IL33558A0 - New antibiotic pirrolobenzodiazepine compounds,its derivatives and processes for their production - Google Patents
New antibiotic pirrolobenzodiazepine compounds,its derivatives and processes for their productionInfo
- Publication number
- IL33558A0 IL33558A0 IL33558A IL3355869A IL33558A0 IL 33558 A0 IL33558 A0 IL 33558A0 IL 33558 A IL33558 A IL 33558A IL 3355869 A IL3355869 A IL 3355869A IL 33558 A0 IL33558 A0 IL 33558A0
- Authority
- IL
- Israel
- Prior art keywords
- pirrolobenzodiazepine
- derivatives
- compounds
- processes
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8368 | 1968-12-30 | ||
JP44050780A JPS4843755B1 (en) | 1969-06-26 | 1969-06-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL33558A0 true IL33558A0 (en) | 1970-04-20 |
IL33558A IL33558A (en) | 1973-10-25 |
Family
ID=26332992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL33558A IL33558A (en) | 1968-12-30 | 1969-12-17 | Antibiotic pyrrolo-benzodiazepine compound,its derivatives and processes for their production |
Country Status (6)
Country | Link |
---|---|
ES (1) | ES375013A1 (en) |
FI (1) | FI46259C (en) |
GB (1) | GB1299198A (en) |
IE (1) | IE33906B1 (en) |
IL (1) | IL33558A (en) |
RO (1) | RO55813A (en) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4464467A (en) * | 1982-07-26 | 1984-08-07 | Bristol-Myers Company | Antitumor antibiotics produced by new streptomyces |
GB9818732D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collection of compounds |
ATE294803T1 (en) | 1998-08-27 | 2005-05-15 | Spirogen Ltd | PYRROLOBENZODIAZEPINES |
GB9818730D0 (en) | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collections of compounds |
US6909006B1 (en) | 1999-08-27 | 2005-06-21 | Spirogen Limited | Cyclopropylindole derivatives |
GB0226593D0 (en) | 2002-11-14 | 2002-12-24 | Consultants Ltd | Compounds |
GB0321295D0 (en) | 2003-09-11 | 2003-10-15 | Spirogen Ltd | Synthesis of protected pyrrolobenzodiazepines |
GB0404577D0 (en) | 2004-03-01 | 2004-04-07 | Spirogen Ltd | Pyrrolobenzodiazepines |
DK2270010T3 (en) | 2004-03-01 | 2012-05-14 | Spirogen Ltd | 11-Hydroxy-5h-pyrrolo [2,1-c] [1,4] benzodiazepin-5-one derivatives as important intermediates in the preparation of c2-substituted pyrrolobenzodiazepines |
EP1723152B1 (en) | 2004-03-09 | 2015-02-11 | Spirogen Sàrl | Pyrrolobenzodiazepines |
GB0819095D0 (en) | 2008-10-17 | 2008-11-26 | Spirogen Ltd | Pyrrolobenzodiazepines |
US8697688B2 (en) | 2010-04-15 | 2014-04-15 | Seattle Genetics Inc. | Pyrrolobenzodiazepines used to treat proliferative diseases |
WO2011130613A1 (en) | 2010-04-15 | 2011-10-20 | Seattle Genetics, Inc. | Targeted pyrrolobenzodiazapine conjugates |
GB201006340D0 (en) | 2010-04-15 | 2010-06-02 | Spirogen Ltd | Synthesis method and intermediates |
AU2012311505B2 (en) | 2011-09-20 | 2016-09-29 | Medimmune Limited | Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates |
AU2012322613B2 (en) | 2011-10-14 | 2016-04-21 | Medimmune Limited | Pyrrolobenzodiazepines and targeted conjugates |
AU2012322933B2 (en) | 2011-10-14 | 2017-02-02 | Medimmune Limited | Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines |
US9388187B2 (en) | 2011-10-14 | 2016-07-12 | Medimmune Limited | Pyrrolobenzodiazepines |
CN108164551A (en) | 2011-10-14 | 2018-06-15 | 西雅图基因公司 | Pyrrolobenzodiazepines Zhuo and targeting conjugate |
AU2012322934B2 (en) | 2011-10-14 | 2016-09-08 | Medimmune Limited | Pyrrolobenzodiazepines |
CN110256469B (en) | 2012-10-12 | 2022-05-17 | 麦迪穆有限责任公司 | Pyrrolobenzodiazepines and conjugates thereof |
ES2680153T3 (en) | 2012-10-12 | 2018-09-04 | Adc Therapeutics Sa | Anti-PSMA-pyrrolobenzodiazepine antibody conjugates |
NZ707543A (en) | 2012-10-12 | 2018-09-28 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
AU2013328623B8 (en) | 2012-10-12 | 2017-06-15 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
US10695433B2 (en) | 2012-10-12 | 2020-06-30 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
SI2906253T1 (en) | 2012-10-12 | 2018-11-30 | Adc Therapeutics Sa | Pyrrolobenzodiazepine - anti-psma antibody conjugates |
ES2649990T3 (en) | 2012-10-12 | 2018-01-16 | Medimmune Limited | Anti-CD22-pyrrolobenzodiazepine antibody conjugates |
ES2530968T3 (en) | 2012-10-12 | 2015-03-09 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
CA2885305C (en) | 2012-10-12 | 2019-11-12 | Spirogen Sarl | Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation |
WO2015052535A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
WO2015052532A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
GB201317981D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
WO2015052534A1 (en) | 2013-10-11 | 2015-04-16 | Spirogen Sàrl | Pyrrolobenzodiazepine-antibody conjugates |
GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
CA2968447A1 (en) | 2014-11-25 | 2016-06-02 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates and their use to treat neoplasms |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
AU2018217926B2 (en) | 2017-02-08 | 2019-10-03 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
JP2020517609A (en) | 2017-04-18 | 2020-06-18 | メディミューン リミテッド | Pyrrolobenzodiazepine complex |
EP3612234B1 (en) | 2017-04-20 | 2024-03-13 | ADC Therapeutics SA | Combination therapy with an anti-axl antibody-drug conjugate |
US11318211B2 (en) | 2017-06-14 | 2022-05-03 | Adc Therapeutics Sa | Dosage regimes for the administration of an anti-CD19 ADC |
SI3668874T1 (en) | 2017-08-18 | 2022-04-29 | Medimmune Limited | Pyrrolobenzodiazepine conjugates |
GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
-
1969
- 1969-12-17 IL IL33558A patent/IL33558A/en unknown
- 1969-12-22 FI FI693710A patent/FI46259C/en active
- 1969-12-24 GB GB62863/69A patent/GB1299198A/en not_active Expired
- 1969-12-29 ES ES375013A patent/ES375013A1/en not_active Expired
- 1969-12-30 IE IE1726/69A patent/IE33906B1/en unknown
- 1969-12-30 RO RO62025A patent/RO55813A/ro unknown
Also Published As
Publication number | Publication date |
---|---|
IL33558A (en) | 1973-10-25 |
FI46259B (en) | 1972-10-31 |
GB1299198A (en) | 1972-12-06 |
IE33906L (en) | 1970-06-30 |
IE33906B1 (en) | 1974-12-11 |
FI46259C (en) | 1973-02-12 |
ES375013A1 (en) | 1972-03-01 |
RO55813A (en) | 1974-02-01 |
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