ZA931637B - Pyrrolobenzodiazepine derivatives, their preparation and compositions containing them - Google Patents

Pyrrolobenzodiazepine derivatives, their preparation and compositions containing them

Info

Publication number
ZA931637B
ZA931637B ZA931637A ZA931637A ZA931637B ZA 931637 B ZA931637 B ZA 931637B ZA 931637 A ZA931637 A ZA 931637A ZA 931637 A ZA931637 A ZA 931637A ZA 931637 B ZA931637 B ZA 931637B
Authority
ZA
South Africa
Prior art keywords
preparation
compositions containing
pyrrolobenzodiazepine derivatives
pyrrolobenzodiazepine
derivatives
Prior art date
Application number
ZA931637A
Inventor
David Edwin Thurston
Deverakonda Subhas Bose
Original Assignee
Cancer Res Campaign Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Res Campaign Tech filed Critical Cancer Res Campaign Tech
Publication of ZA931637B publication Critical patent/ZA931637B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA931637A 1992-03-09 1993-03-08 Pyrrolobenzodiazepine derivatives, their preparation and compositions containing them ZA931637B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929205051A GB9205051D0 (en) 1992-03-09 1992-03-09 Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them

Publications (1)

Publication Number Publication Date
ZA931637B true ZA931637B (en) 1993-10-04

Family

ID=10711735

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA931637A ZA931637B (en) 1992-03-09 1993-03-08 Pyrrolobenzodiazepine derivatives, their preparation and compositions containing them

Country Status (3)

Country Link
GB (1) GB9205051D0 (en)
WO (1) WO1993018045A1 (en)
ZA (1) ZA931637B (en)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
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GB9818731D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Compounds
US6362331B1 (en) 2001-03-30 2002-03-26 Council Of Scientific And Industrial Research Process for the preparation of antitumor agents
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
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ATE421967T1 (en) * 2003-03-31 2009-02-15 Council Scient Ind Res NON-CROSS-LINKING PYRROLOÄ2,1-CÜÄ1, 4ÜBENZODIAZEPINES AS POTENTIAL ANTITUMOR AGENTS AND THEIR PRODUCTION
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
GB0416511D0 (en) 2003-10-22 2004-08-25 Spirogen Ltd Pyrrolobenzodiazepines
ATE516288T1 (en) 2003-10-22 2011-07-15 Us Gov Health & Human Serv PYRROLOBENZODIAZEPINE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND RELATED METHODS
AU2003300705A1 (en) * 2003-12-31 2005-07-21 Council Of Scientific And Industrial Research C2-fluoro pyrrolo(2,1-c)(1,4)benzodiazepine dimers
CA2558195C (en) 2004-03-01 2012-11-06 Spirogen Limited 11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
EP1723152B1 (en) * 2004-03-09 2015-02-11 Spirogen Sàrl Pyrrolobenzodiazepines
US7189710B2 (en) 2004-03-30 2007-03-13 Council Of Scientific And Industrial Research C2-fluoro pyrrolo [2,1−c][1,4]benzodiazepine dimers
GB0410725D0 (en) * 2004-05-13 2004-06-16 Spirogen Ltd Pyrrolobenzodiazepine therapeutic agents
CA2604805C (en) 2005-04-21 2014-05-27 Spirogen Limited Pyrrolobenzodiazepines
ATE492550T1 (en) * 2006-03-10 2011-01-15 Council Scient Ind Res NEW BIS-2-DIFLUORPYRROLOÄ2,1-CÜÄ1, 4ÜBENZODIAZEPINEDIMERS
WO2009016647A1 (en) * 2007-08-01 2009-02-05 Council Of Scientific & Industrial Research Pyrrolo [2,1-c][1, 4] benzodiazepine-glycoside prodrugs useful as a selective anti tumor agent
GB0813432D0 (en) 2008-07-22 2008-08-27 Spirogen Ltd Pyrrolobenzodiazepines
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
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FR2949469A1 (en) * 2009-08-25 2011-03-04 Sanofi Aventis ANTICANCER DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
US9242013B2 (en) 2010-04-15 2016-01-26 Seattle Genetics Inc. Targeted pyrrolobenzodiazapine conjugates
EP2558475A1 (en) * 2010-04-15 2013-02-20 Spirogen Sàrl Pyrrolobenzodiazepines used to treat proliferative diseases
PL2675479T3 (en) 2011-02-15 2016-09-30 Cytotoxic benzodiazepine derivatives
KR101860174B1 (en) 2011-09-20 2018-05-21 메디뮨 리미티드 Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates
US9399073B2 (en) 2011-10-14 2016-07-26 Seattle Genetics, Inc. Pyrrolobenzodiazepines
US9526798B2 (en) 2011-10-14 2016-12-27 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
CN110183470A (en) 2011-10-14 2019-08-30 麦迪穆有限责任公司 Pyrrolobenzodiazepines are tall and erect
CN104011018B (en) 2011-10-14 2016-12-14 麦迪穆有限责任公司 Can be used for preparing the tall and erect synthetic method of Pyrrolobenzodiazepines and intermediate
BR112014009055B1 (en) 2011-10-14 2021-12-14 Seattle Genetics, Inc. PYRROLOBENZODIAZEPINE COMPOUNDS, TARGET CONJUGATES, DRUG BINDING AND USE OF SAID CONJUGATES TO TREAT A PROLIFERATIVE DISEASE
CN105102068B (en) 2012-10-12 2018-06-01 Adc疗法责任有限公司 Pyrrolobenzodiazepines Zhuo-antibody conjugates
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PL2906253T3 (en) 2012-10-12 2019-02-28 Adc Therapeutics Sa Pyrrolobenzodiazepine - anti-psma antibody conjugates
CA2885315C (en) 2012-10-12 2020-06-23 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
KR101819404B1 (en) 2012-10-12 2018-02-28 메디뮨 리미티드 Pyrrolobenzodiazepines and conjugates thereof
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AU2013328628B2 (en) 2012-10-12 2016-12-15 Adc Therapeutics Sa Pyrrolobenzodiazepine-anti-CD22 antibody conjugates
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GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201407816D0 (en) * 2014-05-02 2014-06-18 King S College London Pyrrolobenzodiazepine Compounds
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GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
KR20190075084A (en) 2016-10-10 2019-06-28 셀러랜트 세라퓨틱스 인코퍼레이티드 (IQB) -1- (chloromethyl) -2,3-dihydro-1H-benzo [E] indole (CBI) dimer
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
US10398783B2 (en) 2016-10-20 2019-09-03 Bristol-Myers Squibb Company Antiproliferative compounds and conjugates made therefrom
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
PL3544636T3 (en) 2017-02-08 2021-12-06 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
RS63502B1 (en) 2017-04-18 2022-09-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
CA3057748A1 (en) 2017-04-20 2018-10-25 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
US11318211B2 (en) 2017-06-14 2022-05-03 Adc Therapeutics Sa Dosage regimes for the administration of an anti-CD19 ADC
NZ761175A (en) 2017-08-18 2024-07-26 Medimmune Ltd Pyrrolobenzodiazepine conjugates
KR20200061376A (en) 2017-09-29 2020-06-02 다이이찌 산쿄 가부시키가이샤 Antibody-pyrrolobenzodiazepine derivative conjugate
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof

Also Published As

Publication number Publication date
GB9205051D0 (en) 1992-04-22
WO1993018045A1 (en) 1993-09-16

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