CO5690587A2 - Derivados de acido bensoilureidopiridil-piperidin-y pirrolidin carboxilico sustituido, metodo para su produccion y su uso - Google Patents

Derivados de acido bensoilureidopiridil-piperidin-y pirrolidin carboxilico sustituido, metodo para su produccion y su uso

Info

Publication number
CO5690587A2
CO5690587A2 CO05089471A CO05089471A CO5690587A2 CO 5690587 A2 CO5690587 A2 CO 5690587A2 CO 05089471 A CO05089471 A CO 05089471A CO 05089471 A CO05089471 A CO 05089471A CO 5690587 A2 CO5690587 A2 CO 5690587A2
Authority
CO
Colombia
Prior art keywords
production
acid derivatives
bensoilureidopiridil
pirrolidin
piperidin
Prior art date
Application number
CO05089471A
Other languages
English (en)
Inventor
Karl Schoenafinger
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of CO5690587A2 publication Critical patent/CO5690587A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

1.- Compuestos de fórmula I dondeR1, R2 son cada uno independientemente H, F, CI, Br, (C1-C6)-alquilo, CF3, OCF3, NO2, CN, O-(C1-C6)-alquilo, COO-(C1-C6)-alquilo, COOH, CO-(C1-C6)-alquilo, (C0-C6)-alquil-COOH, (C0-C6)-alquil-COO(C1-C6)-alquilo, SO2-(C1-C6)-alquilo;R3 es OH, (C1-C6)-alquilo, (C0-C6)-alquil-arilo, O-(C1-C6)-alquilo, O-(C2-C6)alquenilo, O-(C2-C6)-alquinilo, donde los radicales alquilo, arilo, alquenilo y alquinilo pueden estar mono- o polisustituidos por F, CI o Br;X es OH, O(C1-C6)-alquilo, NH2, NH(C1-C6)-alquilo, N((C1-C6)-alquilo)2;A, B, D y E son cada uno independientemente CH o N, y al menos uno de los grupos A, B, D y E tienen el significado de N;m es 0, 1, 2;y sus sales fisiológicamente toleradas.
CO05089471A 2003-03-07 2005-09-06 Derivados de acido bensoilureidopiridil-piperidin-y pirrolidin carboxilico sustituido, metodo para su produccion y su uso CO5690587A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10309929A DE10309929B4 (de) 2003-03-07 2003-03-07 Substituierte Benzoylureidopyridyl-piperidin- und -pyrrolidin-carbonsäurederivate, Verfahren zu deren Herstellung und deren Verwendung

Publications (1)

Publication Number Publication Date
CO5690587A2 true CO5690587A2 (es) 2006-10-31

Family

ID=32945839

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05089471A CO5690587A2 (es) 2003-03-07 2005-09-06 Derivados de acido bensoilureidopiridil-piperidin-y pirrolidin carboxilico sustituido, metodo para su produccion y su uso

Country Status (18)

Country Link
EP (1) EP1603895B1 (es)
JP (1) JP2006519795A (es)
KR (1) KR20050108487A (es)
CN (1) CN1759109A (es)
AT (1) ATE386735T1 (es)
AU (1) AU2004218267A1 (es)
BR (1) BRPI0408148A (es)
CA (1) CA2518322A1 (es)
CO (1) CO5690587A2 (es)
DE (2) DE10309929B4 (es)
HR (1) HRP20050779A2 (es)
MA (1) MA27745A1 (es)
MX (1) MXPA05009122A (es)
NO (1) NO20054418L (es)
PL (1) PL377293A1 (es)
RU (1) RU2005131011A (es)
WO (1) WO2004078743A1 (es)
ZA (1) ZA200506119B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006053274A2 (en) 2004-11-15 2006-05-18 Bristol-Myers Squibb Company 2-amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
US7226942B2 (en) 2004-11-15 2007-06-05 Bristol-Myers Squibb Company 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
US7223786B2 (en) 2004-11-15 2007-05-29 Bristol-Myers Squibb Company 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors
US7365061B2 (en) 2004-11-15 2008-04-29 Bristol-Myers Squibb Company 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
BR112012007979A2 (pt) * 2009-10-06 2016-03-29 Bristol Myers Squibb Co moduladores de gpr40 de pirrolidina

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3034004A1 (de) * 1980-09-10 1982-04-22 Hoechst Ag, 6000 Frankfurt Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
DE10116768A1 (de) * 2001-04-04 2002-10-10 Aventis Pharma Gmbh Acylphenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
ATE265424T1 (de) * 2000-06-09 2004-05-15 Aventis Pharma Gmbh Acylphenylharnstoffderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE10125567B4 (de) * 2001-05-25 2004-08-26 Aventis Pharma Deutschland Gmbh Carbonamid substituierte Phenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PE20021091A1 (es) * 2001-05-25 2003-02-04 Aventis Pharma Gmbh Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion
DE10215907A1 (de) * 2002-04-11 2003-11-06 Aventis Pharma Gmbh Acyl-4-carboxyphenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung
MXPA05000055A (es) * 2002-07-11 2005-04-08 Aventis Pharma Gmbh Acilureas sustituidas con urea y uretano, metodos para su produccion y su uso.
BR0312697A (pt) * 2002-07-12 2005-04-26 Aventis Pharma Gmbh Benzoiluréias substituìdas heterociclicamente, processo para a sua preparação e sua aplicação como medicamento

Also Published As

Publication number Publication date
DE502004006253D1 (de) 2008-04-03
JP2006519795A (ja) 2006-08-31
DE10309929B4 (de) 2006-02-23
KR20050108487A (ko) 2005-11-16
ZA200506119B (en) 2006-11-29
HRP20050779A2 (en) 2006-10-31
MA27745A1 (fr) 2006-02-01
BRPI0408148A (pt) 2006-03-01
ATE386735T1 (de) 2008-03-15
AU2004218267A1 (en) 2004-09-16
CN1759109A (zh) 2006-04-12
PL377293A1 (pl) 2006-01-23
DE10309929A1 (de) 2004-12-02
NO20054418L (no) 2005-09-23
WO2004078743A1 (de) 2004-09-16
CA2518322A1 (en) 2004-09-16
MXPA05009122A (es) 2005-10-20
EP1603895A1 (de) 2005-12-14
RU2005131011A (ru) 2006-05-10
EP1603895B1 (de) 2008-02-20

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