ATE305459T1 - Verfahren für die enantioselektive synthese von azetidinon-zwischenprodukten - Google Patents
Verfahren für die enantioselektive synthese von azetidinon-zwischenproduktenInfo
- Publication number
- ATE305459T1 ATE305459T1 AT02728561T AT02728561T ATE305459T1 AT E305459 T1 ATE305459 T1 AT E305459T1 AT 02728561 T AT02728561 T AT 02728561T AT 02728561 T AT02728561 T AT 02728561T AT E305459 T1 ATE305459 T1 AT E305459T1
- Authority
- AT
- Austria
- Prior art keywords
- intermediate products
- enantioselective synthesis
- azetidinone intermediate
- azetidinone
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27928801P | 2001-03-28 | 2001-03-28 | |
PCT/US2002/009123 WO2002079174A2 (en) | 2001-03-28 | 2002-03-25 | Enantioselective synthesis of azetidinone intermediate compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE305459T1 true ATE305459T1 (de) | 2005-10-15 |
Family
ID=23068350
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02728561T ATE305459T1 (de) | 2001-03-28 | 2002-03-25 | Verfahren für die enantioselektive synthese von azetidinon-zwischenprodukten |
Country Status (29)
Country | Link |
---|---|
US (1) | US6627757B2 (de) |
EP (1) | EP1373230B1 (de) |
JP (1) | JP4145663B2 (de) |
KR (1) | KR100590342B1 (de) |
CN (1) | CN1275949C (de) |
AT (1) | ATE305459T1 (de) |
AU (1) | AU2002258605B2 (de) |
BG (1) | BG66189B1 (de) |
BR (1) | BRPI0208384B1 (de) |
CA (1) | CA2442219C (de) |
CZ (1) | CZ304929B6 (de) |
DE (1) | DE60206365T2 (de) |
DK (1) | DK1373230T3 (de) |
EA (1) | EA006898B1 (de) |
EE (1) | EE05453B1 (de) |
ES (1) | ES2245733T3 (de) |
HK (1) | HK1057546A1 (de) |
HR (1) | HRP20030760B1 (de) |
HU (1) | HU230229B1 (de) |
IL (2) | IL157552A0 (de) |
MX (1) | MXPA03008803A (de) |
NZ (1) | NZ527852A (de) |
PL (1) | PL205952B1 (de) |
RS (1) | RS50386B (de) |
SI (1) | SI1373230T1 (de) |
SK (1) | SK287408B6 (de) |
UA (1) | UA75644C2 (de) |
WO (1) | WO2002079174A2 (de) |
ZA (1) | ZA200306612B (de) |
Families Citing this family (35)
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GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
US20040132058A1 (en) | 2002-07-19 | 2004-07-08 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
US7135556B2 (en) | 2002-07-19 | 2006-11-14 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
AR040588A1 (es) | 2002-07-26 | 2005-04-13 | Schering Corp | Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa |
EP1918000A2 (de) | 2003-11-05 | 2008-05-07 | Schering Corporation | Verbindungen aus lipidverändernden Wirkstoffen und substituierten Azetidinonen und Behandlungen für Gefäßzustände |
DE602004029715D1 (de) | 2003-12-23 | 2010-12-02 | Astrazeneca Ab | Diphenylazetidinonderivate mit die cholesterinabsorption hemmender wirkung |
JP4590417B2 (ja) | 2004-01-16 | 2010-12-01 | メルク・シャープ・エンド・ドーム・コーポレイション | Npc1l1(npc3)およびこのリガンドの同定方法 |
WO2006039334A1 (en) * | 2004-09-29 | 2006-04-13 | Schering Corporation | Combinations of substituted azetidonones and cb1 antagonists |
