GB9205051D0 - Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them - Google Patents

Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them

Info

Publication number
GB9205051D0
GB9205051D0 GB929205051A GB9205051A GB9205051D0 GB 9205051 D0 GB9205051 D0 GB 9205051D0 GB 929205051 A GB929205051 A GB 929205051A GB 9205051 A GB9205051 A GB 9205051A GB 9205051 D0 GB9205051 D0 GB 9205051D0
Authority
GB
United Kingdom
Prior art keywords
preparation
compositions containing
pyrrolobenzodiazepine derivatives
pyrrolobenzodiazepine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB929205051A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Campaign Technology Ltd
Original Assignee
Cancer Research Campaign Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Campaign Technology Ltd filed Critical Cancer Research Campaign Technology Ltd
Priority to GB929205051A priority Critical patent/GB9205051D0/en
Publication of GB9205051D0 publication Critical patent/GB9205051D0/en
Priority to AU36435/93A priority patent/AU3643593A/en
Priority to PCT/GB1993/000483 priority patent/WO1993018045A1/en
Priority to ZA931637A priority patent/ZA931637B/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
GB929205051A 1992-03-09 1992-03-09 Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them Pending GB9205051D0 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB929205051A GB9205051D0 (en) 1992-03-09 1992-03-09 Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them
AU36435/93A AU3643593A (en) 1992-03-09 1993-03-08 Anti-cancer pyrrolobenzodiazepine derivatives
PCT/GB1993/000483 WO1993018045A1 (en) 1992-03-09 1993-03-08 Anti-cancer pyrrolobenzodiazepine derivatives
ZA931637A ZA931637B (en) 1992-03-09 1993-03-08 Pyrrolobenzodiazepine derivatives, their preparation and compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929205051A GB9205051D0 (en) 1992-03-09 1992-03-09 Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them

Publications (1)

Publication Number Publication Date
GB9205051D0 true GB9205051D0 (en) 1992-04-22

Family

ID=10711735

Family Applications (1)

Application Number Title Priority Date Filing Date
GB929205051A Pending GB9205051D0 (en) 1992-03-09 1992-03-09 Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them

Country Status (3)

Country Link
GB (1) GB9205051D0 (en)
WO (1) WO1993018045A1 (en)
ZA (1) ZA931637B (en)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2341471C (en) 1998-08-27 2009-04-07 Spirogen Limited Pyrrolbenzodiazepines
GB9818731D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Compounds
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
US6362331B1 (en) 2001-03-30 2002-03-26 Council Of Scientific And Industrial Research Process for the preparation of antitumor agents
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
WO2004087716A1 (en) * 2003-03-31 2004-10-14 Council Of Scientific And Industrial Research Pyrrolo[(2,1-c)(1,4) benzodiazepines dimers as antitumour agents and process thereof
EP1608664B1 (en) * 2003-03-31 2009-01-28 Council of Scientific and Industrial Research Non-cross-linking pyrrolo[2,1-c][1,4]benzodiazepines as potential antitumour agents and process thereof
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
GB0416511D0 (en) 2003-10-22 2004-08-25 Spirogen Ltd Pyrrolobenzodiazepines
US7511032B2 (en) 2003-10-22 2009-03-31 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
AU2003300705A1 (en) * 2003-12-31 2005-07-21 Council Of Scientific And Industrial Research C2-fluoro pyrrolo(2,1-c)(1,4)benzodiazepine dimers
AU2005219626B2 (en) 2004-03-01 2010-11-18 Medimmune Limited 11-hydroxy-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of C2 substituted pyrrolobenzodiazepines
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
WO2005085260A1 (en) * 2004-03-09 2005-09-15 Spirogen Limited Pyrrolobenzodiazepines
US7189710B2 (en) 2004-03-30 2007-03-13 Council Of Scientific And Industrial Research C2-fluoro pyrrolo [2,1−c][1,4]benzodiazepine dimers
GB0410725D0 (en) * 2004-05-13 2004-06-16 Spirogen Ltd Pyrrolobenzodiazepine therapeutic agents
MX2007013039A (en) 2005-04-21 2008-03-13 Spirogen Ltd Pyrrolobenzodiazepines.
CA2645350C (en) * 2006-03-10 2014-09-09 Council Of Scientific And Industrial Research Novel bis-2-difluoro-pyrrolo[2,1-c][1,4]benzodiazepine dimmers
EP2188297B1 (en) * 2007-08-01 2012-02-01 Council of Scientific & Industrial Research Pyrrolo [2,1-c][1, 4] benzodiazepine-glycoside prodrugs useful as a selective anti tumor agent
GB0813432D0 (en) 2008-07-22 2008-08-27 Spirogen Ltd Pyrrolobenzodiazepines
GB0819097D0 (en) * 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
CA3014224C (en) * 2009-02-05 2022-05-24 Immunogen, Inc. Condensed benzodiazepine-indoline derivatives and processes to prepare said derivatives
FR2949469A1 (en) * 2009-08-25 2011-03-04 Sanofi Aventis ANTICANCER DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
AU2011239522B2 (en) 2010-04-15 2014-10-23 Medimmune Limited Targeted pyrrolobenzodiazapine conjugates
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
EP2789622B1 (en) 2010-04-15 2017-03-01 MedImmune Limited Pyrrolobenzodiazepines used to treat proliferative diseases
SG191955A1 (en) 2011-02-15 2013-08-30 Immunogen Inc Cytotoxic benzodiazepine derivatives
US9399641B2 (en) 2011-09-20 2016-07-26 Medimmune Limited Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates
EA028457B1 (en) 2011-10-14 2017-11-30 Медимьюн Лимитед Pyrrolobenzodiazepines
ES2687246T3 (en) 2011-10-14 2018-10-24 Seattle Genetics, Inc. Pyrrolobenzodiazepines and directed conjugates
AU2012322613B2 (en) 2011-10-14 2016-04-21 Medimmune Limited Pyrrolobenzodiazepines and targeted conjugates
CN103998449A (en) 2011-10-14 2014-08-20 斯皮罗根有限公司 Pyrrolobenzodiazepines
EA029046B1 (en) 2011-10-14 2018-02-28 Медимьюн Лимитед Pyrrolobenzodiazepines and intermediates for the preparation thereof, synthesis methods thereof
DK2906296T3 (en) 2012-10-12 2018-05-22 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
ES2660029T3 (en) 2012-10-12 2018-03-20 Medimmune Limited Antibody-pyrrolobenzodiazepine conjugates
BR112015008173A2 (en) 2012-10-12 2017-11-28 Adc Therapeutics Sarl pyrrolobenzodiazepine-anti-psma antibody conjugates
SI2906251T1 (en) 2012-10-12 2018-01-31 Adc Therapeutics Sa Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
EP2906250B1 (en) 2012-10-12 2018-05-30 ADC Therapeutics SA Pyrrolobenzodiazepine-anti-psma antibody conjugates
WO2014057072A1 (en) 2012-10-12 2014-04-17 Spirogen Sàrl Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
CN105050661B (en) 2012-10-12 2018-03-30 Adc疗法责任有限公司 Pyrrolobenzodiazepines Zhuo antibody conjugates
HUE045435T2 (en) 2012-10-12 2019-12-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
HUE052835T2 (en) 2012-10-12 2021-05-28 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
EP3054985B1 (en) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
WO2015052532A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
WO2015052535A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201407816D0 (en) * 2014-05-02 2014-06-18 King S College London Pyrrolobenzodiazepine Compounds
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
BR112017011111A2 (en) 2014-11-25 2017-12-26 Adc Therapeutics Sa pyrrolobenzodiazepine-antibody conjugates
US9504694B2 (en) 2015-03-19 2016-11-29 Cellerant Therapeutics, Inc. Isoquinolidinobenzodiazepines
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
EP3325485B1 (en) 2015-07-21 2020-04-08 ImmunoGen, Inc. Methods of preparing cytotoxic benzodiazepine derivatives
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
JP2019530707A (en) 2016-10-10 2019-10-24 セレラント セラピューティクス インコーポレイテッド Isoquinolidinobenzodiazepine (IQB) -1 (chloromethyl) -2,3-dihydro-1H-benzo [E] indole (CBI) dimer
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
US10398783B2 (en) 2016-10-20 2019-09-03 Bristol-Myers Squibb Company Antiproliferative compounds and conjugates made therefrom
DK3544636T3 (en) 2017-02-08 2021-05-10 Adc Therapeutics Sa Pyrrolobenzodiazepine antibody conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
DK3612537T3 (en) 2017-04-18 2022-08-08 Medimmune Ltd PYRROLOBENZODIAZEPIN CONJUGATES
CA3057748A1 (en) 2017-04-20 2018-10-25 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
KR102442736B1 (en) 2017-06-14 2022-09-16 에이디씨 테라퓨틱스 에스에이 Dosage regime for administration of anti-CD19 ADCs
KR102312910B1 (en) 2017-08-18 2021-10-15 메디뮨 리미티드 Pyrrolobenzodiazepine conjugates
BR112020004126A2 (en) 2017-09-29 2020-09-08 Daiichi Sankyo Company, Limited antibody-derived pyrrolbenzodiazepine conjugate
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof

Also Published As

Publication number Publication date
ZA931637B (en) 1993-10-04
WO1993018045A1 (en) 1993-09-16

Similar Documents

Publication Publication Date Title
ZA931637B (en) Pyrrolobenzodiazepine derivatives, their preparation and compositions containing them
IL106904A (en) Pyridylamino- ethoxybenzyl- thiazolidine-2, 4-dione derivatives, their preparation and pharmaceutical compositions containing them
IL106141A0 (en) Thiazolylvinylphenyl derivatives,their manufacture and pharmaceutical compositions containing them
IL112384A0 (en) Tetracyclic derivatives, their preparation and pharmaceutical compositions containing them
IL99225A0 (en) 3-amidopyrazole derivatives,their preparation and pharmaceutical compositions containing them
IL111314A0 (en) Indole derivatives, their preparation and pharmaceutical compositions containing them
IL105412A0 (en) Indole derivatives,their preparation and pharmaceutical compositions containing them
IL101864A0 (en) Thiopyranopyrrole derivatives,their preparation and pharmaceutical compositions containing them
ZA937321B (en) Taxol derivatives their preparation and compositions containing them
IL110946A0 (en) 3-aryl-4-hydroxy- delta3- dihydrofuranone derivatives their preparation and pesticidal compositions containing them
IL104703A0 (en) Benzimidazolyl derivatives,their preparation and pharmaceutical compositions containing them
IL100262A0 (en) Alpha-oxoacetamide derivatives,their preparation and pharmaceutical compositions containing them
IL109234A0 (en) Indole derivatives, their preparation and pharmaceutical compositions containing them
IL108859A0 (en) Indole derivatives, their preparation and pharmaceutical compositions containing them
IL97050A0 (en) 4-isoxazolecarboxamide derivatives,pharmaceutical compositions containing them and their preparation
IL98542A0 (en) Benzoquinazoline derivatives,their preparation and pharmaceutical compositions containing them
IL110980A0 (en) Indole derivatives, their preparation and pharmaceutical compositions containing them
IL111294A0 (en) Indole derivatives, their preparation and pharmaceutical compositions containing them
IL108636A0 (en) Polysubstitued 2-amino-thiazole derivatives, their preparation and pharmaceutical compositions containing them
IL108703A0 (en) Substituted azolone derivatives, their preparation and pharmaceutical compositions containing them
IL109073A0 (en) Amidine derivatives, their preparation and pharmaceutical compositions containing them
IL103502A0 (en) Benzodiazepine derivatives,their preparation and pharmaceutical compositions containing them
IL102500A0 (en) 3-deoxy-mannosamine derivatives,their preparation and pharmaceutical compositions containing them
IL105774A0 (en) Thienothiazine derivatives,their preparation and pharmaceutical compositions containing them
IL106549A0 (en) Heterocyclic derivatives,their preparation and pharmaceutical compositions containing them