PE20040167A1 - Amidas del acido sulfamico - Google Patents

Amidas del acido sulfamico

Info

Publication number
PE20040167A1
PE20040167A1 PE2003000308A PE2003000308A PE20040167A1 PE 20040167 A1 PE20040167 A1 PE 20040167A1 PE 2003000308 A PE2003000308 A PE 2003000308A PE 2003000308 A PE2003000308 A PE 2003000308A PE 20040167 A1 PE20040167 A1 PE 20040167A1
Authority
PE
Peru
Prior art keywords
aryl
piperidinyl
atom
acid amides
alcoxycarbonyl
Prior art date
Application number
PE2003000308A
Other languages
English (en)
Inventor
Philipp Lehr
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0207500A external-priority patent/GB0207500D0/en
Priority claimed from GB0225679A external-priority patent/GB0225679D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20040167A1 publication Critical patent/PE20040167A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 Y R2, JUNTO CON EL ATOMO DE NITROGENO CON EL QUE ESTAN UNIDOS, SON PIPERAZINILO EN DONDE EL SEGUNDO ATOMO DE NITROGENO ES ALCOXICARBONILO C1-C6, ARILO SUSTITUIDO, ENTRE OTROS; O R1 ES HIDROGENO Y R2 ES PIPERIDINILO, UNIDOS MEDIANTE UN ATOMO DE CARBONO DEL ANILLO PIPERIDINILO, EN DONDE EL ATOMO DE NITROGENO ESTA SUSTITUIDO POR ALCOXICARBONILO C1-C6, ARILO, ENTRE OTROS; R3 ES ARILO C6-C18 ENTRE OTROS. UN COMPUESTO PREFERIDO ES: N-[[4-[1-(2-AMINOCARBONIL-5-TRIFLUOROMETIL-FENIL)]-PIPERIDINIL]-AMINO]-SULFONIL-3,5-BIS-TRIFLUOROMETIL-BENZAMIDA, ENTRE OTROS. LOS COMPUESTOS DERIVADOS DE FORMULA I ACTUAN SOBRE LA SULFATASA DE ESTEROIDE Y SON UTILES PARA EL TRATAMIENTO LOCAL DE DESORDENES DEPENDIENTES DE ANDROGENOS TAL COMO ACNE, SEBORREA, ALOPECIA
PE2003000308A 2002-03-28 2003-03-26 Amidas del acido sulfamico PE20040167A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0207500A GB0207500D0 (en) 2002-03-28 2002-03-28 Organic compounds
GB0225679A GB0225679D0 (en) 2002-11-04 2002-11-04 Organic compounds

Publications (1)

Publication Number Publication Date
PE20040167A1 true PE20040167A1 (es) 2004-05-26

Family

ID=28676499

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000308A PE20040167A1 (es) 2002-03-28 2003-03-26 Amidas del acido sulfamico

Country Status (20)

Country Link
US (2) US7439362B2 (es)
EP (1) EP1492782A1 (es)
JP (1) JP4580652B2 (es)
KR (1) KR20040094877A (es)
CN (1) CN1293065C (es)
AR (1) AR039156A1 (es)
AU (1) AU2003226732B2 (es)
BR (1) BR0308795A (es)
CA (1) CA2480686A1 (es)
CO (1) CO5640113A2 (es)
IL (1) IL164267A0 (es)
MX (1) MXPA04009453A (es)
MY (1) MY136880A (es)
NO (1) NO20044321L (es)
NZ (1) NZ535617A (es)
PE (1) PE20040167A1 (es)
PL (1) PL372602A1 (es)
RU (1) RU2329258C2 (es)
TW (1) TW200306806A (es)
WO (1) WO2003082842A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0505541D0 (en) * 2005-03-17 2005-04-27 Novartis Ag Organic compounds
GB0505539D0 (en) * 2005-03-17 2005-04-27 Novartis Ag Organic compounds
GB0511190D0 (en) * 2005-06-01 2005-07-06 Sterix Ltd Use
CA2698814A1 (en) 2007-09-17 2009-03-26 Preglem S.A. Treatment of oestrogen dependant conditions in pre-menopausal women
JP2019507741A (ja) * 2016-02-08 2019-03-22 シンアフィックス ビー．ブイ． 治療において使用するためのスルファミドリンカーを含むバイオコンジュゲート
EP3413922A1 (en) 2016-02-08 2018-12-19 SynAffix B.V. Improved sulfamide linkers for use in bioconjugates
CN109069658B (zh) 2016-02-08 2022-10-14 西纳福克斯股份有限公司 用于靶向her2肿瘤的具有改善的治疗指数的抗体-缀合物以及用于改善抗体-缀合物的治疗指数的方法
WO2018102419A1 (en) * 2016-11-29 2018-06-07 Epizyme, Inc. Compounds containing a sulfonic group as kat inhibitors
US20220267300A1 (en) * 2019-06-12 2022-08-25 NodThera Limited Sulfonamide derivatives and uses thereof
CN110590896B (zh) * 2019-11-04 2022-08-30 上海高准医药有限公司 雌酚酮硫酸酯哌嗪的制备方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US51547A (en) * 1865-12-19 Improvement in guide and tuck-marker for sewing-machines
US183459A (en) * 1876-10-17 Improvement in hinges
US478328A (en) * 1892-07-05 Glass-heating oven
US89089A (en) * 1869-04-20 Improved car-coupling
US71516A (en) * 1867-11-26 William b
US876846A (en) * 1907-05-28 1908-01-14 Stephen W Smith Road-machine.
US1122242A (en) * 1912-05-13 1914-12-29 Sanitary Can Company Can-body-feeding device.
US2103610A (en) * 1935-04-30 1937-12-28 Sofal Ltd Alloy steels
DE876846C (de) * 1943-06-01 1953-05-18 Bayer Ag Verfahren zur Herstellung von Abkoemmlingen des Sulfondiamids
US3004487A (en) * 1959-12-07 1961-10-17 Bank Of America Nat Trust & Savings Ass Imprinters
GB1593609A (en) 1978-01-31 1981-07-22 Christiaens Sa A Pyridine sulfonamides
FR2510106A1 (fr) 1981-07-27 1983-01-28 Rhone Poulenc Agrochimie Composes herbicides derives d'acides phenoxybenzoiques, et leurs procedes de preparation et d'utilisation
DK101683A (da) * 1982-03-12 1983-09-13 Duphar Int Res Phenylpiperazinderivater og fremgangsmaade til fremstilling heraf
US5238923A (en) * 1989-05-26 1993-08-24 Warner-Lambert Company Amino-substituted heterocycles as renin inhibitors
US5256632A (en) 1990-05-30 1993-10-26 Bayer Aktiengesellschaft Herbicidal sulphonylated carboxamides
IL99537A (en) 1990-09-27 1995-11-27 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical preparations containing them
FR2716882B1 (fr) 1994-03-04 1996-04-05 Roussel Uclaf Utilisation de dérivés de l'imidazole au traitement d'affections impliquant les récepteurs AT1 et AT2 de l'Angiotensine, certains de ces produits, leur préparation, compositions pharmaceutiques.
FR2716883B1 (fr) 1994-03-04 1996-04-26 Roussel Uclaf Nouveaux dérivés tétrasubstitués de l'imidazole, leur préparation, nouveaux intermédiaires obtenus, leur application à titre de médicaments, compositions pharmaceutiques les renfermant.
US5464788A (en) 1994-03-24 1995-11-07 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
US5783582A (en) 1994-07-20 1998-07-21 Merck & Co., Inc. Piperidines and hexahydro-1H-azepines spiro substituted at the 4-position promote release of growth hormone
WO1996010559A1 (en) 1994-10-04 1996-04-11 Fujisawa Pharmaceutical Co., Ltd. Urea derivatives and their use as acat-inhibitors
WO1997020820A1 (en) 1995-12-01 1997-06-12 Novartis Ag Heteroaryl compounds
DE19621483A1 (de) 1996-05-29 1997-12-04 Hoechst Ag Substituierte 2-Naphthoylguanidine, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19621482A1 (de) 1996-05-29 1997-12-04 Hoechst Ag Substituierte 1-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
NZ500353A (en) 1997-04-14 2002-02-01 Cor Therapeutics Inc Cyclic diaza compounds that are selective inhibitors of factor Xa
ATE384048T1 (de) 1998-09-22 2008-02-15 Astellas Pharma Inc Cyanophenyl-derivate
CA2362778A1 (en) 1999-03-03 2000-09-08 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
JP2003500390A (ja) 1999-05-24 2003-01-07 シーオーアール セラピューティクス インコーポレイテッド Ｘａ因子阻害剤
JP4320089B2 (ja) * 1999-07-06 2009-08-26 あすか製薬株式会社 フェニルスルファメート誘導体
US6632815B2 (en) 1999-09-17 2003-10-14 Millennium Pharmaceuticals, Inc. Inhibitors of factor Xa
EA005677B1 (ru) 2000-05-04 2005-04-28 Басф Акциенгезельшафт Гетероциклилзамещенные фенилсульфамоилкарбоксамиды
BR0210391A (pt) * 2001-06-12 2004-06-15 Elan Pharm Inc Composto, métodos de tratar um paciente que tenha ou de prevenir um paciente de contrair uma doença ou condição e de preparar um composto, e, uso de um composto
ATE319703T1 (de) 2001-07-02 2006-03-15 Piperidinverbindungen, die sich als modulatoren der chemokinrezeptoraktivität eignen

Also Published As

Publication number Publication date
AU2003226732B2 (en) 2006-12-21
CO5640113A2 (es) 2006-05-31
MY136880A (en) 2008-11-28
CN1293065C (zh) 2007-01-03
PL372602A1 (en) 2005-07-25
US20060052393A1 (en) 2006-03-09
RU2329258C2 (ru) 2008-07-20
NO20044321L (no) 2004-10-12
US7439362B2 (en) 2008-10-21
EP1492782A1 (en) 2005-01-05
MXPA04009453A (es) 2005-01-25
NZ535617A (en) 2006-04-28
BR0308795A (pt) 2005-01-18
JP4580652B2 (ja) 2010-11-17
KR20040094877A (ko) 2004-11-10
IL164267A0 (en) 2005-12-18
AU2003226732A1 (en) 2003-10-13
CA2480686A1 (en) 2003-10-09
AR039156A1 (es) 2005-02-09
US20090042899A1 (en) 2009-02-12
JP2005526812A (ja) 2005-09-08
WO2003082842A1 (en) 2003-10-09
RU2004131822A (ru) 2005-07-10
TW200306806A (en) 2003-12-01
CN1646509A (zh) 2005-07-27

Similar Documents

Publication Publication Date Title
CO5700772A2 (es) Composiciones de pirazole utiles como inhibidores de gsk-3
PE20040167A1 (es) Amidas del acido sulfamico
SV2010003495A (es) Mejoras en compuestos organicos o relacionadas con los mismos
ECSP066406A (es) Derivados de pirimidina para el tratamiento del crecimiento celular anormal
ECSP045317A (es) Piridinoilpiperidinas como agonistas de 5-ht1f
BRPI0515133A (pt) derivados de uréia como bloqueadores do canal de cálcio
SV2006002126A (es) Derivados de tetrahidroisoquinolilsulfonamidas, su preparacion y su utilizacion en terapeutica
BR0312999A (pt) Compostos, composições farmacêticas, método para aumentar a cognição, de tratamento, de inibição da atividade de enzima pde4 em um paciente
AR038136A1 (es) Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
PE20141726A1 (es) Heterociclilaminas como inhibidores de pi 3k
UY28823A1 (es) Compuestos de ácido alfa aril o heteroaril metil beta piperidino propanoico como antagonistas del receptor orl1
CU23413B7 (es) Nuevos derivados de benzoimidazol útiles como agentes antiproliferativos
NO20054224L (no) Nye 2-pyridinkarboksamidderivater
ES2592713T3 (es) Derivados de indazolil-triazol como inhibidores de IRAK
NO20044744L (no) Karbaminsyreforbindelser omfattende et piperazinledd som HDASinbibitorer
EA200801607A1 (ru) Производные бензимидазолонкарбоновой кислоты
AR045557A1 (es) Sintesis selectivas de pirimidinas sustituidas con cf3
HN2009002099A (es) Nuevos compuesto heterociclicos nitrogenos, su preparacion y su utilizacion como medicamentos antibacterianos.
PE20080835A1 (es) Derivados novedosos de aminopiridina que tienen accion inhibidora selectiva sobre aurora a
HRP20070286T3 (en) Substituted diketopiperazines and their use as oxytocyn antagonists
AR041861A1 (es) Feniliso (tio) cianatos, procesos e intermediarios para su preparacion.
ES2118333T3 (es) Derivados del acido naftilacetico como agonistas y antagonistas de pgez.
DK1701940T3 (da) 2-(1H-indolylsulfanyl)-bensylaminderivater som SSRI
NO20050871L (no) 6-amino-1H-indazol- og 4-aminobenzofuranforbindelser som fosfodiesterase 4-inhibitorer
PA8589801A1 (es) Aminoalcoxiindoles

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed