RS50386B - Enantioselektivna sinteza intermedijarnih jedinjenja azetidinona - Google Patents

Enantioselektivna sinteza intermedijarnih jedinjenja azetidinona

Info

Publication number
RS50386B
RS50386B YUP-748/03A YUP74803A RS50386B RS 50386 B RS50386 B RS 50386B YU P74803 A YUP74803 A YU P74803A RS 50386 B RS50386 B RS 50386B
Authority
RS
Serbia
Prior art keywords
compound
formula
intermediate compounds
enantioselective synthesis
tetrahydrofuran
Prior art date
Application number
YUP-748/03A
Other languages
English (en)
Inventor
Xiaoyong FU
Timothi MCALLISTER
Thiruvengadam T.K.
Chou Hong TANN
Original Assignee
Schering Corporation,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation, filed Critical Schering Corporation,
Publication of YU74803A publication Critical patent/YU74803A/sh
Publication of RS50386B publication Critical patent/RS50386B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Postupak za dobijanje jedinjenja Formule I naznačen time, što se sastoji od: (a)mešanja jedinjenja Formule II u tetrahidrofuranu u prisustvu kiseline, ili alternativno, u tetrahidrofuranu bez prisustva kiseline, formirajući smešu; (b)kombinovanja smeše iz koraka (a) i katalizatora koji se bira između ili (A) jedinjenja koje se bira iz grupe jedinjenja predstavljenih Formulom III, ili (B) jedinjenja Formule IV,gde R1 u formuli III predstavlja (C1-6)alkil, a R i S označavaju stereohimiju hiralnih ugljenika: (c) redukovanja ketona susednog p-fluorefenilu, sa kompleksom borantetrahidrofunat; i (d) okončavanja reakcije sa MeOH.Prijava sadrži 19 patentnih zahteva
YUP-748/03A 2001-03-28 2002-03-25 Enantioselektivna sinteza intermedijarnih jedinjenja azetidinona RS50386B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27928801P 2001-03-28 2001-03-28

Publications (2)

Publication Number Publication Date
YU74803A YU74803A (sh) 2006-05-25
RS50386B true RS50386B (sr) 2009-12-31

Family

ID=23068350

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-748/03A RS50386B (sr) 2001-03-28 2002-03-25 Enantioselektivna sinteza intermedijarnih jedinjenja azetidinona

Country Status (29)

Country Link
US (1) US6627757B2 (sr)
EP (1) EP1373230B1 (sr)
JP (1) JP4145663B2 (sr)
KR (1) KR100590342B1 (sr)
CN (1) CN1275949C (sr)
AT (1) ATE305459T1 (sr)
AU (1) AU2002258605B2 (sr)
BG (1) BG66189B1 (sr)
BR (1) BRPI0208384B1 (sr)
CA (1) CA2442219C (sr)
CZ (1) CZ304929B6 (sr)
DE (1) DE60206365T2 (sr)
DK (1) DK1373230T3 (sr)
EA (1) EA006898B1 (sr)
EE (1) EE05453B1 (sr)
ES (1) ES2245733T3 (sr)
HK (1) HK1057546A1 (sr)
HR (1) HRP20030760B1 (sr)
HU (1) HU230229B1 (sr)
IL (2) IL157552A0 (sr)
MX (1) MXPA03008803A (sr)
NZ (1) NZ527852A (sr)
PL (1) PL205952B1 (sr)
RS (1) RS50386B (sr)
SI (1) SI1373230T1 (sr)
SK (1) SK287408B6 (sr)
UA (1) UA75644C2 (sr)
WO (1) WO2002079174A2 (sr)
ZA (1) ZA200306612B (sr)

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Also Published As

Publication number Publication date
YU74803A (sh) 2006-05-25
HUP0303526A3 (en) 2004-11-29
UA75644C2 (en) 2006-05-15
ATE305459T1 (de) 2005-10-15
CA2442219C (en) 2007-09-11
EE05453B1 (et) 2011-08-15
KR20030085573A (ko) 2003-11-05
HRP20030760A2 (en) 2004-08-31
IL157552A0 (en) 2004-03-28
DK1373230T3 (da) 2005-11-07
CA2442219A1 (en) 2002-10-10
EA006898B1 (ru) 2006-04-28
HK1057546A1 (en) 2004-04-08
WO2002079174A3 (en) 2003-02-27
PL363864A1 (en) 2004-11-29
MXPA03008803A (es) 2004-02-18
EP1373230B1 (en) 2005-09-28
BRPI0208384B1 (pt) 2016-05-31
DE60206365D1 (de) 2005-11-03
SK11862003A3 (sk) 2004-04-06
BG66189B1 (bg) 2011-12-30
US6627757B2 (en) 2003-09-30
HU230229B1 (hu) 2015-10-28
JP2004532210A (ja) 2004-10-21
HUP0303526A2 (hu) 2004-01-28
JP4145663B2 (ja) 2008-09-03
IL157552A (en) 2009-08-03
US20020193607A1 (en) 2002-12-19
EA200300970A1 (ru) 2004-04-29
BR0208384A (pt) 2004-06-15
HRP20030760B1 (en) 2011-07-31
ZA200306612B (en) 2004-10-12
SK287408B6 (sk) 2010-09-07
NZ527852A (en) 2005-03-24
CZ304929B6 (cs) 2015-01-28
PL205952B1 (pl) 2010-06-30
DE60206365T2 (de) 2006-07-06
CN1275949C (zh) 2006-09-20
ES2245733T3 (es) 2006-01-16
AU2002258605B2 (en) 2006-01-12
CN1500083A (zh) 2004-05-26
KR100590342B1 (ko) 2006-06-15
EP1373230A2 (en) 2004-01-02
SI1373230T1 (sl) 2005-12-31
BG108168A (en) 2004-09-30
EE200300464A (et) 2003-12-15
CZ20032610A3 (en) 2004-03-17
WO2002079174A2 (en) 2002-10-10

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