RS50386B - Enantioselektivna sinteza intermedijarnih jedinjenja azetidinona - Google Patents
Enantioselektivna sinteza intermedijarnih jedinjenja azetidinonaInfo
- Publication number
- RS50386B RS50386B YUP-748/03A YUP74803A RS50386B RS 50386 B RS50386 B RS 50386B YU P74803 A YUP74803 A YU P74803A RS 50386 B RS50386 B RS 50386B
- Authority
- RS
- Serbia
- Prior art keywords
- compound
- formula
- intermediate compounds
- enantioselective synthesis
- tetrahydrofuran
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- MNFORVFSTILPAW-UHFFFAOYSA-N azetidin-2-one Chemical compound O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Postupak za dobijanje jedinjenja Formule I naznačen time, što se sastoji od: (a)mešanja jedinjenja Formule II u tetrahidrofuranu u prisustvu kiseline, ili alternativno, u tetrahidrofuranu bez prisustva kiseline, formirajući smešu; (b)kombinovanja smeše iz koraka (a) i katalizatora koji se bira između ili (A) jedinjenja koje se bira iz grupe jedinjenja predstavljenih Formulom III, ili (B) jedinjenja Formule IV,gde R1 u formuli III predstavlja (C1-6)alkil, a R i S označavaju stereohimiju hiralnih ugljenika: (c) redukovanja ketona susednog p-fluorefenilu, sa kompleksom borantetrahidrofunat; i (d) okončavanja reakcije sa MeOH.Prijava sadrži 19 patentnih zahteva
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27928801P | 2001-03-28 | 2001-03-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
YU74803A YU74803A (sh) | 2006-05-25 |
RS50386B true RS50386B (sr) | 2009-12-31 |
Family
ID=23068350
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-748/03A RS50386B (sr) | 2001-03-28 | 2002-03-25 | Enantioselektivna sinteza intermedijarnih jedinjenja azetidinona |
Country Status (29)
Country | Link |
---|---|
US (1) | US6627757B2 (sr) |
EP (1) | EP1373230B1 (sr) |
JP (1) | JP4145663B2 (sr) |
KR (1) | KR100590342B1 (sr) |
CN (1) | CN1275949C (sr) |
AT (1) | ATE305459T1 (sr) |
AU (1) | AU2002258605B2 (sr) |
BG (1) | BG66189B1 (sr) |
BR (1) | BRPI0208384B1 (sr) |
CA (1) | CA2442219C (sr) |
CZ (1) | CZ304929B6 (sr) |
DE (1) | DE60206365T2 (sr) |
DK (1) | DK1373230T3 (sr) |
EA (1) | EA006898B1 (sr) |
EE (1) | EE05453B1 (sr) |
ES (1) | ES2245733T3 (sr) |
HK (1) | HK1057546A1 (sr) |
HR (1) | HRP20030760B1 (sr) |
HU (1) | HU230229B1 (sr) |
IL (2) | IL157552A0 (sr) |
MX (1) | MXPA03008803A (sr) |
NZ (1) | NZ527852A (sr) |
PL (1) | PL205952B1 (sr) |
RS (1) | RS50386B (sr) |
SI (1) | SI1373230T1 (sr) |
SK (1) | SK287408B6 (sr) |
UA (1) | UA75644C2 (sr) |
WO (1) | WO2002079174A2 (sr) |
ZA (1) | ZA200306612B (sr) |
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MX2007006695A (es) | 2004-12-03 | 2007-08-14 | Schering Corp | Piperazinas sustituidas como antagonistas de cb1. |
US8308559B2 (en) * | 2007-05-07 | 2012-11-13 | Jay Chun | Paradise box gaming system |
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JP2008543744A (ja) * | 2005-05-09 | 2008-12-04 | マイクロビア インコーポレーテッド | 有機金属ベンゼンホスホナートカップリング剤 |
MX2007014172A (es) * | 2005-05-11 | 2008-04-02 | Microbia Inc | Procedimiento para la produccion de 4-bifenililacetidina-2-onas fenolicos. |
AU2006249905A1 (en) * | 2005-05-25 | 2006-11-30 | Microbia, Inc. | Processes for production of 4-(biphenylyl)azetidin-2-one phosphonic acids |
KR20080021082A (ko) * | 2005-06-20 | 2008-03-06 | 쉐링 코포레이션 | 히스타민 h3 길항제로서 유용한 피페리딘 유도체 |
SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
CA2616058A1 (en) * | 2005-09-08 | 2007-03-15 | Vinod Kumar Kansal | Processes for the preparation of (3r,4s)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((s)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe |
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JP2010502702A (ja) * | 2006-09-05 | 2010-01-28 | シェーリング コーポレイション | 脂質管理およびアテローム性動脈硬化症および脂肪肝の治療治療において使用される医薬組成物 |
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-
2002
- 2002-03-25 EE EEP200300464A patent/EE05453B1/xx unknown
- 2002-03-25 MX MXPA03008803A patent/MXPA03008803A/es active IP Right Grant
- 2002-03-25 WO PCT/US2002/009123 patent/WO2002079174A2/en active IP Right Grant
- 2002-03-25 RS YUP-748/03A patent/RS50386B/sr unknown
- 2002-03-25 ES ES02728561T patent/ES2245733T3/es not_active Expired - Lifetime
- 2002-03-25 AT AT02728561T patent/ATE305459T1/de active
- 2002-03-25 BR BRPI0208384A patent/BRPI0208384B1/pt active IP Right Grant
- 2002-03-25 HU HU0303526A patent/HU230229B1/hu unknown
- 2002-03-25 JP JP2002577801A patent/JP4145663B2/ja not_active Expired - Lifetime
- 2002-03-25 AU AU2002258605A patent/AU2002258605B2/en not_active Expired
- 2002-03-25 IL IL15755202A patent/IL157552A0/xx unknown
- 2002-03-25 SK SK1186-2003A patent/SK287408B6/sk unknown
- 2002-03-25 EP EP02728561A patent/EP1373230B1/en not_active Expired - Lifetime
- 2002-03-25 KR KR1020037012486A patent/KR100590342B1/ko active IP Right Grant
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