PE20070007A1 - Metodos para sintetizar derivados de 6-alquilaminoquinolina - Google Patents
Metodos para sintetizar derivados de 6-alquilaminoquinolinaInfo
- Publication number
- PE20070007A1 PE20070007A1 PE2006000538A PE2006000538A PE20070007A1 PE 20070007 A1 PE20070007 A1 PE 20070007A1 PE 2006000538 A PE2006000538 A PE 2006000538A PE 2006000538 A PE2006000538 A PE 2006000538A PE 20070007 A1 PE20070007 A1 PE 20070007A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- alkylaminoquinoline
- synthesizing
- derivatives
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
SE REFIERE A UN PROCEDIMIENTO DE PREPARACION QUE CONSISTE: A) ACOPLAR UNA ANILINOQUINONA DE FORMULA III CON UN ACIDO DE FORMULA VII PARA OBTENER II; B) DESPROTEGER II PARA OBTENER UN COMPUESTO DE FORMULA I; DONDE X ES CICLOALQUILO C3-C7 SUSTITUIDO O NO, ARILO BICICLICO O HETEROARILO DE 8-12 ATOMOS QUE CONTIENE 1-4 HETEROATOMOS SELECCIONADOS DE N, S, O, ENTRE OTROS; V ES ETILENO, ACETILENO; PG ES UN GRUPO PROTECTOR DE AMINOS; R4 ES ALQUILO C1-C6; Z ES NH, N-(ALQUILO C1-C6); R1, G2 Y R3 SON CADA UNO H, HALOGENO, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; n ES 0-1; x ES 0-3; y ES 0-1; z ES 0-3. UN COMPUESTO OBTENIDO MEDIANTE DICHO PROCEDIMIENTO ES: (E) N-{4-[3-CLORO-4-(2-PIRIDINILMETOXI)ANILINO]3-CIANO-7-ETOXI-6-QUINOLINIL}-4-(METILAMINO)-2-BUTENAMIDA, SIENDO UTIL EN EL TRATAMIENTO DE CANCER
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68504005P | 2005-05-25 | 2005-05-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20070007A1 true PE20070007A1 (es) | 2007-02-12 |
Family
ID=36794434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000538A PE20070007A1 (es) | 2005-05-25 | 2006-05-22 | Metodos para sintetizar derivados de 6-alquilaminoquinolina |
Country Status (20)
Country | Link |
---|---|
US (1) | US20060270670A1 (es) |
EP (1) | EP1883630A2 (es) |
JP (1) | JP2008542266A (es) |
KR (1) | KR20080016604A (es) |
CN (1) | CN101180273A (es) |
AR (1) | AR054192A1 (es) |
AU (1) | AU2006249596A1 (es) |
BR (1) | BRPI0610142A2 (es) |
CA (1) | CA2608589A1 (es) |
CR (1) | CR9545A (es) |
GT (1) | GT200600215A (es) |
IL (1) | IL187301A0 (es) |
MX (1) | MX2007014774A (es) |
NO (1) | NO20075726L (es) |
PA (1) | PA8676301A1 (es) |
PE (1) | PE20070007A1 (es) |
RU (1) | RU2007140957A (es) |
TW (1) | TW200716556A (es) |
WO (1) | WO2006127203A2 (es) |
ZA (1) | ZA200710143B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070135499A1 (en) * | 2005-07-11 | 2007-06-14 | Aerie Pharmaceuticals, Inc. | Hydrazide compounds |
ES2580108T3 (es) * | 2005-07-11 | 2016-08-19 | Aerie Pharmaceuticals, Inc | Compuestos de isoquinolina |
CA2664335C (en) | 2006-09-20 | 2014-12-02 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
US8455514B2 (en) * | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
EP3053913B1 (en) | 2009-05-01 | 2018-03-07 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
JP5622842B2 (ja) * | 2009-05-14 | 2014-11-12 | コーロン ライフ サイエンス インク | アルキルアミン誘導体の製造方法 |
AU2011310592B2 (en) | 2010-09-29 | 2015-01-22 | Intervet International B.V. | N-heteroaryl compounds |
AR083199A1 (es) | 2010-09-29 | 2013-02-06 | Intervet Internationale B V | Compuestos de n-heteroarilo con unidad de puente ciclico |
CN102649778A (zh) * | 2011-02-23 | 2012-08-29 | 苏州波锐生物医药科技有限公司 | 喹唑啉衍生物及其在制备抗恶性肿瘤药物中的用途 |
WO2013152135A1 (en) * | 2012-04-04 | 2013-10-10 | Dawei Zhang | Substituted quinolines as bruton's tyrosine kinases inhibitors |
CN109528721B (zh) | 2013-03-15 | 2021-10-01 | 爱瑞制药公司 | 联合治疗 |
WO2014177038A1 (en) * | 2013-04-28 | 2014-11-06 | Sunshine Lake Pharma Co., Ltd. | Aminoquinazoline derivatives and their salts and methods of use thereof |
US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
KR102579582B1 (ko) | 2015-11-17 | 2023-09-15 | 에어리 파마슈티컬즈, 인코포레이티드 | 키나아제 억제제 및 이의 중간체의 제조 방법 |
