PE20100233A1 - Imidazoles sustituidos con heterociclilamida - Google Patents

Imidazoles sustituidos con heterociclilamida

Info

Publication number
PE20100233A1
PE20100233A1 PE2010000032A PE2010000032A PE20100233A1 PE 20100233 A1 PE20100233 A1 PE 20100233A1 PE 2010000032 A PE2010000032 A PE 2010000032A PE 2010000032 A PE2010000032 A PE 2010000032A PE 20100233 A1 PE20100233 A1 PE 20100233A1
Authority
PE
Peru
Prior art keywords
formula
procedure
reacting
compound
phenyl
Prior art date
Application number
PE2010000032A
Other languages
English (en)
Inventor
Holger Zimmermann
David Bruckner
Kerstin Henninger
Ulrich Rosentreter
Martin Hendrix
Jorg Keldenich
Dieter Lang
Martin Radtke
Daniela Paulsen
Armin Kern
Original Assignee
Aicuris Gmbh And Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36675125&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20100233(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aicuris Gmbh And Co Kg filed Critical Aicuris Gmbh And Co Kg
Publication of PE20100233A1 publication Critical patent/PE20100233A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A PROCEDIMIENTOS DE PREPARACION DE COMPUESTOS DERIVADOS DE IMIDAZOL DE FORMULA (I) DONDE R1 ES UN GRUPO DE FORMULA (a) O (b), DONDE R4 Y R5 SON CADA UNO FENILO O HETEROARILO DE 5 O 6 MIEMBROS, R6 Y R7 SON CADA UNO H, METILO O ETILO, * ES EL LUGAR DE UNION AL GRUPO CARBONILO; R2 ES ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO; R3 ES FENILO; EN DONDE EL PROCEDIMIENTO (A) COMPRENDE: i) HACER REACCIONAR EL COMPUESTO DE FORMULA (II) CON UN AGENTE REDUCTOR TAL COMO CINC/ACIDO CLORHIDRICO, SULFURO DE SODIO, DICLORURO DE ESTANO, ENTRE OTROS, Y ii) EL PRODUCTO OBTENIDO SE HACE REACCIONAR CON H2N-R3 EN PRESENCIA DE N,N-CARBONILDIIMIDAZOL, FOSGENO, ENTRE OTROS; EL PROCEDIMIENTO (B) COMPRENDE: i) HACER REACCIONAR EL COMPUESTO DE FORMULA (II) CON UN AGENTE REDUCTOR AL IGUAL QUE EN EL PROCEDIMIENTO (A), Y ii) EL PRODUCTO OBTENIDO SE HACE REACCIONAR CON OCN-R3; Y EL PROCEDIMIENTO (C) COMPRENDE: i) HACER REACCIONAR EL COMPUESTO DE FORMULA (V) CON UNA BASE TAL COMO HIDROXIDOS ALCALINOS O CARBONATOS ALCALINOS, EN DONDE R8 ES METILO O ETILO, Y ii) EL PRODUCTO OBTENIDO SE HACE REACCIONAR CON R1-H EN PRESENCIA DE REACTIVOS DE DESHIDRATACION TAL COMO N,N'-DICICLOHEXILCARBODIIMIDA, 1-HIDROXIBENZOTRIAZOL, ENTRE OTROS
PE2010000032A 2005-02-23 2006-02-22 Imidazoles sustituidos con heterociclilamida PE20100233A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005008183A DE102005008183A1 (de) 2005-02-23 2005-02-23 Heterocyclylamid-substituierte Imidazole

Publications (1)

Publication Number Publication Date
PE20100233A1 true PE20100233A1 (es) 2010-04-22

Family

ID=36675125

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2010000032A PE20100233A1 (es) 2005-02-23 2006-02-22 Imidazoles sustituidos con heterociclilamida
PE2006000214A PE20061141A1 (es) 2005-02-23 2006-02-22 Imidazoles sustituidos con heterociclilamida

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2006000214A PE20061141A1 (es) 2005-02-23 2006-02-22 Imidazoles sustituidos con heterociclilamida

Country Status (29)

Country Link
US (1) US7919489B2 (es)
EP (1) EP1853582B1 (es)
JP (1) JP5208522B2 (es)
KR (1) KR101276003B1 (es)
CN (1) CN101128455B (es)
AR (1) AR053141A1 (es)
AT (1) ATE446292T1 (es)
AU (1) AU2006218276C1 (es)
BR (1) BRPI0607995B8 (es)
CA (1) CA2598521C (es)
DE (2) DE102005008183A1 (es)
DK (1) DK1853582T3 (es)
ES (1) ES2333249T3 (es)
GT (1) GT200600077A (es)
HK (1) HK1110857A1 (es)
HN (2) HN2006007774A (es)
IL (1) IL185050A (es)
MX (1) MX2007010308A (es)
MY (1) MY140543A (es)
NO (1) NO338997B1 (es)
NZ (1) NZ560811A (es)
PE (2) PE20100233A1 (es)
PL (1) PL1853582T3 (es)
PT (1) PT1853582E (es)
RU (1) RU2415851C2 (es)
TW (1) TWI388553B (es)
UY (1) UY29387A1 (es)
WO (1) WO2006089664A2 (es)
ZA (1) ZA200707412B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004015007A1 (de) 2004-03-26 2005-10-13 Bayer Healthcare Ag Substituierte Imidazole
DE102005008183A1 (de) 2005-02-23 2006-08-31 Bayer Healthcare Ag Heterocyclylamid-substituierte Imidazole
DE102011101446A1 (de) * 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
DE102011113749A1 (de) * 2011-09-14 2013-03-14 Aicuris Gmbh & Co. Kg Sulfonsäuresalze Heterocyclylamid-substituiertr Imidazole
CN104610160A (zh) * 2013-11-04 2015-05-13 南京大学 含哌嗪环的5-硝基咪唑类衍生物及其制备与在抗菌药物中的应用
CN104016925B (zh) * 2014-06-17 2016-03-30 遵义医学院 4-烷基咪唑-2-羧酸的合成方法
US10807945B2 (en) 2015-06-22 2020-10-20 Sumitomo Dainippon Pharma Co., Ltd. 1,4-disubstituted imidazole derivative
JP6507976B2 (ja) * 2015-09-30 2019-05-08 東レ株式会社 イミダゾール−２−カルボン酸エステル誘導体又はその塩の製造方法
CN116120238B (zh) * 2023-03-01 2023-09-22 山东梅奥华卫科技有限公司 一种咪唑衍生物的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342501B1 (en) 1994-02-25 2002-01-29 The Regents Of The University Of Michigan Pyrrolo[2,3-d] pyrimidines as antiviral agents
WO1998052558A1 (en) * 1997-05-23 1998-11-26 Bayer Corporation INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS
WO1999023091A1 (en) 1997-11-03 1999-05-14 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as anti-inflammatory agents
CN1367785A (zh) 1998-12-09 2002-09-04 美国家庭用品有限公司 含取代的苯二胺基团的含杂环羧酰胺的疱疹病毒硫脲抑制剂
DE10257358A1 (de) * 2002-12-09 2004-07-08 Bayer Healthcare Ag Substituierte Pyrrole
DE102004015007A1 (de) * 2004-03-26 2005-10-13 Bayer Healthcare Ag Substituierte Imidazole
EP1745032B1 (en) * 2004-05-12 2013-07-31 Merck Sharp & Dohme Corp. CXCR1 and CXCR2 chemokine antagonists
DE102005008183A1 (de) 2005-02-23 2006-08-31 Bayer Healthcare Ag Heterocyclylamid-substituierte Imidazole

Also Published As

Publication number Publication date
JP5208522B2 (ja) 2013-06-12
GT200600077A (es) 2006-10-03
IL185050A0 (en) 2007-12-03
JP2008531508A (ja) 2008-08-14
HN2006007774A (es) 2010-03-29
NO20074780L (no) 2007-11-01
NZ560811A (en) 2010-07-30
BRPI0607995B8 (pt) 2021-05-25
WO2006089664A3 (de) 2006-11-02
ES2333249T3 (es) 2010-02-18
UY29387A1 (es) 2006-10-02
BRPI0607995A2 (pt) 2009-10-27
ZA200707412B (en) 2008-12-31
DE502006005182D1 (de) 2009-12-03
PE20061141A1 (es) 2006-12-29
NO338997B1 (no) 2016-11-07
RU2415851C2 (ru) 2011-04-10
WO2006089664A2 (de) 2006-08-31
EP1853582B1 (de) 2009-10-21
PT1853582E (pt) 2009-11-13
CN101128455B (zh) 2013-01-16
KR101276003B1 (ko) 2013-06-20
BRPI0607995B1 (pt) 2019-07-16
EP1853582A2 (de) 2007-11-14
CN101128455A (zh) 2008-02-20
RU2007135277A (ru) 2009-03-27
AU2006218276B2 (en) 2011-04-07
MX2007010308A (es) 2007-10-17
AU2006218276A1 (en) 2006-08-31
HK1110857A1 (en) 2008-07-25
ATE446292T1 (de) 2009-11-15
CA2598521C (en) 2012-11-27
DK1853582T3 (da) 2010-01-18
TW200700411A (en) 2007-01-01
TWI388553B (zh) 2013-03-11
PL1853582T3 (pl) 2010-03-31
DE102005008183A1 (de) 2006-08-31
AR053141A1 (es) 2007-04-25
HN2010000128A (es) 2010-03-29
MY140543A (en) 2009-12-31
US20080176859A1 (en) 2008-07-24
CA2598521A1 (en) 2006-08-31
US7919489B2 (en) 2011-04-05
IL185050A (en) 2013-01-31
AU2006218276C1 (en) 2012-06-28
KR20080002772A (ko) 2008-01-04

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