NO20083822L - Farmasoytisk antikreftpreparat - Google Patents
Farmasoytisk antikreftpreparatInfo
- Publication number
- NO20083822L NO20083822L NO20083822A NO20083822A NO20083822L NO 20083822 L NO20083822 L NO 20083822L NO 20083822 A NO20083822 A NO 20083822A NO 20083822 A NO20083822 A NO 20083822A NO 20083822 L NO20083822 L NO 20083822L
- Authority
- NO
- Norway
- Prior art keywords
- group
- substituted
- inhibitor
- membered
- salt
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Det er beskrevet et farmasøytisk antikreftpreparat for anvendelse ved forebyggelse eller behandling av et karsinom, et sarkom eller hematopoesekreft. Preparatet omfatter en forbindelse representert ved den generelle formel (I) eller et salt derav som en aktiv bestanddel, hvor R er en fenylgruppe substituert med 1-5 substituenter valgt blant et halogenatom, en hydroksygruppe, en Cl-C6-alkylgruppe, en halogen-C1-C6-alkylgruppe, en C1-C6--alkoksygruppe, en Cl-C6-alkyltiogruppe, en amingruppe som kan være substituert, en C3-C10-sykloalkylgruppe som kan være substituert, en alifatisk Cl-C7-acyloksygruppe, en nitrogenert 4-7leddet, mettet, heterosyklisk gruppe, en nitrogenert 5-6-leddet, aromatisk, heterosyklisk gruppe, en nitrogruppe og en cyangruppe; og X er et oksygen- eller svovelatom. Også beskrevet er et farmasøytisk antikreftpreparat som omfatter en inhibitor av epidermal vekstfaktorreseptor (EGFR), en inhibitor av vaskulær endotelvekstfaktorreseptor (VEGFR) eller en Raf-kinaseinhibitor, og en forbindelse representert ved den generelle formel (I) ovenfor, eller et salt derav, som aktive bestanddeler.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006031791 | 2006-02-09 | ||
PCT/JP2007/052178 WO2007091622A1 (ja) | 2006-02-09 | 2007-02-08 | 抗癌医薬組成物 |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20083822L true NO20083822L (no) | 2008-11-05 |
Family
ID=38345216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20083822A NO20083822L (no) | 2006-02-09 | 2008-09-08 | Farmasoytisk antikreftpreparat |
Country Status (15)
Country | Link |
---|---|
US (4) | US8263631B2 (no) |
EP (1) | EP1982718A4 (no) |
JP (2) | JP5133071B2 (no) |
KR (1) | KR20080101888A (no) |
CN (1) | CN101415422B (no) |
AU (1) | AU2007213028C1 (no) |
BR (1) | BRPI0707671A2 (no) |
CA (1) | CA2642665C (no) |
IL (1) | IL193243A0 (no) |
NO (1) | NO20083822L (no) |
NZ (1) | NZ570381A (no) |
RU (1) | RU2419430C2 (no) |
TW (1) | TW200800181A (no) |
WO (1) | WO2007091622A1 (no) |
ZA (1) | ZA200807721B (no) |
Families Citing this family (31)
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US20070087005A1 (en) | 2005-10-14 | 2007-04-19 | Lazar Gregory A | Anti-glypican-3 antibody |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
JP5133071B2 (ja) | 2006-02-09 | 2013-01-30 | 第一三共株式会社 | 抗癌医薬組成物 |
TW200838512A (en) * | 2007-02-08 | 2008-10-01 | Daiichi Sankyo Co Ltd | Crystalline forms of a thiazolidinedione compound and manufacturing methods thereof |
WO2008126732A1 (ja) * | 2007-04-05 | 2008-10-23 | Daiichi Sankyo Company, Limited | 縮合二環式ヘテロアリール誘導体 |
US8722710B2 (en) | 2007-09-26 | 2014-05-13 | Deuterx, Llc | Deuterium-enriched pioglitazone |
EP2196541B1 (en) | 2007-09-28 | 2012-11-07 | Chugai Seiyaku Kabushiki Kaisha | Anti-glypican-3 antibody having improved kinetics in plasma |
CL2009000647A1 (es) * | 2008-04-04 | 2010-06-04 | Chugai Pharmaceutical Co Ltd | Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto. |
TW201008935A (en) * | 2008-07-31 | 2010-03-01 | Daiichi Sankyo Co Ltd | Crystalline forms of thiazolidinedione compound and its manufacturing method |
US20110160462A1 (en) | 2008-07-31 | 2011-06-30 | Daiichi Sankyo Company, Limited | Crystalline forms of thiazolidinedione compound and its manufacturing method |
WO2010037041A2 (en) | 2008-09-26 | 2010-04-01 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
WO2010070379A1 (en) * | 2008-12-17 | 2010-06-24 | Centre National De La Recherche Scientifique | Rxr-ppargamma agonist/growth factor inhibitor combination therapy for inducing apoptosis and the treatment of cancer |
EP2404918B1 (en) | 2009-03-05 | 2016-11-30 | Daiichi Sankyo Company, Limited | Pyridine derivative as ppary inhibitor |
CA2781800A1 (en) | 2009-11-26 | 2011-06-03 | Daiichi Sankyo Company, Limited | Method for manufacturing a 6-substituted 1-methyl-1h-benzimidazole derivative and an intermediate of said method |
TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
EP2788378A4 (en) * | 2011-12-09 | 2015-09-09 | Oncomed Pharm Inc | ASSOCIATION THERAPY FOR THE TREATMENT OF CANCER |
ES2894830T3 (es) | 2012-04-03 | 2022-02-16 | Novartis Ag | Productos combinados con inhibidores de tirosina·cinasa y su uso |
US20140221369A1 (en) * | 2013-02-01 | 2014-08-07 | Deuterx, Llc | 5-deutero-2,4-thiazolidinedione and 5-deutero-2,4-oxazolidinedione derivatives and compositions comprising and methods of using the same |
JP2016510411A (ja) | 2013-02-04 | 2016-04-07 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Wnt経路インヒビターによる処置の方法およびモニタリング |
US8969581B2 (en) | 2013-03-14 | 2015-03-03 | Deuterx, Llc | 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same |
MX371382B (es) * | 2013-03-15 | 2020-01-28 | Aerpio Therapeutics Inc | Composiciones, formulaciones y metodos para tratar enfermedades oculares. |
GB201400034D0 (en) * | 2014-01-02 | 2014-02-19 | Astrazeneca Ab | Pharmaceutical Compositions comprising AZD9291 |
US10188639B2 (en) | 2014-01-15 | 2019-01-29 | Deuterx, Llc | Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone |
JP2016062874A (ja) * | 2014-09-22 | 2016-04-25 | 株式会社ジャパンディスプレイ | 画像表示装置及びその製造方法、並びに画像表示装置の検査方法 |
MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
JP2019510780A (ja) * | 2016-04-04 | 2019-04-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 癌治療用lls化合物 |
EP3518918A4 (en) * | 2016-09-28 | 2020-04-22 | Eiger Biopharmaceuticals, Inc. | METHOD AND PHARMACEUTICAL COMPOSITIONS FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS |
RU2692129C1 (ru) * | 2018-03-19 | 2019-06-21 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) | Способ прогнозирования лимфогенного метастазирования у больных при аденокарциноме прямой кишки |
US11319313B2 (en) | 2020-06-30 | 2022-05-03 | Poxel Sa | Crystalline forms of deuterium-enriched pioglitazone |
US11767317B1 (en) | 2020-06-30 | 2023-09-26 | Poxel Sa | Methods of synthesizing enantiopure deuterium-enriched pioglitazone |
CN113262306A (zh) * | 2021-07-21 | 2021-08-17 | 北京大学第三医院(北京大学第三临床医学院) | Pparg拮抗剂在肿瘤治疗药物中的应用 |
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CA2458452C (en) * | 2001-08-10 | 2011-04-19 | Takeda Chemical Industries, Ltd. | Gnrh agonist combination drugs |
JP2003192592A (ja) * | 2001-10-17 | 2003-07-09 | Sankyo Co Ltd | 医薬組成物 |
WO2003032988A1 (fr) * | 2001-10-17 | 2003-04-24 | Sankyo Company, Limited | Composition pharmaceutique |
JP2005506366A (ja) * | 2001-10-25 | 2005-03-03 | ノバルティス アクチエンゲゼルシャフト | 選択的シクロオキシゲナーゼ−2阻害剤を含む組合せ剤 |
JP5249484B2 (ja) * | 2001-12-11 | 2013-07-31 | 第一三共株式会社 | 医薬組成物 |
TW200300677A (en) * | 2001-12-11 | 2003-06-16 | Sankyo Co | A pharmaceutical composition |
US7071216B2 (en) | 2002-03-29 | 2006-07-04 | Chiron Corporation | Substituted benz-azoles and methods of their use as inhibitors of Raf kinase |
JP2004083558A (ja) | 2002-04-01 | 2004-03-18 | Sankyo Co Ltd | 抗腫瘍医薬組成物 |
AU2003220855A1 (en) | 2002-04-01 | 2003-10-13 | Sankyo Company, Limited | Medicinal antitumor composition |
WO2003106417A1 (en) | 2002-06-14 | 2003-12-24 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
JP2004083574A (ja) * | 2002-06-25 | 2004-03-18 | Sankyo Co Ltd | 利尿剤及びペルオキシソーム増殖因子活性化受容体(PPAR)γ活性化剤を含有する医薬組成物 |
TW200403055A (en) * | 2002-06-25 | 2004-03-01 | Sankyo Co | Pharmaceutical composition of a peroxisome proliferator-activated receptor (PPAR) gamma atcivetor and a diuretic |
JP2005162727A (ja) * | 2003-03-18 | 2005-06-23 | Sankyo Co Ltd | スルファミド誘導体及びその医薬組成物 |
TW200505834A (en) | 2003-03-18 | 2005-02-16 | Sankyo Co | Sulfamide derivative and the pharmaceutical composition thereof |
JP2004315404A (ja) * | 2003-04-15 | 2004-11-11 | Sankyo Co Ltd | ベンゾイミダゾール誘導体を含有する医薬 |
WO2005046665A1 (en) * | 2003-11-13 | 2005-05-26 | Warner-Lambert Company Llc | Combination chemotherapy comprising a mek inhibitor and a erbb1/2 receptor inhibitor |
JP2008501651A (ja) * | 2004-06-03 | 2008-01-24 | エフ.ホフマン−ラ ロシュ アーゲー | イリノテカン(cpt−11)およびegfr阻害剤を用いた処置 |
JP5133071B2 (ja) | 2006-02-09 | 2013-01-30 | 第一三共株式会社 | 抗癌医薬組成物 |
-
2007
- 2007-02-08 JP JP2007557880A patent/JP5133071B2/ja not_active Expired - Fee Related
- 2007-02-08 BR BRPI0707671-1A patent/BRPI0707671A2/pt not_active IP Right Cessation
- 2007-02-08 KR KR1020087019248A patent/KR20080101888A/ko not_active Application Discontinuation
- 2007-02-08 NZ NZ570381A patent/NZ570381A/en not_active IP Right Cessation
- 2007-02-08 WO PCT/JP2007/052178 patent/WO2007091622A1/ja active Application Filing
- 2007-02-08 TW TW096104600A patent/TW200800181A/zh unknown
- 2007-02-08 CA CA2642665A patent/CA2642665C/en not_active Expired - Fee Related
- 2007-02-08 RU RU2008136188/15A patent/RU2419430C2/ru not_active IP Right Cessation
- 2007-02-08 EP EP07708202A patent/EP1982718A4/en not_active Withdrawn
- 2007-02-08 CN CN2007800124996A patent/CN101415422B/zh not_active Expired - Fee Related
- 2007-02-08 AU AU2007213028A patent/AU2007213028C1/en not_active Ceased
-
2008
- 2008-07-30 US US12/221,019 patent/US8263631B2/en not_active Expired - Fee Related
- 2008-08-05 IL IL193243A patent/IL193243A0/en unknown
- 2008-09-08 NO NO20083822A patent/NO20083822L/no not_active Application Discontinuation
- 2008-09-08 ZA ZA200807721A patent/ZA200807721B/xx unknown
-
2012
- 2012-06-18 US US13/525,932 patent/US20120258991A1/en not_active Abandoned
- 2012-06-19 US US13/527,002 patent/US20120263716A1/en not_active Abandoned
- 2012-10-04 JP JP2012222130A patent/JP2012255042A/ja active Pending
-
2013
- 2013-02-26 US US13/776,997 patent/US20130183297A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL193243A0 (en) | 2009-02-11 |
CA2642665C (en) | 2013-01-08 |
AU2007213028B2 (en) | 2010-10-28 |
NZ570381A (en) | 2011-02-25 |
CA2642665A1 (en) | 2007-08-16 |
TW200800181A (en) | 2008-01-01 |
CN101415422B (zh) | 2012-11-07 |
AU2007213028A1 (en) | 2007-08-16 |
US20130183297A1 (en) | 2013-07-18 |
EP1982718A4 (en) | 2010-05-12 |
EP1982718A1 (en) | 2008-10-22 |
JP2012255042A (ja) | 2012-12-27 |
RU2008136188A (ru) | 2010-03-20 |
AU2007213028C1 (en) | 2011-05-19 |
RU2419430C2 (ru) | 2011-05-27 |
US20120258991A1 (en) | 2012-10-11 |
CN101415422A (zh) | 2009-04-22 |
US8263631B2 (en) | 2012-09-11 |
KR20080101888A (ko) | 2008-11-21 |
WO2007091622A1 (ja) | 2007-08-16 |
BRPI0707671A2 (pt) | 2011-05-10 |
JPWO2007091622A1 (ja) | 2009-07-02 |
US20090028868A1 (en) | 2009-01-29 |
JP5133071B2 (ja) | 2013-01-30 |
ZA200807721B (en) | 2010-02-24 |
US20120263716A1 (en) | 2012-10-18 |
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