BRPI0413741A - métodos para preparar thip e para preparar um composto, e, composto - Google Patents
métodos para preparar thip e para preparar um composto, e, compostoInfo
- Publication number
- BRPI0413741A BRPI0413741A BRPI0413741-8A BRPI0413741A BRPI0413741A BR PI0413741 A BRPI0413741 A BR PI0413741A BR PI0413741 A BRPI0413741 A BR PI0413741A BR PI0413741 A BRPI0413741 A BR PI0413741A
- Authority
- BR
- Brazil
- Prior art keywords
- preparing
- compound
- thip
- methods
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
"MéTODOS PARA PREPARAR THIP E PARA PREPARAR UM COMPOSTO, E, COMPOSTO". A presente invenção refere-se a um método inédito de preparar gaboxadol (THIP) que é útil para tratar distúrbios do sono. Em particular, a um método para preparar THIP compreendendo reagir um composto de fórmula (8b) ou um sal do mesmo com um ácido, tipicamente um ácido mineral, para se obter THIP como um sal de adição de ácido. A presente invenção também se refere a vários intermediários.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50042203P | 2003-09-05 | 2003-09-05 | |
DKPA200301277 | 2003-09-05 | ||
PCT/DK2004/000579 WO2005023820A1 (en) | 2003-09-05 | 2004-09-01 | Method for the manufacture of thip |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0413741A true BRPI0413741A (pt) | 2006-10-24 |
Family
ID=58707236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0413741-8A BRPI0413741A (pt) | 2003-09-05 | 2004-09-01 | métodos para preparar thip e para preparar um composto, e, composto |
Country Status (21)
Country | Link |
---|---|
US (1) | US7371863B2 (pt) |
EP (1) | EP1664060A1 (pt) |
JP (1) | JP4745233B2 (pt) |
KR (1) | KR20060069482A (pt) |
CN (2) | CN100482668C (pt) |
AR (1) | AR045540A1 (pt) |
AU (1) | AU2004270323B2 (pt) |
BR (1) | BRPI0413741A (pt) |
CA (1) | CA2537840C (pt) |
EA (1) | EA200600542A1 (pt) |
HK (1) | HK1096398A1 (pt) |
IL (1) | IL174070A (pt) |
IS (1) | IS8333A (pt) |
ME (1) | MEP1708A (pt) |
MX (1) | MXPA06002434A (pt) |
NO (1) | NO20061424L (pt) |
NZ (1) | NZ545178A (pt) |
RS (1) | RS20060157A (pt) |
UA (1) | UA91496C2 (pt) |
WO (1) | WO2005023820A1 (pt) |
ZA (1) | ZA200602178B (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0402118D0 (en) | 2004-01-30 | 2004-03-03 | Merck Sharp & Dohme | Polymorphic forms of a GABAA agonist |
CA2561883A1 (en) * | 2004-04-02 | 2005-10-13 | H. Lundbeck A/S | Treatment of impaired respiratory function with gaboxadol |
CN104974175A (zh) * | 2014-04-11 | 2015-10-14 | 天津药物研究院 | 一种氨甲基羟异恶唑类似物的制备方法 |
MA41802B1 (fr) | 2015-03-24 | 2020-04-30 | H Lundbeck As | Fabrication de 4,5,6,7-tétrahydroisozaxolo[5,4-c]pyridine-3-ol |
CN113395962A (zh) | 2018-11-21 | 2021-09-14 | Certego治疗公司 | 加波沙朵用于降低自杀风险和快速缓解抑郁症 |
CN111320577B (zh) * | 2018-12-13 | 2023-06-23 | 广东东阳光药业有限公司 | 一种吡啶酰胺的制备方法及其应用 |
KR20230028244A (ko) | 2020-05-20 | 2023-02-28 | 썰테고 테라퓨틱스 아이엔씨. | 고리 중수소화 가복사돌 및 정신 장애의 치료를 위한 이의 용도 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK270378A (da) * | 1977-06-20 | 1978-12-21 | Krogsgaard Larsen P | Isoxazolderivater |
DE3145473A1 (de) | 1980-11-27 | 1982-08-26 | Kefalas A/S, Koebenhavn-Valby | 2-substituierte 4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridin-3-on-verbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
