FR2586683B1 - Nouveaux derives de neothramycine, leur procede de preparation et leur application en tant que medicaments - Google Patents

Nouveaux derives de neothramycine, leur procede de preparation et leur application en tant que medicaments

Info

Publication number
FR2586683B1
FR2586683B1 FR8512882A FR8512882A FR2586683B1 FR 2586683 B1 FR2586683 B1 FR 2586683B1 FR 8512882 A FR8512882 A FR 8512882A FR 8512882 A FR8512882 A FR 8512882A FR 2586683 B1 FR2586683 B1 FR 2586683B1
Authority
FR
France
Prior art keywords
neothramycin
medicaments
derivatives
novel
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8512882A
Other languages
English (en)
Other versions
FR2586683A1 (fr
Inventor
Nicole Langlois
Ratremaniaina Z Andriamialisoa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR8512882A priority Critical patent/FR2586683B1/fr
Publication of FR2586683A1 publication Critical patent/FR2586683A1/fr
Application granted granted Critical
Publication of FR2586683B1 publication Critical patent/FR2586683B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
FR8512882A 1985-08-29 1985-08-29 Nouveaux derives de neothramycine, leur procede de preparation et leur application en tant que medicaments Expired FR2586683B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR8512882A FR2586683B1 (fr) 1985-08-29 1985-08-29 Nouveaux derives de neothramycine, leur procede de preparation et leur application en tant que medicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8512882A FR2586683B1 (fr) 1985-08-29 1985-08-29 Nouveaux derives de neothramycine, leur procede de preparation et leur application en tant que medicaments

Publications (2)

Publication Number Publication Date
FR2586683A1 FR2586683A1 (fr) 1987-03-06
FR2586683B1 true FR2586683B1 (fr) 1988-07-01

Family

ID=9322473

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8512882A Expired FR2586683B1 (fr) 1985-08-29 1985-08-29 Nouveaux derives de neothramycine, leur procede de preparation et leur application en tant que medicaments

Country Status (1)

Country Link
FR (1) FR2586683B1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9415117B2 (en) 2012-10-12 2016-08-16 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
GB9818732D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collection of compounds
GB9818731D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Compounds
DK1109812T3 (da) 1998-08-27 2005-09-05 Spirogen Ltd Pyrrolobenzodiazepiner
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
EP2270010B1 (fr) 2004-03-01 2012-01-25 Spirogen Limited Dérivés 11-hydroxy-5h-pyrrolo[2,1-c][1,4]benzodiazépin-5-one en tant que intermédiaires clés pour la préparation de pyrrolobenzodiazépines substitués c2
EP1723152B1 (fr) 2004-03-09 2015-02-11 Spirogen Sàrl Pyrrolobenzodiazépines
GB0813432D0 (en) 2008-07-22 2008-08-27 Spirogen Ltd Pyrrolobenzodiazepines
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
AU2011239522B2 (en) 2010-04-15 2014-10-23 Medimmune Limited Targeted pyrrolobenzodiazapine conjugates
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
AU2011239525B2 (en) 2010-04-15 2015-04-09 Medimmune Limited Pyrrolobenzodiazepines used to treat proliferative diseases
AU2012311505B2 (en) 2011-09-20 2016-09-29 Medimmune Limited Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates
JP6117801B2 (ja) 2011-10-14 2017-04-19 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ ピロロベンゾジアゼピン
KR101891859B1 (ko) 2011-10-14 2018-08-24 메디뮨 리미티드 피롤로벤조디아제핀
US9526798B2 (en) 2011-10-14 2016-12-27 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
AU2012322933B2 (en) 2011-10-14 2017-02-02 Medimmune Limited Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines
EA036202B1 (ru) 2011-10-14 2020-10-14 Сиэтл Дженетикс, Инк. Пирролбензодиазепины и конъюгаты направленного действия
AU2013328625B2 (en) 2012-10-12 2016-12-15 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
AU2013328673B2 (en) 2012-10-12 2017-07-13 Medimmune Limited Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
SI2906253T1 (sl) 2012-10-12 2018-11-30 Adc Therapeutics Sa Konjugati pirolobenzodiazepin-protitelo proti PSMA
HUE045435T2 (hu) 2012-10-12 2019-12-30 Medimmune Ltd Pirrolobenzodiazepinek és konjugátumaik
HUE042731T2 (hu) 2012-10-12 2019-07-29 Adc Therapeutics Sa Pirrolobenzodiazepin-antitest konjugátumok
ES2680153T3 (es) 2012-10-12 2018-09-04 Adc Therapeutics Sa Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas
WO2014057120A1 (fr) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Conjugués anticorps - pyrrolobenzodiazépine
BR112015008238A2 (pt) 2012-10-12 2017-11-28 Adc Therapeutics Sarl conjugados de pirrolbenzodiazepina-anticorpo anti-cd22
US9956299B2 (en) 2013-10-11 2018-05-01 Medimmune Limited Pyrrolobenzodiazepine—antibody conjugates
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
WO2015052534A1 (fr) 2013-10-11 2015-04-16 Spirogen Sàrl Conjugués anticorps-pyrrolobenzodiazépine
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
EP3054983B1 (fr) 2013-10-11 2019-03-20 Medimmune Limited Conjugués anticorps-pyrrolobenzodiazépines
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
CN107148285B (zh) 2014-11-25 2022-01-04 Adc治疗股份有限公司 吡咯并苯并二氮杂䓬-抗体缀合物
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
JP6671555B2 (ja) 2017-02-08 2020-03-25 アーデーセー セラピューティクス ソシエテ アノニム ピロロベンゾジアゼピン抗体複合体
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
AU2018255876B2 (en) 2017-04-18 2020-04-30 Medimmune Limited Pyrrolobenzodiazepine conjugates
AU2018253948A1 (en) 2017-04-20 2019-09-19 Adc Therapeutics Sa Combination therapy with an anti-AXL Antibody-Drug Conjugate
MX2019015042A (es) 2017-06-14 2020-08-06 Adc Therapeutics Sa Regimen de dosificacion.
KR102270107B1 (ko) 2017-08-18 2021-06-30 메디뮨 리미티드 피롤로벤조디아제핀 컨쥬게이트
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4932556A (fr) * 1972-07-22 1974-03-25
JPS5247992A (en) * 1975-10-15 1977-04-16 Microbial Chem Res Found Method of manufacturing new antibiotics, neothramycin a and b
JPS585916B2 (ja) * 1977-12-27 1983-02-02 株式会社ミドリ十字 新規ベンゾジアゼピン系化合物
JPS5841878A (ja) * 1981-09-07 1983-03-11 Fujisawa Pharmaceut Co Ltd ベンゾジアゼピン誘導体、その製法およびそれを有効成分として含有する抗がん剤
JPS58180487A (ja) * 1982-04-16 1983-10-21 Kyowa Hakko Kogyo Co Ltd 抗生物質ｄｃ−８１およびその製造法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9415117B2 (en) 2012-10-12 2016-08-16 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof

