IL33558A - Antibiotic pyrrolo-benzodiazepine compound,its derivatives and processes for their production - Google Patents

Antibiotic pyrrolo-benzodiazepine compound,its derivatives and processes for their production

Info

Publication number
IL33558A
IL33558A IL33558A IL3355869A IL33558A IL 33558 A IL33558 A IL 33558A IL 33558 A IL33558 A IL 33558A IL 3355869 A IL3355869 A IL 3355869A IL 33558 A IL33558 A IL 33558A
Authority
IL
Israel
Prior art keywords
pyrrolo
antibiotic
derivatives
processes
production
Prior art date
Application number
IL33558A
Other versions
IL33558A0 (en
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP44050780A external-priority patent/JPS4843755B1/ja
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of IL33558A0 publication Critical patent/IL33558A0/en
Publication of IL33558A publication Critical patent/IL33558A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL33558A 1968-12-30 1969-12-17 Antibiotic pyrrolo-benzodiazepine compound,its derivatives and processes for their production IL33558A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8368 1968-12-30
JP44050780A JPS4843755B1 (en) 1969-06-26 1969-06-26

Publications (2)

Publication Number Publication Date
IL33558A0 IL33558A0 (en) 1970-04-20
IL33558A true IL33558A (en) 1973-10-25

Family

ID=26332992

Family Applications (1)

Application Number Title Priority Date Filing Date
IL33558A IL33558A (en) 1968-12-30 1969-12-17 Antibiotic pyrrolo-benzodiazepine compound,its derivatives and processes for their production

Country Status (6)

Country Link
ES (1) ES375013A1 (en)
FI (1) FI46259C (en)
GB (1) GB1299198A (en)
IE (1) IE33906B1 (en)
IL (1) IL33558A (en)
RO (1) RO55813A (en)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464467A (en) * 1982-07-26 1984-08-07 Bristol-Myers Company Antitumor antibiotics produced by new streptomyces
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
GB9818732D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collection of compounds
ES2260570T3 (en) * 1998-08-27 2006-11-01 Spirogen Limited PIRROLOBENZIODIAZEPINAS DIMERICAS.
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
WO2005085251A1 (en) 2004-03-01 2005-09-15 Spirogen Limited 11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazepin-5-one derivatives as key intermediates for the preparation of c2 substituted pyrrolobenzodiazepines
US7528126B2 (en) 2004-03-09 2009-05-05 Spirogen Limited Pyrrolobenzodiazepines
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
JP5875083B2 (en) 2010-04-15 2016-03-02 メディミューン リミテッド Pyrrolobenzodiazepine for the treatment of proliferative diseases
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
EP4039280A1 (en) 2010-04-15 2022-08-10 Seagen Inc. Targeted pyrrolobenzodiazepine conjugates
EP2751120B1 (en) 2011-09-20 2018-08-22 MedImmune Limited Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates
EP2751076B1 (en) 2011-10-14 2018-04-25 MedImmune Limited Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines
WO2013055993A1 (en) 2011-10-14 2013-04-18 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
WO2013053873A1 (en) 2011-10-14 2013-04-18 Spirogen Sàrl Pyrrolobenzodiazepines
WO2013053871A1 (en) 2011-10-14 2013-04-18 Spirogen Sàrl Pyrrolobenzodiazepines
CN103987384A (en) 2011-10-14 2014-08-13 西雅图基因公司 Pyrrolobenzodiazepines and targeted conjugates
MX364326B (en) 2012-10-12 2019-04-23 Medimmune Ltd Pyrrolobenzodiazepine - anti-psma antibody conjugates.
MX364328B (en) 2012-10-12 2019-04-23 Medimmune Ltd Pyrrolobenzodiazepine-antibody conjugates.
WO2014057074A1 (en) 2012-10-12 2014-04-17 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
US10736903B2 (en) 2012-10-12 2020-08-11 Medimmune Limited Pyrrolobenzodiazepine-anti-PSMA antibody conjugates
EP2906249B1 (en) 2012-10-12 2018-06-27 MedImmune Limited Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
RS56520B1 (en) 2012-10-12 2018-02-28 Adc Therapeutics Sa Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
KR20200003278A (en) 2012-10-12 2020-01-08 메디뮨 리미티드 Pyrrolobenzodiazepines and conjugates thereof
EP2906297B1 (en) 2012-10-12 2017-12-06 ADC Therapeutics SA Pyrrolobenzodiazepine-antibody conjugates
DK2906298T3 (en) 2012-10-12 2018-12-17 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
US10010624B2 (en) 2013-10-11 2018-07-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
WO2015052534A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
US9956299B2 (en) 2013-10-11 2018-05-01 Medimmune Limited Pyrrolobenzodiazepine—antibody conjugates
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
AU2015352545B2 (en) 2014-11-25 2020-10-15 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
US11160872B2 (en) 2017-02-08 2021-11-02 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
DK3612537T3 (en) 2017-04-18 2022-08-08 Medimmune Ltd PYRROLOBENZODIAZEPIN CONJUGATES
KR20190141666A (en) 2017-04-20 2019-12-24 에이디씨 테라퓨틱스 에스에이 Combination Therapy with Anti-AXL Antibody-Drug Conjugates
JP7145891B2 (en) 2017-06-14 2022-10-03 アーデーセー セラピューティクス ソシエテ アノニム Dosing Regimens for Administering Anti-CD19 ADCs
SG11202000358YA (en) 2017-08-18 2020-02-27 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
SG11202108900WA (en) 2019-03-15 2021-09-29 Medimmune Ltd Azetidobenzodiazepine dimers and conjugates comprising them for use in the treatment of cancer

