CO5640113A2 - Amidas de acido pieprazinil o piepridinilamin-sulfamico como inhibidores de la sulfatasa esteroidal - Google Patents

Amidas de acido pieprazinil o piepridinilamin-sulfamico como inhibidores de la sulfatasa esteroidal

Info

Publication number
CO5640113A2
CO5640113A2 CO04096497A CO04096497A CO5640113A2 CO 5640113 A2 CO5640113 A2 CO 5640113A2 CO 04096497 A CO04096497 A CO 04096497A CO 04096497 A CO04096497 A CO 04096497A CO 5640113 A2 CO5640113 A2 CO 5640113A2
Authority
CO
Colombia
Prior art keywords
carbon atoms
aryl
r4ss
r3ss
aminocarbonyl
Prior art date
Application number
CO04096497A
Other languages
English (en)
Inventor
Philipp Lehr
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0207500A external-priority patent/GB0207500D0/en
Priority claimed from GB0225679A external-priority patent/GB0225679D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CO5640113A2 publication Critical patent/CO5640113A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Abstract

1.- Un compuesto de la fórmula:en donde cualquiera de: - R1 y R2, junto con el átomo de nitrógeno con el que están unidos, son piperazinilo, en donde el segundo átomo de nitrógeno está sustituido por alcoxilo(de 1 a 6 átomos de carbono) -carbonilo, o por arilo (de 6 a 18 átomos de carbono), cuyo arilo (de 6 a 18 átomos de carbono) está sustituido por uno o más de halógeno, haloalquilo (de 1 a 6 átomos de carbono), por ejemplo CF3, ó aminocarbonilo;ó - R1 es hidrógeno y R2 es piperidinilo, unido por medio de un átomo de carbono del anillo de piperidinilo, en donde el átomo de nitrógeno está sustituido por alcoxilo(de 1 a 6 átomos de carbono)-carbonilo, o por arilo (de 6 a 18 átomos de carbono), y R3 es arilo (de 6 a 18 átomos de carbono) ó arilo (de 6 a 18 átomos de carbono) -alquilo (de 1 a 4 átomos de carbono), cuyo arilo está sustituido por uno o más de halógeno, aminocarbonilo, ó haloalquilo (de 1 a 6 átomos de carbono).2.- Un compuesto de la reivindicación 1, seleccionado a partir del grupo que consiste en los compuestos de la fórmula:en donde: a. R3ss es 3, 5-bis (trifluorometil) fenilo, y R4ss es 2-aminocarbonil-5-trifluorometilfenilo, b. R3ss es 2,3-diclorofenilo, R4ss es 2-aminocarbonil-5-trifluorometilfenilo, c. R3ss es 3,5-diclorofenilo, R4ss es 2-amino-carbonil-5-trifluorometilfenilo, y d. R3ss es 3,5-bis(trifluorometil)fenilo, y R4ss es terbutoxicarbonilo.
CO04096497A 2002-03-28 2004-09-28 Amidas de acido pieprazinil o piepridinilamin-sulfamico como inhibidores de la sulfatasa esteroidal CO5640113A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0207500A GB0207500D0 (en) 2002-03-28 2002-03-28 Organic compounds
GB0225679A GB0225679D0 (en) 2002-11-04 2002-11-04 Organic compounds

Publications (1)

Publication Number Publication Date
CO5640113A2 true CO5640113A2 (es) 2006-05-31

Family

ID=28676499

Family Applications (1)

Application Number Title Priority Date Filing Date
CO04096497A CO5640113A2 (es) 2002-03-28 2004-09-28 Amidas de acido pieprazinil o piepridinilamin-sulfamico como inhibidores de la sulfatasa esteroidal

Country Status (20)

