DE60209122D1 - Bernsteinsäurederivate - Google Patents

Bernsteinsäurederivate

Info

Publication number
DE60209122D1
DE60209122D1 DE60209122T DE60209122T DE60209122D1 DE 60209122 D1 DE60209122 D1 DE 60209122D1 DE 60209122 T DE60209122 T DE 60209122T DE 60209122 T DE60209122 T DE 60209122T DE 60209122 D1 DE60209122 D1 DE 60209122D1
Authority
DE
Germany
Prior art keywords
acid derivatives
amber acid
pharmaceutical compositions
amber
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60209122T
Other languages
English (en)
Other versions
DE60209122T2 (de
Inventor
Thomas Roelle
Thomas Lehmann
Markus Albers
Gerhard Mueller
Gerhard Hessler
Ruediger Fischer
Masaomi Tajimi
Karl Ziegelbauer
Kevin Bacon
Haruki Hasegawa
Hiromi Okigami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Publication of DE60209122D1 publication Critical patent/DE60209122D1/de
Application granted granted Critical
Publication of DE60209122T2 publication Critical patent/DE60209122T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/55—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
DE60209122T 2001-07-06 2002-06-24 Bernsteinsäurederivate Expired - Fee Related DE60209122T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0116577A GB2377933A (en) 2001-07-06 2001-07-06 Succinic acid derivatives useful as integrin antagonists
GB0116577 2001-07-06
PCT/EP2002/006941 WO2003004460A2 (en) 2001-07-06 2002-06-24 Succinic acid derivatives

Publications (2)

Publication Number Publication Date
DE60209122D1 true DE60209122D1 (de) 2006-04-20
DE60209122T2 DE60209122T2 (de) 2006-08-03

Family

ID=9918063

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60209122T Expired - Fee Related DE60209122T2 (de) 2001-07-06 2002-06-24 Bernsteinsäurederivate

Country Status (9)

Country Link
US (1) US7064229B2 (de)
EP (1) EP1406865B1 (de)
AT (1) ATE317380T1 (de)
DE (1) DE60209122T2 (de)
DK (1) DK1406865T3 (de)
ES (1) ES2258636T3 (de)
GB (1) GB2377933A (de)
PT (1) PT1406865E (de)
WO (1) WO2003004460A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2430978C (en) 2000-12-28 2012-05-15 Daiichi Pharmaceutical Co., Ltd. Vla-4 inhibitors
JP4617449B2 (ja) 2002-07-11 2011-01-26 ヴィキュロン ファーマシューティカルズ インコーポレイテッド 抗菌活性を有するｎ−ヒドロキシアミド誘導体
TWI340134B (en) 2003-07-24 2011-04-11 Daiichi Seiyaku Co Cyclohexanecarboxylic acids
CA2764387A1 (en) 2009-06-05 2010-12-09 Link Medicine Corporation Aminopyrrolidinone derivatives and uses thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT205017B (de) * 1956-12-20 1959-08-25 Lannacher Heilmittel Verfahern zur Herstellung neuer, substituierter Halbamide der Bernsteinsäure
US4482572A (en) * 1983-05-05 1984-11-13 Smithkline Beckman Corporation 1-Acylamino-1-cyclopentanecarboxylic acids
DE3535247A1 (de) * 1985-10-03 1987-04-09 Agfa Gevaert Ag Farbfotografisches aufzeichnungsmaterial mit leicht dispergierbaren farbkupplern
US6306840B1 (en) 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
US6248713B1 (en) 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
NZ333904A (en) 1996-07-25 2000-06-23 Biogen Inc VLA-4 and IIb/IIIa cell adhesion inhibitors
WO1999020272A1 (en) 1997-10-21 1999-04-29 Merck & Co., Inc. Azapeptide acids as cell adhesion inhibitors
AU1411499A (en) 1997-11-20 1999-06-15 Merck & Co., Inc. Para-aminomethylaryl carboxamide derivatives
AU747907B2 (en) 1997-12-23 2002-05-30 Aventis Pharma Limited Substituted beta-alanines
CN1294576A (zh) 1998-01-23 2001-05-09 诺瓦提斯公司 Vla－4拮抗剂
AU758939B2 (en) 1998-06-30 2003-04-03 Pfizer Products Inc. Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases
DE19962936A1 (de) 1999-12-24 2001-06-28 Bayer Ag Neue beta-Aminosäureverbindungen als Integrinantagonisten
DE10006453A1 (de) 2000-02-14 2001-08-16 Bayer Ag Piperidylcarbonsäuren als Integrinantagonisten
DE10019755A1 (de) 2000-04-20 2001-11-08 Bayer Ag Neue Aminoaryl/cycloalkylcarbonsäuren als Integrinantagonisten
GB2367817A (en) 2000-10-09 2002-04-17 Bayer Ag Cyclic carboxylic acids as integrin antagonists
GB2369357A (en) 2000-10-09 2002-05-29 Bayer Ag Aliphatic, cyclic amino carboxylic acids as integrin antagonists
GB2367816A (en) * 2000-10-09 2002-04-17 Bayer Ag Urea- and thiourea-containing derivatives of beta-amino acids

Also Published As

Publication number Publication date
WO2003004460A3 (en) 2003-12-11
GB0116577D0 (en) 2001-08-29
DK1406865T3 (da) 2006-05-08
EP1406865A2 (de) 2004-04-14
US7064229B2 (en) 2006-06-20
US20040254157A1 (en) 2004-12-16
ES2258636T3 (es) 2006-09-01
GB2377933A (en) 2003-01-29
EP1406865B1 (de) 2006-02-08
DE60209122T2 (de) 2006-08-03
ATE317380T1 (de) 2006-02-15
PT1406865E (pt) 2006-06-30
WO2003004460A2 (en) 2003-01-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee