ATE512154T1 - Kondensiertes pyrimidinderivat und xanthinoxidaseinhibitor - Google Patents
Kondensiertes pyrimidinderivat und xanthinoxidaseinhibitorInfo
- Publication number
- ATE512154T1 ATE512154T1 AT05751417T AT05751417T ATE512154T1 AT E512154 T1 ATE512154 T1 AT E512154T1 AT 05751417 T AT05751417 T AT 05751417T AT 05751417 T AT05751417 T AT 05751417T AT E512154 T1 ATE512154 T1 AT E512154T1
- Authority
- AT
- Austria
- Prior art keywords
- xanthine
- oxidasine
- inhibitor
- pyrimidine derivative
- carbon atoms
- Prior art date
Links
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 title 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229940075420 xanthine Drugs 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Chemical group 0.000 abstract 2
- 229940123769 Xanthine oxidase inhibitor Drugs 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000003064 xanthine oxidase inhibitor Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004175798 | 2004-06-14 | ||
| PCT/JP2005/011188 WO2005121153A1 (ja) | 2004-06-14 | 2005-06-13 | 縮合ピリミジン誘導体、及びキサンチンオキシダーゼ阻害剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE512154T1 true ATE512154T1 (de) | 2011-06-15 |
Family
ID=35503006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05751417T ATE512154T1 (de) | 2004-06-14 | 2005-06-13 | Kondensiertes pyrimidinderivat und xanthinoxidaseinhibitor |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7598254B2 (de) |
| EP (1) | EP1757610B1 (de) |
| JP (3) | JP4914210B2 (de) |
| CN (1) | CN1993367B (de) |
| AT (1) | ATE512154T1 (de) |
| DK (1) | DK1757610T3 (de) |
| ES (1) | ES2367118T3 (de) |
| PL (1) | PL1757610T3 (de) |
| PT (1) | PT1757610E (de) |
| WO (1) | WO2005121153A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4914210B2 (ja) * | 2004-06-14 | 2012-04-11 | 日本ケミファ株式会社 | 縮合ピリミジン誘導体、及びキサンチンオキシダーゼ阻害剤 |
| US20090149452A1 (en) * | 2005-07-01 | 2009-06-11 | Nippon Chemiphar Co., Ltd. | Xanthine oxidase inhibitor |
| EP2036561B1 (de) | 2006-06-22 | 2017-05-10 | Nippon Chemiphar Co., Ltd. | Mittel zur überwindung von resistenz gegen ein anti-krebs-mittel |
| KR20150073963A (ko) | 2012-10-23 | 2015-07-01 | 데이진 화-마 가부시키가이샤 | 종양 융해 증후군의 치료약 및 예방약 |
| CN103848798B (zh) | 2012-11-30 | 2016-01-06 | 镇江新元素医药科技有限公司 | 2-芳基硒唑化合物及其药物组合物 |
| WO2014194226A2 (en) | 2013-05-31 | 2014-12-04 | Takeda Pharmaceuticals U.S.A., Inc. | Methods of treatment and compositions with xanthine oxidase inhibitors |
| EP3263109B1 (de) * | 2015-02-24 | 2020-06-17 | National University Corporation Tottori University | Arzneimittel zur prävention und/oder behandlung von demenz |
| TWI780270B (zh) | 2017-11-28 | 2022-10-11 | 靜岡縣公立大學法人 | 固體分散體 |
| JP2021127289A (ja) * | 2018-04-27 | 2021-09-02 | 日本ケミファ株式会社 | 縮合ピリミジン誘導体 |
| CN113924145A (zh) * | 2019-06-04 | 2022-01-11 | 日本化学药品株式会社 | 痛风或高尿酸血症的治疗药 |
| JP6903252B2 (ja) * | 2019-06-04 | 2021-07-14 | 日本ケミファ株式会社 | キサンチンオキシダーゼ阻害剤含有腸溶性製剤 |
| WO2022124325A1 (ja) | 2020-12-08 | 2022-06-16 | 国立大学法人東京大学 | 細胞内ａｔｐ増強剤 |
| CN116640095A (zh) * | 2023-04-19 | 2023-08-25 | 山东大学 | 一种含脂肪羧基的二芳基胺类衍生物及其制备方法与应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6421431A (en) | 1987-07-16 | 1989-01-24 | Fuji Photo Film Co Ltd | Film carrying device |
| JP2691317B2 (ja) * | 1989-08-25 | 1997-12-17 | 株式会社大塚製薬工場 | ４―ヒドロキシ―８―（３―低級アルコキシ―４―フェニルスルフィニルフェニル）ピラゾロ〔１，５―ａ〕―１，３，５―トリアジン光学活性体の塩類及びその製造方法 |
| DK0513379T3 (da) * | 1990-11-30 | 1996-09-30 | Teijin Ltd | 2-Arylthiazolderivater og farmaceutisk præparat indeholdende sådanne |
| ID21775A (id) | 1996-10-25 | 1999-07-22 | Yoshitomi Pharmaceutical | Senyawa-senyawa 1-fenilpirazol dan penggunaan farmasinya |
| JP2000001431A (ja) * | 1998-06-15 | 2000-01-07 | Kotobuki Seiyaku Kk | 尿酸排泄剤 |
| US7253154B2 (en) * | 2001-11-16 | 2007-08-07 | Nippon Chemiphar Co., Ltd. | Substituted thiazolopyrimidines as xanthine oxidase inhibitors |
| JP4914210B2 (ja) * | 2004-06-14 | 2012-04-11 | 日本ケミファ株式会社 | 縮合ピリミジン誘導体、及びキサンチンオキシダーゼ阻害剤 |
-
2005
- 2005-06-13 JP JP2006514620A patent/JP4914210B2/ja not_active Expired - Fee Related
- 2005-06-13 AT AT05751417T patent/ATE512154T1/de active
- 2005-06-13 CN CN2005800267399A patent/CN1993367B/zh not_active Expired - Lifetime
- 2005-06-13 DK DK05751417.6T patent/DK1757610T3/da active
- 2005-06-13 US US11/629,277 patent/US7598254B2/en active Active
- 2005-06-13 ES ES05751417T patent/ES2367118T3/es not_active Expired - Lifetime
- 2005-06-13 PL PL05751417T patent/PL1757610T3/pl unknown
- 2005-06-13 EP EP05751417A patent/EP1757610B1/de not_active Expired - Lifetime
- 2005-06-13 PT PT05751417T patent/PT1757610E/pt unknown
- 2005-06-13 WO PCT/JP2005/011188 patent/WO2005121153A1/ja not_active Ceased
-
2011
- 2011-12-16 JP JP2011276232A patent/JP5456757B2/ja not_active Expired - Fee Related
-
2013
- 2013-06-03 JP JP2013117370A patent/JP5554439B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4914210B2 (ja) | 2012-04-11 |
| JPWO2005121153A1 (ja) | 2008-04-10 |
| JP2013189460A (ja) | 2013-09-26 |
| DK1757610T3 (da) | 2011-08-01 |
| EP1757610A4 (de) | 2009-06-24 |
| WO2005121153A1 (ja) | 2005-12-22 |
| US20070293512A1 (en) | 2007-12-20 |
| EP1757610B1 (de) | 2011-06-08 |
| PL1757610T3 (pl) | 2011-10-31 |
| CN1993367A (zh) | 2007-07-04 |
| US7598254B2 (en) | 2009-10-06 |
| JP5456757B2 (ja) | 2014-04-02 |
| JP2012092128A (ja) | 2012-05-17 |
| CN1993367B (zh) | 2012-05-30 |
| JP5554439B2 (ja) | 2014-07-23 |
| EP1757610A1 (de) | 2007-02-28 |
| ES2367118T3 (es) | 2011-10-28 |
| PT1757610E (pt) | 2011-08-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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