patent/US6242439B1/en not_active Expired - Lifetime
- 1998-10-06 EP EP98947256A patent/EP1021405B1/de not_active Expired - Lifetime
- 1998-10-06 CA CA002301543A patent/CA2301543C/en not_active Expired - Fee Related
- 1998-10-06 AT AT98947256T patent/ATE224872T1/de active
- 1998-10-06 WO PCT/CA1998/000953 patent/WO1999018072A1/en active IP Right Grant
- 1998-10-06 AU AU94260/98A patent/AU9426098A/en not_active Abandoned
- 1998-10-06 DK DK98947256T patent/DK1021405T3/da active
- 1998-10-06 ES ES98947256T patent/ES2180201T3/es not_active Expired - Lifetime
- 1998-10-06 JP JP2000514884A patent/JP2001519329A/ja not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
DE69808326D1 (de) | 2002-10-31 |
US6242439B1 (en) | 2001-06-05 |
EP1021405A1 (de) | 2000-07-26 |
JP2001519329A (ja) | 2001-10-23 |
EP1021405B1 (de) | 2002-09-25 |
ES2180201T3 (es) | 2003-02-01 |
ATE224872T1 (de) | 2002-10-15 |
CA2301543A1 (en) | 1999-04-15 |
WO1999018072A1 (en) | 1999-04-15 |
PT1021405E (pt) | 2003-02-28 |
CA2301543C (en) | 2005-05-17 |
DK1021405T3 (da) | 2003-02-03 |
AU9426098A (en) | 1999-04-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |