NO20061424L - Fremgangsmote for fremstillingen av THIP - Google Patents

Fremgangsmote for fremstillingen av THIP

Info

Publication number
NO20061424L
NO20061424L NO20061424A NO20061424A NO20061424L NO 20061424 L NO20061424 L NO 20061424L NO 20061424 A NO20061424 A NO 20061424A NO 20061424 A NO20061424 A NO 20061424A NO 20061424 L NO20061424 L NO 20061424L
Authority
NO
Norway
Prior art keywords
thip
preparation
alkyl
acid
procedure
Prior art date
Application number
NO20061424A
Other languages
English (en)
Inventor
Robert Dancer
Hans Petersen
Michael Bech Somrner
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58707236&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20061424(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of NO20061424L publication Critical patent/NO20061424L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Abstract

Den foreliggende oppfinnelse vedrører en ny fremgangsmåte for å fremstille gaboxadol (THIP), som er nyttig for å behandle søvnforstyrrelser. Spesielt en fremgangsmåte for å fremstille THIP omfattende å reagere en forbindelse med formel (8b) eller et salt derav hvori, R er C1-12 alkyl, C2-12 alkenyl, C3-8cykloalkyl, C3-8 cykloalkenyl, acyl eller aryl eventuelt substituert med en eller flere C1-12 alkyl, C1-12 alkoksy eller aryl, U' er NH eller CHR1, hvori R1 er H eller R, W er O, S eller NR4, hvori R4 er H eller R, med en syre, typisk en mineralsyre, for a oppnå THIP som et syreaddisjonssalt. Den foreliggende oppfinnelse vedrører også flere intermediater.
NO20061424A 2003-09-05 2006-03-29 Fremgangsmote for fremstillingen av THIP NO20061424L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50042203P 2003-09-05 2003-09-05
DKPA200301277 2003-09-05
PCT/DK2004/000579 WO2005023820A1 (en) 2003-09-05 2004-09-01 Method for the manufacture of thip

Publications (1)

Publication Number Publication Date
NO20061424L true NO20061424L (no) 2006-03-29

Family

ID=58707236

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061424A NO20061424L (no) 2003-09-05 2006-03-29 Fremgangsmote for fremstillingen av THIP

Country Status (21)

Country Link
US (1) US7371863B2 (no)
EP (1) EP1664060A1 (no)
JP (1) JP4745233B2 (no)
KR (1) KR20060069482A (no)
CN (2) CN100482668C (no)
AR (1) AR045540A1 (no)
AU (1) AU2004270323B2 (no)
BR (1) BRPI0413741A (no)
CA (1) CA2537840C (no)
EA (1) EA200600542A1 (no)
HK (1) HK1096398A1 (no)
IL (1) IL174070A (no)
IS (1) IS8333A (no)
ME (1) MEP1708A (no)
MX (1) MXPA06002434A (no)
NO (1) NO20061424L (no)
NZ (1) NZ545178A (no)
RS (1) RS20060157A (no)
UA (1) UA91496C2 (no)
WO (1) WO2005023820A1 (no)
ZA (1) ZA200602178B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402118D0 (en) * 2004-01-30 2004-03-03 Merck Sharp & Dohme Polymorphic forms of a GABAA agonist
BRPI0509210A (pt) * 2004-04-02 2007-08-28 Lundbeck & Co As H uso de gaboxadol, e, métodos para tratar função respiratória enfraquecida, e apnéia do sono
CN104974175A (zh) * 2014-04-11 2015-10-14 天津药物研究院 一种氨甲基羟异恶唑类似物的制备方法
JP6735284B2 (ja) 2015-03-24 2020-08-05 ハー・ルンドベック・アクチエゼルスカベット ４，５，６，７−テトラヒドロイソオキサゾロ［５，４−ｃ］ピリジン−３−オールの製造
US11123332B2 (en) 2018-11-21 2021-09-21 Certego Therapeutics Inc. Gaboxadol for reducing risk of suicide and rapid relief of depression
CN111320577B (zh) * 2018-12-13 2023-06-23 广东东阳光药业有限公司 一种吡啶酰胺的制备方法及其应用
KR20230028244A (ko) 2020-05-20 2023-02-28 썰테고 테라퓨틱스 아이엔씨. 고리 중수소화 가복사돌 및 정신 장애의 치료를 위한 이의 용도

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK270278A (da) 1977-06-20 1978-12-21 Krogsgaard Larsen P Cycliske aminosyrer
GB2088370B (en) * 1980-11-27 1984-08-01 Kefalas As Tetrahydroisoxazolopyridine compounds
DE3145473A1 (de) * 1980-11-27 1982-08-26 Kefalas A/S, Koebenhavn-Valby 2-substituierte 4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridin-3-on-verbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4353910A (en) * 1981-11-27 1982-10-12 Kefalas A/S Derivatives of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-one, pharmaceutical compositions and methods of treatment
DE19525598C2 (de) 1995-07-13 1997-09-25 Max Planck Gesellschaft Schlafmittel

Also Published As

Publication number Publication date
CN1845928A (zh) 2006-10-11
CN101497619A (zh) 2009-08-05
RS20060157A (en) 2008-06-05
CA2537840A1 (en) 2005-03-17
JP2007504179A (ja) 2007-03-01
JP4745233B2 (ja) 2011-08-10
IS8333A (is) 2006-02-28
IL174070A0 (en) 2006-08-01
US7371863B2 (en) 2008-05-13
CN100482668C (zh) 2009-04-29
MXPA06002434A (es) 2006-06-20
NZ545178A (en) 2009-11-27
BRPI0413741A (pt) 2006-10-24
US20070112198A1 (en) 2007-05-17
ZA200602178B (en) 2007-07-25
WO2005023820A1 (en) 2005-03-17
AR045540A1 (es) 2005-11-02
AU2004270323A1 (en) 2005-03-17
UA91496C2 (en) 2010-08-10
IL174070A (en) 2011-03-31
MEP1708A (xx) 2010-02-10
KR20060069482A (ko) 2006-06-21
AU2004270323B2 (en) 2010-01-07
CA2537840C (en) 2011-10-25
EA200600542A1 (ru) 2006-08-25
HK1096398A1 (en) 2007-06-01
EP1664060A1 (en) 2006-06-07

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Representative=s name: PLOUGMANN & VINGTOFT, POSTBOKS 1003 SENTRUM, 0104

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