MX2007007473A - Procedimiento para la sintesis de azetidinonas. - Google Patents

Procedimiento para la sintesis de azetidinonas.

Info

Publication number
MX2007007473A
MX2007007473A MX2007007473A MX2007007473A MX2007007473A MX 2007007473 A MX2007007473 A MX 2007007473A MX 2007007473 A MX2007007473 A MX 2007007473A MX 2007007473 A MX2007007473 A MX 2007007473A MX 2007007473 A MX2007007473 A MX 2007007473A
Authority
MX
Mexico
Prior art keywords
quaternary ammonium
substituted
amino
alkali metal
arylalkyl
Prior art date
Application number
MX2007007473A
Other languages
English (en)
Inventor
Xiaoyong Fu
Timothy L Mcallister
John S Chiu
Thiruvengadam K Thiruvettipuram
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX2007007473A publication Critical patent/MX2007007473A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se provee un procedimiento para preparar azetidinonas utiles como intermediarios en la sintesis de penems y como agentes hipocolesterolemicos, que comprende hacer reaccionar una (-(amino sustituido)amida, un ester de acido (-(amino sustituido) o ester de acido (-(amino sustituido)tiolcarbonico con un agente de sililacion y un agente de ciclizacion seleccionados del grupo que consiste en carboxilatos de metales alcalinos, carboxilatos de amonio cuaternario, hidroxidos de amonio cuaternario, alcoxidos de amonio cuaternario, ariloxidos de amonio cuaternario e hidratos de los mismos, o el producto de reaccion de: (i) por lo menos un haluro de amonio cuaternario y por lo menos un carboxilato de metal alcalino; o (ii) por lo menos un cloruro de amonio cuaternario, bromuro de amonio cuaternario y yoduro de amonio cuaternario y por lo menos un fluoruro de metal alcalino, en donde la porcion de amonio cuaternario del agente de ciclizacion esta no sustituido o sustsituido por uno o cuatro grupos seleccionados independientemente del grupo que consiste en alquilo, arilalquilo y arilalquilalquilo.
MX2007007473A 2004-12-20 2005-12-19 Procedimiento para la sintesis de azetidinonas. MX2007007473A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63759404P 2004-12-20 2004-12-20
PCT/US2005/045901 WO2006068990A1 (en) 2004-12-20 2005-12-19 Process for the synthesis of azetidinones

Publications (1)

Publication Number Publication Date
MX2007007473A true MX2007007473A (es) 2007-09-04

Family

ID=36218762

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007007473A MX2007007473A (es) 2004-12-20 2005-12-19 Procedimiento para la sintesis de azetidinonas.

Country Status (13)

Country Link
US (3) US20060135755A1 (es)
EP (1) EP1831162B1 (es)
JP (2) JP4890466B2 (es)
CN (1) CN101119966B (es)
AR (1) AR052067A1 (es)
CA (1) CA2591564A1 (es)
HK (1) HK1102030A1 (es)
HR (1) HRP20121007T1 (es)
MX (1) MX2007007473A (es)
SG (1) SG158132A1 (es)
SI (1) SI1831162T1 (es)
WO (1) WO2006068990A1 (es)
ZA (1) ZA200705130B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
WO2005061452A1 (en) 2003-12-23 2005-07-07 Astrazeneca Ab Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
WO2005062824A2 (en) * 2003-12-23 2005-07-14 Merck & Co., Inc. Anti-hypercholesterolemic compounds
UY29607A1 (es) 2005-06-20 2007-01-31 Astrazeneca Ab Compuestos quimicos
AR057072A1 (es) 2005-06-22 2007-11-14 Astrazeneca Ab Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
WO2007030721A2 (en) * 2005-09-08 2007-03-15 Teva Pharmaceutical Industries Ltd. Processes for the preparation of (3r,4s)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((s)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe
TW200811098A (en) 2006-04-27 2008-03-01 Astrazeneca Ab Chemical compounds
JP2010529148A (ja) * 2007-06-07 2010-08-26 テバ ファーマシューティカル インダストリーズ リミティド エゼチミブ製造のための還元方法
CZ2008317A3 (cs) * 2008-05-21 2009-12-02 Zentiva, A. S. Zpusob výroby (3R,4S)-1-(4-fluorfenyl)-3-[(3S)-3-(4-fluorfenyl)-3-hydroxypropyl)]-4-(4-hydroxyfenyl)-2-azetidinonu
EP2414529A2 (en) 2009-04-01 2012-02-08 Matrix Laboratories Ltd Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
WO2010141494A2 (en) * 2009-06-02 2010-12-09 Codexis, Inc. Synthesis of ezetimibe
CN102234246A (zh) * 2010-04-23 2011-11-09 浙江华海药业股份有限公司 一种合成依替米贝的新方法
CN106397292A (zh) * 2016-09-20 2017-02-15 苏州普罗达生物科技有限公司 依替米贝的中间体及其合成方法与依替米贝的合成方法
CN112939835A (zh) * 2021-02-09 2021-06-11 中国科学技术大学 一种β-内酰胺类化合物的合成方法
CN115160179A (zh) * 2022-08-04 2022-10-11 湖南方盛堂制药有限公司 依折麦布中间体的制备工艺

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2107548T3 (es) 1991-07-23 1997-12-01 Schering Corp Compuestos de beta-lactama sustituidos utiles como agentes hipocolesterolemicos y procedimientos para su preparacion.
AU681419B2 (en) * 1993-07-09 1997-08-28 Schering Corporation Process for the synthesis of azetidinones
AU7472896A (en) 1995-11-02 1997-05-22 Schering Corporation Process for preparing 1-(4-fluorophenyl)-3(r)-(3(s)-hydroxy-3-({phenyl or 4-fluorophenyl})-propyl)-4(s)-(4-hydroxyphenyl)-2-azetidinon
US6207822B1 (en) * 1998-12-07 2001-03-27 Schering Corporation Process for the synthesis of azetidinones
JP3640888B2 (ja) * 1998-12-07 2005-04-20 シェーリング コーポレイション アゼチジノンの合成プロセス
BR0116325A (pt) 2000-12-21 2003-10-14 Aventis Pharma Gmbh 1,2-difenilazetidinonas, processos para a sua preparação, medicamentos contendo estes compostos e sua aplicação para o tratamento de distúrbios do metabolismo de lipìdios
JP2008539255A (ja) 2005-04-26 2008-11-13 マイクロビア インコーポレーテッド 高コレステロール血症のための４−ビアリーリル−１−フェニルアゼチジン−２−オングルクロニド誘導体
EA200702614A1 (ru) 2005-05-25 2008-04-28 Майкробиа, Инк. Способы получения 4-(бифенилил)азетидин-2-оналкилфосфиновых кислот
RU2008102236A (ru) 2005-06-22 2009-07-27 РЕДДИ Манне САТЬЯНАРАЯНА (IN) Улучшенный способ получения эзетимиб
US20070049748A1 (en) 2005-08-26 2007-03-01 Uppala Venkata Bhaskara R Preparation of ezetimibe
HU0501164D0 (en) 2005-12-20 2006-02-28 Richter Gedeon Vegyeszet New industrial process for the production of ezetimibe
US20080032964A1 (en) 2006-04-10 2008-02-07 Kansal Vinod K Process for the synthesis of azetidinone

Also Published As

Publication number Publication date
US20060135755A1 (en) 2006-06-22
US20120083601A1 (en) 2012-04-05
EP1831162B1 (en) 2012-10-31
JP4890466B2 (ja) 2012-03-07
EP1831162A1 (en) 2007-09-12
ZA200705130B (en) 2008-09-25
SI1831162T1 (sl) 2013-03-29
US8383810B2 (en) 2013-02-26
HK1102030A1 (en) 2007-11-02
HRP20121007T1 (hr) 2013-01-31
CA2591564A1 (en) 2006-06-29
JP2008524251A (ja) 2008-07-10
WO2006068990A1 (en) 2006-06-29
CN101119966A (zh) 2008-02-06
CN101119966B (zh) 2014-08-13
SG158132A1 (en) 2010-01-29
US20110144327A1 (en) 2011-06-16
JP2012036224A (ja) 2012-02-23
AR052067A1 (es) 2007-02-28

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