PE20030860A1 - Derivados de nicotamida utiles como inhibidores de pde4 - Google Patents
Derivados de nicotamida utiles como inhibidores de pde4Info
- Publication number
- PE20030860A1 PE20030860A1 PE2003000149A PE2003000149A PE20030860A1 PE 20030860 A1 PE20030860 A1 PE 20030860A1 PE 2003000149 A PE2003000149 A PE 2003000149A PE 2003000149 A PE2003000149 A PE 2003000149A PE 20030860 A1 PE20030860 A1 PE 20030860A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- pde4
- nucleotidon
- hydroxybenzoylamine
- fluorophenoxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
Abstract
SE REFIERE A DERIVADOS DE NICOTINA DE FORMULA 1 DONDE ; m Y n SON 0-3; R1 Y R2 SON H, HALO, CIANO, ALQUILO, ALCOXI; X ES O, S, NH; R3 ES FENILO, NAFTILO, HETEROARILO, CICLOALQUILO, GRUPOS BICICLICOS DE FORMULA 1.1, 1.2, ENTRE OTROS; Y ES CO, CONH, SO2, SO2NH, ENTRE OTROS; R4 ES FENILO, NAFTILO, HETEROARILO, ALQUILO. SON COMPUESTOS PREFERIDOS 2-(4-FLUOROFENOXI)-N-{4-[(2-HIDROXI-3-METILBENZOILAMINO)METIL]BENCIL}-NICOTINAMIDA; ESTER ETILICO DE ACIDO 3-(3-{4-[(2-HIDROXI-3-HIDROXIBENZOILAMINO)METIL]BENCILCARBAMOIL}-PIRIDIN-2-ILOXIBENZOICO; 2-(4-FLUOROFENOXI)-N-{4-[(6-FLUORO-2-HIDROXIBENZOILAMINO)METIL]BENCIL}-NICOTINAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO ES INHIBIDOR DE FOSFODIESTERASAS QUE ACTUAN SOBRE NUCLEOTIDOS (PDE4) Y PUEDE SER UTIL PARA EL TRATAMIENTO DE ASMA, BRONCOCONSTRICCION, ENFERMEDADES OBSTRUCTIVAS O INFLAMATORIAS DE LAS VIAS RESPIRATORIAS, PNEUMOCONIOSIS, BRONQUITIS, BRONQUIECTASIA, RINITS ALERGICA, ARTRITIS REUMATOIDEA, GOTA, FIEBRE, DERMATITIS ATOPICA URTICARIA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0203193.8A GB0203193D0 (en) | 2002-02-11 | 2002-02-11 | Nicotinamide derivatives useful as pde4 inhibitors |
Publications (1)
Publication Number | Publication Date |
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PE20030860A1 true PE20030860A1 (es) | 2003-10-25 |
Family
ID=9930842
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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PE2003000148A PE20030921A1 (es) | 2002-02-11 | 2003-02-11 | Derivados de nicotinamida y una sal de tiotropio en combinacion para el tratamiento de enfermedades |
PE2003000149A PE20030860A1 (es) | 2002-02-11 | 2003-02-11 | Derivados de nicotamida utiles como inhibidores de pde4 |
Family Applications Before (1)
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PE2003000148A PE20030921A1 (es) | 2002-02-11 | 2003-02-11 | Derivados de nicotinamida y una sal de tiotropio en combinacion para el tratamiento de enfermedades |
Country Status (16)
Country | Link |
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EP (1) | EP1476157A1 (es) |
JP (1) | JP2005522449A (es) |
AR (1) | AR038404A1 (es) |
AU (2) | AU2003202116A1 (es) |
BR (1) | BR0307574A (es) |
CA (1) | CA2475708A1 (es) |
GB (1) | GB0203193D0 (es) |
GT (2) | GT200300033A (es) |
HN (1) | HN2003000062A (es) |
MX (1) | MXPA04007736A (es) |
PA (2) | PA8566601A1 (es) |
PE (2) | PE20030921A1 (es) |
SV (1) | SV2004001481A (es) |
TW (2) | TW200307545A (es) |
UY (2) | UY27657A1 (es) |
WO (2) | WO2003068232A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
US6878714B2 (en) | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
KR100698982B1 (ko) | 2002-02-11 | 2007-03-26 | 화이자 인코포레이티드 | Pde4 억제제로서 유용한 니코틴아미드 유도체 |
US7307088B2 (en) | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
US7153870B2 (en) | 2003-07-25 | 2006-12-26 | Pfizer Inc. | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317482D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
GB0317484D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
GB0317516D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317509D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
JPWO2005026132A1 (ja) * | 2003-09-17 | 2007-11-08 | 日本新薬株式会社 | ホスホジエステラーゼのcAMP基質特異的阻害剤 |
EP2067779B9 (de) | 2003-11-03 | 2013-10-16 | Boehringer Ingelheim International GmbH | Tiotropiumsalze, Verfahren zu deren Herstellung und Arzneimittelformulierungen diese enthaltend |
EP1706118A1 (en) * | 2004-01-09 | 2006-10-04 | Boehringer Ingelheim International GmbH | New pharmaceutical compositions based on a scopineester and nicotinamide derivatives |
EP1864980A4 (en) * | 2005-03-30 | 2010-08-18 | Eisai R&D Man Co Ltd | A PYRIDINE DERIVATIVE ANTIPILIC AGENT |
WO2007017436A2 (en) * | 2005-08-08 | 2007-02-15 | Boehringer Ingelheim International Gmbh | Method for the protection against the risk of cardiac disorders comprising administration of tiotropium salts |
DE102005049429A1 (de) | 2005-10-15 | 2007-04-19 | Cognis Ip Management Gmbh | Verfahren zur Ausrüstung von Textilien |
AU2006305620A1 (en) * | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Compositions of phosphodiesterase type IV inhibitors |
US8247556B2 (en) | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
EP2068873B1 (en) * | 2006-09-14 | 2011-11-09 | Bridge BioResearch Rights (Jersey) Limited | Isoniazid mediated healing of wounds and ulcers |
US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
CN109020825B (zh) * | 2017-06-12 | 2021-03-19 | 重庆医科大学 | 抗流感病毒化合物及其制备方法 |
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DE3931041C2 (de) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
AU738037B2 (en) * | 1997-04-04 | 2001-09-06 | Pfizer Products Inc. | Nicotinamide derivatives |
-
2002
- 2002-02-11 GB GBGB0203193.8A patent/GB0203193D0/en not_active Ceased
-
2003
- 2003-02-03 WO PCT/IB2003/000377 patent/WO2003068232A1/en not_active Application Discontinuation
- 2003-02-03 EP EP03700974A patent/EP1476157A1/en not_active Withdrawn
- 2003-02-03 AU AU2003202116A patent/AU2003202116A1/en not_active Abandoned
- 2003-02-03 CA CA002475708A patent/CA2475708A1/en not_active Abandoned
- 2003-02-03 AU AU2003245812A patent/AU2003245812A1/en not_active Abandoned
- 2003-02-03 JP JP2003567414A patent/JP2005522449A/ja not_active Withdrawn
- 2003-02-03 BR BR0307574-5A patent/BR0307574A/pt not_active IP Right Cessation
- 2003-02-03 WO PCT/IB2003/000379 patent/WO2003068234A1/en not_active Application Discontinuation
- 2003-02-03 MX MXPA04007736A patent/MXPA04007736A/es active IP Right Grant
- 2003-02-06 TW TW092102422A patent/TW200307545A/zh unknown
- 2003-02-06 TW TW092102415A patent/TW200304824A/zh unknown
- 2003-02-10 GT GT200300033A patent/GT200300033A/es unknown
- 2003-02-10 SV SV2003001481A patent/SV2004001481A/es not_active Application Discontinuation
- 2003-02-10 AR ARP030100406A patent/AR038404A1/es not_active Application Discontinuation
- 2003-02-10 HN HN2003000062A patent/HN2003000062A/es unknown
- 2003-02-10 GT GT200300034A patent/GT200300034A/es unknown
- 2003-02-11 UY UY27657A patent/UY27657A1/es not_active Application Discontinuation
- 2003-02-11 PE PE2003000148A patent/PE20030921A1/es not_active Application Discontinuation
- 2003-02-11 UY UY27658A patent/UY27658A1/es not_active Application Discontinuation
- 2003-02-11 PA PA20038566601A patent/PA8566601A1/es unknown
- 2003-02-11 PA PA20038566501A patent/PA8566501A1/es unknown
- 2003-02-11 PE PE2003000149A patent/PE20030860A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2475708A1 (en) | 2003-08-21 |
AR038404A1 (es) | 2005-01-12 |
AU2003245812A1 (en) | 2003-09-04 |
SV2004001481A (es) | 2004-05-07 |
AU2003202116A1 (en) | 2003-09-04 |
TW200307545A (en) | 2003-12-16 |
MXPA04007736A (es) | 2004-10-15 |
PE20030921A1 (es) | 2003-11-05 |
EP1476157A1 (en) | 2004-11-17 |
BR0307574A (pt) | 2004-12-21 |
UY27657A1 (es) | 2003-09-30 |
PA8566501A1 (es) | 2003-11-12 |
GT200300033A (es) | 2003-10-11 |
WO2003068232A1 (en) | 2003-08-21 |
JP2005522449A (ja) | 2005-07-28 |
HN2003000062A (es) | 2003-09-24 |
WO2003068234A1 (en) | 2003-08-21 |
UY27658A1 (es) | 2003-09-30 |
PA8566601A1 (es) | 2003-11-12 |
GB0203193D0 (en) | 2002-03-27 |
GT200300034A (es) | 2003-09-11 |
TW200304824A (en) | 2003-10-16 |
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