Also Published As

Publication number Publication date
ES375013A1 (en) 1972-03-01
IE33906B1 (en) 1974-12-11
IE33906L (en) 1970-06-30
FI46259B (en) 1972-10-31
FI46259C (en) 1973-02-12
GB1299198A (en) 1972-12-06
IL33558A0 (en) 1970-04-20
RO55813A (en) 1974-02-01

Similar Documents

Publication Publication Date Title
IL33558A (en) Antibiotic pyrrolo-benzodiazepine compound,its derivatives and processes for their production
ZA703207B (en) Antibiotic compounds and process for preparing the same
PH12529A (en) Antibiotic a168861,a1688611,salts thereof and process for preparing same
ZA714274B (en) New triazine derivatives,processes for their production,and their use
CA988081A (en) Antibiotic derivatives
ZA698792B (en) Novel antibiotic and derivatives and production thereof
CA921412A (en) Antibiotic aabomycin-a and process for preparing the same
CA931515A (en) Antibiotic 66-40 and methods for its production
CA941323A (en) Antibiotic cochliodinol and production by chaetomium
PH10699A (en) 2-iminobenzodiazepine derivatives and process for their production
CA801006A (en) N-cyanoaziridines, n-cyanoimines and process for their production
ZA718136B (en) New imidazolidinone derivatives and processes for their production
AU417129B2 (en) Benzyl-hexamethylene-tetrammonium compounds and process for their production
CA682223A (en) Isourea derivatives and processes for their production
MTP578B (en) Antibiotic purificator process
AU450921B2 (en) New triazine derivatives, processes for their production, and their use
CA859756A (en) Naphthyridene derivatives and processes for their production
AU446917B2 (en) Antibacterial compositions and processes for their production
AU436229B2 (en) Erythromycin derivatives
CA793335A (en) Thioepichlorohydrin production
AU5709969A (en) Benzyl-hexamethylene-tetrammonium compounds and process for their production
CA780404A (en) Antibiotic substance and production thereof
CA782571A (en) Antibiotic
CA798859A (en) Polybasic compounds and processes for their production
AU436536B2 (en) 1-formyl-2-halogen-azacycloalkenes and process for their production