SK3796A3 - Process for the synthesis of azetidinones - Google Patents

Process for the synthesis of azetidinones Download PDF

Info

Publication number
SK3796A3
SK3796A3 SK37-96A SK3796A SK3796A3 SK 3796 A3 SK3796 A3 SK 3796A3 SK 3796 A SK3796 A SK 3796A SK 3796 A3 SK3796 A3 SK 3796A3
Authority
SK
Slovakia
Prior art keywords
phenyl
group
substituted
lower alkyl
benzyl
Prior art date
Application number
SK37-96A
Other languages
English (en)
Slovak (sk)
Inventor
Tiruvertipuram K Thiruvengadam
Timothy Mcallister
Chou-Hong Tann
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22217215&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK3796(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of SK3796A3 publication Critical patent/SK3796A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SK37-96A 1993-07-09 1994-07-01 Process for the synthesis of azetidinones SK3796A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8935793A 1993-07-09 1993-07-09
PCT/US1994/007291 WO1995001961A1 (en) 1993-07-09 1994-07-01 Process for the synthesis of azetidinones

Publications (1)

Publication Number Publication Date
SK3796A3 true SK3796A3 (en) 1997-02-05

Family

ID=22217215

Family Applications (1)

Application Number Title Priority Date Filing Date
SK37-96A SK3796A3 (en) 1993-07-09 1994-07-01 Process for the synthesis of azetidinones

Country Status (21)

Country Link
US (1) US5728827A (de)
EP (1) EP0707567B1 (de)
JP (1) JP2840452B2 (de)
KR (1) KR0176001B1 (de)
CN (1) CN1071745C (de)
AT (1) ATE205475T1 (de)
AU (1) AU681419B2 (de)
CA (1) CA2166784C (de)
CZ (1) CZ7696A3 (de)
DE (1) DE69428280T2 (de)
DK (1) DK0707567T3 (de)
ES (1) ES2160125T3 (de)
FI (1) FI960095A0 (de)
HU (1) HUT73237A (de)
MX (1) MX9405152A (de)
NO (1) NO306294B1 (de)
NZ (1) NZ268798A (de)
PL (1) PL312502A1 (de)
PT (1) PT707567E (de)
SK (1) SK3796A3 (de)
WO (1) WO1995001961A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
AR025144A1 (es) * 1998-12-07 2002-11-13 Schering Corp Proceso para preparar azetidinonas, proceso para preparar compuestos intermediarios asi como dichos compuestos intermediarios
US6207822B1 (en) 1998-12-07 2001-03-27 Schering Corporation Process for the synthesis of azetidinones
AU4343500A (en) * 1999-04-16 2000-11-02 Schering Corporation Use of azetidinone compounds
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
PT1413331E (pt) * 2001-01-26 2007-12-18 Schering Corp Combinações do activador do receptor activado por proliferador do peroxisoma (ppar) fenofibrato e inibidor da absorção de esterol para indicações vasculares.
CN1275949C (zh) * 2001-03-28 2006-09-20 先灵公司 2－吖丁啶酮中间体化合物的对映体选择性合成
ATE345793T1 (de) * 2001-09-21 2006-12-15 Schering Corp Behandlung von xanthom mittels azetidinon- derivate als hemmer der sterol absorption
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US20030204096A1 (en) * 2002-03-25 2003-10-30 Schering Corporation Enantioselective synthesis of azetidinone intermediate compounds
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
US7135556B2 (en) * 2002-07-19 2006-11-14 Schering Corporation NPC1L1 (NPC3) and methods of use thereof
WO2004081002A1 (en) 2003-03-07 2004-09-23 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7208486B2 (en) * 2003-03-07 2007-04-24 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CA2550215A1 (en) 2003-12-23 2005-07-07 Astrazeneca Ab Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
JP2007516287A (ja) * 2003-12-23 2007-06-21 メルク　エンド　カムパニー　インコーポレーテッド 抗高コレステロール血症化合物
EP1723414A4 (de) * 2004-01-16 2008-03-26 Merck & Co Inc Npc1l1 (npc3) und verfahren zur identifizierung seiner liganden
DE102004025071B4 (de) * 2004-05-21 2006-12-21 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Diphenylazetidinon-Derivaten
NZ551413A (en) 2004-05-21 2009-07-31 Sanofi Aventis Deutschland Method for producing 1,4-diphenyl azetidinone derivatives
MX2007007473A (es) * 2004-12-20 2007-09-04 Schering Corp Procedimiento para la sintesis de azetidinonas.
MX2008000115A (es) * 2005-06-20 2008-03-18 Schering Corp Derivados de piperidina utiles como antagonistas de histamina h3.
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
WO2007100807A2 (en) 2006-02-24 2007-09-07 Schering Corporation Npc1l1 orthologues
TW200811098A (en) 2006-04-27 2008-03-01 Astrazeneca Ab Chemical compounds
WO2008030382A1 (en) * 2006-09-05 2008-03-13 Schering Corporation Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis
WO2008032338A2 (en) * 2006-09-11 2008-03-20 Manne Satyanarayana Reddy Improved process for the preparation of ezetimibe and its intermediates
CN101679236B (zh) 2007-01-24 2013-03-06 克尔克公司 依泽替米贝的制备方法和其的衍生物
WO2010113175A2 (en) 2009-04-01 2010-10-07 Matrix Laboratories Ltd Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
CN104803858B (zh) * 2014-01-23 2019-03-01 东莞东阳光科研发有限公司 一种制备四丁基氟化铵三水合物的方法
IL295281A (en) 2020-02-07 2022-10-01 Gasherbrum Bio Inc Heterocyclic glp-1 agonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0333268A1 (de) * 1988-03-18 1989-09-20 Merck & Co. Inc. Verfahren zur Synthese eines chiralen 3-beta-Wasserstoff-(3R) 4-aroyloxyazetidinons
US4876365A (en) * 1988-12-05 1989-10-24 Schering Corporation Intermediate compounds for preparing penems and carbapenems
US4983597A (en) * 1989-08-31 1991-01-08 Merck & Co., Inc. Beta-lactams as anticholesterolemic agents
US5085473A (en) * 1990-10-09 1992-02-04 Yuhe Yang Air actuated car curtain device
HUT67341A (en) * 1991-07-23 1995-03-28 Schering Corp Substituted beta-lactam compounds useful as hypocholesterolemic agents, pharmaceutical compositions containing the same and process for the production thereof

Also Published As

Publication number Publication date
EP0707567A1 (de) 1996-04-24
EP0707567B1 (de) 2001-09-12
CA2166784C (en) 2001-12-11
JP2840452B2 (ja) 1998-12-24
HU9503748D0 (en) 1996-02-28
ES2160125T3 (es) 2001-11-01
NO306294B1 (no) 1999-10-18
CN1126989A (zh) 1996-07-17
PT707567E (pt) 2002-01-30
NZ268798A (en) 1997-01-29
CA2166784A1 (en) 1995-01-19
FI960095A (fi) 1996-01-09
MX9405152A (es) 1995-01-31
NO960083L (no) 1996-03-04
AU681419B2 (en) 1997-08-28
CZ7696A3 (en) 1996-04-17
AU7214694A (en) 1995-02-06
CN1071745C (zh) 2001-09-26
FI960095A0 (fi) 1996-01-09
HUT73237A (en) 1996-07-29
KR960703853A (ko) 1996-08-31
ATE205475T1 (de) 2001-09-15
DE69428280T2 (de) 2002-06-13
KR0176001B1 (ko) 1999-03-20
NO960083D0 (no) 1996-01-08
DK0707567T3 (da) 2001-11-26
PL312502A1 (en) 1996-04-29
JPH08507085A (ja) 1996-07-30
US5728827A (en) 1998-03-17
DE69428280D1 (de) 2001-10-18
WO1995001961A1 (en) 1995-01-19

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