EA200401077A1 - 2-оксазоламины и их применение в качестве антагонистов рецептора 5-ht2b - Google Patents

2-оксазоламины и их применение в качестве антагонистов рецептора 5-ht2b

Info

Publication number
EA200401077A1
EA200401077A1 EA200401077A EA200401077A EA200401077A1 EA 200401077 A1 EA200401077 A1 EA 200401077A1 EA 200401077 A EA200401077 A EA 200401077A EA 200401077 A EA200401077 A EA 200401077A EA 200401077 A1 EA200401077 A1 EA 200401077A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
possibly substituted
cycloalkyl
compounds
independently selected
Prior art date
Application number
EA200401077A
Other languages
English (en)
Inventor
Александер Вильям Оксфорд
Ричард Антони Борман
Роберт Александер Колеман
Кенет Лайл Кларк
Джордж Хинд
Джанет Энн Арчер
Аманда Алей
Нейл Виктор Харрис
Original Assignee
Фармажен Лабораториз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармажен Лабораториз Лимитед filed Critical Фармажен Лабораториз Лимитед
Publication of EA200401077A1 publication Critical patent/EA200401077A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/48—Nitrogen atoms not forming part of a nitro radical

Abstract

Настоящее изобретение относится к соединениям формулы Iили его фармацевтически приемлемым солям, где один из заместителей Rи Rвыбран из группы, состоящей из H, а также возможно замещенного алкила C, циклоалкила C, циклоалкила C-алкила Cи фенила-алкила C;и другой из Rи Rпредставляет собой возможно замещенную арильную группу C;Rи Rили:(i) независимо выбраны из H, R, R', SOR, C(=O)R, (CH)NRR, где n принимает значения от 1 до 4 и Rи Rнезависимо выбраны из H и R, где R представляет собой возможно замещенный алкил Cи R' представляет собой возможно замещенный фенил-алкил C, или(ii) совместно с атомом азота, к которому они присоединены, образуют возможно замещенную гетероциклическую группу C,и применению указанных соединений в качестве лекарственных составов, в частности для лечения состояний, протекание которых облегчается при антагонистическом воздействии на 5-HTрецептор.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401077A 2002-02-13 2003-02-11 2-оксазоламины и их применение в качестве антагонистов рецептора 5-ht2b EA200401077A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0203412.2A GB0203412D0 (en) 2002-02-13 2002-02-13 5-HT 2B receptor antagonists
PCT/GB2003/000552 WO2003068226A1 (en) 2002-02-13 2003-02-11 2-oxazolamines and their use as 5-ht2b receptor antagonists

Publications (1)

Publication Number Publication Date
EA200401077A1 true EA200401077A1 (ru) 2005-06-30

Family

ID=9930999

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401077A EA200401077A1 (ru) 2002-02-13 2003-02-11 2-оксазоламины и их применение в качестве антагонистов рецептора 5-ht2b

Country Status (17)

Country Link
US (1) US7429607B2 (ru)
EP (1) EP1474140B1 (ru)
JP (1) JP4439266B2 (ru)
KR (1) KR20040084905A (ru)
CN (1) CN1633291A (ru)
AU (1) AU2003207297B2 (ru)
CA (1) CA2472762A1 (ru)
DE (1) DE60317632T2 (ru)
EA (1) EA200401077A1 (ru)
GB (1) GB0203412D0 (ru)
IL (1) IL163110A (ru)
MX (1) MXPA04007738A (ru)
NO (1) NO327465B1 (ru)
NZ (1) NZ534539A (ru)
PL (1) PL370221A1 (ru)
WO (1) WO2003068226A1 (ru)
ZA (1) ZA200406010B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050176791A1 (en) * 2002-02-13 2005-08-11 Oxford Alexander W. 5-HT2B receptor antagonists
WO2005012263A1 (en) * 2003-07-24 2005-02-10 Pharmagene Laboratories Limited 5-ht2b receptor antagonists
US20080161419A1 (en) 2004-02-20 2008-07-03 Shinobu Akuzawa Prophylactic Antimigraine Agents
SE0400850D0 (sv) * 2004-03-30 2004-03-31 Astrazeneca Ab Novel Compounds
WO2005097113A2 (en) * 2004-04-08 2005-10-20 Pharmagene Laboratories Limited 5-ht2b receptor antagonists
US8877933B2 (en) 2004-09-29 2014-11-04 Bayer Intellectual Property Gmbh Thermodynamically stable form of a tosylate salt
WO2014085413A1 (en) * 2012-11-28 2014-06-05 Temple University - Of The Commonwealth System Of Higher Education Disubstituted oxazolidin-2-ones 5-hydroxytryptamine receptor 2b activity modulators
KR101592068B1 (ko) 2013-11-08 2016-02-05 순천향대학교 산학협력단 플라즈마 아포리포프로테인 h를 포함하는 아스피린 과민성 호흡계 질환 및 아스피린 내성 천식 구별 진단용 마커 및 구별 진단용 키트

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0658559A1 (de) * 1993-12-14 1995-06-21 Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren
JPH09510216A (ja) 1994-03-11 1997-10-14 イーライ・リリー・アンド・カンパニー ５−ｈｔ▲下２ｂ▼受容体に関連する病態を治療するための方法
US5663178A (en) 1995-02-06 1997-09-02 Eli Lilly And Company Tetrahydro-beta carbolines
ATE227710T1 (de) * 1996-04-03 2002-11-15 Takeda Chemical Industries Ltd Oxazole derivate,ihre herstellung und verwendung
US5952331A (en) 1996-05-23 1999-09-14 Syntex (Usa) Inc. Aryl pyrimidine derivatives
US5958934A (en) 1996-05-23 1999-09-28 Syntex (U.S.A.) Inc. Aryl pyrimidine derivatives and uses thereof
TW440563B (en) * 1996-05-23 2001-06-16 Hoffmann La Roche Aryl pyrimidine derivatives and a pharmaceutical composition thereof
WO2000023444A1 (en) * 1998-10-21 2000-04-27 Abbott Laboratories 5,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds
EP1200093B1 (en) 1999-07-30 2003-09-24 Pharmagene Laboratories Ltd Use of 2-amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine in the treatment of gi disorders
AR035016A1 (es) * 1999-08-25 2004-04-14 Takeda Chemical Industries Ltd Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.

Also Published As

Publication number Publication date
AU2003207297A2 (en) 2003-09-04
AU2003207297A1 (en) 2003-09-04
GB0203412D0 (en) 2002-04-03
ZA200406010B (en) 2005-06-08
US20040010022A1 (en) 2004-01-15
NO327465B1 (no) 2009-07-06
NZ534539A (en) 2006-02-24
JP2005528341A (ja) 2005-09-22
MXPA04007738A (es) 2004-10-15
US7429607B2 (en) 2008-09-30
DE60317632D1 (de) 2008-01-03
WO2003068226A1 (en) 2003-08-21
JP4439266B2 (ja) 2010-03-24
DE60317632T2 (de) 2008-10-30
EP1474140B1 (en) 2007-11-21
EP1474140A1 (en) 2004-11-10
PL370221A1 (en) 2005-05-16
CN1633291A (zh) 2005-06-29
IL163110A (en) 2010-12-30
NO20043799L (no) 2004-09-10
KR20040084905A (ko) 2004-10-06
AU2003207297B2 (en) 2008-11-06
CA2472762A1 (en) 2003-08-21

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