DK1720881T3 - 11-hydroxy-5h-(2,1-c)(1,4)benzodiazepin-5-on-derivater som nøglemellemprodukter i fremstilling afc2-substituerede pyrrolobenzodiazepiner - Google Patents

11-hydroxy-5h-(2,1-c)(1,4)benzodiazepin-5-on-derivater som nøglemellemprodukter i fremstilling afc2-substituerede pyrrolobenzodiazepiner

Info

Publication number
DK1720881T3
DK1720881T3 DK05717846.9T DK05717846T DK1720881T3 DK 1720881 T3 DK1720881 T3 DK 1720881T3 DK 05717846 T DK05717846 T DK 05717846T DK 1720881 T3 DK1720881 T3 DK 1720881T3
Authority
DK
Denmark
Prior art keywords
pyrrolobenzodiazepines
benzodiazepin
hydroxy
substituted
derivatives
Prior art date
Application number
DK05717846.9T
Other languages
English (en)
Inventor
Philip Wilson Howard
Stephen John Gregson
Original Assignee
Spirogen Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0404575A external-priority patent/GB0404575D0/en
Priority claimed from GB0426392A external-priority patent/GB0426392D0/en
Application filed by Spirogen Sarl filed Critical Spirogen Sarl
Application granted granted Critical
Publication of DK1720881T3 publication Critical patent/DK1720881T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
DK05717846.9T 2004-03-01 2005-03-01 11-hydroxy-5h-(2,1-c)(1,4)benzodiazepin-5-on-derivater som nøglemellemprodukter i fremstilling afc2-substituerede pyrrolobenzodiazepiner DK1720881T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0404575A GB0404575D0 (en) 2004-03-01 2004-03-01 Pyrrolobenzodiazepines
GB0426392A GB0426392D0 (en) 2004-12-01 2004-12-01 Pyrrolobenzodiazepines
PCT/GB2005/000768 WO2005085251A1 (en) 2004-03-01 2005-03-01 11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines

Publications (1)

Publication Number Publication Date
DK1720881T3 true DK1720881T3 (da) 2013-02-11

Family

ID=34921487

Family Applications (2)

Application Number Title Priority Date Filing Date
DK05717846.9T DK1720881T3 (da) 2004-03-01 2005-03-01 11-hydroxy-5h-(2,1-c)(1,4)benzodiazepin-5-on-derivater som nøglemellemprodukter i fremstilling afc2-substituerede pyrrolobenzodiazepiner
DK10174003.3T DK2270010T3 (da) 2004-03-01 2005-03-01 11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-derivater som vigtige mellemprodukter i fremstillingen af c2-substituerede pyrrolobenzodiazepiner

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK10174003.3T DK2270010T3 (da) 2004-03-01 2005-03-01 11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-derivater som vigtige mellemprodukter i fremstillingen af c2-substituerede pyrrolobenzodiazepiner

Country Status (13)

Country Link
US (1) US7741319B2 (da)
EP (2) EP2270010B1 (da)
JP (2) JP4909258B2 (da)
AT (1) ATE542821T1 (da)
AU (1) AU2005219626B2 (da)
CA (1) CA2558195C (da)
CY (2) CY1112541T1 (da)
DK (2) DK1720881T3 (da)
ES (2) ES2398975T3 (da)
PL (2) PL1720881T3 (da)
PT (2) PT2270010E (da)
SI (2) SI1720881T1 (da)
WO (1) WO2005085251A1 (da)

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* Cited by examiner, † Cited by third party
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PT2270010E (pt) 2012-03-12
US7741319B2 (en) 2010-06-22
CY1112541T1 (el) 2015-12-09
EP1720881A1 (en) 2006-11-15
PL1720881T3 (pl) 2013-05-31
EP1720881B8 (en) 2013-01-16
JP2011157367A (ja) 2011-08-18
CY1113782T1 (el) 2016-07-27
WO2005085251A1 (en) 2005-09-15
ATE542821T1 (de) 2012-02-15
SI2270010T1 (sl) 2012-05-31
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AU2005219626B2 (en) 2010-11-18
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CA2558195A1 (en) 2005-09-15
ES2398975T3 (es) 2013-03-25
PL2270010T3 (pl) 2012-07-31
AU2005219626A1 (en) 2005-09-15
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