Also Published As

Publication number Publication date
FR2586683A1 (fr) 1987-03-06

Similar Documents

Publication Publication Date Title
FR2586683B1 (fr) Nouveaux derives de neothramycine, leur procede de preparation et leur application en tant que medicaments
BE892270A (fr) Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
FR2337718A1 (fr) Nouveaux hydroxy-benzodiheterocycles etherifies, leur procede de preparation et leur application en tant que medicaments
FR2531083B1 (fr) Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
FR2578540B1 (fr) Nouveaux derives de pyridylmethoxy- et -methylmercaptoanilines, utilses notamment comme antiasthmatiques, leur fabrication et medicaments les contenant
FR2582309B1 (fr) Nouveaux derives du morphinane et de la morphine, leur preparation, leur application comme medicaments et les compositions pharmaceutiques les contenant
FR2560195B1 (fr) Derives d'alanyl-proline, leur procede de preparation et leurs applications pharmaceutiques
MA20660A1 (fr) Derives de nitrofuranne, leur preparation et leur application
FR2499081B1 (fr) Derives de 7-oxo-1-azabicyclo (3-2-0) hept-2-ene, leur preparation et leur application en tant que medicaments
BE884620A (fr) Nouveaux derives d'halovincamone, leur procede de preparation et medicaments les contenant
FR2582835B1 (fr) Derives de la quinoleine, leur procede de preparation et compositions pharmaceutiques les contenant
FR2573077B1 (fr) Nouveaux derives thiosulfonates, leur procede de preparation ainsi que les compositions pharmaceutiques les contenant
FR2596759B1 (fr) Nouveaux derives du chromane et du thiochromane, leur procede de preparation et compositions medicamenteuse et cosmetique les contenant
FR2595697B1 (fr) Derives de benzyl-pyrimidine, leur procede de preparation ainsi que les compositions en contenant
FR2341584A1 (fr) Nouveaux derives de thienothiazine, leur procede de preparation et leur application en tant que medicaments
BE882675A (fr) Nouveaux derives de la benzo-as-triazine, leur procede de preparation et medicaments les contenant
FR2325381A1 (fr) Nouveaux derives de la dibenzo(b, e)(1,4)diazepine, leur preparation et leur application comme medicaments
BE882535A (fr) Nouveaux derives de la phenothiazine et leur procede de preparation, et medicaments contenant lesdits derives
FR2617481B1 (fr) Nouveaux derives de la tetrahydropyridine, leur procede de preparation et les intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2617164B1 (fr) Nouveaux derives de la decahydroquinoleine, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2584072B1 (fr) Nouveaux derives d'isoquinoleine, leur procede de preparation, leur application en therapeutique et produits intermediaires
FR2330391A1 (fr) Nouveaux derives d'imidazole, leur application en tant que medicaments et leur procede de preparation
MA20725A1 (fr) Nouveaux benzamides, leur procede de preparation et leur application
FR2508040B1 (fr) Derives de proline, leur procede de preparation et medicament les contenant
FR2582650B1 (fr) Nouveaux derives de morphine, leur preparation et leur application en tant que medicaments

Legal Events

Date Code Title Description
ER Errata listed in the french official journal (bopi)

Free format text: 10/87

ST Notification of lapse