ATE517885T1 - Substituierte pyrazolyl-harnstoff-derivate zur behandlung von krebs - Google Patents
Substituierte pyrazolyl-harnstoff-derivate zur behandlung von krebsInfo
- Publication number
- ATE517885T1 ATE517885T1 AT05778149T AT05778149T ATE517885T1 AT E517885 T1 ATE517885 T1 AT E517885T1 AT 05778149 T AT05778149 T AT 05778149T AT 05778149 T AT05778149 T AT 05778149T AT E517885 T1 ATE517885 T1 AT E517885T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- cancer
- treatment
- urea derivatives
- substituted pyrazolyl
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- XAEGRAIWWBXIRR-UHFFFAOYSA-N 1h-pyrazol-5-ylurea Chemical class NC(=O)NC=1C=CNN=1 XAEGRAIWWBXIRR-UHFFFAOYSA-N 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004957 naphthylene group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56644504P | 2004-04-30 | 2004-04-30 | |
| PCT/US2005/015106 WO2005110994A2 (en) | 2004-04-30 | 2005-05-02 | Substituted pyrazolyl urea derivatives useful in the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE517885T1 true ATE517885T1 (de) | 2011-08-15 |
Family
ID=35064925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05778149T ATE517885T1 (de) | 2004-04-30 | 2005-05-02 | Substituierte pyrazolyl-harnstoff-derivate zur behandlung von krebs |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7838524B2 (de) |
| EP (3) | EP1751139B1 (de) |
| JP (1) | JP2007535565A (de) |
| CN (1) | CN101010315A (de) |
| AT (1) | ATE517885T1 (de) |
| CA (1) | CA2564325A1 (de) |
| MX (1) | MXPA06012394A (de) |
| WO (1) | WO2005110994A2 (de) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE538794T1 (de) | 1999-01-13 | 2012-01-15 | Bayer Healthcare Llc | Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| US7838541B2 (en) | 2002-02-11 | 2010-11-23 | Bayer Healthcare, Llc | Aryl ureas with angiogenesis inhibiting activity |
| US7202257B2 (en) * | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
| WO2004113274A2 (en) * | 2003-05-20 | 2004-12-29 | Bayer Pharmaceuticals Corporation | Diaryl ureas with kinase inhibiting activity |
| RS52625B (sr) | 2003-07-23 | 2013-06-28 | Bayer Healthcare Llc | Fluoro supstituisana omega-karboksiaril difenil urea za lečenje i prevenciju bolesti i stanja bolesti |
| ATE517885T1 (de) | 2004-04-30 | 2011-08-15 | Bayer Healthcare Llc | Substituierte pyrazolyl-harnstoff-derivate zur behandlung von krebs |
| KR101381454B1 (ko) * | 2004-09-29 | 2014-04-04 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 열역학적으로 안정한 형태의 ｂａｙ 43-9006 토실레이트 |
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| GB0500435D0 (en) * | 2005-01-10 | 2005-02-16 | Novartis Ag | Organic compounds |
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| PL2010528T3 (pl) | 2006-04-19 | 2018-03-30 | Novartis Ag | 6-0-podstawione związki benzoksazolowe i benzotiazolowe i sposoby hamowania sygnalizacji csf-1r |
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| US20100150863A1 (en) * | 2006-12-20 | 2010-06-17 | Bayer Pharmaceuticals Corporation | Hydroxy methyl phenyl pyrazolyl urea compound useful in treatment of cancer |
| EP2111401B1 (de) * | 2006-12-20 | 2011-02-16 | Bayer HealthCare, LLC | 4-{4-[({3-tert-butyl-1-[3-(hydroxymethyl)-phenyl]-1h-pyrazol-5-yl}-carbamoyl)-amino]-3-fluorophenoxy} -n-methylpyridin-2-carboxamid sowie prodrugs und salze davon zur behandlung von krebs |
| EP2136639B1 (de) | 2007-04-02 | 2016-03-09 | Evotec AG | Pyrid-2-yl-anellierte heterocyclische verbindungen, und ihre zusammensetzungen und verwendungen |
| MX373178B (es) | 2007-04-03 | 2020-04-22 | Fmc Corp Star | Fungicidas de benceno sustituido. |
| EP2070929A1 (de) | 2007-12-11 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Alkynylarylverbindungen und Salze davon, pharmazeutische Zusammensetzungen damit sowie Verfahren zu ihrer Herstellung und Verwendung |
| BRPI0920707A2 (pt) | 2008-10-02 | 2015-12-29 | Respivert Ltd | compostos |
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| CN102395586A (zh) | 2009-02-17 | 2012-03-28 | 奇斯药制品公司 | 作为p38map激酶抑制剂的三唑并吡啶衍生物 |
| GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
| JP5767631B2 (ja) | 2009-05-07 | 2015-08-19 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | バニロイド受容体リガンドとしての置換された芳香族カルボキサミドおよび尿素誘導体 |
| NZ598171A (en) | 2009-07-10 | 2014-11-28 | Linzy O Scott Iii | Methods and compositions for treating thyroid-related medical conditions with reduced folates |
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| US9024041B2 (en) | 2010-04-08 | 2015-05-05 | Respivert Ltd. | P38 MAP kinase inhibitors |
| AR081060A1 (es) | 2010-04-15 | 2012-06-06 | Bayer Schering Pharma Ag | Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida |
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| MY173181A (en) * | 2011-05-13 | 2020-01-02 | Array Biopharma Inc | Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as trka kinase inhibitors |
| EP2731439A4 (de) | 2011-07-12 | 2014-12-03 | Merck Sharp & Dohme | Trka-kinase-hemmer, zusammensetzungen daraus und verfahren dafür |
| JP2014528404A (ja) | 2011-10-03 | 2014-10-27 | レスピバート・リミテツド | ｐ３８ＭＡＰキナーゼ阻害剤としての１−ピラゾリル−３−（４−（（２−アニリノピリミジン−４−イル）オキシ）ナフタレン−１−イル）尿素 |
| EP2578582A1 (de) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) Harnstoffe als p38 MAP Kinasehemmer |
| FR2985256B1 (fr) * | 2011-12-30 | 2016-03-04 | Pitty Marc Henry | Derives piperazinyles pour le traitement de cancers |
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| GB201215357D0 (en) | 2012-08-29 | 2012-10-10 | Respivert Ltd | Compounds |
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| US9822118B2 (en) | 2012-11-13 | 2017-11-21 | Array Biopharma Inc. | Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors |
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-
2005
- 2005-05-02 AT AT05778149T patent/ATE517885T1/de not_active IP Right Cessation
- 2005-05-02 US US11/579,093 patent/US7838524B2/en not_active Expired - Fee Related
- 2005-05-02 CA CA002564325A patent/CA2564325A1/en not_active Abandoned
- 2005-05-02 EP EP05778149A patent/EP1751139B1/de not_active Expired - Lifetime
- 2005-05-02 WO PCT/US2005/015106 patent/WO2005110994A2/en not_active Ceased
- 2005-05-02 CN CNA2005800222909A patent/CN101010315A/zh active Pending
- 2005-05-02 JP JP2007511073A patent/JP2007535565A/ja active Pending
- 2005-05-02 MX MXPA06012394A patent/MXPA06012394A/es active IP Right Grant
- 2005-05-02 EP EP10185804A patent/EP2295426A1/de not_active Withdrawn
- 2005-05-02 EP EP10185914A patent/EP2295427A1/de not_active Withdrawn
-
2010
- 2010-11-08 US US12/941,841 patent/US8207166B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8207166B2 (en) | 2012-06-26 |
| EP1751139A2 (de) | 2007-02-14 |
| JP2007535565A (ja) | 2007-12-06 |
| EP2295426A1 (de) | 2011-03-16 |
| CA2564325A1 (en) | 2005-11-24 |
| MXPA06012394A (es) | 2007-01-31 |
| US20080214545A1 (en) | 2008-09-04 |
| WO2005110994A3 (en) | 2006-02-02 |
| US7838524B2 (en) | 2010-11-23 |
| EP1751139B1 (de) | 2011-07-27 |
| EP2295427A1 (de) | 2011-03-16 |
| US20110136809A1 (en) | 2011-06-09 |
| CN101010315A (zh) | 2007-08-01 |
| WO2005110994A8 (en) | 2006-12-21 |
| WO2005110994A2 (en) | 2005-11-24 |
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