GB2088370B (en) * | 1980-11-27 | 1984-08-01 | Kefalas As | Tetrahydroisoxazolopyridine compounds |
US4353910A (en) * | 1981-11-27 | 1982-10-12 | Kefalas A/S | Derivatives of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-one, pharmaceutical compositions and methods of treatment |
DE19525598C2 (de) | 1995-07-13 | 1997-09-25 | Max Planck Gesellschaft | Schlafmittel |
-
2004
- 2004-08-30 AR ARP040103118A patent/AR045540A1/es not_active Application Discontinuation
- 2004-09-01 US US10/570,551 patent/US7371863B2/en not_active Expired - Fee Related
- 2004-09-01 EA EA200600542A patent/EA200600542A1/ru unknown
- 2004-09-01 ZA ZA200602178A patent/ZA200602178B/en unknown
- 2004-09-01 KR KR1020067004221A patent/KR20060069482A/ko active IP Right Grant
- 2004-09-01 CN CNB2004800254248A patent/CN100482668C/zh not_active Expired - Fee Related
- 2004-09-01 JP JP2006525046A patent/JP4745233B2/ja not_active Expired - Fee Related
- 2004-09-01 UA UAA200603678A patent/UA91496C2/ru unknown
- 2004-09-01 MX MXPA06002434A patent/MXPA06002434A/es active IP Right Grant
- 2004-09-01 RS YUP-2006/0157A patent/RS20060157A/sr unknown
- 2004-09-01 CN CNA2009100081718A patent/CN101497619A/zh active Pending
- 2004-09-01 ME MEP-17/08A patent/MEP1708A/xx unknown
- 2004-09-01 CA CA2537840A patent/CA2537840C/en not_active Expired - Fee Related
- 2004-09-01 AU AU2004270323A patent/AU2004270323B2/en not_active Ceased
- 2004-09-01 WO PCT/DK2004/000579 patent/WO2005023820A1/en active Application Filing
- 2004-09-01 NZ NZ545178A patent/NZ545178A/en not_active IP Right Cessation
- 2004-09-01 BR BRPI0413741-8A patent/BRPI0413741A/pt not_active IP Right Cessation
- 2004-09-01 EP EP04762799A patent/EP1664060A1/en not_active Withdrawn
-
2006
- 2006-02-28 IS IS8333A patent/IS8333A/is unknown
- 2006-03-02 IL IL174070A patent/IL174070A/en not_active IP Right Cessation
- 2006-03-29 NO NO20061424A patent/NO20061424L/no not_active Application Discontinuation
-
2007
- 2007-04-10 HK HK07103694.6A patent/HK1096398A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2537840A1 (en) | 2005-03-17 |
MXPA06002434A (es) | 2006-06-20 |
CN1845928A (zh) | 2006-10-11 |
WO2005023820A1 (en) | 2005-03-17 |
RS20060157A (en) | 2008-06-05 |
US7371863B2 (en) | 2008-05-13 |
IS8333A (is) | 2006-02-28 |
HK1096398A1 (en) | 2007-06-01 |
CN100482668C (zh) | 2009-04-29 |
AU2004270323A1 (en) | 2005-03-17 |
NZ545178A (en) | 2009-11-27 |
CN101497619A (zh) | 2009-08-05 |
JP4745233B2 (ja) | 2011-08-10 |
CA2537840C (en) | 2011-10-25 |
UA91496C2 (en) | 2010-08-10 |
NO20061424L (no) | 2006-03-29 |
IL174070A (en) | 2011-03-31 |
EP1664060A1 (en) | 2006-06-07 |
JP2007504179A (ja) | 2007-03-01 |
US20070112198A1 (en) | 2007-05-17 |
ZA200602178B (en) | 2007-07-25 |
AR045540A1 (es) | 2005-11-02 |
AU2004270323B2 (en) | 2010-01-07 |
IL174070A0 (en) | 2006-08-01 |
EA200600542A1 (ru) | 2006-08-25 |
KR20060069482A (ko) | 2006-06-21 |
MEP1708A (xx) | 2010-02-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: PARA: INT. CL. C07D 498/04; A61P 25/22, 25/00 Ipc: C07D 498/04 (2011.01), A61P 25/22 (2011.01), A61P |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014. |