CO5690542A2 - Metodo para la produccion de derivados de acil-fenil-urea sustituidos por animo-carbonilo y el uso de los mismos - Google Patents

Metodo para la produccion de derivados de acil-fenil-urea sustituidos por animo-carbonilo y el uso de los mismos

Info

Publication number
CO5690542A2
CO5690542A2 CO05071890A CO05071890A CO5690542A2 CO 5690542 A2 CO5690542 A2 CO 5690542A2 CO 05071890 A CO05071890 A CO 05071890A CO 05071890 A CO05071890 A CO 05071890A CO 5690542 A2 CO5690542 A2 CO 5690542A2
Authority
CO
Colombia
Prior art keywords
fenil
animo
acil
carbon
production
Prior art date
Application number
CO05071890A
Other languages
English (en)
Inventor
Elisabeth Defossa
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of CO5690542A2 publication Critical patent/CO5690542A2/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/48—Y being a hydrogen or a carbon atom
    • C07C275/54—Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Abstract

1.- Compuestos de fórmula I en la queR8, R9, R10, R11 son, cada uno, independientemente, H, F, CI, Br, OH, NO2, CN, O-(C1-C6)alquilo, O-(C2-C6)alquenilo, O-(C2-C6)alquinilo, O-SO2-(C1-C4)-alquilo, (C1-C6)-alquilo, (C2-C6)-alquenilo o (C2-C6)alquinilo, en donde alquilo, alquenilo y alquinilo pueden estar polisustituidos por F, CI o Br;R1, R2 son, cada uno, independientemente, H, (C1-C6)-alquilo, en donde alquilo puede estar sustituido por OH, O-(C1-C4)-alquilo, NH2, NH(C1-C4)-alquilo, N[(C1-C6)-alquilo]2, o son O-(C1-C6)-alquilo, CO-(C1-C6)-alquilo, COO-(C1-C6)-alquilo, (C1-C6)-alquileno-COOH o (C1-C6)-alquileno-COO-(C1-C6)-alquilo;R3, R4, R5, R6 son, cada uno, independientemente, H, F, CI, Br, NO2, CN, O-R12, O-fenil, S-R12, COOR12, N(R13)(R14), (C1-C6)-alquilo, (C2-C6)-alquenilo, (C2-C6)-alquinilo, (C3-C7)-cicloalquilo, (C3-C7)cicloalquilo-(C1-C4)-alquileno o O-(C1-C5)-alquilo-COOR12, en donde alquilo, cicloalquilo, alquileno y alquinilo pueden estar polisustituidos por F, CI, Br, OR12, COOR12 o N(R13)(R14);R7 es H, (C1-C6)-alquilo, (C3-C7)-cicloalquilo, (C3-C7)-cicloalquilo(C1-C4)-alquileno, (C2-C6)-alquenilo, (C2-C6)-alquinilo, (C1-C6)alquilcarboxi-(C1-C6)-alquileno, COOR12, (C6-C10)-arilo, (C6-C10)arilo-(C1-C4)-alquileno, radical heteroclclico, heteroaril-(C1-C4)-alquileno o heteroarilcarbonilo, en donde alquilo, cicloalquilo, alquileno, alquenilo y alquinilo pueden estar polisustituidos por F, CI, Br, OR12, COOR12, CONH2, CONH(C1-C6)-alquilo, CON[(C1-C6)-alquilo]2 o N(R13)(R14), y en donde arilo y heteroarilo pueden estar polisustituidos por F, CI, Br, NO2, CN, O-R12, S-R12, COOR12, N(R13)(R14) o (C1-C6)-alquilo; ....
CO05071890A 2003-01-23 2005-07-21 Metodo para la produccion de derivados de acil-fenil-urea sustituidos por animo-carbonilo y el uso de los mismos CO5690542A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10302452A DE10302452B4 (de) 2003-01-23 2003-01-23 Carbonylamino-substituierte Acyl-phenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung

Publications (1)

Publication Number Publication Date
CO5690542A2 true CO5690542A2 (es) 2006-10-31

Family

ID=32694928

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05071890A CO5690542A2 (es) 2003-01-23 2005-07-21 Metodo para la produccion de derivados de acil-fenil-urea sustituidos por animo-carbonilo y el uso de los mismos

