BR0307574A - Derivados de nicotinamida úteis como inibidores de pde4 - Google Patents

Derivados de nicotinamida úteis como inibidores de pde4

Info

Publication number
BR0307574A
BR0307574A BR0307574-5A BR0307574A BR0307574A BR 0307574 A BR0307574 A BR 0307574A BR 0307574 A BR0307574 A BR 0307574A BR 0307574 A BR0307574 A BR 0307574A
Authority
BR
Brazil
Prior art keywords
nicotinamide derivatives
pde4 inhibitors
derivatives
derivatives useful
nicotinamide
Prior art date
Application number
BR0307574-5A
Other languages
English (en)
Inventor
Thomas Victor Magee
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR0307574A publication Critical patent/BR0307574A/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

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Abstract

"DERIVADOS DE NICOTINAMIDA úTEIS COMO INIBIDORES DE PDE4". A invenção refere-se a derivados de nicotinamida de fórmula (1) e a processos para a preparação de composições contendo esses derivados e utilizações desses derivados. Os derivados de nicotinamida de acordo com a presente invenção são inibidores de fosfodiesterase-4 e são úteis em inúmeros, doenças, distúrbios e condições, em particular, doenças, distúrbios e condições inflamatórias, alérgicas e respiratórias, bem como para a cura de feridas.
BR0307574-5A 2002-02-11 2003-02-03 Derivados de nicotinamida úteis como inibidores de pde4 BR0307574A (pt)

Applications Claiming Priority (2)

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GBGB0203193.8A GB0203193D0 (en) 2002-02-11 2002-02-11 Nicotinamide derivatives useful as pde4 inhibitors
PCT/IB2003/000377 WO2003068232A1 (en) 2002-02-11 2003-02-03 Nicotinamide derivatives useful as pde4 inhibitors

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TW (2) TW200307545A (pt)
UY (2) UY27658A1 (pt)
WO (2) WO2003068232A1 (pt)

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US6995162B2 (en) 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
RS70104A (en) 2002-02-11 2007-02-05 Pfizer Limited, Nicotinamide derivatives useful as pde4 inhibitors
US7307088B2 (en) 2002-07-09 2007-12-11 Amgen Inc. Substituted anthranilic amide derivatives and methods of use
US7153870B2 (en) 2003-07-25 2006-12-26 Pfizer Inc. Nicotinamide derivatives useful as PDE4 inhibitors
GB0317482D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
GB0317484D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
GB0317509D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as PDE4 inhibitors
GB0317516D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as PDE4 inhibitors
JPWO2005026132A1 (ja) * 2003-09-17 2007-11-08 日本新薬株式会社 ホスホジエステラーゼのｃＡＭＰ基質特異的阻害剤
SG137859A1 (en) 2003-11-03 2007-12-28 Boehringer Ingelheim Int Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same
CA2547394A1 (en) * 2004-01-09 2005-07-28 Boehringer Ingelheim International Gmbh New pharmaceutical compositions based on a scopineester and nicotinamide derivatives
EP1864980A4 (en) * 2005-03-30 2010-08-18 Eisai R&D Man Co Ltd A PYRIDINE DERIVATIVE ANTIPILIC AGENT
CA2617101A1 (en) * 2005-08-08 2007-02-15 Boehringer Ingelheim International Gmbh Method for the protection against the risk of cardiac disorders comprising administration of tiotropium salts
DE102005049429A1 (de) 2005-10-15 2007-04-19 Cognis Ip Management Gmbh Verfahren zur Ausrüstung von Textilien
WO2007045980A1 (en) * 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type iv inhibitors
US8247556B2 (en) 2005-10-21 2012-08-21 Amgen Inc. Method for preparing 6-substituted-7-aza-indoles
TWI385169B (zh) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
US20100184811A1 (en) * 2006-09-14 2010-07-22 Finn Buxbom Isoniazid mediated healing of wounds and ulcers
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
CN109020825B (zh) * 2017-06-12 2021-03-19 重庆医科大学 抗流感病毒化合物及其制备方法

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DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
PL336148A1 (en) * 1997-04-04 2000-06-05 Pfizer Prod Inc Nicotinamide derivatives

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UY27657A1 (es) 2003-09-30
PE20030860A1 (es) 2003-10-25
HN2003000062A (es) 2003-09-24
TW200304824A (en) 2003-10-16
CA2475708A1 (en) 2003-08-21
AU2003202116A1 (en) 2003-09-04
AU2003245812A1 (en) 2003-09-04
GT200300033A (es) 2003-10-11
AR038404A1 (es) 2005-01-12
EP1476157A1 (en) 2004-11-17
SV2004001481A (es) 2004-05-07
JP2005522449A (ja) 2005-07-28
GB0203193D0 (en) 2002-03-27
UY27658A1 (es) 2003-09-30
WO2003068234A1 (en) 2003-08-21
GT200300034A (es) 2003-09-11
TW200307545A (en) 2003-12-16
PA8566601A1 (es) 2003-11-12
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