DE69428280D1 - Verfahren zur herstellung von azetidinonen - Google Patents

Verfahren zur herstellung von azetidinonen

Info

Publication number
DE69428280D1
DE69428280D1 DE69428280T DE69428280T DE69428280D1 DE 69428280 D1 DE69428280 D1 DE 69428280D1 DE 69428280 T DE69428280 T DE 69428280T DE 69428280 T DE69428280 T DE 69428280T DE 69428280 D1 DE69428280 D1 DE 69428280D1
Authority
DE
Germany
Prior art keywords
substituted
pct
beta
amino
azetidinones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69428280T
Other languages
English (en)
Other versions
DE69428280T2 (de
Inventor
Kannapan Thiruvengadam
Timothy Mcallister
Chou-Hong Tann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22217215&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69428280(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE69428280D1 publication Critical patent/DE69428280D1/de
Publication of DE69428280T2 publication Critical patent/DE69428280T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
DE69428280T 1993-07-09 1994-07-01 Verfahren zur herstellung von azetidinonen Expired - Lifetime DE69428280T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8935793A 1993-07-09 1993-07-09
PCT/US1994/007291 WO1995001961A1 (en) 1993-07-09 1994-07-01 Process for the synthesis of azetidinones

Publications (2)

Publication Number Publication Date
DE69428280D1 true DE69428280D1 (de) 2001-10-18
DE69428280T2 DE69428280T2 (de) 2002-06-13

Family

ID=22217215

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69428280T Expired - Lifetime DE69428280T2 (de) 1993-07-09 1994-07-01 Verfahren zur herstellung von azetidinonen

Country Status (21)

Country Link
US (1) US5728827A (de)
EP (1) EP0707567B1 (de)
JP (1) JP2840452B2 (de)
KR (1) KR0176001B1 (de)
CN (1) CN1071745C (de)
AT (1) ATE205475T1 (de)
AU (1) AU681419B2 (de)
CA (1) CA2166784C (de)
CZ (1) CZ7696A3 (de)
DE (1) DE69428280T2 (de)
DK (1) DK0707567T3 (de)
ES (1) ES2160125T3 (de)
FI (1) FI960095A0 (de)
HU (1) HUT73237A (de)
MX (1) MX9405152A (de)
NO (1) NO306294B1 (de)
NZ (1) NZ268798A (de)
PL (1) PL312502A1 (de)
PT (1) PT707567E (de)
SK (1) SK3796A3 (de)
WO (1) WO1995001961A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US6207822B1 (en) 1998-12-07 2001-03-27 Schering Corporation Process for the synthesis of azetidinones
EP1137634B1 (de) * 1998-12-07 2005-06-15 Schering Corporation Verfahren zur herstellung von azetidinonen
AU4343500A (en) 1999-04-16 2000-11-02 Schering Corporation Use of azetidinone compounds
RS51449B (sr) * 2001-01-26 2011-04-30 Schering Corporation Kombinacija aktivatora peroksizom proliferator-aktiviranog receptora (ppar) i inhibitora apsorpcije sterola i lečenje vaskularnih indikacija
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
BRPI0208384B1 (pt) 2001-03-28 2016-05-31 Merck Sharp & Dohme síntese enantiosseletiva de compostos intermediários de azetidinona
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
DE60216300T2 (de) * 2001-09-21 2007-06-28 Schering Corp. Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption
US20030204096A1 (en) * 2002-03-25 2003-10-30 Schering Corporation Enantioselective synthesis of azetidinone intermediate compounds
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
US7135556B2 (en) * 2002-07-19 2006-11-14 Schering Corporation NPC1L1 (NPC3) and methods of use thereof
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP5137228B2 (ja) * 2003-03-07 2013-02-06 メルク・シャープ・アンド・ドーム・コーポレーション 高コレステロール血症の処置のための置換アゼチジノン化合物、置換アゼチジノン処方物およびそれらの使用
DE602004018617D1 (de) * 2003-03-07 2009-02-05 Schering Corp Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
AU2004308332B2 (en) * 2003-12-23 2008-04-10 Merck Sharp & Dohme Corp. Anti-hypercholesterolemic compounds
ATE485267T1 (de) 2003-12-23 2010-11-15 Astrazeneca Ab Diphenylazetidinonderivate mit die cholesterinabsorption hemmender wirkung
MXPA06008124A (es) * 2004-01-16 2007-01-26 Merck & Co Inc Npc1l1 (npc3) y metodos para identificar ligandos del mismo.
DE102004025071B4 (de) * 2004-05-21 2006-12-21 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Diphenylazetidinon-Derivaten
PL1756049T3 (pl) * 2004-05-21 2008-02-29 Sanofi Aventis Deutschland Sposób wytwarzania pochodnych 1,4-difenyloazetydynonu
SG158132A1 (en) * 2004-12-20 2010-01-29 Schering Corp Process for the synthesis of azetidinones
WO2007001975A1 (en) * 2005-06-20 2007-01-04 Schering Corporation Piperidine derivatives useful as histamine h3 antagonists
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
US7910698B2 (en) * 2006-02-24 2011-03-22 Schering Corporation NPC1L1 orthologues
AR060623A1 (es) 2006-04-27 2008-07-02 Astrazeneca Ab Compuestos derivados de 2-azetidinona y un metodo de preparacion
JP2010502702A (ja) * 2006-09-05 2010-01-28 シェーリング コーポレイション 脂質管理およびアテローム性動脈硬化症および脂肪肝の治療治療において使用される医薬組成物
WO2008032338A2 (en) * 2006-09-11 2008-03-20 Manne Satyanarayana Reddy Improved process for the preparation of ezetimibe and its intermediates
EP2125715A2 (de) 2007-01-24 2009-12-02 Krka Verfahren zur herstellung von ezetimib und derivaten davon
CA2757722C (en) 2009-04-01 2018-05-22 Matrix Laboratories Ltd. Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
CN104803858B (zh) * 2014-01-23 2019-03-01 东莞东阳光科研发有限公司 一种制备四丁基氟化铵三水合物的方法
MX2022009524A (es) 2020-02-07 2023-01-11 Gasherbrum Bio Inc Agonistas heterociclicos de glp-1.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0333268A1 (de) * 1988-03-18 1989-09-20 Merck & Co. Inc. Verfahren zur Synthese eines chiralen 3-beta-Wasserstoff-(3R) 4-aroyloxyazetidinons
US4876365A (en) * 1988-12-05 1989-10-24 Schering Corporation Intermediate compounds for preparing penems and carbapenems
US4983597A (en) * 1989-08-31 1991-01-08 Merck & Co., Inc. Beta-lactams as anticholesterolemic agents
US5085473A (en) * 1990-10-09 1992-02-04 Yuhe Yang Air actuated car curtain device
ES2107548T3 (es) * 1991-07-23 1997-12-01 Schering Corp Compuestos de beta-lactama sustituidos utiles como agentes hipocolesterolemicos y procedimientos para su preparacion.

Also Published As

Publication number Publication date
SK3796A3 (en) 1997-02-05
FI960095A (fi) 1996-01-09
EP0707567A1 (de) 1996-04-24
FI960095A0 (fi) 1996-01-09
DE69428280T2 (de) 2002-06-13
EP0707567B1 (de) 2001-09-12
PL312502A1 (en) 1996-04-29
HU9503748D0 (en) 1996-02-28
KR960703853A (ko) 1996-08-31
MX9405152A (es) 1995-01-31
CA2166784C (en) 2001-12-11
CN1071745C (zh) 2001-09-26
NO306294B1 (no) 1999-10-18
HUT73237A (en) 1996-07-29
ES2160125T3 (es) 2001-11-01
NO960083L (no) 1996-03-04
NZ268798A (en) 1997-01-29
PT707567E (pt) 2002-01-30
AU7214694A (en) 1995-02-06
AU681419B2 (en) 1997-08-28
KR0176001B1 (ko) 1999-03-20
CN1126989A (zh) 1996-07-17
WO1995001961A1 (en) 1995-01-19
JP2840452B2 (ja) 1998-12-24
DK0707567T3 (da) 2001-11-26
US5728827A (en) 1998-03-17
CZ7696A3 (en) 1996-04-17
NO960083D0 (no) 1996-01-08
JPH08507085A (ja) 1996-07-30
CA2166784A1 (en) 1995-01-19
ATE205475T1 (de) 2001-09-15

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings