EA200700441A1 - НОВЫЕ ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ NF-κB - Google Patents

НОВЫЕ ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ NF-κB

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EA200700441A1
EA200700441A1 EA200700441A EA200700441A EA200700441A1 EA 200700441 A1 EA200700441 A1 EA 200700441A1 EA 200700441 A EA200700441 A EA 200700441A EA 200700441 A EA200700441 A EA 200700441A EA 200700441 A1 EA200700441 A1 EA 200700441A1
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Eurasian Patent Office
Prior art keywords
independently
heteroaryl
aryl
cycloalkyl
alkyl
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EA200700441A
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EA012607B1 (ru
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Иоганн Лебан
Харальд Шмитт
Кристина Вольф
Стефано Пегораро
Андреас Вуцик
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4Сц Аг
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Priority claimed from EP04022363A external-priority patent/EP1637529A1/en
Application filed by 4Сц Аг filed Critical 4Сц Аг
Publication of EA200700441A1 publication Critical patent/EA200700441A1/ru
Publication of EA012607B1 publication Critical patent/EA012607B1/ru

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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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Abstract

Настоящее изобретение относится к соединениям общей формулы (I) и его солям и физиологически функциональным производным, где Rнезависимо представляет собой водород, алкил, циклоалкил, гидроксиалкил, галогеноалкил, галогеноалкилокси, арил, замещенный арил, гетероарил, замещенный гетероарил, арилалкил или замещенный арилалкил; Rнезависимо представляет собой -NRR, (II) или (III); Rнезависимо представляет собой алкил, циклоалкил, алкокси, алкиламин, -ОН, -SH, алкилтио, гидроксиалкил, галогеноалкил, галогеноалкилокси, арил или гетероарил; Rнезависимо представляет собой алкил, циклоалкил, алкокси, алкиламин, алкилтио, гидроксиалкил, галогеноалкил, галогеноалкилокси, арил или гетероарил; Rнезависимо представляет собой Н, COR, COR, SOR, SOR, SOR, алкил, циклоалкил, алкокси, -NH, алкиламин, -NRCOR, галоген, -ОН, -SH, алкилтио, гидроксиалкил, галогеноалкил, галогеноалкилокси, арил или гетероарил; Rнезависимо представляет собой Н, алкил, циклоалкил, -NH, алкиламин, арил или гетероарил; Rнезависимо представляет собой Н, алкил, циклоалкил, алкокси, -ОН, -SH, алкилтио, гидроксиалкил, арил или гетероарил; р равен 0 или 1; q равен 0 или 1; Х представляет собой СО или SO.
EA200700441A 2004-09-20 2005-07-29 НОВЫЕ ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ NF-κB EA012607B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04022363A EP1637529A1 (en) 2004-09-20 2004-09-20 Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof
US61279404P 2004-09-27 2004-09-27
PCT/EP2005/008261 WO2006032322A1 (en) 2004-09-20 2005-07-29 NOVEL HETEROCYCLIC NF-κB INHIBITORS

Publications (2)

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EA200700441A1 true EA200700441A1 (ru) 2007-10-26
EA012607B1 EA012607B1 (ru) 2009-10-30

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US (1) US8106048B2 (ru)
EP (1) EP1797084A1 (ru)
JP (1) JP2008513386A (ru)
CN (1) CN101031567B (ru)
AU (1) AU2005287692B2 (ru)
BR (1) BRPI0516958A (ru)
CA (1) CA2580725A1 (ru)
EA (1) EA012607B1 (ru)
MX (1) MX2007003115A (ru)
NZ (1) NZ553734A (ru)
WO (1) WO2006032322A1 (ru)

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US20100267717A1 (en) * 2005-07-29 2010-10-21 4Sc Ag Novel Heterocyclic NF-kB Inhibitors
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DE102005033103A1 (de) * 2005-07-15 2007-01-25 Bayer Healthcare Ag Heterocyclylamid-substituierte Thiazole, Pyrrole und Thiophene
TW200738701A (en) * 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
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AU2005287692A1 (en) 2006-03-30
US20080261971A1 (en) 2008-10-23
CN101031567A (zh) 2007-09-05
US8106048B2 (en) 2012-01-31
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