Country Link
US (2) US7439362B2 (es)
EP (1) EP1492782A1 (es)
JP (1) JP4580652B2 (es)
KR (1) KR20040094877A (es)
CN (1) CN1293065C (es)
AR (1) AR039156A1 (es)
AU (1) AU2003226732B2 (es)
BR (1) BR0308795A (es)
CA (1) CA2480686A1 (es)
CO (1) CO5640113A2 (es)
IL (1) IL164267A0 (es)
MX (1) MXPA04009453A (es)
MY (1) MY136880A (es)
NO (1) NO20044321L (es)
NZ (1) NZ535617A (es)
PE (1) PE20040167A1 (es)
PL (1) PL372602A1 (es)
RU (1) RU2329258C2 (es)
TW (1) TW200306806A (es)
WO (1) WO2003082842A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0505541D0 (en) * 2005-03-17 2005-04-27 Novartis Ag Organic compounds
GB0505539D0 (en) * 2005-03-17 2005-04-27 Novartis Ag Organic compounds
GB0511190D0 (en) * 2005-06-01 2005-07-06 Sterix Ltd Use
BRPI0817045A2 (pt) 2007-09-17 2015-03-24 Preglem Sa Tratamento de condições estrogênio-dependentes em mulheres pré-menopáusicas
EP3413922A1 (en) 2016-02-08 2018-12-19 SynAffix B.V. Improved sulfamide linkers for use in bioconjugates
CN109069658B (zh) 2016-02-08 2022-10-14 西纳福克斯股份有限公司 用于靶向her2肿瘤的具有改善的治疗指数的抗体-缀合物以及用于改善抗体-缀合物的治疗指数的方法
EP3413920A1 (en) 2016-02-08 2018-12-19 Synaffix B.V. Bioconjugates containing sulfamide linkers for use in treatment
WO2018102419A1 (en) * 2016-11-29 2018-06-07 Epizyme, Inc. Compounds containing a sulfonic group as kat inhibitors
EP3983388A1 (en) * 2019-06-12 2022-04-20 Nodthera Limited Sulfonamide derivatives and uses thereof
CN110590896B (zh) * 2019-11-04 2022-08-30 上海高准医药有限公司 雌酚酮硫酸酯哌嗪的制备方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US89089A (en) * 1869-04-20 Improved car-coupling
US478328A (en) * 1892-07-05 Glass-heating oven
US71516A (en) * 1867-11-26 William b
US51547A (en) * 1865-12-19 Improvement in guide and tuck-marker for sewing-machines
US183459A (en) * 1876-10-17 Improvement in hinges
US876846A (en) * 1907-05-28 1908-01-14 Stephen W Smith Road-machine.
US1122242A (en) * 1912-05-13 1914-12-29 Sanitary Can Company Can-body-feeding device.
US2103610A (en) * 1935-04-30 1937-12-28 Sofal Ltd Alloy steels
DE876846C (de) * 1943-06-01 1953-05-18 Bayer Ag Verfahren zur Herstellung von Abkoemmlingen des Sulfondiamids
US3004487A (en) * 1959-12-07 1961-10-17 Bank Of America Nat Trust & Savings Ass Imprinters
GB1593609A (en) * 1978-01-31 1981-07-22 Christiaens Sa A Pyridine sulfonamides
FR2510106A1 (fr) 1981-07-27 1983-01-28 Rhone Poulenc Agrochimie Composes herbicides derives d'acides phenoxybenzoiques, et leurs procedes de preparation et d'utilisation
DK101683A (da) * 1982-03-12 1983-09-13 Duphar Int Res Phenylpiperazinderivater og fremgangsmaade til fremstilling heraf
US5238923A (en) * 1989-05-26 1993-08-24 Warner-Lambert Company Amino-substituted heterocycles as renin inhibitors
US5256632A (en) * 1990-05-30 1993-10-26 Bayer Aktiengesellschaft Herbicidal sulphonylated carboxamides
IL99537A (en) 1990-09-27 1995-11-27 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical preparations containing them
FR2716882B1 (fr) * 1994-03-04 1996-04-05 Roussel Uclaf Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques.
FR2716883B1 (fr) * 1994-03-04 1996-04-26 Roussel Uclaf Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant.
US5464788A (en) 1994-03-24 1995-11-07 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
AU3128195A (en) 1994-07-20 1996-02-16 Merck & Co., Inc. Piperidines and hexahydro-1h-azepines spiro substituted at the 4-position promote release of growth hormone
WO1996010559A1 (en) 1994-10-04 1996-04-11 Fujisawa Pharmaceutical Co., Ltd. Urea derivatives and their use as acat-inhibitors
WO1997020820A1 (en) 1995-12-01 1997-06-12 Novartis Ag Heteroaryl compounds
DE19621483A1 (de) * 1996-05-29 1997-12-04 Hoechst Ag Substituierte 2-Naphthoylguanidine, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19621482A1 (de) * 1996-05-29 1997-12-04 Hoechst Ag Substituierte 1-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
NZ500353A (en) 1997-04-14 2002-02-01 Cor Therapeutics Inc Cyclic diaza compounds that are selective inhibitors of factor Xa
AU754529B2 (en) 1998-09-22 2002-11-21 Yamanouchi Pharmaceutical Co., Ltd. Cyanophenyl derivatives
CA2362778A1 (en) 1999-03-03 2000-09-08 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
WO2000071515A2 (en) 1999-05-24 2000-11-30 Cor Therapeutics, Inc INHIBITORS OF FACTOR Xa
JP4320089B2 (ja) * 1999-07-06 2009-08-26 あすか製薬株式会社 フェニルスルファメート誘導体
US6632815B2 (en) * 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
EP1226127B1 (en) 2000-05-04 2009-07-01 Basf Se Substituted phenyl sulfamoyl carboxamides
WO2002100399A1 (en) * 2001-06-12 2002-12-19 Elan Pharmaceuticals, Inc. Macrocycles useful in the treatment of alzheimer's disease
NZ530202A (en) 2001-07-02 2005-06-24 Astrazeneca Ab Piperidine derivatives useful as modulators of chemokine receptor activity

Also Published As

Publication number Publication date
MY136880A (en) 2008-11-28
EP1492782A1 (en) 2005-01-05
US20060052393A1 (en) 2006-03-09
MXPA04009453A (es) 2005-01-25
AU2003226732A1 (en) 2003-10-13
NZ535617A (en) 2006-04-28
CN1293065C (zh) 2007-01-03
BR0308795A (pt) 2005-01-18
RU2004131822A (ru) 2005-07-10
AR039156A1 (es) 2005-02-09
PE20040167A1 (es) 2004-05-26
CN1646509A (zh) 2005-07-27
JP4580652B2 (ja) 2010-11-17
US7439362B2 (en) 2008-10-21
JP2005526812A (ja) 2005-09-08
RU2329258C2 (ru) 2008-07-20
WO2003082842A1 (en) 2003-10-09
AU2003226732B2 (en) 2006-12-21
TW200306806A (en) 2003-12-01
CA2480686A1 (en) 2003-10-09
IL164267A0 (en) 2005-12-18
KR20040094877A (ko) 2004-11-10
US20090042899A1 (en) 2009-02-12
NO20044321L (no) 2004-10-12
PL372602A1 (en) 2005-07-25

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