Country Status (18)

Country Link
EP (1) EP1590322B1 (es)
JP (1) JP4557963B2 (es)
KR (1) KR20050104351A (es)
CN (1) CN1798730A (es)
AT (1) ATE443697T1 (es)
AU (1) AU2004205352A1 (es)
BR (1) BRPI0406840A (es)
CA (1) CA2513286A1 (es)
CO (1) CO5690542A2 (es)
DE (2) DE10302452B4 (es)
HR (1) HRP20050667A2 (es)
MA (1) MA27649A1 (es)
MX (1) MXPA05007515A (es)
NO (1) NO20053876L (es)
PL (1) PL376456A1 (es)
RU (1) RU2005126606A (es)
WO (1) WO2004065356A1 (es)
ZA (1) ZA200504647B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2363128B1 (en) * 2005-03-11 2016-02-17 Vertex Pharmaceuticals Incorporated Indole modulators of ATP-binding cassette transporters
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
WO2009081892A1 (ja) * 2007-12-25 2009-07-02 Kissei Pharmaceutical Co., Ltd. 新規なカテコール誘導体、それを含有する医薬組成物およびそれらの用途
WO2011108724A1 (ja) * 2010-03-04 2011-09-09 味の素株式会社 糖尿病又は肥満症の予防又は治療剤
GB201223308D0 (en) 2012-12-21 2013-02-06 Univ Sunderland Enzyme inhibitors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH508019A (de) * 1968-12-12 1971-05-31 Ciba Geigy Ag Verfahren zur Herstellung neuer Azofarbstoffpigmente
ATE37869T1 (de) * 1983-01-24 1988-10-15 Duphar Int Res Benzoylharnstoffderivate und diese verbindungen enthaltende pestizide kompositionen.
ZA861446B (en) * 1985-03-01 1986-10-29 Duphar Int Res Benzoyl urea derivatives having anti-tumor activity
ZA89135B (en) * 1988-01-11 1989-10-25 Duphar Int Res Method of treating hematologic diseases and pharmaceutical composition to be used therefor
TWI238064B (en) * 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
AU2713699A (en) * 1998-03-12 1999-09-27 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
IL141183A0 (en) * 1998-08-04 2002-02-10 Astrazeneca Ab Amide derivatives useful as inhibitors of the production of cytokines
GB0001662D0 (en) * 1999-02-06 2000-03-15 Zeneca Ltd Pharmaceutical compositions
BR0111457A (pt) * 2000-06-09 2003-06-24 Aventis Pharma Deustschland Gm Derivados de acilfeniluréia, processos para a sua preparação e sua aplicação como medicamentos
PE20021091A1 (es) * 2001-05-25 2003-02-04 Aventis Pharma Gmbh Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion
DE10225635C1 (de) * 2002-06-07 2003-12-24 Aventis Pharma Gmbh N-Benzoylureido-Zimtsäurederivate, Verfahren zu deren Herstellung und deren Verwendung

Also Published As

Publication number Publication date
JP4557963B2 (ja) 2010-10-06
DE10302452B4 (de) 2005-02-24
NO20053876D0 (no) 2005-08-18
CA2513286A1 (en) 2004-08-05
JP2006516971A (ja) 2006-07-13
MXPA05007515A (es) 2006-01-27
HRP20050667A2 (en) 2006-09-30
KR20050104351A (ko) 2005-11-02
WO2004065356A1 (de) 2004-08-05
NO20053876L (no) 2005-10-12
EP1590322A1 (de) 2005-11-02
MA27649A1 (fr) 2005-12-01
AU2004205352A1 (en) 2004-08-05
DE10302452A1 (de) 2004-08-12
PL376456A1 (en) 2005-12-27
BRPI0406840A (pt) 2005-12-13
EP1590322B1 (de) 2009-09-23
CN1798730A (zh) 2006-07-05
RU2005126606A (ru) 2006-01-20
ZA200504647B (en) 2006-04-26
DE502004010108D1 (de) 2009-11-05
ATE443697T1 (de) 2009-10-15

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