DK3447051T3 (da) * | 2016-04-28 | 2022-01-17 | Jiangsu Hengrui Medicine Co | Fremgangsmåde til fremstilling af tyrosinkinaseinhibitor og derivat deraf |
CA3035566A1 (en) | 2016-08-31 | 2018-03-08 | Aerie Pharmaceuticals, Inc. | Ophthalmic compositions |
CN110506037A (zh) | 2017-03-31 | 2019-11-26 | 爱瑞制药公司 | 芳基环丙基-氨基-异喹啉酰胺化合物 |
US11427563B2 (en) | 2018-09-14 | 2022-08-30 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
US6297258B1 (en) * | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
US6288082B1 (en) * | 1998-09-29 | 2001-09-11 | American Cyanamid Company | Substituted 3-cyanoquinolines |
HUP0300547A2 (hu) * | 2000-03-13 | 2003-07-28 | American Cyanamid Co. | Ciano-kinolin vegyületek alkalmazása vastagbél polipok kezelésére és gátlására alkalmas gyógyszerkészítmények előállítására |
UA77200C2 (en) * | 2001-08-07 | 2006-11-15 | Wyeth Corp | Antineoplastic combination of cci-779 and bkb-569 |
EP1472213B1 (en) * | 2002-02-05 | 2010-06-09 | Wyeth a Corporation of the State of Delaware | Process for the synthesis of n-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids |
CL2004000016A1 (es) * | 2003-01-21 | 2005-04-15 | Wyeth Corp | Compuesto derivado de cloruro de 4-amino-2-butenoilo o una sal farmaceuticamente aceptable del mismo; procedimiento para preparar dicho compuesto, util como intermediario en la sintesis de compuestos inhibidores de proteina quinasa tirosina. |
MXPA06001590A (es) * | 2003-08-19 | 2006-05-19 | Wyeth Corp | Proceso para la preparacion de 4-amino-3-quinolincarbonitrilos. |
CA2553729A1 (en) * | 2004-01-16 | 2005-08-04 | Wyeth | Quinoline intermediates of receptor tyrosine kinase inhibitors and the synthesis thereof |
-
2006
- 2006-04-26 JP JP2008513496A patent/JP2008542266A/ja not_active Withdrawn
- 2006-04-26 MX MX2007014774A patent/MX2007014774A/es unknown
- 2006-04-26 EP EP06751575A patent/EP1883630A2/en not_active Withdrawn
- 2006-04-26 WO PCT/US2006/015931 patent/WO2006127203A2/en active Application Filing
- 2006-04-26 CA CA002608589A patent/CA2608589A1/en not_active Abandoned
- 2006-04-26 AU AU2006249596A patent/AU2006249596A1/en not_active Abandoned
- 2006-04-26 BR BRPI0610142-9A patent/BRPI0610142A2/pt not_active IP Right Cessation
- 2006-04-26 KR KR1020077028377A patent/KR20080016604A/ko not_active Application Discontinuation
- 2006-04-26 RU RU2007140957/04A patent/RU2007140957A/ru not_active Application Discontinuation
- 2006-04-26 CN CNA2006800177664A patent/CN101180273A/zh active Pending
- 2006-05-04 TW TW095115892A patent/TW200716556A/zh unknown
- 2006-05-18 AR ARP060102011A patent/AR054192A1/es unknown
- 2006-05-22 PE PE2006000538A patent/PE20070007A1/es not_active Application Discontinuation
- 2006-05-24 GT GT200600215A patent/GT200600215A/es unknown
- 2006-05-25 US US11/442,562 patent/US20060270670A1/en not_active Abandoned
- 2006-05-25 PA PA20068676301A patent/PA8676301A1/es unknown
-
2007
- 2007-11-09 NO NO20075726A patent/NO20075726L/no not_active Application Discontinuation
- 2007-11-11 IL IL187301A patent/IL187301A0/en unknown
- 2007-11-23 CR CR9545A patent/CR9545A/es not_active Application Discontinuation
- 2007-11-26 ZA ZA200710143A patent/ZA200710143B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
WO2006127203A2 (en) | 2006-11-30 |
AR054192A1 (es) | 2007-06-06 |
RU2007140957A (ru) | 2009-06-27 |
TW200716556A (en) | 2007-05-01 |
AU2006249596A1 (en) | 2006-11-30 |
PA8676301A1 (es) | 2009-03-31 |
CR9545A (es) | 2008-01-10 |
KR20080016604A (ko) | 2008-02-21 |
US20060270670A1 (en) | 2006-11-30 |
ZA200710143B (en) | 2008-11-26 |
IL187301A0 (en) | 2008-04-13 |
WO2006127203A3 (en) | 2007-05-03 |
BRPI0610142A2 (pt) | 2011-01-04 |
MX2007014774A (es) | 2008-02-19 |
CA2608589A1 (en) | 2006-11-30 |
EP1883630A2 (en) | 2008-02-06 |
CN101180273A (zh) | 2008-05-14 |
GT200600215A (es) | 2006-12-26 |
JP2008542266A (ja) | 2008-11-27 |
NO20075726L (no) | 2008-02-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FX | Voluntary withdrawal |