EA200600542A1 - Способ для производства thip - Google Patents

Способ для производства thip

Info

Publication number
EA200600542A1
EA200600542A1 EA200600542A EA200600542A EA200600542A1 EA 200600542 A1 EA200600542 A1 EA 200600542A1 EA 200600542 A EA200600542 A EA 200600542A EA 200600542 A EA200600542 A EA 200600542A EA 200600542 A1 EA200600542 A1 EA 200600542A1
Authority
EA
Eurasian Patent Office
Prior art keywords
thip
manufacture
acid
relates
salt
Prior art date
Application number
EA200600542A
Other languages
English (en)
Inventor
Ханс Петерсен
Микаэль Бек Соммер
Роберт Дансер
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=58707236&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200600542(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of EA200600542A1 publication Critical patent/EA200600542A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Данное изобретение относится к новому способу получения габоксадола (THIP) , который пригоден для лечения расстройств сна. В частности, способ получения THIP, включающий взаимодействие соединения формулы (8b) или его соли с кислотой, обычно минеральной кислотой, с получением THIP в виде кислотно-аддитивной соли. Данное изобретение относится также к нескольким промежуточным соединениям.
EA200600542A 2003-09-05 2004-09-01 Способ для производства thip EA200600542A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200301277 2003-09-05
PCT/DK2004/000579 WO2005023820A1 (en) 2003-09-05 2004-09-01 Method for the manufacture of thip

Publications (1)

Publication Number Publication Date
EA200600542A1 true EA200600542A1 (ru) 2006-08-25

Family

ID=58707236

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600542A EA200600542A1 (ru) 2003-09-05 2004-09-01 Способ для производства thip

Country Status (21)

Country Link
US (1) US7371863B2 (ru)
EP (1) EP1664060A1 (ru)
JP (1) JP4745233B2 (ru)
KR (1) KR20060069482A (ru)
CN (2) CN101497619A (ru)
AR (1) AR045540A1 (ru)
AU (1) AU2004270323B2 (ru)
BR (1) BRPI0413741A (ru)
CA (1) CA2537840C (ru)
EA (1) EA200600542A1 (ru)
HK (1) HK1096398A1 (ru)
IL (1) IL174070A (ru)
IS (1) IS8333A (ru)
ME (1) MEP1708A (ru)
MX (1) MXPA06002434A (ru)
NO (1) NO20061424L (ru)
NZ (1) NZ545178A (ru)
RS (1) RS20060157A (ru)
UA (1) UA91496C2 (ru)
WO (1) WO2005023820A1 (ru)
ZA (1) ZA200602178B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402118D0 (en) 2004-01-30 2004-03-03 Merck Sharp & Dohme Polymorphic forms of a GABAA agonist
BRPI0509210A (pt) * 2004-04-02 2007-08-28 Lundbeck & Co As H uso de gaboxadol, e, métodos para tratar função respiratória enfraquecida, e apnéia do sono
CN104974175A (zh) * 2014-04-11 2015-10-14 天津药物研究院 一种氨甲基羟异恶唑类似物的制备方法
SI3274331T1 (sl) 2015-03-24 2020-08-31 H. Lundbeck A/S Izdelava 4,5,6,7-tetrahidroizozaksolo (5,4-C)piridin-3-ol
WO2020106927A1 (en) 2018-11-21 2020-05-28 Certego Therapeutics Gaboxadol for reducing risk of suicide and rapid relief of depression
CN111320577B (zh) * 2018-12-13 2023-06-23 广东东阳光药业有限公司 一种吡啶酰胺的制备方法及其应用
IL298334A (en) 2020-05-20 2023-01-01 Certego Therapeutics Inc A canceled gaboxadol ring and its use for the treatment of psychiatric disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK270278A (da) * 1977-06-20 1978-12-21 Krogsgaard Larsen P Cycliske aminosyrer
DE3145473A1 (de) 1980-11-27 1982-08-26 Kefalas A/S, Koebenhavn-Valby 2-substituierte 4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridin-3-on-verbindungen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
GB2088370B (en) * 1980-11-27 1984-08-01 Kefalas As Tetrahydroisoxazolopyridine compounds
US4353910A (en) * 1981-11-27 1982-10-12 Kefalas A/S Derivatives of 4,5,6,7-tetrahydroisoxazolo [5,4-c] pyridine-3-one, pharmaceutical compositions and methods of treatment
DE19525598C2 (de) 1995-07-13 1997-09-25 Max Planck Gesellschaft Schlafmittel

Also Published As

Publication number Publication date
CA2537840C (en) 2011-10-25
CN1845928A (zh) 2006-10-11
US20070112198A1 (en) 2007-05-17
IL174070A0 (en) 2006-08-01
US7371863B2 (en) 2008-05-13
BRPI0413741A (pt) 2006-10-24
CN100482668C (zh) 2009-04-29
MEP1708A (xx) 2010-02-10
JP4745233B2 (ja) 2011-08-10
UA91496C2 (en) 2010-08-10
AR045540A1 (es) 2005-11-02
AU2004270323A1 (en) 2005-03-17
JP2007504179A (ja) 2007-03-01
KR20060069482A (ko) 2006-06-21
IL174070A (en) 2011-03-31
HK1096398A1 (en) 2007-06-01
RS20060157A (en) 2008-06-05
AU2004270323B2 (en) 2010-01-07
NO20061424L (no) 2006-03-29
NZ545178A (en) 2009-11-27
IS8333A (is) 2006-02-28
EP1664060A1 (en) 2006-06-07
CN101497619A (zh) 2009-08-05
CA2537840A1 (en) 2005-03-17
MXPA06002434A (es) 2006-06-20
WO2005023820A1 (en) 2005-03-17
ZA200602178B (en) 2007-07-25

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