ES2435790T3 (es) | 2004-12-03 | 2013-12-23 | Intervet International B.V. | Piperazinas sustituidas como antagonistas de CB1 |
US8308559B2 (en) * | 2007-05-07 | 2012-11-13 | Jay Chun | Paradise box gaming system |
TW200726746A (en) * | 2005-05-06 | 2007-07-16 | Microbia Inc | Processes for production of 4-biphenylylazetidin-2-ones |
EA200702450A1 (ru) * | 2005-05-09 | 2008-04-28 | Майкробиа, Инк. | Металлоорганические бензолфосфонатные связующие вещества |
AU2006244043A1 (en) * | 2005-05-11 | 2006-11-16 | Microbia, Inc. | Processes for production of phenolic 4-biphenylylazetidin-2-ones |
US20090099355A1 (en) * | 2005-05-25 | 2009-04-16 | Microbia, Inc. | Processes for Production of 4-(Biphenylyl)Azetidin-2-One Phosphonic Acids |
JP2008546784A (ja) * | 2005-06-20 | 2008-12-25 | シェーリング コーポレイション | ヒスタミンh3アンタゴニストとして有用なピペリジン誘導体 |
SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
BRPI0605934A2 (pt) * | 2005-09-08 | 2009-05-26 | Teva Pharma | processos para a preparação de ( 3r, 4s) - 4 - ( (4-benziloxi ) fenil ) - 1 - ( 4 - fluorofenil ) - 3 - ( (s) - 3 - ( 4 - fluorofenil ) - 3 - hidroxipropil) - 2 - azetidinona, um intermediário para a sìntese da ezetimiba |
HUP0501164A2 (en) * | 2005-12-20 | 2007-07-30 | Richter Gedeon Nyrt | New industrial process for the production of ezetimibe |
MX2008009354A (es) | 2006-01-18 | 2008-09-30 | Schering Corp | Moduladores de receptores cannabinoides. |
CA2642388C (en) * | 2006-02-16 | 2013-11-05 | Kotobuki Pharmaceutical Co., Ltd. | Process for preparing optically active alcohols |
WO2007100807A2 (en) | 2006-02-24 | 2007-09-07 | Schering Corporation | Npc1l1 orthologues |
AR060623A1 (es) | 2006-04-27 | 2008-07-02 | Astrazeneca Ab | Compuestos derivados de 2-azetidinona y un metodo de preparacion |
CA2661404A1 (en) * | 2006-09-05 | 2008-03-13 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
WO2008130616A2 (en) * | 2007-04-19 | 2008-10-30 | Schering Corporation | Diaryl morpholines as cb1 modulators |
JP2010529148A (ja) * | 2007-06-07 | 2010-08-26 | テバ ファーマシューティカル インダストリーズ リミティド | エゼチミブ製造のための還元方法 |
US20100286160A1 (en) * | 2007-06-28 | 2010-11-11 | Intervet Inc. | Substituted piperazines as cb1 antagonists |
NZ582249A (en) * | 2007-06-28 | 2012-06-29 | Intervet Int Bv | Substituted piperazines as cb1 antagonists |
WO2009032264A1 (en) * | 2007-08-30 | 2009-03-12 | Teva Pharmaceutical Industries Ltd. | Processes for preparing intermediates of ezetimibe by microbial reduction |
US20090312302A1 (en) * | 2008-06-17 | 2009-12-17 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating nonalcoholic fatty liver disease-associated disorders |
CN102186972B (zh) | 2008-08-29 | 2014-08-20 | 科德克希思公司 | 用于立体选择性生产(4s)-3-[(5s)-5-(4-氟苯基)-5-羟基戊酰基]-4-苯基-1,3-噁唑烷-2-酮的酮还原酶多肽 |
EP2414529A2 (de) | 2009-04-01 | 2012-02-08 | Matrix Laboratories Ltd | Enzymatisches verfahren zur herstellung von (s)-5-(4-fluorphenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-on, einer zwischenstufe von ezetimib, und weitere umwandlung zu ezetimib |
SG10201405022PA (en) | 2009-08-19 | 2014-10-30 | Codexis Inc | Ketoreductase polypeptides for the preparation of phenylephrine |
EP2566497B1 (de) | 2010-05-04 | 2015-07-29 | Codexis, Inc. | Biokatalysatoren zur ezetimib-synthese |
WO2012155932A1 (en) | 2011-05-17 | 2012-11-22 | Pharmathen S.A. | Improved process for the preparation of ezetimibe |
CN111518046B (zh) * | 2020-06-04 | 2022-04-15 | 中山奕安泰医药科技有限公司 | 依泽替米贝中间体及依泽替米贝的制备方法 |
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JP3679715B2 (ja) | 1999-04-05 | 2005-08-03 | シェーリング コーポレイション | 1−(4−フルオロフェニル)−3(r)−[3(s)−ヒドロキシ−3−(4−フルオロフェニル)プロピル)]−4(s)−(4−ヒドロキシフェニル)−2−アゼチジノンの調製のための立体選択的微生物還元 |
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-
2002
- 2002-03-25 CN CNB028075374A patent/CN1275949C/zh not_active Expired - Lifetime
- 2002-03-25 NZ NZ527852A patent/NZ527852A/en not_active IP Right Cessation
- 2002-03-25 EP EP02728561A patent/EP1373230B1/de not_active Expired - Lifetime
- 2002-03-25 SK SK1186-2003A patent/SK287408B6/sk unknown
- 2002-03-25 CZ CZ2003-2610A patent/CZ304929B6/cs not_active IP Right Cessation
- 2002-03-25 PL PL363864A patent/PL205952B1/pl unknown
- 2002-03-25 BR BRPI0208384A patent/BRPI0208384B1/pt active IP Right Grant
- 2002-03-25 CA CA002442219A patent/CA2442219C/en not_active Expired - Lifetime
- 2002-03-25 AT AT02728561T patent/ATE305459T1/de active
- 2002-03-25 KR KR1020037012486A patent/KR100590342B1/ko active IP Right Grant
- 2002-03-25 JP JP2002577801A patent/JP4145663B2/ja not_active Expired - Lifetime
- 2002-03-25 EE EEP200300464A patent/EE05453B1/xx unknown
- 2002-03-25 WO PCT/US2002/009123 patent/WO2002079174A2/en active IP Right Grant
- 2002-03-25 UA UA2003109666A patent/UA75644C2/uk unknown
- 2002-03-25 SI SI200230193T patent/SI1373230T1/sl unknown
- 2002-03-25 DE DE60206365T patent/DE60206365T2/de not_active Expired - Lifetime
- 2002-03-25 MX MXPA03008803A patent/MXPA03008803A/es active IP Right Grant
- 2002-03-25 HU HU0303526A patent/HU230229B1/hu unknown
- 2002-03-25 EA EA200300970A patent/EA006898B1/ru not_active IP Right Cessation
- 2002-03-25 DK DK02728561T patent/DK1373230T3/da active
- 2002-03-25 IL IL15755202A patent/IL157552A0/xx unknown
- 2002-03-25 RS YUP-748/03A patent/RS50386B/sr unknown
- 2002-03-25 ES ES02728561T patent/ES2245733T3/es not_active Expired - Lifetime
- 2002-03-25 US US10/105,710 patent/US6627757B2/en not_active Expired - Lifetime
- 2002-03-25 AU AU2002258605A patent/AU2002258605B2/en not_active Expired
-
2003
- 2003-08-24 IL IL157552A patent/IL157552A/en unknown
- 2003-08-25 ZA ZA200306612A patent/ZA200306612B/en unknown
- 2003-09-09 BG BG108168A patent/BG66189B1/bg unknown
- 2003-09-19 HR HR20030760A patent/HRP20030760B1/xx not_active IP Right Cessation
-
2004
- 2004-01-07 HK HK04100111A patent/HK1057546A1/xx not_active IP Right Cessation
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