ATE517885T1 - SUBSTITUTED PYRAZOLYL UREA DERIVATIVES FOR THE TREATMENT OF CANCER - Google Patents

SUBSTITUTED PYRAZOLYL UREA DERIVATIVES FOR THE TREATMENT OF CANCER

Info

Publication number
ATE517885T1
ATE517885T1 AT05778149T AT05778149T ATE517885T1 AT E517885 T1 ATE517885 T1 AT E517885T1 AT 05778149 T AT05778149 T AT 05778149T AT 05778149 T AT05778149 T AT 05778149T AT E517885 T1 ATE517885 T1 AT E517885T1
Authority
AT
Austria
Prior art keywords
optionally substituted
cancer
treatment
urea derivatives
substituted pyrazolyl
Prior art date
Application number
AT05778149T
Other languages
German (de)
Inventor
Wendy Lee
Gaetan Ladouceur
Jacques Dumas
Roger Smith
Shihong Ying
Gan Wang
Zhi Chen
Qingjie Liu
Holia Mokdad
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Application granted granted Critical
Publication of ATE517885T1 publication Critical patent/ATE517885T1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I). wherein R 1 and R 2 are independently: (a) hydrogen; (b) (C 1 -C 5 )alkyl, optionally substituted with one or more of hydroxy or fluoro; or (c) halogen; A is phenyl, pyridine, or pyrimidine, optionally substituted with 1 or 2 substituents that are independently (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, (C 1 -C 5 )haloalkyl, (C 1 -C 5 )haloalkoxy, or halogen; B is phenylene or naphthylene, optionally substituted with 1 to 4 substituents that are independently (C 1 -C 5 )alkyl, (C 1 -C 5 )alkoxy, (C 1 -C 5 )haloalkyl, (C 1 -C 5 )haloalkoxy, or halogen; L is a bridging group which is -O-, -S-, -CH 2 -. M is phenyl, pyridine or pyrimidine, optionally substituted.
AT05778149T 2004-04-30 2005-05-02 SUBSTITUTED PYRAZOLYL UREA DERIVATIVES FOR THE TREATMENT OF CANCER ATE517885T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56644504P 2004-04-30 2004-04-30
PCT/US2005/015106 WO2005110994A2 (en) 2004-04-30 2005-05-02 Substituted pyrazolyl urea derivatives useful in the treatment of cancer

Publications (1)

Publication Number Publication Date
ATE517885T1 true ATE517885T1 (en) 2011-08-15

Family

ID=35064925

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05778149T ATE517885T1 (en) 2004-04-30 2005-05-02 SUBSTITUTED PYRAZOLYL UREA DERIVATIVES FOR THE TREATMENT OF CANCER

Country Status (8)

Country Link
US (2) US7838524B2 (en)
EP (3) EP2295426A1 (en)
JP (1) JP2007535565A (en)
CN (1) CN101010315A (en)
AT (1) ATE517885T1 (en)
CA (1) CA2564325A1 (en)
MX (1) MXPA06012394A (en)
WO (1) WO2005110994A2 (en)

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